Article
Medicine, General & Internal
Hailong Hao, Huiqing Chen, Liwu Xie, Hongyu Liu
Summary: The study aimed to investigate the relationship between YKL-40 and recurrence and progression of bladder cancer, and to determine its potential as a therapeutic target. Results showed that YKL-40 promoted migration and invasion of bladder cancer cells, with its expression closely linked to the invasiveness and metastasis of bladder cancer.
ANNALS OF MEDICINE
(2021)
Article
Cell Biology
Camilla Bjornbak Holst, Henriette Pedersen, Elisabeth Anne Adanma Obara, Kristoffer Vitting-Seerup, Kamilla Ellermann Jensen, Jane Skjoth-Rasmussen, Eva Lobner Lund, Hans Skovgaard Poulsen, Julia Sidenius Johansen, Petra Hamerlik
Summary: In the study, the challenges in treating GBM patients were explored, including the frustrations brought by anti-angiogenic agents and immunotherapy, the historical trajectory of bevacizumab as a treatment modality, and the role of dual targeting strategies in therapy. The study emphasizes that pursuing pleiotropic targets and leaning toward multitarget strategies may be key to more effective therapeutic intervention in GBM.
Article
Biochemistry & Molecular Biology
Jakub Rech, Daniel Sypniewski, Dorota Zelaszczyk, Natalia Szkaradek, Wojciech Rogoz, Anna Waszkielewicz, Henryk Marona, Ilona Bednarek
Summary: The study revealed that four novel xanthone derivatives have the potential to inhibit proliferation, motility, and induce apoptosis in colon cancer cells, with comparable activity to cisplatin and 5-fluorouracil. Further research and development of these compounds as novel drugs for colorectal cancer treatment is recommended.
Review
Biotechnology & Applied Microbiology
Rongyan Qin, Ming Liao, Weili Qin, Jiawei Wang, Fengque Zheng, Nana Ma, Yunxiao Zhao, Aiping Qin
Summary: Serum YKL-40 is a potential biomarker for the early diagnosis of endometrial cancer (EC), and its combination with other biomarkers can improve diagnostic accuracy.
Article
Engineering, Biomedical
Philipp Globig, Roshani Madurawala, Regine Willumeit-Roemer, Fernanda Martini, Elisa Mazzoni, Berengere J. C. Luthringer-Feyerabend
Summary: Cancer metastases are the leading cause of cancer-related deaths, and traditional treatment methods often come with side effects. Recent studies have shown that specially designed degradable magnesium alloys can reduce cancer cell proliferation and inhibit different steps of cancer metastasis, including cell migration, invasion, and angiogenesis.
BIOACTIVE MATERIALS
(2023)
Article
Oncology
Zhen Wang, Gentao Fan, Hao Zhu, Lingfeng Yu, Diankun She, Yanting Wei, Jianhao Huang, Tianhang Li, Shoubin Zhan, Shenkai Zhou, Yan Zhu, Yicun Wang, Xi Chen, Jianning Zhao, Guangxin Zhou
Summary: The study found that PLOD2 is highly expressed in osteosarcoma and is associated with poor prognosis in patients. PLOD2 promotes migration, invasion, and angiogenesis of osteosarcoma cells, contributing to metastasis and angiogenesis of osteosarcoma. Additionally, PLOD2 is associated with immune cell infiltration in osteosarcoma.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Shuyun Wang, Limin Nie, Yuxiao Song, Fang Zhang, Xiaozheng Chen, Wenjing Shi, Zijiang Yang, Yuping Sun, Qi Dang, Aiqin Gao
Summary: The study found that NRTN is enriched in colorectal cancer cells and predicts poor patient outcomes. Upregulated NRTN enhances cancer cell motility and angiogenesis, promoting tumor invasion and metastasis.
EXPERIMENTAL CELL RESEARCH
(2022)
Review
Oncology
Bin Wang, Hanfei Guo, Hongquan Yu, Yong Chen, Haiyang Xu, Gang Zhao
Summary: EGR1, a transcription factor, plays a role in tissue injury, immune responses, and fibrosis. Recent studies suggest EGR1's involvement in cancer initiation and progression, potentially affecting tumor cell proliferation, invasion, metastasis, and angiogenesis. The specific mechanisms by which EGR1 modulates these processes are still under investigation.
FRONTIERS IN ONCOLOGY
(2021)
Article
Food Science & Technology
Fan Zhang, Zhi-Jing Ni, Lei Ye, Yuan-Yuan Zhang, Kiran Thakur, Carlos L. Cespedes-Acuna, Jinzhi Han, Jian-Guo Zhang, Zhao-Jun Wei
Summary: The study elucidated the anti-metastasis mechanism of Asparanin A on Ishikawa cells, showing that AA could suppress human EC cell migration and invasion through the Ras/ERK/MAPK pathway based on miRNA-seq and mRNA-seq integrated analyses.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Medicine, General & Internal
Honggui Ma, Liansheng Zhang, Facai Zhang, Fanghao Sun, Jianquan Hou
Summary: The study found that the expression of YKL-40 is significantly increased in prostate cancer, and the expression level of YKL-40 in prostate cancer DU145 and PC3 cell lines is positively correlated with cell migration and invasion abilities.
ACTA MEDICA MEDITERRANEA
(2021)
Article
Oncology
Yen-Yun Wang, Anupama Vadhan, Ching-Hu Wu, Cheng-Yang Hsu, Yu-Chieh Chen, Yuk-Kwan Chen, Pang-Yu Chen, Hieu D. H. Nguyen, Yu-Chiuan Chang, Shyng-Shiou F. Yuan
Summary: This study found that the expression of fumarase hydratase (FH) is significantly lower in endometrial cancer tissues compared to normal tissues, and this decreased expression is associated with increased tumor size and lymph node metastasis. Further analysis showed that knockdown of FH increases cell proliferation, migration, and invasion abilities, while overexpression of FH decreases these abilities.
Article
Nanoscience & Nanotechnology
Muhammad R. Haque, Caitlin R. Wessel, Daniel D. Leary, Chengyao Wang, Abhinav Bhushan, Faraz Bishehsari
Summary: Pancreatic ductal adenocarcinoma (PDAC) is highly heterogeneous, which hampers treatment and clinical trials. Patient-derived organoids (PDOs) have opened the door for personalized medicine. This study developed a tumor-chip device that replicates the PDAC tumor microenvironment and validated its application in drug testing.
MICROSYSTEMS & NANOENGINEERING
(2022)
Article
Oncology
Xiangrong Wang, Tianquan Chen
Summary: The study found that CUL4A was highly expressed in endometrial cancer cells, and knockdown of CUL4A significantly inhibited cell proliferation, invasion, and migration. However, overexpression of CSN6 alleviated the effects of CUL4A knockdown on the cells.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Piotr Ciesielski, Pawel Jozwiak, Ewa Forma, Anna Krzeslak
Summary: The study demonstrated the impact of TET3 and OGT on the expression of EMT genes and histone modifications in endometrial cancer cells, with different effects on FOXC1 expression and migratory potential. Analysis of gene expressions in cancer tissue samples confirmed the association between OGT or TET3 and EMT genes in endometrial cancer patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Yuan You, Patrick Stelzl, Dana N. Joseph, Paulomi B. Aldo, Anthony J. Maxwell, Nava Dekel, Aihua Liao, Shannon Whirledge, Gil Mor
Summary: In this study, a 3D in vitro model was used to investigate the interaction between trophoblasts and human endometrial stroma cells, demonstrating how stromal factors promote trophoblast invasion in an inflammatory environment modulated by TNF-alpha. Additionally, stromal-derived IL-17 was found to play a role in promoting trophoblast migration by inducing essential genes for invasive capacity. These findings provide new insights into the complex process of implantation and highlight the importance of inflammation in embryo implantation.
FRONTIERS IN IMMUNOLOGY
(2021)