The Gut Microbiome as Therapeutic Target in Central Nervous System Diseases: Implications for Stroke

Post-Stroke Depression: A Review

(2016) Robert G. Robinson et al.   AMERICAN JOURNAL OF PSYCHIATRY

The Carnitine-butyrobetaine-trimethylamine-N-oxide pathway and its association with cardiovascular mortality in patients with carotid atherosclerosis

(2016) Karolina Skagen et al.   ATHEROSCLEROSIS

L-Carnitine intake and high trimethylamine N-oxide plasma levels correlate with low aortic lesions in ApoE−/− transgenic mice expressing CETP

(2016) Heidi L. Collins et al.   ATHEROSCLEROSIS

Brain injury induces specific changes in the caecal microbiota of mice via altered autonomic activity and mucoprotein production

(2016) A. Houlden et al.   BRAIN BEHAVIOR AND IMMUNITY

Clostridium butyricum attenuates cerebral ischemia/reperfusion injury in diabetic mice via modulation of gut microbiota

(2016) Jing Sun et al.   BRAIN RESEARCH

Gut Microbial Metabolite TMAO Enhances Platelet Hyperreactivity and Thrombosis Risk

(2016) Weifei Zhu et al.   CELL

Brain–Gut–Bone Marrow Axis

(2016) Monica M. Santisteban et al.   CIRCULATION RESEARCH

Gut microbiome as a novel cardiovascular therapeutic target

(2016) Vishal Singh et al.   CURRENT OPINION IN PHARMACOLOGY

Gut microbiota and protection from pneumococcal pneumonia

(2016) Robert P Dickson et al.   GUT

Dysbiosis in intestinal inflammation: Cause or consequence

(2016) Ludovica F. Buttó et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

Growing up in a Bubble: Using Germ-Free Animals to Assess the Influence of the Gut Microbiota on Brain and Behavior

(2016) Pauline Luczynski et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Gut microbiota impact on stroke outcome: Fad or fact?

(2016) Katarzyna Winek et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Microbiota Dysbiosis Controls the Neuroinflammatory Response after Stroke

(2016) V. Singh et al.   JOURNAL OF NEUROSCIENCE

Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor

(2016) Veit Rothhammer et al.   NATURE MEDICINE

Commensal microbiota affects ischemic stroke outcome by regulating intestinal γδ T cells

(2016) Corinne Benakis et al.   NATURE MEDICINE

The microbial pharmacists within us: a metagenomic view of xenobiotic metabolism

(2016) Peter Spanogiannopoulos et al.   NATURE REVIEWS MICROBIOLOGY

Microbiota-gut-brain signalling in Parkinson's disease: Implications for non-motor symptoms

(2016) Valeria D. Felice et al.   PARKINSONISM & RELATED DISORDERS

Depletion of Cultivatable Gut Microbiota by Broad-Spectrum Antibiotic Pretreatment Worsens Outcome After Murine Stroke

(2016) Katarzyna Winek et al.   STROKE

Alterations of the human gut microbiome in multiple sclerosis

(2016) Sushrut Jangi et al.   Nature Communications

The effects of antibiotics on the microbiome throughout development and alternative approaches for therapeutic modulation

(2016) Amy Langdon et al.   Genome Medicine

Peripheral Neuropathy After Fecal Microbiota Transplantation for Clostridium difficile Infection: A Case Report

(2016) Michelle M. Didesch et al.   PM&R

Modulatory Effects of Gut Microbiota on the Central Nervous System: How Gut Could Play a Role in Neuropsychiatric Health and Diseases

(2016) Shadi S Yarandi et al.   Journal of Neurogastroenterology and Motility

Regulation of prefrontal cortex myelination by the microbiota

(2016) A E Hoban et al.   Translational Psychiatry

Intestinal Microbiota in Patients with Spinal Cord Injury

(2016) Bilgi Gungor et al.   PLoS One

Multiple sclerosis patients have a distinct gut microbiota compared to healthy controls

(2016) Jun Chen et al.   Scientific Reports

Antibiotic-induced perturbations in gut microbial diversity influences neuro-inflammation and amyloidosis in a murine model of Alzheimer’s disease

(2016) Myles R. Minter et al.   Scientific Reports

Obese-type Gut Microbiota Induce Neurobehavioral Changes in the Absence of Obesity

(2015) Annadora J. Bruce-Keller et al.   BIOLOGICAL PSYCHIATRY

Altered fecal microbiota composition in patients with major depressive disorder

(2015) Haiyin Jiang et al.   BRAIN BEHAVIOR AND IMMUNITY

Indigenous Bacteria from the Gut Microbiota Regulate Host Serotonin Biosynthesis

(2015) Jessica M. Yano et al.   CELL

Non-lethal Inhibition of Gut Microbial Trimethylamine Production for the Treatment of Atherosclerosis

(2015) Zeneng Wang et al.   CELL

The Gut Microbiota Regulates Intestinal CD4 T Cells Expressing RORγt and Controls Metabolic Disease

(2015) Lucile Garidou et al.   Cell Metabolism

The Gut Microbiome Contributes to a Substantial Proportion of the Variation in Blood LipidsNovelty and Significance

(2015) Jingyuan Fu et al.   CIRCULATION RESEARCH

The gut microbiota plays a protective role in the host defence against pneumococcal pneumonia

(2015) Tim J Schuijt et al.   GUT

Gut/brain axis and the microbiota

(2015) Emeran A. Mayer et al.   JOURNAL OF CLINICAL INVESTIGATION

Donor Species Richness Determines Faecal Microbiota Transplantation Success in Inflammatory Bowel Disease

(2015) Severine Vermeire et al.   Journal of Crohns & Colitis

TNFR2 Deficiency Acts in Concert with Gut Microbiota To Precipitate Spontaneous Sex-Biased Central Nervous System Demyelinating Autoimmune Disease

(2015) Patrick G. Miller et al.   JOURNAL OF IMMUNOLOGY

Prevention of stroke-associated pneumonia: where next?

(2015) Andreas Meisel et al.   LANCET

Drugging the gut microbiome

(2015) Ken Garber   NATURE BIOTECHNOLOGY

Host microbiota constantly control maturation and function of microglia in the CNS

(2015) Daniel Erny et al.   NATURE NEUROSCIENCE

The Intestinal Microbiota in Acute Anorexia Nervosa and During Renourishment

(2015) Susan C. Kleiman et al.   PSYCHOSOMATIC MEDICINE

Commensal Bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacy

(2015) A. Sivan et al.   SCIENCE

Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota

(2015) M. Vetizou et al.   SCIENCE

Microbiome as mediator: Do systemic infections start in the gut?

(2015) Melissa Latorre   WORLD JOURNAL OF GASTROENTEROLOGY

Microbiota and host determinants of behavioural phenotype in maternally separated mice

(2015) G. De Palma et al.   Nature Communications

Human microbiomes and their roles in dysbiosis, common diseases, and novel therapeutic approaches

(2015) José E. Belizário et al.   Frontiers in Microbiology

Dysbiosis of Gut Microbiota With Reduced Trimethylamine‐N‐Oxide Level in Patients With Large‐Artery Atherosclerotic Stroke or Transient Ischemic Attack

(2015) Jia Yin et al.   Journal of the American Heart Association

Insights Into the Role of the Microbiome in Obesity and Type 2 Diabetes

(2014) Annick V. Hartstra et al.   DIABETES CARE

Transmission of Atherosclerosis Susceptibility with Gut Microbial Transplantation

(2014) Jill C. Gregory et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gut Microbes and the Brain: Paradigm Shift in Neuroscience

(2014) E. A. Mayer et al.   JOURNAL OF NEUROSCIENCE

Gut microbiota are related to Parkinson's disease and clinical phenotype

(2014) Filip Scheperjans et al.   MOVEMENT DISORDERS

Microbiome therapy gains market traction

(2014) Sara Reardon   NATURE

Intestinal Barrier Dysfunction Develops at the Onset of Experimental Autoimmune Encephalomyelitis, and Can Be Induced by Adoptive Transfer of Auto-Reactive T Cells

(2014) Mehrnaz Nouri et al.   PLoS One

The gut microbiota influences blood-brain barrier permeability in mice

(2014) V. Braniste et al.   Science Translational Medicine

Catabolic Signaling and Muscle Wasting After Acute Ischemic Stroke in Mice

(2014) Jochen Springer et al.   STROKE

Microbiota and neurodevelopmental windows: implications for brain disorders

(2014) Yuliya E. Borre et al.   TRENDS IN MOLECULAR MEDICINE

Bacterial ClpB heat-shock protein, an antigen-mimetic of the anorexigenic peptide α-MSH, at the origin of eating disorders

(2014) N Tennoune et al.   Translational Psychiatry

The role of microbiome in central nervous system disorders

(2013) Yan Wang et al.   BRAIN BEHAVIOR AND IMMUNITY

Emerging roles of the microbiome in cancer

(2013) S. J. Bultman   CARCINOGENESIS

Microbiota Modulate Behavioral and Physiological Abnormalities Associated with Neurodevelopmental Disorders

(2013) Elaine Y. Hsiao et al.   CELL

Immune System Stimulation by Probiotic Microorganisms

(2013) Rabia Ashraf et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Gut metagenome in European women with normal, impaired and diabetic glucose control

(2013) Fredrik H. Karlsson et al.   NATURE

Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis

(2013) Robert A Koeth et al.   NATURE MEDICINE

Intestinal microbiota influence the early postnatal development of the enteric nervous system

(2013) J. Collins et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Altered colonic function and microbiota profile in a mouse model of chronic depression

(2013) A. J. Park et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Intestinal Microbial Metabolism of Phosphatidylcholine and Cardiovascular Risk

(2013) W.H. Wilson Tang et al.   NEW ENGLAND JOURNAL OF MEDICINE

Duodenal Infusion of Donor Feces for Recurrent Clostridium difficile

(2013) Els van Nood et al.   NEW ENGLAND JOURNAL OF MEDICINE

Stool substitute transplant therapy for the eradication of Clostridium difficile infection: ‘RePOOPulating’ the gut

(2013) Elaine O Petrof et al.   Microbiome

The Human Microbiome: Our Second Genome

(2012) Elizabeth A. Grice et al.   Annual Review of Genomics and Human Genetics

The interplay between the intestinal microbiota and the brain

(2012) Stephen M. Collins et al.   NATURE REVIEWS MICROBIOLOGY

Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour

(2012) John F. Cryan et al.   NATURE REVIEWS NEUROSCIENCE

Restoring Specific Lactobacilli Levels Decreases Inflammation and Muscle Atrophy Markers in an Acute Leukemia Mouse Model

(2012) Laure B. Bindels et al.   PLoS One

Is It Time for a Metagenomic Basis of Therapeutics?

(2012) H. J. Haiser et al.   SCIENCE

Microbiota-Targeted Therapies: An Ecological Perspective

(2012) K. P. Lemon et al.   Science Translational Medicine

Symptomatic atherosclerosis is associated with an altered gut metagenome

(2012) Fredrik H. Karlsson et al.   Nature Communications

Post-stroke infection: A systematic review and meta-analysis

(2011) Willeke F Westendorp et al.   BMC Neurology

Lactobacillus rhamnosus administration causes sepsis in a cardiosurgical patient—is the time right to revise probiotic safety guidelines?

(2011) P. Kochan et al.   CLINICAL MICROBIOLOGY AND INFECTION

The new link between gut–brain axis and neuropsychiatric disorders

(2011) Sergueï O. Fetissov et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

The Intestinal Microbiota Affect Central Levels of Brain-Derived Neurotropic Factor and Behavior in Mice

(2011) Premysl Bercik et al.   GASTROENTEROLOGY

Absence of Microbiota (Germ-Free Conditions) Accelerates the Atherosclerosis in ApoE-Deficient Mice Fed Standard Low Cholesterol Diet

(2011) Renata Stepankova et al.   Journal of Atherosclerosis and Thrombosis

Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination

(2011) Kerstin Berer et al.   NATURE

Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease

(2011) Zeneng Wang et al.   NATURE

The anxiolytic effect of Bifidobacterium longum NCC3001 involves vagal pathways for gut-brain communication

(2011) P. Bercik et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve

(2011) J. A. Bravo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Normal gut microbiota modulates brain development and behavior

(2011) R. D. Heijtz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Body Weight After Stroke

(2011) Nadja Scherbakov et al.   STROKE

Gut, bugs, and brain: Role of commensal bacteria in the control of central nervous system disease

(2010) Javier Ochoa-Repáraz et al.   ANNALS OF NEUROLOGY

The PROPATRIA trial: best practices at the time were followed

(2010) Hein G Gooszen   LANCET

A polysaccharide from the human commensal Bacteroides fragilis protects against CNS demyelinating disease

(2010) J Ochoa-Repáraz et al.   Mucosal Immunology

Reduced anxiety-like behavior and central neurochemical change in germ-free mice

(2010) K. M. Neufeld et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Proinflammatory T-cell responses to gut microbiota promote experimental autoimmune encephalomyelitis

(2010) Y. K. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Composition, variability, and temporal stability of the intestinal microbiota of the elderly

(2010) M. J. Claesson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alleviating Cancer Drug Toxicity by Inhibiting a Bacterial Enzyme

(2010) B. D. Wallace et al.   SCIENCE

Colonic bacterial translocation as a possible factor in stress-worsening experimental stroke outcome

(2009) Javier R. Caso et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Intestinal Barrier Dysfunction in a Randomized Trial of a Specific Probiotic Composition in Acute Pancreatitis

(2009) Marc G. Besselink et al.   ANNALS OF SURGERY

Mood and gut feelings

(2009) Paul Forsythe et al.   BRAIN BEHAVIOR AND IMMUNITY

Getting the Bugs out of the Immune System: Do Bacterial Microbiota “Fix” Intestinal T Cell Responses?

(2009) Janet Chow et al.   Cell Host & Microbe

Gut microbiota: Changes throughout the lifespan from infancy to elderly

(2009) Paul W. O'Toole et al.   INTERNATIONAL DAIRY JOURNAL

Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43

(2009) Kendle M. Maslowski et al.   NATURE

Principles and clinical implications of the brain–gut–enteric microbiota axis

(2009) Sang H. Rhee et al.   Nature Reviews Gastroenterology & Hepatology

Differential Affection of Intestinal Immune Cell Populations after Cerebral Ischemia in Mice

(2009) Olaf Schulte-Herbrüggen et al.   NEUROIMMUNOMODULATION

Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites

(2009) W. R. Wikoff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Early Life Stress Alters Behavior, Immunity, and Microbiota in Rats: Implications for Irritable Bowel Syndrome and Psychiatric Illnesses

(2008) Siobhain M. O'Mahony et al.   BIOLOGICAL PSYCHIATRY

Diet-Induced Obesity Is Linked to Marked but Reversible Alterations in the Mouse Distal Gut Microbiome

(2008) Peter J. Turnbaugh et al.   Cell Host & Microbe

The gastrointestinal microbiota as a site for the biotransformation of drugs

(2008) Tiago Sousa et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

A core gut microbiome in obese and lean twins

(2008) Peter J. Turnbaugh et al.   NATURE

Gut microbiota: a potential new territory for drug targeting

(2008) Wei Jia et al.   NATURE REVIEWS DRUG DISCOVERY