One-pot N-glycosylation remodeling of IgG with non-natural sialylglycopeptides enables glycosite-specific and dual-payload antibody–drug conjugates

Optimal Synthetic Glycosylation of a Therapeutic Antibody

(2016) Thomas B. Parsons et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

One-Step Conjugation Method for Site-Specific Antibody–Drug Conjugates through Reactive Cysteine-Engineered Antibodies

(2016) Daisuke Shinmi et al.   BIOCONJUGATE CHEMISTRY

Development of Solid-Phase Site-Specific Conjugation and Its Application toward Generation of Dual Labeled Antibody and Fab Drug Conjugates

(2016) Sujiet Puthenveetil et al.   BIOCONJUGATE CHEMISTRY

Harnessing Fc receptor biology in the design of therapeutic antibodies

(2016) Peter Sondermann et al.   CURRENT OPINION IN IMMUNOLOGY

Host-directed therapies for infectious diseases: current status, recent progress, and future prospects

(2016) Alimuddin Zumla et al.   LANCET INFECTIOUS DISEASES

Construction of homogeneous antibody–drug conjugates using site-selective protein chemistry

(2016) Padma Akkapeddi et al.   Chemical Science

Advances in the Development of Site-Specific Antibody-Drug Conjugation

(2015) Qun Zhou et al.   Anti-Cancer Agents in Medicinal Chemistry

Chemoenzymatic Conjugation of Toxic Payloads to the Globally Conserved N-Glycan of Native mAbs Provides Homogeneous and Highly Efficacious Antibody–Drug Conjugates

(2015) Remon van Geel et al.   BIOCONJUGATE CHEMISTRY

Site-Specific Dual Antibody Conjugation via Engineered Cysteine and Selenocysteine Residues

(2015) Xiuling Li et al.   BIOCONJUGATE CHEMISTRY

An emerging playbook for antibody–drug conjugates: lessons from the laboratory and clinic suggest a strategy for improving efficacy and safety

(2015) Penelope M Drake et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Fc receptor inside-out signaling and possible impact on antibody therapy

(2015) Arianne M. Brandsma et al.   IMMUNOLOGICAL REVIEWS

Antibody Glycosylation and Its Impact on the Pharmacokinetics and Pharmacodynamics of Monoclonal Antibodies and Fc-Fusion Proteins

(2015) Liming Liu   JOURNAL OF PHARMACEUTICAL SCIENCES

Current ADC Linker Chemistry

(2015) Nareshkumar Jain et al.   PHARMACEUTICAL RESEARCH

A common glycan structure on immunoglobulin G for enhancement of effector functions

(2015) Chin-Wei Lin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fc-Receptor Interactions Regulate Both Cytotoxic and Immunomodulatory Therapeutic Antibody Effector Functions

(2015) D. J. DiLillo et al.   Cancer Immunology Research

Control of Cytokine Production by Human Fc Gamma Receptors: Implications for Pathogen Defense and Autoimmunity

(2015) Lisa T. C. Vogelpoel et al.   Frontiers in Immunology

Preparation of Well-Defined Antibody-Drug Conjugates through Glycan Remodeling and Strain-Promoted Azide-Alkyne Cycloadditions

(2014) Xiuru Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Production of Site-Specific Antibody–Drug Conjugates Using Optimized Non-Natural Amino Acids in a Cell-Free Expression System

(2014) Erik S. Zimmerman et al.   BIOCONJUGATE CHEMISTRY

Site-Specific Antibody–Drug Conjugation through Glycoengineering

(2014) Qun Zhou et al.   BIOCONJUGATE CHEMISTRY

A simplified procedure for gram-scale production of sialylglycopeptide (SGP) from egg yolks and subsequent semi-synthesis of Man3GlcNAc oxazoline

(2014) Bingyang Sun et al.   CARBOHYDRATE RESEARCH

The Expanding Role of Therapeutic Antibodies

(2014) Simonetta Salemi et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Site-specific antibody-drug conjugation through an engineered glycotransferase and a chemically reactive sugar

(2014) Zhongyu Zhu et al.   mAbs

Type I and type II Fc receptors regulate innate and adaptive immunity

(2014) Andrew Pincetic et al.   NATURE IMMUNOLOGY

A general approach to site-specific antibody drug conjugates

(2014) Feng Tian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enzyme-Mediated Methodology for the Site-Specific Radiolabeling of Antibodies Based on Catalyst-Free Click Chemistry

(2013) Brian M. Zeglis et al.   BIOCONJUGATE CHEMISTRY

Methods for site-specific drug conjugation to antibodies

(2013) Christopher R Behrens et al.   mAbs

Novel roles for the IgG Fc glycan

(2012) Robert M. Anthony et al.   Annals of the New York Academy of Sciences

An Endoglycosidase with Alternative Glycan Specificity Allows Broadened Glycoprotein Remodelling

(2012) Jonathan J. Goodfellow et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Chemoenzymatic Glycoengineering of Intact IgG Antibodies for Gain of Functions

(2012) Wei Huang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Lepidopteran cells, an alternative for the production of recombinant antibodies?

(2012) Martine Cérutti et al.   mAbs

Marketing approval of mogamulizumab

(2012) Alain Beck et al.   mAbs

Increased serum clearance of oligomannose species present on a human IgG1 molecule

(2012) Leslie Alessandri et al.   mAbs

Synthesis of site-specific antibody-drug conjugates using unnatural amino acids

(2012) J. Y. Axup et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Increasing the Efficacy of Bioorthogonal Click Reactions for Bioconjugation: A Comparative Study

(2011) Christen Besanceney-Webler et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Modulation of antibody galactosylation through feeding of uridine, manganese chloride, and galactose

(2011) Michael J. Gramer et al.   BIOTECHNOLOGY AND BIOENGINEERING

High-mannose glycans on the Fc region of therapeutic IgG antibodies increase serum clearance in humans

(2011) A. M. Goetze et al.   GLYCOBIOLOGY

What's fueling the biotech engine—2010 to 2011

(2011) Saurabh Aggarwal   NATURE BIOTECHNOLOGY

Unique carbohydrate-carbohydrate interactions are required for high affinity binding between Fc RIII and antibodies lacking core fucose

(2011) C. Ferrara et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Arthrobacter Endo-β-N-Acetylglucosaminidase Shows Transglycosylation Activity on Complex-Type N-Glycan Oxazolines: One-Pot Conversion of Ribonuclease B to Sialylated Ribonuclease C

(2010) Wei Huang et al.   CHEMBIOCHEM

The role of differential IgG glycosylation in the interaction of antibodies with FcγRs in vivo

(2010) Robert M Anthony et al.   Current Opinion in Organ Transplantation

Production of therapeutic antibodies with controlled fucosylation

(2010) Naoko Yamane-Ohnuki et al.   mAbs

Site Specific Conjugation of Fluoroprobes to the Remodeled Fc N-Glycans of Monoclonal Antibodies Using Mutant Glycosyltransferases: Application for Cell Surface Antigen Detection

(2009) Elizabeth Boeggeman et al.   BIOCONJUGATE CHEMISTRY

GlycoFi's technology to control the glycosylation of recombinant therapeutic proteins

(2009) Alain Beck et al.   Expert Opinion on Drug Discovery

Efficient Synthesis of Sugar Oxazolines from UnprotectedN-Acetyl-2-amino Sugars by Using Chloroformamidinium Reagent in Water

(2009) Masato Noguchi et al.   JOURNAL OF ORGANIC CHEMISTRY

Glycosynthases Enable a Highly Efficient Chemoenzymatic Synthesis ofN-Glycoproteins Carrying Intact NaturalN-Glycans

(2009) Wei Huang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Visualizing Metabolically Labeled Glycoconjugates of Living Cells by Copper-Free and Fast Huisgen Cycloadditions

(2008) Xinghai Ning et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Antibody-Drug Conjugates for Cancer Therapy

(2008) Paul J. Carter et al.   CANCER JOURNAL

Introducing N-glycans into natural products through a chemoenzymatic approach

(2008) Wei Huang et al.   CARBOHYDRATE RESEARCH

Endohexosaminidase-Catalysed Glycosylation with Oxazoline Donors: Fine Tuning of Catalytic Efficiency and Reversibility

(2008) Thomas W. D. F. Rising et al.   CHEMISTRY-A EUROPEAN JOURNAL

Terminal sugars of Fc glycans influence antibody effector functions of IgGs

(2008) T Shantha Raju   CURRENT OPINION IN IMMUNOLOGY

Screening a limited structure-based library identifies UDP-GalNAc-specific mutants of  -1,3-galactosyltransferase

(2008) P. Tumbale et al.   GLYCOBIOLOGY

Expeditious Chemoenzymatic Synthesis of Homogeneous N-Glycoproteins Carrying Defined Oligosaccharide Ligands

(2008) Hirofumi Ochiai et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Identification of a receptor required for the anti-inflammatory activity of IVIG

(2008) R. M. Anthony et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recapitulation of IVIG Anti-Inflammatory Activity with a Recombinant IgG Fc

(2008) R. M. Anthony et al.   SCIENCE