Article
Environmental Sciences
Bharath Kumar Velmurugan, Jen-Tsun Lin, B. Mahalakshmi, Chia-Chieh Lin, Yi-Ching Chuang, Yu-Sheng Lo, Hsin-Yu Ho, Ming-Ju Hsieh, Mu-Kuan Chen
Summary: This study demonstrates that dehydrocrenatidine treatment significantly reduces the motility, migration, and invasion of head and neck cancer cells, decreases MMP-2 expression, and inhibits cell migration by reducing the phosphorylation of ERK1/2 and JNK1/2. Combined treatment with inhibitors enhances the anti-metastatic effects of dehydrocrenatidine.
ENVIRONMENTAL TOXICOLOGY
(2021)
Article
Oncology
Guowei Gong, Kumar Ganesan, Qingping Xiong, Yuzhong Zheng
Summary: Osteosarcoma is a common malignant bone tumor with high metastatic properties and no effective treatment. In this study, the efficacy of ononin on osteosarcoma cell migration, invasion, and the underlying mechanisms was investigated. The dose-dependent treatment of ononin increased apoptosis and inhibited cell proliferation in MG-63 and U2OS osteosarcoma cell lines through the EGFR-Erk1/2 signaling pathways. The in vivo anti-tumorigenic and anti-migratory efficacy of ononin was confirmed using the MG-63-xenograft mice model. These findings suggest that ononin could be a potentially effective agent against osteosarcoma metastasis.
Article
Physics, Multidisciplinary
Lubiao Liang, Chen Cheng, Yongxiang Song, Gang Xu, Yajin Zhao
Summary: Cell clusters, through cell-cell connectivity and the cell-interstitial microenvironment, play a significant role in the malignant progression of tumors. This study identified that the proliferation rate of posterior cells is higher than that of anterior cells, and closely related to the activation of the Ras-ERK1/2-YAP axis. The study also highlighted the importance of cytoskeleton and the role of myosin in cell proliferation and the nuclear entry activation of ERK1/2-YAP.
EUROPEAN PHYSICAL JOURNAL-SPECIAL TOPICS
(2023)
Article
Biochemistry & Molecular Biology
Junichi Sato, Koya Nakano, Hiroaki Miyazaki
Summary: This study found that changes in intracellular chloride ion concentration affect cell migration and invasion in cancer cells. Culturing cells in a low chloride ion medium enhances cell migration and invasion, and leads to transient activation of the ERK1/2 signaling pathway and increased levels of MMP-1 mRNA. Inhibition of ERK1/2 activation reduces the enhancement of MMP-1 mRNA levels and decreases cell migration and invasion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Cell Biology
Hong-Yan Chen, Zhao-Yu Zhou, Yan-Lu Luo, Qin Luo, Jiang-Tao Fan
Summary: In endometrial cancer, inhibition of YKL-40 with siYKL-40 effectively suppresses angiogenesis and reduces microvessel density through the VEGF/VEGFR2 and ERK1/2 signaling pathways, leading to inhibition of tumor growth.
CELL BIOLOGY INTERNATIONAL
(2021)
Article
Oncology
Adjabhak Wongviriya, Richard M. Shelton, Paul R. Cooper, Michael R. Milward, Gabriel Landini
Summary: This study aimed to determine the involvement of S1PR2 in EGF-induced migration and invasion of OSCC lines, as well as any potential crosstalk between the two pathways. The results demonstrated that S1PR2 inhibition reduced EGF-induced migration, invasion, and Rac1 activity. However, S1PR2 activation did not enhance the effect of EGF on migration, invasion, or Rac1 activity. Additionally, EGF promoted S1P production through the upregulation of Sphk1.
CANCER CELL INTERNATIONAL
(2023)
Article
Cell Biology
Jinli Ding, Chaogang Yang, Yi Zhang, Jiayu Wang, Sainan Zhang, Duanying Guo, Tailang Yin, Jing Yang
Summary: Macrophages were found to promote epithelial-to-mesenchymal transition (EMT) of trophoblasts, enhancing their migrative and invasive abilities. The key factor G-CSF derived from M2 macrophages was shown to activate the PI3K/Akt/Erk1/2 signaling pathway, promoting EMT, migration, and invasion of trophoblasts. High expression of G-CSF in placental villous tissues of normal pregnancy patients compared to those with recurrent spontaneous abortion suggests its important role in regulating trophoblasts EMT, migration, and invasion.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Plant Sciences
Hoon Kim, Byungdoo Hwang, Seongbin Cho, Woo Jung Kim, Soon Chul Myung, Yung Hyun Choi, Wun-Jae Kim, Sanghyun Lee, Sung-Kwon Moon
Summary: This study investigated the antitumor effect of Cyperus exaltatus var. iwasakii (CE) ethanol extract against prostate cancer. The results showed that CE has a significant inhibitory effect on prostate cancer cell proliferation by regulating the cell cycle, activating signaling pathways, and suppressing migration and invasion. In vivo experiments confirmed the inhibitory effect of CE on tumor growth in a mouse model without adverse effects. These findings suggest that CE may be a potential candidate for the prevention or treatment of prostate cancer.
Article
Genetics & Heredity
Jiacheng Xu, Jie Wang, Miaomiao Chen, Bingdi Chao, Jie He, Yuxiang Bai, Xiaofang Luo, Hongli Liu, Lumei Xie, Yuelan Tao, Hongbo Qi, Xin Luo
Summary: This study found that miR-101-5p was upregulated in preeclampsia (PE) placental tissue and mainly located in different trophoblast cell subtypes. Overexpression of miR-101-5p impaired the migration and invasion abilities of HTR8/SVneo trophoblast cells. DUSP6 was identified as a potential downstream target of miR-101-5p, and its upregulation rescued the migratory and invasive abilities of HTR8/SVneo cells in the presence of miR-101-5p overexpression.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2023)
Article
Immunology
Mohammed E. E. Abo-El Fetoh, Maha M. M. Abdel-Fattah, Wafaa R. R. Mohamed, Laila A. A. Ramadan, Hassan Afify
Summary: This study investigated the modulatory effect of COX-2 inhibition on the ADAM-17/EGFR/ERK1/2 axis. The results showed that COX-2 stimulates the ERK1/2 pathway via PGE2-ADAM-17-catalyzed shedding of TGF-alpha in testosterone-induced BPH, highlighting the functional correlation between inflammation and hyperplasia in BPH.
INFLAMMOPHARMACOLOGY
(2023)
Review
Oncology
Li Zhang, Xingyue Chen, Shun Yao, Liming Zheng, Xingyue Yang, Yongfeng Wang, Xin Li, Enqin Wu, Biguang Tuo
Summary: Chloride, as a major intracellular anion, plays a crucial role in maintaining ion homeostasis, osmotic pressure, and cell volume. Intracellular chloride channel 1 (CLIC1), besides its function as an ion channel, is involved in cell cycle regulation and intracellular oxidation. It has been found that CLIC1 is highly expressed in tumor cells and associated with malignancy and poor prognosis, suggesting its potential role in systemic diseases.
AMERICAN JOURNAL OF CANCER RESEARCH
(2023)
Article
Oncology
Yang Liu, Lin Kang, Shao-Min Shi, Bing-Jie Li, Yang Zhang, Xiu-Zhi Zhang, Xiao-Wan Guo, Gang Fu, Guo-Na Zheng, Han Hao, Huan-Fen Zhao
Summary: The study found that skimmianine (SK) has potential anti-tumor effects on esophageal squamous cell carcinoma (ESCC) by regulating the cell cycle, inhibiting cell migration and invasion, and blocking the ERK1/2 signaling pathway.
Review
Biochemistry & Molecular Biology
Eleonora Sarantelli, Apostolis Mourkakis, Lefteris C. Zacharia, Andreas Stylianou, Vasiliki Gkretsi
Summary: As metastasis is a major cause of cancer-related deaths, understanding the cellular and molecular events involved in cancer cell migration and invasion is crucial for developing novel anti-metastatic therapies. Fascin-1, an actin-bundling protein, plays a fundamental role in cell migration processes. It is significantly elevated in most cancers and its high expression is associated with aggressive disease and poor prognosis. Recent studies show that Fascin-1 is critically involved in metastasis and suggest it as a promising target for anti-metastatic treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Medicinal
Ji Hye Jeong, Jae-Ha Ryu, Hwa Jin Lee
Summary: Several dietary and medicinal herbs have demonstrated efficacy in treating and preventing cancer, with Piper nigrum showing anti-cancer activities. The present study found that Piper nigrum extract inhibited the proliferation of PANC-1 pancreatic cancer cells by causing cell cycle arrest and suppressing cell cycle regulators. Additionally, the major alkaloid piperine in Piper nigrum was identified as the main component contributing to the anti-pancreatic cancer effects by attenuating cell growth, migration, and invasion of cancer cells.
NATURAL PRODUCT COMMUNICATIONS
(2021)
Article
Cell & Tissue Engineering
Huaping Gong, Long Chen, Ruipeng Dong
Summary: Downregulating TRIM14 expression can inhibit the proliferation, invasion, and migration of PANC-1 cells, and promote apoptosis. The mechanism may be associated with the inhibition of AKT signaling pathway activation.
JOURNAL OF BIOMATERIALS AND TISSUE ENGINEERING
(2021)