Neuroendocrine prostate cancer (NEPCa) increased the neighboring PCa chemoresistance via altering the PTHrP/p38/Hsp27/androgen receptor (AR)/p21 signals

Global cancer statistics, 2012

(2015) Lindsey A. Torre et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Neuroendocrine Transdifferentiation in Human Prostate Cancer Cells: An Integrated Approach

(2015) M. Cerasuolo et al.   CANCER RESEARCH

Androgen deprivation therapy plus docetaxel and estramustine versus androgen deprivation therapy alone for high-risk localised prostate cancer (GETUG 12): a phase 3 randomised controlled trial

(2015) Karim Fizazi et al.   LANCET ONCOLOGY

Anti-androgen enzalutamide enhances prostate cancer neuroendocrine (NE) differentiation via altering the infiltrated mast cells → androgen receptor (AR) → miRNA32 signals

(2015) Qiang Dang et al.   Molecular Oncology

CXCL12/CXCR4 signaling counteracts docetaxel-induced microtubule stabilization via p21-activated kinase 4-dependent activation of LIM domain kinase 1

(2015) Arun Bhardwaj et al.   Oncotarget

Androgen Receptor Splice Variants Determine Taxane Sensitivity in Prostate Cancer

(2014) Maria Thadani-Mulero et al.   CANCER RESEARCH

Suppression of Heat Shock Protein 27 Using OGX-427 Induces Endoplasmic Reticulum Stress and Potentiates Heat Shock Protein 90 Inhibitors to Delay Castrate-resistant Prostate Cancer

(2014) François Lamoureux et al.   EUROPEAN UROLOGY

Epithelial-to-Mesenchymal Transition Mediates Docetaxel Resistance and High Risk of Relapse in Prostate Cancer

(2014) M. Marin-Aguilera et al.   MOLECULAR CANCER THERAPEUTICS

Infiltrating T cells promote prostate cancer metastasis via modulation of FGF11→miRNA-541→androgen receptor (AR)→MMP9 signaling

(2014) Shuai Hu et al.   Molecular Oncology

Parathyroid Hormone Related-Protein Promotes Epithelial-to-Mesenchymal Transition in Prostate Cancer

(2014) Weg M. Ongkeko et al.   PLoS One

The Many Faces of Neuroendocrine Differentiation in Prostate Cancer Progression

(2014) Stéphane Terry et al.   Frontiers in Oncology

Parathyroid Hormone-Related Protein Drives a CD11b+Gr1+ Cell-Mediated Positive Feedback Loop to Support Prostate Cancer Growth

(2013) S. I. Park et al.   CANCER RESEARCH

Inhibition of ABCB1 Expression Overcomes Acquired Docetaxel Resistance in Prostate Cancer

(2013) Y. Zhu et al.   MOLECULAR CANCER THERAPEUTICS

Prostate cancer progression after androgen deprivation therapy: mechanisms of castrate resistance and novel therapeutic approaches

(2013) T Karantanos et al.   ONCOGENE

p38MAPK inhibition: a new combined approach to reduce neuroblastoma resistance under etoposide treatment

(2013) B Marengo et al.   Cell Death & Disease

Suppression of Acquired Docetaxel Resistance in Prostate Cancer through Depletion of Notch- and Hedgehog-Dependent Tumor-Initiating Cells

(2012) Josep Domingo-Domenech et al.   CANCER CELL

Androgen Receptor on the Move: Boarding the Microtubule Expressway to the Nucleus

(2012) M. Thadani-Mulero et al.   CANCER RESEARCH

Galectin-1 Promotes Lung Cancer Progression and Chemoresistance by Upregulating p38 MAPK, ERK, and Cyclooxygenase-2

(2012) L.-Y. Chung et al.   CLINICAL CANCER RESEARCH

Neuroendocrine-derived peptides promote prostate cancer cell survival through activation of IGF-1R signaling

(2012) John O. DaSilva et al.   PROSTATE

Chemoresistance of lung cancer stemlike cells depends on activation of Hsp27

(2010) Han-Shui Hsu et al.   CANCER

Siah2-Dependent Concerted Activity of HIF and FoxA2 Regulates Formation of Neuroendocrine Phenotype and Neuroendocrine Prostate Tumors

(2010) Jianfei Qi et al.   CANCER CELL

ID1 Enhances Docetaxel Cytotoxicity in Prostate Cancer Cells through Inhibition of p21

(2010) H. Geng et al.   CANCER RESEARCH

Heat Shock Protein 27 Is Required for Sex Steroid Receptor Trafficking to and Functioning at the Plasma Membrane

(2010) M. Razandi et al.   MOLECULAR AND CELLULAR BIOLOGY

Comparative Analysis of Metastasis Variants Derived from Human Prostate Carcinoma Cells

(2009) Erin M. Conn et al.   AMERICAN JOURNAL OF PATHOLOGY

The Neuroendocrine-Derived Peptide Parathyroid Hormone-Related Protein Promotes Prostate Cancer Cell Growth by Stabilizing the Androgen Receptor

(2009) J. DaSilva et al.   CANCER RESEARCH

Heat Shock Protein 27 as a New Therapeutic Target for Radiation Sensitization of Head and Neck Squamous Cell Carcinoma

(2009) Elie Hadchity et al.   MOLECULAR THERAPY

Serotonin activates MAP kinase and PI3K/Akt signaling pathways in prostate cancer cell lines

(2009) Nishtman Dizeyi et al.   UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS

The Nuclear Factor- B Pathway Controls the Progression of Prostate Cancer to Androgen-Independent Growth

(2008) R. J. Jin et al.   CANCER RESEARCH

Calcitonin promotes in vivo metastasis of prostate cancer cells by altering cell signaling, adhesion, and inflammatory pathways

(2008) G. V Shah et al.   ENDOCRINE-RELATED CANCER

Insulin-Like Growth Factor II Activates Phosphatidylinositol 3-Kinase-Protooncogenic Protein Kinase 1 and Mitogen-Activated Protein Kinase Cell Signaling Pathways, and Stimulates Migration of Ovine Trophectoderm Cells

(2008) Jinyoung Kim et al.   ENDOCRINOLOGY

Tumor expressed PTHrP facilitates prostate cancer-induced osteoblastic lesions

(2008) Jinhui Liao et al.   INTERNATIONAL JOURNAL OF CANCER

Docetaxel Plus Prednisone or Mitoxantrone Plus Prednisone for Advanced Prostate Cancer: Updated Survival in the TAX 327 Study

(2008) Dominik R. Berthold et al.   JOURNAL OF CLINICAL ONCOLOGY

Androgen receptor is a tumor suppressor and proliferator in prostate cancer

(2008) Y. Niu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PKD, PKD2, and p38 MAPK mediate Hsp27 serine-82 phosphorylation induced by neurotensin in pancreatic cancer PANC-1 cells

(2007) Jingzhen Yuan et al.   JOURNAL OF CELLULAR BIOCHEMISTRY