Article
Multidisciplinary Sciences
Yingchun Xia, Ziyuan Song, Zhengzhong Tan, Tianrui Xue, Shiqi Wei, Lingyang Zhu, Yingfeng Yang, Hailin Fu, Yunjiang Jiang, Yao Lin, Yanbing Lu, Andrew L. Ferguson, Jianjun Cheng
Summary: Recent advances in accelerated polymerization of N-carboxyanhydrides (NCAs) have enriched the toolbox for preparing well-defined polypeptide materials. The use of crown ethers to catalyze NCA polymerization enables efficient preparation of functionalized polypeptides, while also guiding catalyst design.
NATURE COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Dhruba P. Poudel, Richard T. Taylor
Summary: This article describes a protecting group free multicomponent reaction that produces a versatile dendron. The resulting dendron can be easily modified, leading to highly fluorescent polyurethane dendrimers with symmetrical and unsymmetrical structures. Fluorescence studies confirm the occurrence of FRET between different fluorophores.
Article
Chemistry, Physical
Ya-Cheng Zhu, Fu-Hua Xue, Li-Xia Kang, Jian-Wei Liu, Ying Wang, Deng-Yuan Li, Pei-Nian Liu
Summary: Dendronized polymers (DPs) are composed of a linear polymeric backbone with dendritic side chains, and the fine-tuning of the functional groups in the side chains enriches the structural versatility and imparts novel physical properties to DPs. In this study, the first on-surface synthesis of DPs on Au(111) was achieved via postfunctionalization, and the surface confinement effects on the planar conformation and chiral configurations were characterized.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2022)
Article
Chemistry, Multidisciplinary
Jiadong Tang, Maosheng Li, Xianhong Wang, Youhua Tao
Summary: We have achieved the one-pot production of sequence-controlled block copolymer from mixed monomers using a switchable catalyst. The method allows for chemoselective and efficient polymerization reactions, resulting in a high conversion rate of CO2.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Review
Materials Science, Biomaterials
Luigi Stagi, Davide de Forni, Plinio Innocenzi
Summary: This review critically compares the antiviral activities and mechanisms of action of lysine and its analogues, and finds that antiviral drugs can inhibit virus replication by preventing virus entry into cells.
BIOMATERIALS SCIENCE
(2022)
Article
Materials Science, Biomaterials
Ali Alazzo, Nurcan Gumus, Pratik Gurnani, Snjezana Stolnik, Ruman Rahman, Keith Spriggs, Cameron Alexander
Summary: Higher molar mass derivatives of poly(lysine) were found to yield smaller polyplexes with greater affinity for siRNA and higher transfection efficiency, although they may come with some cytotoxicity. Histidinylation improved biocompatibility slightly, but did not significantly enhance gene silencing efficiency compared to non-histidinylated derivatives.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Polymer Science
Piotr Polanowski, Krzysztof Halagan, Andrzej Sikorski
Summary: A generic model for studying the polymerization process of branched macromolecules was developed and Monte Carlo simulations were used to investigate the process. The synthesis kinetics, size, and structure of star-branched polymers and dendrimers were studied, as well as the influence of well-defined cores on the system's structure and dispersity.
Article
Chemistry, Multidisciplinary
Yanchao Wang, Maosheng Li, Shixue Wang, Youhua Tao, Xianhong Wang
Summary: SCA monomers derived from amino acids are more reactive than thiolactones for ultrafast and selective ROP, resulting in controlled molecular weight, low dispersities, and retained stereoregularity of the synthesized polythioesters.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Materials Science, Multidisciplinary
Jun-Cai Chen, Zhe Cui, Yu-Zhuang Gao, Yi-Xian Wu
Summary: Through chemical reactions, graft copolymers of PZLL-g-PTHF and PLL-g-PTHF were synthesized, which exhibit different properties and applications, such as protein adsorption inhibition and antibacterial activity, with potential biomedical applications.
ACS APPLIED POLYMER MATERIALS
(2022)
Review
Health Care Sciences & Services
Anne-Marie Caminade
Summary: This review focuses on the clinical trials conducted with dendrimers, assessing their safety and efficacy. It highlights the poor clinical translation of dendrimers thus far.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Maosheng Li, Shuai Zhang, Xiaoyong Zhang, Yanchao Wang, Jinlong Chen, Youhua Tao, Xianhong Wang
Summary: The study describes an effective unimolecular anion-binding organocatalysis for ring-opening polymerization of O-carboxyanhydrides (OCAs), achieving the synthesis of highly isotactic poly(phenyllactic acid) (Ph-PLA) through a dynamic cooperative anion-binding mechanism. This approach addresses the challenge of synthesizing high molecular weight stereoregular polyesters by facilitating efficient chain propagation and maintaining high selectivity for OCA ring-opening over side reactions.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Polymer Science
Yuxiang He, Ying Wu, Minghui Zhang, Yuanxing Zhang, Hao Ding, Ke Zhang
Summary: A novel controlled ring-opening polymerization (ROP) method based on the nucleophilic ring-opening mechanism was developed for the first time, utilizing a quinone methide elimination-based self-immolative spacer as the trigger. This method successfully synthesized backbone functional and sequence-defined polymers with controlled molecular weights and narrow dispersities.
Article
Physics, Fluids & Plasmas
Saad Yalouz, Vincent Pouthier
Summary: This study investigates the energy absorption of photoexcitation at the core of a star network, which is distributed uniformly at the periphery. The existence of an optimal value of energy defect is revealed, which depends on the network architecture. When certain conditions are met, the absorption process can be accelerated. The findings of this study may serve as a potential guide for the design of efficient molecular nanonetworks for photoexcitation absorption.
Article
Polymer Science
Tomaz Kotnik, Gregor Zerjav, Albin Pintar, Ema Zagar, Sebastijan Kovacic
Summary: A new synthetic route to transition-metal free pi-conjugated polyHIPEs was reported, combining Schiff-base condensation reaction and emulsion-templating technology. The resulting highly porous azine- or imine-linked poly(arylene) networks exhibit high chemical resistance, thermal stability, and visible-light harvesting ability. Their photocatalytic properties were investigated in the degradation of aniline dissolved in water.
Article
Chemistry, Multidisciplinary
Jiabin Luan, Danni Wang, Shaohua Zhang, Yusuke Miyazaki, Wataru Shinoda, Daniela A. Wilson
Summary: The field of supramolecular chemistry has made significant progress in accessing traditionally inaccessible structures and functions by bringing the system away from equilibrium. However, vesicular assemblies with complex energy landscapes and pathways resembling cellular vesicles are still rare. This study demonstrates the activation of oligo(ethylene glycol) interdigitation in Janus dendrimers, revealing a rich vesicular landscape and pathway selection. The findings suggest that synthetic vesicles with activated OEG corona conformation emulate dynamic cellular vesicles and hold potential for nanomedicine and advanced materials.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Analytical
Mihai Deleanu, Jean-Francois Hernandez, Luca Cipelletti, Jean-Philippe Biron, Emilie Rossi, Myriam Taverna, Herve Cottet, Joseph Chamieh
Summary: This study demonstrates the efficacy of modern Taylor dispersion analysis (TDA) in unraveling the speciation of beta-amyloid peptides in low-volume peptide samples with a short analysis time. TDA was able to provide a complete and quantitative picture of A beta speciation during the aggregation process, including the sizing of oligomers and protofibrils, the consumption of monomers, and the quantification of different early and late-formed aggregated species.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Camille Malburet, Laurent Leclercq, Jean-Francois Cotte, Jerome Thiebaud, Sergio Marco, Marie-Claire Nicolai, Herve Cottet
Summary: In this study, Taylor dispersion analysis (TDA) was used to characterize the interactions between a polymeric adjuvant (poly(acrylic acid), SPA09) and a vaccine antigen for Staphylococcus aureus. TDA allowed rapid determination of complex sizes and free antigen percentage, as well as interaction parameters. The results were compared with transmission electron microscopy and previous capillary electrophoresis analysis.
ANALYTICAL CHEMISTRY
(2021)
Article
Biochemical Research Methods
Charly Renard, Laurent Leclercq, Herve Cottet
Summary: The study focuses on the generation of microbubbles on hydrophobic Glaco (TM) coated capillaries in water-based electrolyte, including the generation of bubbles at the detection window, identification of experimental parameters for microbubble generation, and characterization of the generated bubbles under constant electric field.
Article
Polymer Science
Yanis Abdelhamid Gueche, Noelia M. Sanchez-Ballester, Bernard Bataille, Adrien Aubert, Jean-Christophe Rossi, Ian Soulairol
Summary: This study investigates the plasticizing effect of di-carboxylic acids on reducing the optimal heating temperature (OHT) of polymer powder during SLS. Succinic acid was found to be the most efficient plasticizer, while only the acid form of ibuprofen demonstrated a plasticizing effect. DSC and FTIR analyses confirmed the decrease in glass transition temperature and the presence of interactions, respectively, without affecting the properties of the sintered SOFs or degrading the API.
Article
Geochemistry & Geophysics
Alan N. Heays, Tereza Kaiserova, Paul B. Rimmer, Antonin Knizek, Lukas Petera, Svatopluk Civis, Libor Juha, Roman Dudzak, Manuel Scherf, Helmut Lammer, Robert Pascal, Martin Ferus
Summary: The high-energy-density synthesis of NxOy species was simulated using laser-induced dielectric breakdown (LIDB), and the results showed that the measured yields of the products were in broad agreement with previous experiments and models, except for N2O, which exceeded the previous experimental results and could not contribute to global warming.
JOURNAL OF GEOPHYSICAL RESEARCH-PLANETS
(2022)
Article
Pharmacology & Pharmacy
Yanis A. Gueche, Noelia M. Sanchez-Ballester, Bernard Bataille, Adrien Aubert, Jean-Christophe Rossi, Ian Soulairol
Summary: This study investigated the effect of process parameters on the printability of a formulation containing copovidone and paracetamol, and the properties of 3D-printed solid oral forms. It was found that heating temperature, laser power, scan speed, and layer thickness significantly influenced the printing yield, height, weight, hardness, disintegration time, and drug release. Optimization of these parameters could personalize the properties of the solid oral forms.
Article
Biochemistry & Molecular Biology
Mihai Deleanu, Olivier Deschaume, Luca Cipelletti, Jean-Francois Hernandez, Carmen Bartic, Herve Cottet, Joseph Chamieh
Summary: The aggregation of amyloid A beta (1-40): A beta (1-42) peptide mixtures with different ratios was studied using Taylor dispersion analysis (TDA) and atomic force microscopy (AFM). TDA allowed for monitoring the kinetics of amyloid assembly and quantifying transient intermediates, while AFM visualized the formation of insoluble fibrils. Together, the two techniques enabled the study of the influence of peptide ratios on the kinetics and the formation of potentially toxic oligomeric species.
ACS CHEMICAL NEUROSCIENCE
(2022)
Article
Chemistry, Analytical
Camille Malburet, Laurent Leclercq, Jean-Francois Cotte, Jerome Thiebaud, Emilie Bazin, Marie Garinot, Herve Cottet
Summary: Messenger RNA vaccines have emerged as a promising alternative to traditional vaccines, requiring a delivery system like lipid nanoparticles to protect the mRNA from degradation and facilitate its entry into cells. The size and charge of the nanoparticles directly affect their behavior and cellular uptake, as analyzed using Taylor dispersion analysis and capillary electrophoresis.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Organic
Salem El Kharrat, Philippe Laurent, Laurent Boiteau
Summary: Novel 2-perfluoroalkylmethyl,4-arylamino substituted tetrahydroquinolines were efficiently synthesized using perfluoroalkyl iodides and monosubstituted anilines. The reaction proceeded through radical bis-addition, Michael addition, and electrophilic aromatic substitution, leading to the target compounds with different substitution patterns.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Camille Malburet, Laurent Leclercq, Jean-Francois Cotte, Jerome Thiebaud, Emilie Bazin, Marie Garinot, Herve Cottet
Summary: Lipid nanoparticles (LNPs) are advanced non-viral mRNA delivery systems that protect and deliver mRNA to cells, allowing it to be translated into the desired protein. The size and formulation process parameters of LNPs play a critical role in cellular internalization. This study investigated the impact of different formulation process parameters on LNPs size and also examined mRNA degradation and encapsulation within LNPs.
Article
Biochemistry & Molecular Biology
Juliet F. F. Nilsson, Hakima Baroudi, Frank Gondelaud, Giulia Pesce, Christophe Bignon, Denis Ptchelkine, Joseph Chamieh, Herve Cottet, Andrey V. V. Kajava, Sonia Longhi
Summary: The Nipah and Hendra viruses, classified as Henipaviruses, are highly dangerous human pathogens that counteract the host immune response. A recent study found that a short region within the shared N-terminal domain (PNT3) of the Phosphoprotein (P protein) can form amyloid-like structures. This study evaluated the role of specific tyrosine residues within this region in fibrillation. Results showed that removal of a single tyrosine significantly decreases fibril formation, mainly affecting the elongation phase, and the C-terminal half of PNT3 inhibits fibril formation. The study sheds light on the molecular mechanisms of fibril formation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biology
Robert Pascal, Addy Pross
Summary: Recent scientific research suggests that the mental state of life may be a result of its physical state, providing further insights into the physico-chemical process by which life emerged from non-life.
Review
Chemistry, Multidisciplinary
Robert Pascal, Addy Pross
Summary: One of the most remarkable aspects of life is its mental dimension, the origin and essence of which remain a mysterious scientific puzzle. Recent discoveries in microbiology suggest that even the simplest life forms possess highly developed cognitive abilities, possibly indicating that these capabilities emerged early in the evolutionary process. Additionally, the discovery of a new dimension within chemical space of dynamic kinetically stable (DKS) chemical systems offers insights into the emergence of systems with non-physical characteristics, including cognition and self. These findings, combined with a physically based understanding of evolution, provide a possible explanation for the physical/chemical basis of life's mental state and its emergence, potentially advancing our understanding of the "mind from matter" problem.
ISRAEL JOURNAL OF CHEMISTRY
(2023)
Article
Biochemical Research Methods
Laura Dhellemmes, Laurent Leclercq, Alisa Hoechsmann, Christian Neusuess, Jean -Philippe Biron, Sebastien Roca, Herve Cottet
Summary: Polyelectrolyte multilayers have been used in capillary electrophoresis for protein separation, and varying different parameters has improved the efficiency of separation. This study investigated critical parameters for constructing efficient successive multiple ionic-polymer layers (SMIL) coatings and found that vial preparation and sample conservation have a significant impact on separation performances. PDADMAC / PSS coated capillaries showed improved capability for protein separation with low residual protein adsorption.
JOURNAL OF CHROMATOGRAPHY A
(2023)
Article
Chemistry, Analytical
Ghassan Al Hamoui Dit Banni, Rouba Nasreddine, Syntia Fayad, Phu Cao-Ngoc, Jean-Christophe Rossi, Laurent Leclercq, Herve Cottet, Axel Marchal, Reine Nehme
Summary: A novel method for screening pancreatic lipase inhibitors was developed using dual detection capillary electrophoresis, allowing for both offline and online reaction monitoring. The method demonstrated advantages such as cost-effectiveness, no need for lipase modification, rapidity, and versatility.