Article
Biochemistry & Molecular Biology
Lingyu Shi, Zongyi Wang, Yujiao Li, Zheng Song, Wu Yin, Bing Hu
Summary: This study reveals the critical role of chd7 in oligodendrocyte migration and myelination in zebrafish, potentially associated with CHARGE syndrome.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Assia Tiane, Melissa Schepers, Renzo Riemens, Ben Rombaut, Patrick Vandormael, Veerle Somers, Jos Prickaerts, Niels Hellings, Daniel van den Hove, Tim Vanmierlo
Summary: In this study, researchers identified Id2 and Id4 as targets of DNA methylation during the differentiation of oligodendrocyte precursor cells. Using CRISPR technology, they confirmed that methylation of Id2/Id4 could drive cell differentiation. Furthermore, they found alterations in methylation and gene expression levels of these genes in multiple sclerosis patients compared to controls.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Review
Cell Biology
Tomohiro Torii, Tomohiro Miyasaka, Hiroaki Misonou
Summary: This review article discusses the presence of tau in oligodendrocytes and its potential impact on oligodendrocyte function. The study shows that the expression levels of tau significantly change in hypomyelination models and in demyelination regions.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Neurosciences
Kun Liu, Bin Yu, Jing-Fei Chen, Rui-Xue Li, Lin Chen, Shu-Yu Ren, Fei Wang, Feng Mei, Lan Xiao
Summary: The deletion of Dicer in astrocytes impairs oligodendroglial differentiation and myelination in both developing and adult central nervous system.
NEUROSCIENCE BULLETIN
(2021)
Article
Biochemistry & Molecular Biology
Young Rae Jo, Hye Ran Kim, So Young Jang, Hana Go, Min-Young Song, Da Kyeong Park, Yuna Oh, Juyeon Jo, Yoon Kyung Shin, Sung Joong Lee, Sang-Myung Cheon, Hyun Kyoung Lee, Kyung Eun Lee, Young Hye Kim, Hwan Tae Park
Summary: The study found that a large population of central neurons are derived from Cnp-expressing neuroglial stem cells; conditional gene targeting using the Cnp promoter, known to be OL-specific, can induce neuron-autonomous phenotypes.
Review
Cell Biology
Irena Smaga
Summary: This review summarizes the current knowledge on the role of myelin-related changes in depression, as well as the relationship among maternal malnutrition, myelination, and depression. The findings suggest that myelin alterations play a significant role in the development of depression.
Article
Biochemistry & Molecular Biology
Ruyi Mei, Wanwan Qiu, Yingying Yang, Siyu Xu, Yueyu Rao, Qingxin Li, Yuhao Luo, Hao Huang, Aifen Yang, Huaping Tao, Mengsheng Qiu, Xiaofeng Zhao
Summary: This study reveals that Ddr1 is selectively upregulated in newly differentiated oligodendrocytes in the early postnatal CNS and plays a crucial role in oligodendrocyte differentiation and myelination. Ddr1 deficiency leads to compromised axonal myelination and motor dysfunction, activating the ERK pathway in the CNS. Additionally, Ddr1 is important for myelin repair after lysolecithin-induced demyelination. Overall, this study sheds light on the role of Ddr1 in myelin development and repair in the CNS and provides a novel target for treating demyelinating diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Shuang-Ling Wu, Bin Yu, Yong-Jie Cheng, Shu-Yu Ren, Fei Wang, Lan Xiao, Jing-Fei Chen, Feng Mei
Summary: Alzheimer's disease (AD) is characterized by the presence of aggregated amyloid beta-protein (Aβ). Recent evidence suggests that inadequate myelinogenesis plays a role in AD-related functional deficits. The relationship between Aβ and myelinogenesis in AD brains, however, remains unclear.
EXPERIMENTAL NEUROLOGY
(2023)
Review
Neurosciences
Minkyung Kang, Yao Yao
Summary: Oligodendrocytes are crucial cells in the central nervous system responsible for myelinating axons and supporting the function of neurons. The function and development of oligodendrocytes are tightly regulated by various molecules, with laminin playing a significant role in processes such as survival, migration, proliferation, differentiation, and myelination. Understanding the specific molecular targets and signaling pathways in oligodendrocyte biology may have implications for therapeutic interventions in demyelinating diseases.
Article
Neurosciences
He Wang, Mengjia Liu, Zhuoyang Ye, Cuihua Zhou, Huiru Bi, Long Wang, Chen Zhang, Hui Fu, Ying Shen, Jian-Jun Yang, Yimin Hu, Guiquan Chen
Summary: This study reveals that the phosphorylation of FoxO1 by Akt plays a critical role in Sox10 expression and OL differentiation. Deletion of all three Akt isoforms leads to downregulation of Sox10, and mutant FoxO1 inhibits Sox10 promoter activity.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Matthew Swire, Peggy Assinck, Peter A. McNaughton, David A. Lyons, Charles Ffrench-Constant, Matthew R. Livesey
Summary: HCN2 ion channels play a key role in regulating myelin sheath length in the central nervous system. Pharmacological blockade or genetic knockout of HCN2 can affect myelin sheath length, highlighting their importance in the relationship between neuronal activity and myelin formation.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Kristin D. Dahl, Adam R. Almeida, Hannah A. Hathaway, Jennifer Bourne, Tanya L. Brown, Lisbet T. Finseth, Teresa L. Wood, Wendy B. Macklin
Summary: In the Central Nervous System (CNS), oligodendrocyte progenitor cells (OPCs) differentiate into mature oligodendrocytes that generate myelin, crucial for normal nervous system function. This study focused on the role of mTORC2 signaling in OPCs using PDGFRa-Cre X Rictorfl/fl mice. Loss of mTORC2 in OPCs led to early reduction in myelin RNAs and proteins, with more severe hypomyelination and increased unmyelinated axons observed in the corpus callosum compared to the spinal cord. The study revealed regionally specific effects of mTORC2 signaling in OPCs, particularly in the corpus callosum.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Cell Biology
Haijiao Huang, Bo Jing, Feiyan Zhu, Wanxiang Jiang, Ping Tang, Liyang Shi, Huiting Chen, Guoru Ren, Shiyao Xia, Luoling Wang, Yiyuan Cui, Zhiwen Yang, Alexander J. Platero, Andrew P. Hutchins, Mina Chen, Paul F. Worley, Bo Xiao
Summary: The mechanism of how neuronal signaling affects brain myelination is still not well understood. Our study reveals that dysregulated neuronal RHEB-mTORC1-DLK1 axis impairs brain myelination. Neuronal Rheb cKO inhibits oligodendrocyte differentiation and myelination, with activated neuronal expression of Dlk1 gene. Neuronal Dlk1 cKO improves myelination deficit in neuronal Rheb cKO mice, indicating that activated neuronal Dlk1 expression contributes to impaired myelination caused by Rheb cKO. The effect of Rheb cKO on Dlk1 expression is mediated by mTORC1; neuronal mTor cKO, Raptor cKO, and pharmacological inhibition of mTORC1 also lead to elevated neuronal Dlk1 expression. We demonstrate that both a secreted form of DLK1 and a membrane-bound DLK1 inhibit the differentiation of cultured oligodendrocyte precursor cells into myelin protein-expressing oligodendrocytes. Furthermore, neuronal expression of Dlk1 in transgenic mice reduces the formation of mature oligodendrocytes and myelination. This study identifies Dlk1 as an inhibitor of oligodendrocyte myelination and provides a mechanism linking altered neuronal signaling with oligodendrocyte dysfunction.
Article
Neurosciences
Na Suo, Bingqing He, Shihao Cui, Ying Yang, Min Wang, Qianting Yuan, Xin Xie
Summary: GPR149, an orphan G protein-coupled receptor enriched in OPCs, negatively regulates OPC to OL differentiation and myelination, impacting myelin development and remyelination. Deficiency of GPR149 enhances myelin regeneration. Further study suggests that GPR149 may regulate OL differentiation and myelin formation via the MAPK/ERK pathway.
Article
Neurosciences
Yongqiang Wu, Yanzi Zhong, Xufeng Liao, Xiangguang Miao, Jianbo Yu, Xinsheng Lai, Yu Zhang, Chaolin Ma, Haili Pan, Shunqi Wang
Summary: This study found that Tmem108 plays an important role in bipolar disorder. Mutant mice with Tmem108 showed behaviors similar to bipolar disorder, while Tmem108 inhibited the proliferation and maturation of oligodendrocytes. These findings may provide a new perspective for studying the pathogenesis and treatment of bipolar disorder.
Article
Multidisciplinary Sciences
Minou Djannatian, Sebastian Timmler, Martina Arends, Manja Luckner, Marie-Theres Weil, Ioannis Alexopoulos, Nicolas Snaidero, Bettina Schmid, Thomas Misgeld, Wiebke Moebius, Martina Schifferer, Elior Peles, Mikael Simons
NATURE COMMUNICATIONS
(2019)
Review
Developmental Biology
Yael Eshed-Eisenbach, Elior Peles
Summary: The clustering of VGSC in excitable membranes enhances excitability at critical sites such as the axon initial segment and the node of Ranvier. This clustering is not limited to axonal regions but is also found in other highly excitable sites, organized by adaptor proteins through submembranous actin-based cytoskeleton.
DEVELOPMENTAL NEUROBIOLOGY
(2021)
Article
Neurosciences
Fei Wang, Shu-Yu Ren, Jing-Fei Chen, Kun Liu, Rui-Xue Li, Zhi-Fang Li, Bo Hu, Jian-Qin Niu, Lan Xiao, Jonah R. Chan, Feng Mei
NATURE NEUROSCIENCE
(2020)
Article
Neurosciences
Yael Eshed-Eisenbach, Jerome Devaux, Anna Vainshtein, Ofra Golani, Se-Jin Lee, Konstantin Feinberg, Natasha Sukhanov, Daniel S. Greenspan, Keiichiro Susuki, Matthew N. Rasband, Elior Peles
Article
Neurosciences
Yanqing Zhang, Stephanie Yuen, Elior Peles, James L. Salzer
JOURNAL OF NEUROSCIENCE
(2020)
Article
Neurosciences
Christina Katanov, Nurit Novak, Anya Vainshtein, Ofra Golani, Jeffery L. Dupree, Elior Peles
JOURNAL OF NEUROSCIENCE
(2020)
Article
Genetics & Heredity
Marcus Keatinge, Themistoklis M. Tsarouchas, Tahimina Munir, Nicola J. Porter, Juan Larraz, Davide Gianni, Hui-Hsin Tsai, Catherina G. Becker, David A. Lyons, Thomas Becker
Summary: Through a rapid in vivo phenotypic screen, researchers identified macrophage-related genes that promote regeneration in zebrafish after spinal cord injury. Disruption of 10 potentially related genes impaired axonal regeneration, with 4 stable mutants validating the approach.
Article
Neurosciences
Jianqin Niu, Guangdan Yu, Xiaorui Wang, Wenlong Xia, Yuxin Wang, Kimberly K. Hoi, Feng Mei, Lan Xiao, Jonah R. Chan, Stephen P. J. Fancy
Summary: A study identifies an intrinsic factor, Rnf43, in controlling OL maturation in human white matter injury and brain injuries, promoting remyelination. Rnf43 is activated by Wnt signaling in OL progenitor cells and marks activated OPCs in MS and HIE. Inhibition of Fzd1 using UM206 promotes remyelination after demyelinating injury.
Article
Neurosciences
Jing-Fei Chen, Kun Liu, Bo Hu, Rong-Rong Li, Wendy Xin, Hao Chen, Fei Wang, Lin Chen, Rui-Xue Li, Shu-Yu Ren, Lan Xiao, Jonah R. Chan, Feng Mei
Summary: The study found a significant increase in new myelin formation rate in the APP/PS1 mouse model of Alzheimer's disease, despite a decrease in overall myelination levels in the cortex and hippocampus. Enhancing myelin renewal through genetic or pharmacological methods improved cognitive performance in memory-related tasks.
Article
Neurosciences
Feng Guo, Yi-Fan Zhang, Kun Liu, Xu Huang, Rui-Xue Li, Shu-Yue Wang, Fei Wang, Lan Xiao, Feng Mei, Tao Li
Summary: Chronic alcohol consumption can inhibit myelinogenesis in the adult mouse brain, potentially contributing to alcohol-related cognitive impairments.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Sarah Moyon, Rebecca Frawley, Damien Marechal, Dennis Huang, Katy L. H. Marshall-Phelps, Linde Kegel, Sunniva M. K. Bostrand, Boguslawa Sadowski, Yong-Hui Jiang, David A. Lyons, Wiebke Moebius, Patrizia Casaccia
Summary: The study reveals that DNA hydroxymethylase TET1 regulates myelin repair in adult mice, but is defective with aging. Furthermore, deletion of TET1 results in decreased repair of demyelinated lesions and altered expression of genes related to neuro-glial communication.
NATURE COMMUNICATIONS
(2021)
Article
Neurosciences
Lin Chen, Shu-Yu Ren, Rui-Xue Li, Kun Liu, Jing-Fei Chen, Yu-Jian Yang, Yong-Bin Deng, Han-Zhi Wang, Lan Xiao, Feng Mei, Fei Wang
Summary: Exposure to chronic hypoxia inhibits myelinogenesis and causes motor coordination deficits in adult mice. Enhancing myelinogenesis protects brain functions against hypoxia-related deficits.
NEUROSCIENCE BULLETIN
(2021)
Article
Biology
Arantxa Cebrian-Silla, Marcos Assis Nascimento, Stephanie A. Redmond, Benjamin Mansky, David Wu, Kirsten Obernier, Ricardo Romero Rodriguez, Susana Gonzalez-Granero, Jose Manuel Garcia-Verdugo, Daniel A. Lim, Arturo Alvarez-Buylla
Summary: By analyzing a single-cell RNA-sequencing dataset of the adult mouse V-SVZ, two distinct populations of NSPCs residing in either the dorsal or ventral V-SVZ were identified. These regional differences in gene expression were validated using a single-nucleus RNA-sequencing reference dataset and immunocytochemistry. The study provides novel markers and territories for understanding the region-specific regulation of adult neurogenesis.
Review
Developmental Biology
Jing-Fei Chen, Fei Wang, Nan-Xing Huang, Lan Xiao, Feng Mei
Summary: Oligodendrocytes and myelin undergo dynamic changes in healthy and neurodegenerative brains, and may play an important role in modulating neuronal function and survival. Targeting oligodendroglial cells could have potential value in treating neurodegenerative diseases.
DEVELOPMENTAL NEUROBIOLOGY
(2022)
Article
Neurosciences
Sarah A. Neely, Jill M. Williamson, Anna Klingseisen, Lida Zoupi, Jason J. Early, Anna Williams, David A. Lyons
Summary: Through research on zebrafish, it was found that surviving oligodendrocytes are less efficient in generating new myelin sheaths and frequently misdirect the myelin to neuronal cell bodies, which is similar to the pathology seen in multiple sclerosis (MS). Conversely, oligodendrocytes generated after demyelination produce abundant and correctly targeted myelin sheaths, suggesting that they may also have a better regenerative potential in MS.
NATURE NEUROSCIENCE
(2022)