Modulatory Effects of Gut Microbiota on the Central Nervous System: How Gut Could Play a Role in Neuropsychiatric Health and Diseases

Autoimmune diseases, gastrointestinal disorders and the microbiome in schizophrenia: more than a gut feeling

(2016) Emily G. Severance et al.   SCHIZOPHRENIA RESEARCH

Serotonin, tryptophan metabolism and the brain-gut-microbiome axis

(2015) S.M. O’Mahony et al.   BEHAVIOURAL BRAIN RESEARCH

Altered fecal microbiota composition in patients with major depressive disorder

(2015) Haiyin Jiang et al.   BRAIN BEHAVIOR AND IMMUNITY

Indigenous Bacteria from the Gut Microbiota Regulate Host Serotonin Biosynthesis

(2015) Jessica M. Yano et al.   CELL

The Effect of Emotional Stress and Depression on the Prevalence of Digestive Diseases

(2015) Sang Pyo Lee et al.   Journal of Neurogastroenterology and Motility

Priming for health: gut microbiota acquired in early life regulates physiology, brain and behaviour

(2014) G Clarke et al.   ACTA PAEDIATRICA

Altered brain-gut axis in autism: Comorbidity or causative mechanisms?

(2014) Emeran A. Mayer et al.   BIOESSAYS

Brain–Gut Microbiome Interactions and Functional Bowel Disorders

(2014) Emeran A. Mayer et al.   GASTROENTEROLOGY

Gut Microbes and the Brain: Paradigm Shift in Neuroscience

(2014) E. A. Mayer et al.   JOURNAL OF NEUROSCIENCE

Genomics of schizophrenia: time to consider the gut microbiome?

(2014) T G Dinan et al.   MOLECULAR PSYCHIATRY

Life at the beginning: perturbation of the microbiota by antibiotics in early life and its role in health and disease

(2014) Sebastian Zeissig et al.   NATURE IMMUNOLOGY

Correlation between the human fecal microbiota and depression

(2014) A. Naseribafrouei et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Gastrointestinal Symptoms in Autism Spectrum Disorder: A Meta-analysis

(2014) B. O. McElhanon et al.   PEDIATRICS

Absence of the gut microbiota enhances anxiety-like behavior and neuroendocrine response to acute stress in rats

(2014) Michèle Crumeyrolle-Arias et al.   PSYCHONEUROENDOCRINOLOGY

Microbiota and neurodevelopmental windows: implications for brain disorders

(2014) Yuliya E. Borre et al.   TRENDS IN MOLECULAR MEDICINE

The short-chain fatty acid acetate reduces appetite via a central homeostatic mechanism

(2014) Gary Frost et al.   Nature Communications

GC-MS-based urine metabolic profiling of autism spectrum disorders

(2013) Patrick Emond et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Ingestion of Mycobacterium vaccae decreases anxiety-related behavior and improves learning in mice

(2013) Dorothy M. Matthews et al.   BEHAVIOURAL PROCESSES

Altered gut microbiota and activity in a murine model of autism spectrum disorders

(2013) Caroline G.M. de Theije et al.   BRAIN BEHAVIOR AND IMMUNITY

Gut microbiota of healthy Canadian infants: profiles by mode of delivery and infant diet at 4 months

(2013) M. B. Azad et al.   CANADIAN MEDICAL ASSOCIATION JOURNAL

Microbiota Modulate Behavioral and Physiological Abnormalities Associated with Neurodevelopmental Disorders

(2013) Elaine Y. Hsiao et al.   CELL

Short-Chain Fatty Acids Activate GPR41 and GPR43 on Intestinal Epithelial Cells to Promote Inflammatory Responses in Mice

(2013) Myung H. Kim et al.   GASTROENTEROLOGY

Consumption of Fermented Milk Product With Probiotic Modulates Brain Activity

(2013) Kirsten Tillisch et al.   GASTROENTEROLOGY

Psychological stress and corticotropin-releasing hormone increase intestinal permeability in humans by a mast cell-dependent mechanism

(2013) Tim Vanuytsel et al.   GUT

Effects of doxycycline on depressive-like behavior in mice after lipopolysaccharide (LPS) administration

(2013) Bruna Stefânia Ferreira Mello et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Microbiota is essential for social development in the mouse

(2013) L Desbonnet et al.   MOLECULAR PSYCHIATRY

The histaminergic network in the brain: basic organization and role in disease

(2013) Pertti Panula et al.   NATURE REVIEWS NEUROSCIENCE

Altered colonic function and microbiota profile in a mouse model of chronic depression

(2013) A. J. Park et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Melancholic microbes: a link between gut microbiota and depression?

(2013) T. G. Dinan et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Probiotics treatment improves diabetes-induced impairment of synaptic activity and cognitive function: Behavioral and electrophysiological proofs for microbiome–gut–brain axis

(2013) S. Davari et al.   NEUROSCIENCE

Discordant patterns of bacterial translocation markers and implications for innate immune imbalances in schizophrenia

(2013) Emily G. Severance et al.   SCHIZOPHRENIA RESEARCH

The gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR43

(2013) Ikuo Kimura et al.   Nature Communications

Microbial Endocrinology in the Microbiome-Gut-Brain Axis: How Bacterial Production and Utilization of Neurochemicals Influence Behavior

(2013) Mark Lyte   PLoS Pathogens

Novel therapeutic targets in depression: Minocycline as a candidate treatment

(2012) Joanna K. Soczynska et al.   BEHAVIOURAL BRAIN RESEARCH

Attenuation of post-myocardial infarction depression in rats by n-3 fatty acids or probiotics starting after the onset of reperfusion

(2012) Kim Gilbert et al.   BRITISH JOURNAL OF NUTRITION

Communication between gastrointestinal bacteria and the nervous system

(2012) Javier A Bravo et al.   CURRENT OPINION IN PHARMACOLOGY

Gut Microbial Products Regulate Murine Gastrointestinal Motility via Toll-Like Receptor 4 Signaling

(2012) Mallappa Anitha et al.   GASTROENTEROLOGY

The enteric bacterial metabolite propionic acid alters brain and plasma phospholipid molecular species: further development of a rodent model of autism spectrum disorders

(2012) Raymond H Thomas et al.   Journal of Neuroinflammation

Metabolic Perturbance in Autism Spectrum Disorders: A Metabolomics Study

(2012) Xue Ming et al.   JOURNAL OF PROTEOME RESEARCH

The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner

(2012) G Clarke et al.   MOLECULAR PSYCHIATRY

Functional interactions between the gut microbiota and host metabolism

(2012) Valentina Tremaroli et al.   NATURE

The interplay between the intestinal microbiota and the brain

(2012) Stephen M. Collins et al.   NATURE REVIEWS MICROBIOLOGY

Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour

(2012) John F. Cryan et al.   NATURE REVIEWS NEUROSCIENCE

The microbiome is essential for normal gut intrinsic primary afferent neuron excitability in the mouse

(2012) K. A. McVey Neufeld et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Gastrointestinal Conditions in Children With Autism Spectrum Disorder: Developing a Research Agenda

(2012) Daniel L. Coury et al.   PEDIATRICS

Histamine Derived from Probiotic Lactobacillus reuteri Suppresses TNF via Modulation of PKA and ERK Signaling

(2012) Carissa M. Thomas et al.   PLoS One

Lactobacillus reuteri Maintains a Functional Mucosal Barrier during DSS Treatment Despite Mucus Layer Dysfunction

(2012) Johan Dicksved et al.   PLoS One

High Fat Diet-Induced Gut Microbiota Exacerbates Inflammation and Obesity in Mice via the TLR4 Signaling Pathway

(2012) Kyung-Ah Kim et al.   PLoS One

Host-Gut Microbiota Metabolic Interactions

(2012) J. K. Nicholson et al.   SCIENCE

Probiotic Bacteria Induce Maturation of Intestinal Claudin 3 Expression and Barrier Function

(2011) Ravi M. Patel et al.   AMERICAN JOURNAL OF PATHOLOGY

Combination of Lactobacillus helveticus R0052 and Bifidobacterium longum R0175 reduces post-myocardial infarction depression symptoms and restores intestinal permeability in a rat model

(2011) Jessica Arseneault-Bréard et al.   BRITISH JOURNAL OF NUTRITION

Roadblocks in the gut: barriers to enteric infection

(2011) Navkiran Gill et al.   CELLULAR MICROBIOLOGY

The Intestinal Microbiota Affect Central Levels of Brain-Derived Neurotropic Factor and Behavior in Mice

(2011) Premysl Bercik et al.   GASTROENTEROLOGY

Increased IgA responses to the LPS of commensal bacteria is associated with inflammation and activation of cell-mediated immunity in chronic fatigue syndrome

(2011) Michael Maes et al.   JOURNAL OF AFFECTIVE DISORDERS

Fatty acid transport protein expression in human brain and potential role in fatty acid transport across human brain microvessel endothelial cells

(2011) Ryan W. Mitchell et al.   JOURNAL OF NEUROCHEMISTRY

Impaired plasma phospholipids and relative amounts of essential polyunsaturated fatty acids in autistic patients from Saudi Arabia

(2011) Afaf K El-Ansary et al.   Lipids in Health and Disease

Desulfovibrio species are potentially important in regressive autism

(2011) Sydney M. Finegold   MEDICAL HYPOTHESES

Gut feelings: the emerging biology of gut–brain communication

(2011) Emeran A. Mayer   NATURE REVIEWS NEUROSCIENCE

The anxiolytic effect of Bifidobacterium longum NCC3001 involves vagal pathways for gut-brain communication

(2011) P. Bercik et al.   NEUROGASTROENTEROLOGY AND MOTILITY

The microbiome-gut-brain axis: from bowel to behavior

(2011) J. F. Cryan et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve

(2011) J. A. Bravo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Short-chain fatty acids and ketones directly regulate sympathetic nervous system via G protein-coupled receptor 41 (GPR41)

(2011) I. Kimura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Normal gut microbiota modulates brain development and behavior

(2011) R. D. Heijtz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gut Microbiota Is a Key Modulator of Insulin Resistance in TLR 2 Knockout Mice

(2011) Andréa M. Caricilli et al.   PLOS BIOLOGY

Pyrosequencing study of fecal microflora of autistic and control children

(2010) Sydney M. Finegold et al.   ANAEROBE

Effects of the enteric bacterial metabolic product propionic acid on object-directed behavior, social behavior, cognition, and neuroinflammation in adolescent rats: Relevance to autism spectrum disorder

(2010) Derrick F. MacFabe et al.   BEHAVIOURAL BRAIN RESEARCH

Chronological assessment of mast cell-mediated gut dysfunction and mucosal inflammation in a rat model of chronic psychosocial stress

(2010) María Vicario et al.   BRAIN BEHAVIOR AND IMMUNITY

Exposure to a social stressor alters the structure of the intestinal microbiota: Implications for stressor-induced immunomodulation

(2010) Michael T. Bailey et al.   BRAIN BEHAVIOR AND IMMUNITY

Chronic Gastrointestinal Inflammation Induces Anxiety-Like Behavior and Alters Central Nervous System Biochemistry in Mice

(2010) Premysl Bercik et al.   GASTROENTEROLOGY

Bacterial infection causes stress-induced memory dysfunction in mice

(2010) M. G. Gareau et al.   GUT

Urinary Metabolic Phenotyping Differentiates Children with Autism from Their Unaffected Siblings and Age-Matched Controls

(2010) Ivan K. S. Yap et al.   JOURNAL OF PROTEOME RESEARCH

Multiple facets of intestinal permeability and epithelial handling of dietary antigens

(2010) S Ménard et al.   Mucosal Immunology

Reduced anxiety-like behavior and central neurochemical change in germ-free mice

(2010) K. M. Neufeld et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Effects of the probiotic Bifidobacterium infantis in the maternal separation model of depression

(2010) L. Desbonnet et al.   NEUROSCIENCE

Low-grade endotoxemia in patients with severe autism

(2010) Enzo Emanuele et al.   NEUROSCIENCE LETTERS

Human milk glycobiome and its impact on the infant gastrointestinal microbiota

(2010) A. M. Zivkovic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns

(2010) M. G. Dominguez-Bello et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Maternal separation as a model of brain–gut axis dysfunction

(2010) Siobhain M. O’Mahony et al.   PSYCHOPHARMACOLOGY

Migration, Ethnicity, and Psychosis: Toward a Sociodevelopmental Model

(2010) C. Morgan et al.   SCHIZOPHRENIA BULLETIN

Amino acids: metabolism, functions, and nutrition

(2009) Guoyao Wu   AMINO ACIDS

The Relationship Between Intestinal Microbiota and the Central Nervous System in Normal Gastrointestinal Function and Disease

(2009) Stephen M. Collins et al.   GASTROENTEROLOGY

Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability

(2009) P. D. Cani et al.   GUT

Toll-like Receptors 3, 4, and 7 Are Expressed in the Enteric Nervous System and Dorsal Root Ganglia

(2009) Isabella Barajon et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

5-HT4 Receptor-Mediated Neuroprotection and Neurogenesis in the Enteric Nervous System of Adult Mice

(2009) M.-T. Liu et al.   JOURNAL OF NEUROSCIENCE

Principles and clinical implications of the brain–gut–enteric microbiota axis

(2009) Sang H. Rhee et al.   Nature Reviews Gastroenterology & Hepatology

Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites

(2009) W. R. Wikoff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intracerebroventricular injections of the enteric bacterial metabolic product propionic acid impair cognition and sensorimotor ability in the Long–Evans rat: Further development of a rodent model of autism

(2008) Sandy R. Shultz et al.   BEHAVIOURAL BRAIN RESEARCH

Early Life Stress Alters Behavior, Immunity, and Microbiota in Rats: Implications for Irritable Bowel Syndrome and Psychiatric Illnesses

(2008) Siobhain M. O'Mahony et al.   BIOLOGICAL PSYCHIATRY

Pathophysiological Mechanisms of Stress-Induced Intestina Damage

(2008) Melanie Gareau et al.   CURRENT MOLECULAR MEDICINE

The probiotic Bifidobacteria infantis: An assessment of potential antidepressant properties in the rat

(2008) Lieve Desbonnet et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Intracerebroventricular injection of propionic acid, an enteric bacterial metabolic end-product, impairs social behavior in the rat: Implications for an animal model of autism

(2008) Sandy R. Shultz et al.   NEUROPHARMACOLOGY

The Probiotic Lactobacillus GG may Augment Intestinal Host Defense by Regulating Apoptosis and Promoting Cytoprotective Responses in the Developing Murine Gut

(2008) Patricia W Lin et al.   PEDIATRIC RESEARCH

Memory and learning behavior in mice is temporally associated with diet-induced alterations in gut bacteria

(2008) Wang Li et al.   PHYSIOLOGY & BEHAVIOR

Campylobacter jejuni infection increases anxiety-like behavior in the holeboard: Possible anatomical substrates for viscerosensory modulation of exploratory behavior

(2007) Lisa E. Goehler et al.   BRAIN BEHAVIOR AND IMMUNITY