期刊
OCULAR SURFACE
卷 19, 期 -, 页码 270-274出版社
ELSEVIER
DOI: 10.1016/j.jtos.2020.10.003
关键词
Anti-inflammatory therapy; Diagnosis dry eye; Inflammatory dry eye; Matrix Metalloproteinase-9; Ocular surface inflammation; Tear production
资金
- Department of Veterans Affairs, Veterans Health Administration, Office of Research and Development, Clinical Sciences Research [I01 CX002015]
- Biomedical Laboratory R&D (BLRD) Service [I01 BX004893]
- Department of Defense [GW190010, R01EY026174]
- NIH Center Core Grant [P30EY014801]
- Research to Prevent Blindness
- National Institutes of Health/National Eye Institute [R01EY030283, R41EY029185-01, R01EY024485]
- Duke NIH Center Core Grant
- Duke Research to Prevent Blindness Unrestricted Grant
The study revealed that eyes with detectable MMP-9 had decreased tear production over time compared to those without detectable MMP-9. Anti-inflammatory treatment more frequently normalized MMP-9 compared to PFATs.
Purpose: To investigate long-term correlations between Matrix Metalloproteinase-9 (MMP-9) testing and dry eye (DE) parameters. Additionally, to evaluate variability in MMP-9 results over time and with anti-inflammatory treatment. Methods: Retrospective cohort study of DE patients with equal MMP-9 testing results (positive or negative) in both eyes and a minimum of 6 months of follow up. Our main outcome measure was to examine whether initial MMP-9 status affected change in DE parameters over time. Secondarily, we evaluated the frequency of MMP-9 status change over time and examined whether MMP-9 status change was impacted by treatment. Results: 67 patients (76% female) fit the inclusion criteria. Mean age was 63 years with a mean follow up of 10.6 months. The majority (37/67, 55%) had concomitant systemic immune disease. MMP-9 testing was positive in both eyes in 39 individuals (58%) and negative in both eyes in 27 (42%) individuals. Of all DE parameters, initial MMP status predicted change in tear production. Individuals in the MMP-9 positive group had a greater decrease in production from baseline to final visit compared to the negative group (-2.6 vs 2.1, P = 0.013). In those initially MMP-9 positive, the frequency of becoming MMP-9 negative was higher in eyes treated with antiinflammatory therapy compared to artificial tears (22.9% vs 3.3%, P = 0.106). However, only Lifitegrast 5% showed statistical significance compared to artificial tears (31.3% vs 3.3%, P = 0.044). Conclusions: Eyes with detectable MMP-9 had significantly decreased tear production over time compared to those without detectable MMP-9. Anti-inflammatory treatment more frequently normalized MMP-9 compared to PFATs.
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