Characterization of activating mutations of NOTCH3 in T-cell acute lymphoblastic leukemia and anti-leukemic activity of NOTCH3 inhibitory antibodies

PEST Domain Mutations in Notch Receptors Comprise an Oncogenic Driver Segment in Triple-Negative Breast Cancer Sensitive to a  -Secretase Inhibitor

(2015) K. Wang et al.   CLINICAL CANCER RESEARCH

Insights into Autoregulation of Notch3 from Structural and Functional Studies of Its Negative Regulatory Region

(2015) Xiang Xu et al.   STRUCTURE

From Fly Wings to Targeted Cancer Therapies: A Centennial for Notch Signaling

(2014) Panagiotis Ntziachristos et al.   CANCER CELL

Endothelial Notch activity promotes angiogenesis and osteogenesis in bone

(2014) Saravana K. Ramasamy et al.   NATURE

Discovery of Biomarkers Predictive of GSI Response in Triple-Negative Breast Cancer and Adenoid Cystic Carcinoma

(2014) A. Stoeck et al.   Cancer Discovery

Whole exome sequencing of adenoid cystic carcinoma

(2013) Philip J. Stephens et al.   JOURNAL OF CLINICAL INVESTIGATION

Insights into Notch3 Activation and Inhibition Mediated by Antibodies Directed against Its Negative Regulatory Region

(2013) Kittichoat Tiyanont et al.   JOURNAL OF MOLECULAR BIOLOGY

The mutational landscape of adenoid cystic carcinoma

(2013) Allen S Ho et al.   NATURE GENETICS

Gauging NOTCH1 Activation in Cancer Using Immunohistochemistry

(2013) Michael J. Kluk et al.   PLoS One

Targeting the Notch Pathway: Twists and Turns on the Road to Rational Therapeutics

(2012) Jon C. Aster et al.   JOURNAL OF CLINICAL ONCOLOGY

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

(2012) Jordi Barretina et al.   NATURE

The Notch signalling system: recent insights into the complexity of a conserved pathway

(2012) K. G. Guruharsha et al.   NATURE REVIEWS GENETICS

Notch signaling: simplicity in design, versatility in function

(2011) E. R. Andersson et al.   DEVELOPMENT

Notch: Architect, Landscaper, and Guardian of the Intestine

(2011) Marc Vooijs et al.   GASTROENTEROLOGY

HuCAL PLATINUM, a Synthetic Fab Library Optimized for Sequence Diversity and Superior Performance in Mammalian Expression Systems

(2011) Josef Prassler et al.   JOURNAL OF MOLECULAR BIOLOGY

Integrated genomic analyses of ovarian carcinoma

(2011) D. Bell et al.   NATURE

Functionally recurrent rearrangements of the MAST kinase and Notch gene families in breast cancer

(2011) Dan R Robinson et al.   NATURE MEDICINE

Therapeutic antibody targeting of individual Notch receptors

(2010) Yan Wu et al.   NATURE

Characterization of Notch1 Antibodies That Inhibit Signaling of Both Normal and Mutated Notch1 Receptors

(2010) Miguel Aste-Amézaga et al.   PLoS One

The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism

(2009) Raphael Kopan et al.   CELL

Integrated Genome-Wide DNA Copy Number and Expression Analysis Identifies Distinct Mechanisms of Primary Chemoresistance in Ovarian Carcinomas

(2009) D. Etemadmoghadam et al.   CLINICAL CANCER RESEARCH

Microdroplet-based PCR enrichment for large-scale targeted sequencing

(2009) Ryan Tewhey et al.   NATURE BIOTECHNOLOGY

Effects of S1 Cleavage on the Structure, Surface Export, and Signaling Activity of Human Notch1 and Notch2

(2009) Wendy R. Gordon et al.   PLoS One

Structure of the Notch1-negative regulatory region: implications for normal activation and pathogenic signaling in T-ALL

(2008) W. R. Gordon et al.   BLOOD

NOTCH3 Signaling Pathway Plays Crucial Roles in the Proliferation of ErbB2-Negative Human Breast Cancer Cells

(2008) N. Yamaguchi et al.   CANCER RESEARCH

Modulation of Notch Signaling by Antibodies Specific for the Extracellular Negative Regulatory Region of NOTCH3

(2008) Kang Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Leukemia-associated NOTCH1 alleles are weak tumor initiators but accelerate K-ras–initiated leukemia

(2008) Mark Y. Chiang et al.   JOURNAL OF CLINICAL INVESTIGATION

RNA-Seq: a revolutionary tool for transcriptomics

(2008) Zhong Wang et al.   NATURE REVIEWS GENETICS