Disrupting the PCSK9/LDLR protein–protein interaction by an imidazole-based minimalist peptidomimetic

Lupin Peptides Modulate the Protein-Protein Interaction of PCSK9 with the Low Density Lipoprotein Receptor in HepG2 Cells

(2016) Carmen Lammi et al.   Scientific Reports

β-Strand Mimetic Foldamers Rigidified through Dipolar Repulsion

(2015) Elizabeth A. German et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Modular Synthesis of Conformationally Preorganised Extended β-Strand Peptidomimetics

(2015) Tohru Yamashita et al.   CHEMISTRY-A EUROPEAN JOURNAL

Proprotein Convertase Subtilisin/Kexin Type 9 Inhibition

(2015) Nathalie Bergeron et al.   CIRCULATION

Reducing LDL with PCSK9 Inhibitors — The Clinical Benefit of Lipid Drugs

(2015) Brendan M. Everett et al.   NEW ENGLAND JOURNAL OF MEDICINE

Application of the Ugi reaction with multiple amino acid-derived components: synthesis and conformational evaluation of piperazine-based minimalist peptidomimetics

(2015) Mattia Stucchi et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Constraining Cyclic Peptides To Mimic Protein Structure Motifs

(2014) Timothy A. Hill et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Drug-Like ProteinProtein Interaction Modulators: Challenges and Opportunities for Drug Discovery and Chemical Biology

(2014) Bruno O. Villoutreix et al.   Molecular Informatics

Identification of a Small Peptide That Inhibits PCSK9 Protein Binding to the Low Density Lipoprotein Receptor

(2013) Yingnan Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of α-helix-mediated protein–protein interactions using designed molecules

(2013) Valeria Azzarito et al.   Nature Chemistry

Synthesis and fungicidal activity of tubulin polymerisation promoters. Part 3: Imidazoles

(2012) Clemens Lamberth et al.   BIOORGANIC & MEDICINAL CHEMISTRY

A 1,3-phenyl-linked hydantoin oligomer scaffold as a β-strand mimetic

(2012) Andrew G. Jamieson et al.   CHEMICAL COMMUNICATIONS

Aryl-linked imidazolidin-2-ones as non-peptidic β-strand mimetics

(2012) Charlotte L. Sutherell et al.   CHEMICAL COMMUNICATIONS

The biology and therapeutic targeting of the proprotein convertases

(2012) Nabil G. Seidah et al.   NATURE REVIEWS DRUG DISCOVERY

Substituted Imidazo[1,2-a]pyridines as β-Strand Peptidomimetics

(2012) Chang Won Kang et al.   ORGANIC LETTERS

Minimalist and universal peptidomimetics

(2011) Eunhwa Ko et al.   CHEMICAL SOCIETY REVIEWS

Mechanistic implications for LDL receptor degradation from the PCSK9/LDLR structure at neutral pH

(2011) Paola Lo Surdo et al.   EMBO REPORTS

Pyrrolinone–Pyrrolidine Oligomers as Universal Peptidomimetics

(2011) Arjun Raghuraman et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Evaluation of Diverse α/β-Backbone Patterns for Functional α-Helix Mimicry: Analogues of the Bim BH3 Domain

(2011) Melissa D. Boersma et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Pyrrolinone-Based Peptidomimetics. “Let the Enzyme or Receptor be the Judge”

(2010) Amos B. Smith et al.   ACCOUNTS OF CHEMICAL RESEARCH

1,5-Diarylimidazoles with strong inhibitory activity against COX-2 catalyzed PGE2 production from LPS-induced RAW 264.7 cells

(2010) Haiyan Che et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Update 1 of: Beta-Strand Mimetics

(2010) Wendy A. Loughlin et al.   CHEMICAL REVIEWS

Disrupting protein–protein interactions with non-peptidic, small molecule α-helix mimetics

(2010) Christopher G Cummings et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Protein-Protein Interactions and Cancer: Targeting the Central Dogma

(2010) Amanda L. Garner et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Universal Peptidomimetics

(2010) Eunhwa Ko et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthetic mimetics of protein secondary structure domains

(2010) N. T. Ross et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES

Downsizing human, bacterial, and viral proteins to short water-stable alpha helices that maintain biological potency

(2010) R. S. Harrison et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amphipathic β-Strand Mimics as Potential Membrane Disruptive Antibiotics

(2009) Jessica L. Watson et al.   JOURNAL OF ORGANIC CHEMISTRY

Alkyne-Linked 2,2-Disubstituted-indolin-3-one Oligomers as Extended β-Strand Mimetics

(2009) Pauline N. Wyrembak et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY