期刊
GENES & DEVELOPMENT
卷 25, 期 12, 页码 1289-1305出版社
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.624711
关键词
MRP-L18; mitochondria; human; ribosome; RNA import; chaperone
资金
- CNRS
- Universite de Strasbourg
- Moscow State University
- AFM (Association Francaise contre les Myopathies)
- ANR (Agence Nationale de la Recherche)
- FRM (Fondation pour la Recherche Medicale)
- ARCUS (cooperation program Alsace-Russia-Ukraine)
5S rRNA is an essential component of ribosomes of all living organisms, the only known exceptions being mitochondrial ribosomes of fungi, animals, and some protists. An intriguing situation distinguishes mammalian cells: Although the mitochondrial genome contains no 5S rRNA genes, abundant import of the nuclear DNA-encoded 5S rRNA into mitochondria was reported. Neither the detailed mechanism of this pathway nor its rationale was clarified to date. In this study, we describe an elegant molecular conveyor composed of a previously identified human 5S rRNA import factor, rhodanese, and mitochondrial ribosomal protein L18, thanks to which 5S rRNA molecules can be specifically withdrawn from the cytosolic pool and redirected to mitochondria, bypassing the classic nucleolar reimport pathway. Inside mitochondria, the cytosolic 5S rRNA is shown to be associated with mitochondrial ribosomes.
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