Article
Chemistry, Multidisciplinary
Mi Zhou, Tianxu Zhang, Bowen Zhang, Xiaolin Zhang, Shaojingya Gao, Tao Zhang, Songhang Li, Xiaoxiao Cai, Yunfeng Lin
Summary: The study demonstrated that tFNA effectively prevented neuronal apoptosis in ischemic stroke by interfering with ischemic cascades in vitro and ameliorating the microenvironment of the ischemic hemisphere in vivo. This pleiotropic nanoneuroprotectant shows promise as a therapeutic strategy for ischemic stroke by attenuating neurological deficits and reducing infarction volume.
Article
Chemistry, Medicinal
Hongzao Ni, Jinxiao Li, Jinyu Zheng, Botao Zhou
Summary: Cardamonin protects against damage and increased permeability caused by ischemic stroke by activating the HIF-1α/VEGFA pathway.
PHYTOTHERAPY RESEARCH
(2022)
Article
Cell Biology
Yan Huang, Xia Xiao, Han Xiao, Zhiping Hu, Fengbo Tan
Summary: The study investigated the role of CUEDC2 in cerebral ischemic stroke and whether CUEDC2-modified MSCs could improve the efficacy of treatment, finding that siRNA-CUEDC2 in MSCs significantly enhanced therapeutic effects by upregulating GPX1 expression levels and suppressing NF-kB activation in co-cultured neurons. These findings suggest a promising strategy for utilizing MSCs to promote outcomes in cerebral ischemic stroke.
Article
Biochemistry & Molecular Biology
Shuai Li, Tangming Peng, Xia Zhao, Marta Silva, Linlin Liu, Wenshu Zhou, Ligang Chen, Wenhua Zheng
Summary: Ischemic stroke is a major cause of death and disability among adults, with limited treatment options. Artemether, a drug used for malaria, has been shown to improve neurological deficits and reduce infarction volume in animal models of stroke. It also promotes cell proliferation, reduces cell apoptosis, and activates signaling pathways related to neuroprotection.
Article
Cell Biology
Lufei Wang, Lichi Han, Peng Xue, Xiangxiang Hu, Sing-Wai Wong, Meng Deng, Henry C. Tseng, Bo-Wen Huang, Ching-Chang Ko
Summary: The study found that dopamine inhibits osteoclast differentiation through the D2R/cAMP/PKA/CREB pathway. This reveals a potential mechanism for how the nervous system impacts bone remodeling and suggests future research directions for understanding bone development, repair, aging, and degenerative diseases.
CELLULAR SIGNALLING
(2021)
Article
Medicine, Research & Experimental
Qin Jiang, Dong-Yuan Su, Zhen-Zhen Wang, Chang Liu, Ya-Nan Sun, Hong Cheng, Xiu-Miao Li, Biao Yan
Summary: This study provides molecular evidence that the retina is a window of the brain from the circRNA perspective. cGLIS3 is a common regulator and diagnostic marker of cerebral neurodegeneration and retinal neurodegeneration.
Article
Chemistry, Medicinal
Sang-Hyun Ahn, Jung-Soo Suh, Yoon-Kwan Jang, Heon-Su Kim, Gyu-Ho Choi, Eunhye Kim, Tae-Jin Kim
Summary: This study demonstrates that the ethanol extract from Rhynchosia volubilis can protect cells against apoptosis by activating the cAMP-PKA/ERK-CREB pathway.
Article
Cell Biology
Na Liu, Aini Peng, Haiyan Sun, Yuansu Zhuang, Ming Yu, Qun Wang, Jinping Wang
Summary: The study demonstrated that AC136007.2 alleviates cerebral ischemia-reperfusion injury by suppressing AMPK/mTOR-dependent autophagy.
Article
Pharmacology & Pharmacy
Xiahenazi Aiyasiding, Hai-Han Liao, Hong Feng, Nan Zhang, Zheng Lin, Wen Ding, Han Yan, Zi-Ying Zhou, Qi-Zhu Tang
Summary: This study revealed that LQ alleviates pressure overload-induced cardiac hypertrophy in vivo and inhibits Ang II-induced cardiomyocyte hypertrophy in vitro via activating cAMP/PKA/LKB1/AMPKα2 signaling. These findings suggest that LQ might be a valuable adjunct to therapeutic approaches for treating pathological cardiac remodeling.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Neurosciences
Jin -Yi Hou, Xiao-Ling Zhou, Xiao-Yuan Wang, Jia Liang, Qun Xue
Summary: PRDX6, a member of the peroxiredoxin family, has been identified as a potential therapeutic target for brain diseases, particularly Alzheimer's disease and ischemic stroke. However, its role in neurons under ischemic conditions was unclear. This study revealed that astrocytes can release PRDX6 extracellularly after OGD/R, exacerbating neuroapoptosis. The PRDX6/RAGE/JNK signaling pathway was found to contribute to this effect. The inhibition of the RAGE signaling pathway showed significant changes in animal behavior in a mouse MCAO model. These findings highlight the crucial role of astrocyte-released PRDX6 in neuroapoptosis caused by OGD/R and provide insights into the molecular mechanism of protecting brain function from ischemia-reperfusion injury.
Article
Environmental Sciences
Miao Chen, Limin Fan, Guoping Wu, Hairong Wang, Shuo Gu
Summary: This study investigated the role of EZH2 and H3K27me3 in cerebral ischemia-reperfusion injury using rat models and primary cortical neuron models. The expression levels of EZH2 and H3K27me3 were upregulated under oxygen-glucose deprivation conditions and further enhanced by GSK-J4, but reduced by EPZ-6438 and AKT inhibitor. Inhibition of EZH2 or AKT effectively counteracted cell apoptosis and reduced infarct size in vivo. These findings suggest that EZH2 inhibition protects against ischemic brain injury through modulation of the H3K27me3/PI3K/AKT/mTOR signaling pathway.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Pharmacology & Pharmacy
Yile Cao, Lei Yang, Hong Cheng
Summary: This study found that Ginkgolide B (GB) can inhibit neuronal apoptosis and reduce neurological damage caused by ischemic stroke by enhancing AMPK activation.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Sadiq Nasrah, Aline Radi, Johanna K. Daberkow, Helmut Hummler, Stefanie Weber, Elie Seaayfan, Martin Koemhoff
Summary: Melanoma-associated antigen D2 (MAGED2) activates the cAMP/PKA pathway under hypoxic conditions, stimulating renal salt reabsorption and explaining the transient variant of Bartter's syndrome. MAGED2 depletion leads to upregulation of autophagy-related genes and accumulation of autophagosome marker LC3II, indicating an inhibitory role of MAGED2 in autophagy under stress conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Wen-Chang Xiao, Gang Zhou, Lu Jun, Jun Tu, Yong-Jie Yu, Zhi-Gang She, Chun-Lin Xu, Lei Wang
Summary: Carnosol, extracted from plants of Mediterranean diet, has shown anti-tumor, anti-inflammatory, and antioxidant effects. This study found that carnosol has a protective effect on ischemic stroke by activating AMPK, as it protected primary neurons from oxygen-glucose deprivation-induced damage in vitro and reduced infarct volume and inflammation in a mouse model of ischemic stroke in vivo. These findings provide a new perspective for the clinical treatment of ischemic stroke.
BRAIN RESEARCH BULLETIN
(2023)
Article
Biochemistry & Molecular Biology
Qifu He, Feng Gao, Shenghui Wu, Shaowen Wang, Zhiming Xu, Xuerui Xu, Tianyang Lan, Kang Zhang, Fusheng Quan
Summary: In dairy goat farming, increasing the female kid rate is economically beneficial. Alkaline incubation enriches the concentration of X-chromosome-bearing sperm, but the mechanism by which pH affects this sperm's motility remains unclear. This study revealed that the sAC/cAMP/PKA signaling pathway plays a role in influencing sperm motility, as inhibiting its protease activity resulted in decreased motility. The results suggest that alkaline dilution incubation slows down the motility of X-sperm through reduced Ca2+ entry, providing a theoretical foundation for further optimization of sex control methods.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Karolina Andraka, Kacper Kondrakiewicz, Karolina Rojek-Sito, Karolina Ziegart-Sadowska, Ksenia Meyza, Tomasz Nikolaev, Adam Hamed, Miron Kursa, Maja Wojcik, Konrad Danielewski, Marta Wiatrowska, Ewa Kublik, Marek Bekisz, Tomasz Lebitko, Daniel Duque, Tomasz Jaworski, Hubert Madej, Witold Konopka, Pawel M. Boguszewski, Ewelina Knapska
Summary: Animals exhibit various defensive responses to threats, which can also be influenced by the behavior of fearful conspecifics. Research shows that observing a partner undergoing aversive stimulation triggers passive defensive responses, while interacting with a partner that has just undergone aversive stimulation prompts active exploration in animals. The study suggests that the responses of observer animals to social triggers are caused by changes in their affective state rather than mimicry, and that different populations of neurons in the central amygdala are involved in promoting passive or active defensive responses.
Article
Clinical Neurology
Helena Domin
Summary: Currently, there is no effective treatment for neurological and psychiatric disorders in which the Glu/GABA balance is disturbed. Recent studies suggest that the neuropeptide Y (NPY)-ergic system could be a potential therapeutic target for these disorders. Research on the neuroprotective roles of Y2 and Y5 receptors (YRs) could lead to the development of novel therapeutic strategies for these diseases.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Article
Chemistry, Medicinal
Edyta Proniewicz, Grzegorz Burnat, Helena Domin, Izabela Maluch, Marta Makowska, Adam Prahl
Summary: The article discusses the application of alanine-scanning technique combined with various spectroscopic methods to study the role of individual amino acid residues in the adsorption process of a peptide fragment on metal nanoparticles. By analyzing spectral profiles and conducting bioactivity studies, conclusions were drawn on the specific interactions between peptides and metal nanoparticles as well as peptide-G protein-coupled receptors (GPCRs).
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Endocrinology & Metabolism
Maria Smialowska, Barbara Zieba, Helena Domin
Summary: CRF is a neuropeptide that plays various roles in the brain, including activating stress and anxiety, but its specific role in the cortex remains unclear. Studies have shown that high doses of CRF injected into the Fr2 area can have an anxiolytic-like effect, primarily through activation of CRF1 receptors. The involvement of alpha1 and alpha2 adrenergic receptors in the noradrenergic system seems to play a key role in these anxiolytic effects, while beta receptors do not appear to have a significant impact.
Review
Clinical Neurology
Lukasz Przykaza, Ewa Kozniewska
Summary: Ischemic stroke is a major global health issue with limited treatment options. Current treatments focus on reperfusion methods, but a small percentage of patients are eligible. Basic research suggests that neuropeptide Y activation may have potential protective effects against stroke.
TRANSLATIONAL STROKE RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Danuta Jantas, Janusz Malarz, Thanh Nguyen Le, Anna Stojakowska
Summary: Flavonols, such as kaempferitrin and alpha-rhamnoisorobin, have shown neuroprotective effects in vitro experiments on SH-SY5Y cells damaged by H2O2 and 6-OHDA. The tested flavonols were not effective in counteracting doxorubicin-induced cytotoxicity. Inhibition of the PI3-K/Akt pathway abolished the neuroprotective effect of the investigated flavonols.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Lukasz Przykaza
Summary: Common concomitant stroke risk factors such as hypertension, diabetes, and hyperlipidemia exacerbate inflammatory processes during cerebral ischemia/reperfusion, leading to dysfunction of neurovascular units. In-depth basic research on these factors is crucial for the success of future neuroprotection, vasculoprotection, and immunomodulation therapies in stroke.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Danuta Jantas, Wladyslaw Lason
Summary: Neurodegenerative diseases are common chronic conditions without definitive treatment. Oxidative stress and necroptosis are thought to be closely related to the pathogenesis of neurodegenerative diseases. Multi-potential neuroprotectants with antioxidant and anti-necroptotic properties may be an effective therapeutic strategy.
Review
Behavioral Sciences
Helena Domin
Summary: This review examines the specific role of group III mGluRs in neuroprotection and highlights the importance of therapeutic time windows and potential mechanisms underlying the neuroprotective activity of these ligands.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2022)
Review
Biochemistry & Molecular Biology
Wladyslaw Lason, Danuta Jantas, Monika Leskiewicz, Magdalena Regulska, Agnieszka Basta-Kaim
Summary: Ischemic stroke is a major cause of death and disability worldwide. In this context, vitamin D3 has emerged as a potential treatment adjunct, with its ability to interfere with key prosurvival pathways and show neuroprotective, anti-inflammatory, regenerative, and anti-aging properties. This narrative review discusses the biochemical mechanisms of stroke-related brain damage, the effects of vitamin D3 on diverse cell death signaling pathways, and the outcomes of experimental and clinical studies on its neuroprotective potential in ischemic stroke.
Article
Multidisciplinary Sciences
Edyta Proniewicz, Grzegorz Burnat, Helena Domin, Adam Roman, Adam Prahl, Emilia Llowska
Summary: This study synthesized multiple analogs of bradykinin and examined their biological activity on cell lines expressing B1 or B2 receptors. The mRNA expression of B1R and B2R in tumor cell lines was also determined. In addition, the adsorption of five B1R antagonists at the liquid/solid interface was discussed.
SCIENTIFIC REPORTS
(2022)
Review
Cell Biology
Wladyslaw Lason, Danuta Jantas, Monika Leskiewicz, Magdalena Regulska, Agnieszka Basta-Kaim
Summary: The vitamin D receptor (VDR) is a nuclear receptor superfamily of transcription factors involved in neuroprotective, antiaging, prosurvival, and anti-inflammatory actions of vitamin D. The relationship between vitamin D insufficiency and susceptibility to neurodegenerative diseases has been suggested, but the role of VDR in brain pathologies remains unclear due to the multitargeted mechanisms of vitamin D.
Article
Multidisciplinary Sciences
Rugmani Meenambal, Tomasz Kruk, Jacek Gurgul, Piotr Warszynski, Danuta Jantas
Summary: In this study, PAA-CeO nanoparticles were synthesized and found to have neuroprotective effects against cell damage induced by H2O2 and 6-OHDA, reducing necrotic changes and partially attenuating caspase-3 activity. However, there was no impact on ROS formation induced by H2O2.
SCIENTIFIC REPORTS
(2023)
Article
Engineering, Biomedical
Aneta Fraczek-Szczypta, Natalia Kondracka, Marcel Zambrzycki, Maciej Gubernat, Pawel Czaja, Miroslawa Pawlyta, Piotr Jelen, Ryszard Wielowski, Danuta Jantas
Summary: The goal of this study was to develop electrode materials for nerve tissue stimulation using carbon-carbon composites with a core of carbon fibers and a pyrolytic carbon matrix. The materials were characterized using various techniques to evaluate their microstructural, chemical, and surface properties, and their biocompatibility was assessed using a neuroblastoma cell line.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
Correction
Neurosciences
Lucia Privitera, Ellen L. Hogg, Matthias Gaestel, Mark J. Wall, Sonia A. L. Correa
Article
Neurosciences
Li-Ya Jiang, Guan-Hao Wang, Jing-Jiao Xu, Xiao-Li Li, Xiao-Yan Lin, Xiang Fang, Hong-Xu Zhang, Mei Feng, Chun-Ming Jiang
Summary: This study reveals the importance of LINC00473 in regulating temozolomide (TMZ) resistance in glioblastoma (GB) and its potential mechanism. By regulating the expression of CEBP alpha and MGMT, LINC00473 promotes the formation of chemoresistance. Furthermore, LINC00473 can transfer chemoresistance to adjacent sensitive cells through exosomes.
Article
Neurosciences
Olga Kopach, Tetyana Pivneva, Nataliya Fedirko, Nana Voitenko
Summary: This study found that diabetic animals exhibit severe xerostomia characterized by reduced saliva flow rate, diminished total protein content, and decreased amylase activity. The impaired saliva production in diabetes is associated with reduced and delayed intracellular Ca2+ signals in submandibular acinar cells, caused by malfunctioning mitochondria. Targeting malfunctioning mitochondria may be a potential strategy for the treatment of diabetic xerostomia.
Article
Neurosciences
Nicholas M. Timme, Cherish E. Ardinger, Seth D. C. Weir, Rachel Zelaya-Escobar, Rachel Kruger, Christopher C. Lapish
Summary: This study aimed to assess aversion-resistant drinking behavior in head-fixed mice and explore the relationship between non-consummatory behaviors and aversion-resistant drinking. The results showed that head-fixed mice exhibited heterogenous levels of aversion-resistant drinking and non-consummatory behaviors were related to the intensity of this behavior.
Article
Neurosciences
David R. Maguire, Charles P. France
Summary: Methocinnamox (MCAM) is a novel, long-acting opioid receptor antagonist that effectively decreases fentanyl self-administration and prevents opioid overdose in monkeys. The study demonstrates the potential therapeutic utility of MCAM in the treatment of opioid use disorder.
Article
Neurosciences
Xiang Li, Dan Feng, Shenglu Ma, Mingxing Li, Shulei Zhao, Man Tang
Summary: This study investigated the effects of fluoxetine on neurochemical, neurobiological, and neurobehavioral changes in different subregions of the hippocampus. The results showed that fluoxetine increased dialysate 5-HT, decreased membrane 5-HTT protein, and increased cytoplasmic fraction. Additionally, fluoxetine reduced immobility times in behavioral tests, with greater effects observed in the ventral subregion compared to the dorsal subregion.
Article
Neurosciences
Alexander V. Zholos, Mariia I. Melnyk, Dariia O. Dryn
Summary: Acetylcholine is an important neurotransmitter in visceral smooth muscles, activating M2 and M3 muscarinic receptors to cause smooth muscle excitation and contraction. This review focuses on the cellular and molecular mechanisms underlying acetylcholine-induced depolarisation and smooth muscle contraction, as well as the effects of anticholinergic drugs on gastrointestinal motility. The knowledge gained from recent studies has greatly expanded our understanding of these processes.
Article
Neurosciences
Zhenlong Li, Hsien-Yu Peng, Chau-Shoun Lee, Tzer-Bin Lin, Ming-Chun Hsieh, Cheng-Yuan Lai, Han-Fang Wu, Lih-Chyang Chen, Mei-Ci Chen, Dylan Chou
Summary: Methylone shows significant efficacy in treating depression and social deficits, making it an ideal candidate for anti-depressant medication.
Article
Neurosciences
Aline Freyssin, Allison Carles, Sarra Guehairia, Gilles Rubinstenn, Tangui Maurice
Summary: This study explores the potential of combining FENM and S1R agonists in the treatment of Alzheimer's disease. The results showed that most FENM-based combinations can protect against learning deficits caused by A beta 25-35, with better efficacy in short-term memory.
Article
Neurosciences
J. D. Lorente, J. Cuitavi, L. Rullo, S. Candeletti, P. Romualdi, L. Hipolito
Summary: This study analyzed the effects of pain on negative affect in different sexes and time courses, as well as the involvement of the dynorphinergic and corticotropin releasing factor systems in these pain-related behaviors. The results showed sex and time-dependent anxiety- and anhedonia-like behaviors induced by pain in female rats. The recruitment of KOR/DYN in the NAc was identified as a key neurological substrate mediating pain-induced behavioral alterations.
Article
Neurosciences
Rongjun Liu, Daofan Sun, Xiuzhong Xing, Qingge Chen, Bo Lu, Bo Meng, Hui Yuan, Lan Mo, Liufang Sheng, Jinwei Zheng, Qiusheng Wang, Junping Chen, Xiaowei Chen
Summary: The coexistence of pain and depression is frequently observed in patients with chronic pain and depression. Oxytocin, a neuropeptide, has been reported to relieve chronic pain and depressive symptoms. This study investigated the effect of intranasal oxytocin on neuropathic pain and comorbid depressive symptoms, and found that oxytocin attenuated depression-like behavior but did not alleviate mechanical hyperalgesia. The results suggest that intranasal oxytocin may have the potential to treat depressive symptoms in neuropathic pain patients.