Review
Ophthalmology
Alireza Shoari, Mozhgan Rezaei Kanavi, Mohammad Javad Rasaee
Summary: Dry eye syndrome (DES) is a multifactorial condition that affects the glands and surface of the eye, with uncontrolled activity of MMP-9 leading to epithelial desquamation. Inhibition of MMP-9 has been proposed as a therapeutic target for DES, with novel pharmaceutical compounds designed to improve symptoms and restore tear production.
EXPERIMENTAL EYE RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Ya-Tang Chiang, Yu-Bai Xiao, Shan-hui Hsu, Shu-Wei Chang, Chia-Ching Chou
Summary: Tannic acid (TA) has antibacterial, antioxidant, and anti-inflammatory properties and acts as an adhesive, hemostatic, and crosslinking agent in hydrogels. TA has been reported to inhibit MMP-2/- 9 activities, thereby improving tissue remodeling and wound healing. In this study, atomistic modeling was used to explore the mechanisms and structures of TA binding with MMP-2 and MMP-9, revealing the specific binding regions and molecular interactions involved. Understanding the binding mechanism and dynamics of TA with these MMPs provides crucial knowledge on the effects of TA on MMPs.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
Review
Biochemistry & Molecular Biology
Shinji Takai, Denan Jin
Summary: Chymase-activated MMP-9 is closely related to the pathogenesis of various diseases, especially inflammation-related diseases. Upregulated chymase and MMP-9 have been observed in tissues from patients and animal models of these diseases. Chymase inhibitors attenuate MMP-9 formation and reduce inflammatory cell numbers, thereby ameliorating the development and progression of these disorders.
Review
Biochemistry & Molecular Biology
Zainab Ahmed Rashid, Sanaa K. Bardaweel
Summary: Matrix metalloproteinases (MMPs), especially MMP-9, play a significant role in cancer pathogenesis and progression. However, no effective MMP-9 inhibitor has been approved by the FDA. This review focuses on exploring the strategies for designing MMP-9 inhibitors and their anticancer effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Ionut Luchian, Mihaela Moscalu, Ancuta Goriuc, Ludovica Nucci, Monica Tatarciuc, Ioana Martu, Mihai Covasa
Summary: Periodontitis results in destructive effects on periodontium, with increased levels of MMP-9. Periodontal treatment alone or combined with orthodontic treatment can improve clinical parameters and lower MMP-9 levels. The degree of malocclusion affects the treatment's impact on MMP-9 levels.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Ophthalmology
Alireza Shoari, Mohammad Javad Rasaee, Mozhgan Rezaei Kanavi, Sasha Afsar Aski, Raheleh Tooyserkani
Summary: The study demonstrated that RSH-12 has a therapeutic effect in rabbit models of dry eye syndrome, significantly improving tear volume and ocular stability while reducing the occurrence of superficial punctate keratopathy.
CURRENT EYE RESEARCH
(2021)
Review
Chemistry, Medicinal
Sanjib Das, Sk Abdul Amin, Tarun Jha
Summary: Matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) play significant roles in solid tumor invasion, metastasis, and angiogenesis, while their role in hematological malignancies is less understood. Recent studies have shown correlations between gelatinases and hematological malignancies, leading to the development of potential inhibitors for these conditions.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
M. Elizabeth Fini, Shinwu Jeong, Mark R. Wilson
Summary: Evidence supports the potential of the glycoprotein CLU as a novel therapeutic for dry eye, protecting and repairing the ocular surface while dampening the autoimmune response. Future work will focus on human clinical trials to further investigate the therapeutic promise of CLU.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Ophthalmology
Matias Soifer, Hazem M. Mousa, Sandra S. Stinnett, Anat Galor, Victor L. Perez
Summary: The study revealed that eyes with detectable MMP-9 had decreased tear production over time compared to those without detectable MMP-9. Anti-inflammatory treatment more frequently normalized MMP-9 compared to PFATs.
Article
Biochemistry & Molecular Biology
Yihe Wang, Christine Y. Chuang, Clare L. Hawkins, Michael J. Davies
Summary: Matrix metalloproteinase-9 (MMP9) plays a crucial role in the degradation of extracellular matrix (ECM) proteins. This study demonstrates that MMP9 can be activated by both chloramines and oxidation. The activation of MMP9 and ECM degradation are interdependent processes that may contribute to the progression of diseases.
Review
Biochemistry & Molecular Biology
Zhenshengnan Li, Jia Wei, Bowen Chen, Yaoqi Wang, Shuai Yang, Kehui Wu, Xianying Meng
Summary: Matrix metalloproteinase-9 (MMP-9) is a zinc-dependent proteolytic metalloenzyme that degrades the extracellular matrix (ECM) and has been proven to be elevated in various pathological conditions, including thyroid carcinoma. Its expression level in malignant or metastatic thyroid tumor tissues is higher than in normal or benign tissues, and it correlates closely with clinical features such as lymph node metastasis, TNM stage, and tumor size.
Article
Surgery
Jing Shen, Jian-bo Song, Jun Fan, Zhe Zhang, Zheng-jia Yi, Shuo Bai, Xiao-lin Mu, Yao-bo Yang, Liang Xiao
Summary: This study simulated the process of neointima generation and regression after stent implantation, demonstrating the spatial distribution and dynamic changes of MMP-2, MMP-9, and collagen in ISR. The expression of MMP-2 and MMP-9 decreased and collagen content reached its maximum when ISR occurred, suggesting their potential contribution to ISR.
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2021)
Article
Clinical Neurology
Giuseppe Cosentino, Vincenzo Di Stefano, Rosalia Lo Presti, Maria Montana, Massimiliano Todisco, Matteo Gastaldi, Andrea Cortese, Enrico Alfonsi, Cristina Tassorelli, Brigida Fierro, Gregorio Caimi, Filippo Brighina
Summary: This study found that the plasmatic levels of MMPs and TIMPs were significantly altered in patients with CIDP, with higher concentrations of MMP-9, downregulation of TIMP-1, and lower concentration of MMP-2. These new biomarkers may have potential usefulness in the clinical setting and further studies are needed to confirm their utility.
NEUROLOGICAL SCIENCES
(2021)
Review
Ophthalmology
Robert O. Baratta, Eric Schlumpf, Brian J. Del Buono, Shawn DeLorey, David J. Calkins
Summary: Dry eye disease is a major cause of ocular discomfort, inflammation, and dysfunction worldwide. The instability of the tear film in DED leads to disruption of the corneal epithelium, triggering a vicious cycle of inflammation at the corneal surface.
SURVEY OF OPHTHALMOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yu-Chung Shih, Po-Yuan Chen, Tai-Ming Ko, Po-Hsun Huang, Hsu Ma, Der-Cherng Tarng
Summary: MMP-9 knockout attenuated AV fistula stenosis by reducing perioperative vascular inflammation through decreasing neointima size, increasing lumen area, and inhibiting the expression of inflammatory genes. Experiments showed that MMP-9 knockout also reduced CD44 and RAC-alpha serine/threonine-protein kinase (Akt) and extracellular signal-regulated kinases (ERK) phosphorylation, ultimately leading to a reduction in AV fistula failure.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Clinical Neurology
Raj G. Kumar, Shannon B. Juengst, Zhensheng Wang, Kristen Dams-O'Connor, Sureyya S. Dikmen, Therese M. O'Neil-Pirozzi, Marie N. Dahdah, Flora M. Hammond, Elizabeth R. Felix, Patricia M. Arenth, Amy K. Wagner
JOURNAL OF HEAD TRAUMA REHABILITATION
(2018)
Article
Ophthalmology
Wan Chen, Hatim Ismail M. Batawi, Jimmy R. Alava, Anat Galor, Jin Yuan, Constantine D. Sarantopoulos, Allison L. McClellan, William J. Feuer, Roy C. Levitt, Jianhua Wang
Article
Rehabilitation
Elizabeth R. Felix, Rachel E. Cowan, Tyler S. Clark, Diana D. Cardenas, Robert W. Irwin
AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION
(2018)
Article
Rehabilitation
Jennifer H. Marwitz, Adam P. Sima, Jeffrey S. Kreutzer, Laura E. Dreer, Thomas F. Bergquist, Ross Zafonte, Douglas Johnson-Greene, Elizabeth R. Felix
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2018)
Article
Clinical Neurology
Laura E. Dreer, Jessica M. Ketchum, Thomas A. Novack, Jennifer Bogner, Elizabeth R. Felix, John D. Corrigan, Doug Johnson-Greene, Flora M. Hammond
JOURNAL OF HEAD TRAUMA REHABILITATION
(2018)
Article
Clinical Neurology
Angelle M. Sander, Anthony H. Lequerica, Jessica M. Ketchum, Flora M. Hammond, Kelli Williams Gary, Monique R. Pappadis, Elizabeth R. Felix, Douglas Johnson-Greene, Tamara Bushnik
JOURNAL OF HEAD TRAUMA REHABILITATION
(2018)
Article
Critical Care Medicine
Kristen Dams-O'Connor, Karla Therese L. Sy, Alexandra Landau, Yelena Bodien, Sureyya Dikmen, Elizabeth R. Felix, Joseph T. Giacino, Laura Gibbons, Flora M. Hammond, Tessa Hart, Doug Johnson-Greene, Jeannie Lengenfelder, Anthony Lequerica, Jody Newman, Thomas Novack, Therese M. O'Neil-Pirozzi, Gale Whiteneck
JOURNAL OF NEUROTRAUMA
(2018)
Review
Ophthalmology
Anat Galor, Hamid-Reza Moein, Charity Lee, Adriana Rodriguez, Elizabeth R. Felix, Konstantinos D. Sarantopoulos, Roy C. Levitt
Article
Ophthalmology
Ryan J. Diel, Jodi Hwang, Zachary A. Kroeger, Roy C. Levitt, Constantine D. Sarantopoulos, Heather Sered, Elizabeth R. Felix, Jasmine Martinez-Barrizonte, Anat Galor
BRITISH JOURNAL OF OPHTHALMOLOGY
(2019)
Article
Medicine, General & Internal
Sneh Patel, Elizabeth R. Felix, Roy C. Levitt, Constantine D. Sarantopoulos, Anat Galor
JOURNAL OF CLINICAL MEDICINE
(2019)
Review
Rehabilitation
Javier A. Santana, Scott Klass, Elizabeth R. Felix
Article
Rehabilitation
Elizabeth R. Felix, Diana D. Cardenas, Thomas N. Bryce, Susan Charlifue, Tae Kyong Lee, Bria MacIntyre, Sara Mulroy, Heather Taylor
Summary: This study compared the prevalence, intensity ratings, and interference ratings of neuropathic pain and nociceptive pain in chronic spinal cord injury patients, finding significant differences in intensity and interference levels between neuropathic pain and non-neuropathic pain. Additionally, women and paraplegic patients were found to have a higher prevalence of neuropathic pain, providing important insights for treatment strategies.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2022)
Article
Rehabilitation
David S. Tulsky, Aaron J. Boulton, Pamela A. Kisala, Allen W. Heinemann, Susan Charlifue, Claire Z. Kalpakjian, Allan J. Kozlowski, Elizabeth R. Felix, Denise C. Fyffe, Mary D. Slavin, Denise G. Tate
Summary: This observational cohort study analyzed the trajectories of functional recovery in 479 patients with spinal cord injury (SCI) during the first 2 years after injury. The results showed that the majority of patients exhibited gradual improvements in functional levels within the first 6 months after injury, while some patients had slower functional recovery and greater initial limitations. There were variations in the improvement patterns for fine motor function and self-care. Injury and demographic factors predicted initial functional levels but had less influence on the rates of recovery.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2022)
Article
Ophthalmology
Erin S. Ong, Elizabeth R. Felix, Roy C. Levitt, William J. Feuer, Constantine D. Sarantopoulos, Anat Galor
BRITISH JOURNAL OF OPHTHALMOLOGY
(2018)
Article
Ophthalmology
Charity J. Lee, Elizabeth R. Felix, Roy C. Levitt, Christopher Eddy, Elizabeth A. Vanner, William J. Feuer, Constantine D. Sarantopoulos, Anat Galor
BRITISH JOURNAL OF OPHTHALMOLOGY
(2018)