C–H activation enables a rapid structure–activity relationship study of arylcyclopropyl amines for potent and selective LSD1 inhibitors

Discovery of a Novel Inhibitor of Histone Lysine-Specific Demethylase 1A (KDM1A/LSD1) as Orally Active Antitumor Agent

(2016) Paola Vianello et al.   JOURNAL OF MEDICINAL CHEMISTRY

Medicinal chemistry insights in the discovery of novel LSD1 inhibitors

(2015) Xueshun Wang et al.   Epigenomics

Stereodivergent Synthesis of Arylcyclopropylamines by Sequential CH Borylation and Suzuki-Miyaura Coupling

(2014) Shin Miyamura et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Lysine-Specific Demethylase 1-Selective Inactivators: Protein-Targeted Drug Delivery Mechanism

(2013) Daisuke Ogasawara et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Novel Selective LSD1/KDM1A Inhibitor Epigenetically Blocks Herpes Simplex Virus Lytic Replication and Reactivation from Latency

(2013) Y. Liang et al.   mBio

An Overview of Phenylcyclopropylamine Derivatives: Biochemical and Biological Significance and Recent Developments

(2012) Mohammed Naseer Ahmed Khan et al.   MEDICINAL RESEARCH REVIEWS

Over-Expression of LSD1 Promotes Proliferation, Migration and Invasion in Non-Small Cell Lung Cancer

(2012) Tangfeng Lv et al.   PLoS One

Brain-Penetrant LSD1 Inhibitors Can Block Memory Consolidation

(2011) Ramesh Neelamegam et al.   ACS Chemical Neuroscience

Enantioselective synthesis of tranylcypromine analogues as lysine demethylase (LSD1) inhibitors

(2011) Hanae Benelkebir et al.   BIOORGANIC & MEDICINAL CHEMISTRY

LSD1 regulates the balance between self-renewal and differentiation in human embryonic stem cells

(2011) Antonio Adamo et al.   NATURE CELL BIOLOGY

Structurally Designedtrans-2-Phenylcyclopropylamine Derivatives Potently Inhibit Histone Demethylase LSD1/KDM1,,§

(2010) Shinya Mimasu et al.   BIOCHEMISTRY

Synthesis and biological activity of optically active NCL-1, a lysine-specific demethylase 1 selective inhibitor

(2010) Daisuke Ogasawara et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Overexpression of LSD1 contributes to human carcinogenesis through chromatin regulation in various cancers

(2010) Shinya Hayami et al.   INTERNATIONAL JOURNAL OF CANCER

Lysine-Specific Demethylase 1 Regulates the Embryonic Transcriptome and CoREST Stability

(2010) C. T. Foster et al.   MOLECULAR AND CELLULAR BIOLOGY

Identification of Cell-Active Lysine Specific Demethylase 1-Selective Inhibitors

(2009) Rie Ueda et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Facile synthesis of substituted trans-2-arylcyclopropylamine inhibitors of the human histone demethylase LSD1 and monoamine oxidases A and B

(2008) David M. Gooden et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS