期刊
NUTRITION
卷 32, 期 2, 页码 206-212出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.nut.2015.08.008
关键词
Antiregurgitation formula; Cow's milk allergy; (Extensive) hydrolysate; Infant nutrition; Thickened formula
资金
- United Pharmaceuticals
Objectives: Cow's milk allergy (CMA) is treated in formula-fed infants with an extensive protein hydrolysate. This study aimed to evaluate the nutritional safety of a non-thickened and thickened extensively casein hydrolyzed protein formula (NT- and T-eCHF) in infants with CMA. Methods: Infants younger than 6 mo old with a positive cow milk challenge test, positive IgE, or skin prick test for cow milk were selected. Weight and length were followed during the 6 mo intervention with the NT-eCHF and T-eCHF. Results: A challenge was performed in 50/71 infants with suspected CMA and was positive in 34/50. All children with confirmed CMA tolerated the eCHF. The T-eCHF leads to a significant improvement of the stool consistency in the whole population and in the subpopulation of infants with proven CMA. Height and weight evolution was satisfactory throughout the 6 mo study. Conclusions: The eCHF fulfills the criteria of a hypoallergenic formula and the NT- and T-eCHF reduced CMA symptoms. Growth was within normal range. (C) 2016 Elsevier Inc. All rights reserved.
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