Review
Food Science & Technology
Divakar Dahiya, Poonam Singh Nigam
Summary: Pure viable strains of probiotics are used in the fermentation process to prepare functional beverages, which can provide nutrition and maintain a healthy gut microbiota. These non-dairy probiotic drinks have various benefits for nutrition and gut health, and can be consumed by a wide range of consumers.
Article
Nutrition & Dietetics
Jorge Amil Dias, Edmundo Santos, Ines Asseiceira, Sylvia Jacob, Carmen Ribes Koninckx
Summary: The incidence of allergic diseases is increasing globally, and experts discuss the role of infant formulas in preventing allergies in infants who cannot be breastfed and are at risk of developing allergies. They focus on risk assessment, the impact of microbiota on immune tolerance, and the importance of certain formula characteristics. The article provides the latest evidence and recommendations for parents in choosing a formula for infants at risk of allergy.
Review
Food Science & Technology
Parisa Janmohammadi, Zeinab Nourmohammadi, Siavash Fazelian, Atieh Mirzababaei, Shahab Alizadeh, Mahtab Zarei, Elnaz Daneshzad, Kurosh Djafarian
Summary: Several studies have suggested that formulas containing synbiotics (composed of prebiotics and probiotics) may have a positive effect on anthropometric indices. However, the results of these studies are inconsistent. This meta-analysis found that the consumption of formulas containing synbiotics did not significantly affect the growth of healthy infants.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Nutrition & Dietetics
Valentina Fabiano, Flavia Indrio, Elvira Verduci, Valeria Calcaterra, Tudor Lucian Pop, Alessandra Mari, Gian Vincenzo Zuccotti, Fugen Cullu Cokugras, Massimo Pettoello-Mantovani, Olivier Goulet
Summary: Intestinal colonization and postnatal immune maturation in neonates are influenced by pregnancy term, delivery mode, and feeding type, with breastfeeding providing benefits for gut development and microbiome diversity. The development of new infant formulas aims to mimic human milk's effects on gut microbiome and immune system, utilizing bioactive ingredients like HMOs, probiotics, prebiotics, and post-biotics. These enriched formulas are designed to guide practitioners in understanding and utilizing the benefits of different microbiota influencing formulas.
Review
Nutrition & Dietetics
Neeraj K. Singh, Jeffrey M. Beckett, Krishnakumar Kalpurath, Muhammad Ishaq, Tauseef Ahmad, Rajaraman D. Eri
Summary: Chemotherapy is the primary treatment for cancer patients, but it often leads to complications. Restoring the gut microbiota through the use of probiotics is a potential approach to reduce chemotherapy-associated complications.
Article
Immunology
Carlos Blazquez-Bondia, Mariona Parera, Francesc Catala-Moll, Maria Casadella, Aleix Elizalde-Torrent, Meritxell Aguilo, Jordi Espadaler-Mazo, Jose Ramon Santos, Roger Paredes, Marc Noguera-Julian
Summary: In a clinical trial, a synbiotic intervention was found to have a slight positive effect on immune reconstitution in HIV-1 infected immuno-discordant patients, with a small increase in CD4/CD8 ratio and minor reductions in sCD14. However, a probiotic intervention alone did not show any impact on immune parameters or faecal microbiome composition.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Agnieszka Chlebicz-Wojcik, Katarzyna Slizewska
Summary: Irritable bowel syndrome is not life-threatening but significantly impacts quality of life and economic loss. Research focuses on the role of intestinal microbiota in disease development, with an emphasis on therapies modulating the microbiota such as probiotics, prebiotics, and synbiotics. Most studies have focused on probiotics, but there are also promising results from studies on prebiotics and synbiotics.
Article
Environmental Sciences
Loret Keulers, Ali Dehghani, Leon Knippels, Johan Garssen, Nikolaos Papadopoulos, Gert Folkerts, Saskia Braber, Jeroen van Bergenhenegouwen
Summary: Air pollution is a major public health issue, causing an estimated seven million deaths worldwide each year. The exposure to air pollutants, both outdoor and indoor, can lead to gastrointestinal and respiratory impairments and diseases. The gut and lung have a crosstalk called the gut-lung axis, which can be influenced by probiotics, prebiotics, and synbiotics, ultimately affecting gut and lung health.
ENVIRONMENTAL POLLUTION
(2022)
Review
Clinical Neurology
Ziran Zhao, Gui Xiao, Jieqiong Xia, Honghua Guo, Xiaoli Yang, Qian Jiang, Hu Wang, Jiaji Hu, Caihong Zhang
Summary: This meta-analysis examines the effects of interventions that alter gut microbes on anxiety and finds that probiotics and synbiotics can reduce anxiety scores, while the reduction in anxiety scores with prebiotics is not significant. However, due to small effect size and sample size, the clinical efficacy of these interventions in alleviating anxiety is uncertain. There is also no consensus on the optimal dose, treatment duration, treatment type, or probiotic strain in improving anxiety.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Review
Biotechnology & Applied Microbiology
Divakar Dahiya, Poonam Singh Nigam
Summary: Biological, social, and psychological practices have a significant impact on dietary intake, leading to health-related complexities. The popularity of functional food and supplements, which offer nutraceutical benefits, has increased, providing people with various choices of fermented food and beverages. This review examines the characteristics of probiotics, prebiotics, post- and paraprobiotics, and their role in nutrition and health sustainability. Synbiotic supplements, which are blends of selected probiotic cultures and prebiotic substrates, have attracted consumers due to the range of health benefits they offer in the nutraceutical market.
FERMENTATION-BASEL
(2022)
Article
Biotechnology & Applied Microbiology
Edgar Torres-Maravilla, Vianey Mendez-Trujillo, Natalia C. Hernandez-Delgado, Luis G. Bermudez-Humaran, Diana Reyes-Pavon
Summary: Currently, emerging alimentary alternatives are growing, providing people with more natural food choices. Studies have found that traditional fermented foods contain functional components that promote health, and combining these foods with the needs of the local population can lead to the development of functional foods suitable for different demographics.
FERMENTATION-BASEL
(2022)
Review
Infectious Diseases
Habtemariam Alekaw Habteweld, Tsegahun Asfaw
Summary: Antimicrobial resistance is a global public health concern caused by the overuse and misuse of antimicrobial agents. Developing new drugs to overcome resistance is not sustainable, as bacteria can quickly develop resistance to new drugs as well. Instead, focusing on improving the body's natural defenses against infections through the use of probiotics, prebiotics, and synbiotics is a viable alternative approach.
INFECTION AND DRUG RESISTANCE
(2023)
Article
Microbiology
Niloofar Akhavan, Katarzyna Hrynkiewicz, Dominika Thiem, Cinzia Randazzo, Ann M. Walsh, Kieran J. Guinan, John T. O'Sullivan, Katarzyna Stadnicka
Summary: The use of probiotics, prebiotics, and synbiotics in poultry diets can promote the health and welfare of the animals by stimulating the growth of gut microbiome. This study analyzed different probiotics and prebiotics to identify the most promising candidates for synbiotic combinations. The results showed that certain prebiotics significantly stimulated the growth of probiotics, with astragalus polysaccharide and vegetable protein hydrolysate being the most effective ones. The strains belonging to L. plantarum (B4), L. rhamnosus (B3), and B. lactis (B2) are considered the best candidates for synbiotic combinations. These findings have implications for future in vivo trials on poultry microbiome modulation.
FRONTIERS IN MICROBIOLOGY
(2023)
Review
Medicine, Research & Experimental
Camila Stofella Sodre, Mayra Stambovsky Vieira, Juliany Lima Estefan, Cristiane Moraes, Fernanda Sampaio Cavalcante, Katia Regina Netto dos Santos, Dennis de Carvalho Ferreira
Summary: A literature review found that probiotics have the potential to improve symptoms of atopic dermatitis in adult patients, reducing itchiness and severity as measured by SCORAD. However, there is still controversy and divergence regarding the actual benefits of probiotics in this context.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2022)
Review
Biotechnology & Applied Microbiology
Manoj Kumar Yadav, Indu Kumari, Bijender Singh, Krishna Kant Sharma, Santosh Kumar Tiwari
Summary: Probiotics are an economical and safe alternative for treating chronic diseases and improving human health. They modulate the host immunity and protect against infectious and non-infectious diseases. Additionally, prebiotics and non-digestible food substances promote the growth of probiotics and human health through modulation of gut microbiota and immune system.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Article
Nutrition & Dietetics
Rossella Turco, Marina Russo, Dario Bruzzese, Annamaria Staiano
Summary: The study compared the efficacy of a partially hydrolysed formula with reduced lactose content and Lactobacillus reuteri with a standard formula in infant colic, showing that the standard formula had a better effect in reducing infant crying time.
CLINICAL NUTRITION
(2021)
Article
Endocrinology & Metabolism
P. Quitadamo, L. Zenzeri, E. Mozzillo, V. Giorgio, A. Rocco, A. Franzese, G. Nardone, A. Staiano
Summary: The study failed to find a significant association between hormone levels and gastric motility. Leptin and ghrelin levels were significantly correlated with obesity parameters, but no significant differences were found in GET and hormone levels in patients with obesity.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2021)
Article
Gastroenterology & Hepatology
Kornilia Nikaki, Chung Lee, Ahsen Ustaoglu, Annalisa Alessandrella, Annamaria Staiano, Philip Woodland, Daniel Sifrim
Summary: The study found that pediatric patients with nonerosive reflux disease have deeper esophageal mucosal innervation compared to healthy controls. Both groups had calcitonin gene-related peptide positive nerve fibers located deep in the mucosa and did not coexpress transient receptor potential cation channel subfamily V member 1.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
Caterina Strisciuglio, Massimo Martinelli, Peter Lu, Michal Rozenfeld Bar Lev, Beate Beinvogl, Marc A. Benninga, Carlo Di Lorenzo, Francesca Fiori Nastro, Samuel Nurko, Haley Pearlstein, Rachel Rosen, Raanan Shamir, Annamaria Staiano
Summary: During the first phase of the COVID-19 pandemic, children with FAPDs experienced improved symptoms, with a decrease in abdominal pain episodes over time, and showed increased quality of life and anxiety levels.
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2021)
Article
Pediatrics
Caterina Strisciuglio, Vincenzo Coppola, Marina Russo, Carlo Tolone, Gian Luigi Marseglia, Alberto Verrotti, Silvia Caimmi, Claudia Caloisi, Valeria D'Argenio, Lucia Sacchetti, Annamaria Staiano
Summary: Promelaxin microenemas are non-inferior to oral PEG in the treatment of pediatric functional constipation, as demonstrated by a randomized trial with evidence of non-inferiority in response rates and overall treatment compliance. Additionally, microbiota analysis showed some differences between the two treatment arms, with potential implications for future research and clinical practice.
FRONTIERS IN PEDIATRICS
(2021)
Review
Gastroenterology & Hepatology
Giovanni Di Nardo, Cesare Cremon, Annamaria Staiano, Vincenzo Stanghellini, Osvaldo Borrelli, Caterina Strisciuglio, Claudio Romano, Saverio Mallardo, Elena Scarpato, Giovanni Marasco, Silvia Salvatore, Letizia Zenzeri, Enrico Felici, Licia Pensabene, Simona Sestito, Ruggiero Francavilla, Paolo Quitadamo, Mariella Baldassarre, Valentina Giorgio, Renato Tambucci, Chiara Ziparo, Pasquale Parisi, Maria Raffaella Barbaro, Giovanni Barbara
Summary: Functional gastrointestinal disorders, such as IBS, affect many children worldwide due to disturbed neuroimmune function. Low-grade inflammation and mucosal immune activation play a significant role in symptom generation among pediatric patients with IBS, potentially influencing new therapeutic strategies.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Article
Nutrition & Dietetics
Caterina Strisciuglio, Sabrina Cenni, Maria Rosaria Serra, Pasquale Dolce, Sanja Kolacek, Sara Sila, Ivana Trivic, Michal Rozenfeld Bar Lev, Raanan Shamir, Aco Kostovski, Alexandra Papadopoulou, Eleftheria Roma, Christina Katsagoni, Danijela Jojkic-Pavkov, Angelo Campanozzi, Elena Scarpato, Erasmo Miele, Annamaria Staiano
Summary: 《Mediterranean diet has a protective effect on functional gastrointestinal disorders》
Review
Pediatrics
Claudia Mandato, Angelo Colucci, Roberta Lanzillo, Annamaria Staiano, Elena Scarpato, Luigi Schiavo, Francesca Felicia Operto, Maria Rosaria Serra, Cristina Di Monaco, Julia Sara Napoli, Grazia Massa, Pietro Vajro
Summary: Purpose of this study was to explore the role of lifestyle and diet in the development and progression of multiple sclerosis (MS) and investigate the potential benefits of diets and dietary supplementations in improving patient outcomes. Findings revealed that there is no universally best diet for MS, but healthy and balanced diets rich in fruits, vegetables, whole grains, and lean proteins while limiting processed foods, sugar, and saturated fat appear to have antioxidant and anti-inflammatory properties and promote a gut microbiota that supports gut and brain barriers. Vitamin D and polyunsaturated fatty acids are the most studied supplements for reducing MS-associated inflammation. In addition, counseling on appropriate diet and maintaining physical activity is recommended for MS prevention and management in both adults and children until more research is available on newer approaches.
Article
Gastroenterology & Hepatology
Massimo Martinelli, Erminia Romeo, Tamara Caldaro, Konstantina Dimakou, Alexandra Papadopoulou, Manar Matar, Amit Assa, Valeria Dipasquale, Claudio Romano, Marina Aloi, Patrizia Alvisi, Dennis Roser, Kaija Leena Kolho, Nadeem Afzal, Oren Ledder, Schlomi Cohen, Jiri Bronsky, Johanna C. Escher, Annecarin Brueckner, Raanan Shamir, Annamaria Staiano, Erasmo Miele
Summary: This study aimed to determine the prevalence and predictive factors of Crohn's disease (CD) in children with ulcerative colitis (UC) after ileal pouch-anal anastomosis (IPAA). The results showed that children with UC undergoing IPAA had a high risk of developing subsequent CD, and a decreased preoperative body mass index was identified as a possible predictive factor for new-onset CD.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Pediatrics
Elena Bozzola, Anna Maria Staiano, Giulia Spina, Nicola Zamperini, Francesco Marino, Marco Roversi, Giovanni Corsello
Summary: This study recruited a group of paediatric influencers to communicate information about children and adolescents' health on social media, showing a significant increase in engagement and reach. Most influencers reported positive experiences, demonstrating the potential success of using influencers to promote correct communication about children's and adolescents' health.
ITALIAN JOURNAL OF PEDIATRICS
(2021)
Article
Pediatrics
Alessandro Rossi, Erasmo Miele, Simona Fecarotta, Maria Veiga-da-Cunha, Massimo Martinelli, Carmine Mollica, Maria D'Armiento, Enza Mozzillo, Pietro Strisciuglio, Terry G. J. Derks, Annamaria Staiano, Giancarlo Parenti
Summary: This study presents for the first time extensive gastrointestinal morphology follow-up in a GSD Ib patient receiving empagliflozin. The results suggest that this treatment can safely and effectively induce IBD remission, potentially postponing surgery. Future studies are needed to confirm long-term effects and assess benefits in different disease stages.
ITALIAN JOURNAL OF PEDIATRICS
(2021)
Article
Pediatrics
Massimo Martinelli, Lucia Quaglietta, Giuseppe Banderali, Pietro Ferrara, Claudio Romano, Annamaria Staiano
Summary: The study found that Italian pediatricians have a sufficient awareness of ibuprofen-prescribing patterns, but there is a concern regarding the relatively high percentage of pediatricians who combine/alternate the use of ibuprofen and paracetamol. The reported adverse events were mostly mild and often related to errors in dosage, frequency, and treatment duration, emphasizing the need for caution in both practitioners and patients in their use.
ITALIAN JOURNAL OF PEDIATRICS
(2021)
Article
Pediatrics
Paolo Quitadamo, Nikhil Thapar, Giovanni Di Nardo, Matilde Pescarin, Luca Bertelli, Clelia Tortora, Osvaldo Borrelli, Roberto De Giorgio, Annamaria Staiano
Summary: The study found a higher prevalence of joint hypermobility (JH) in children with ulcerative colitis, but the difference compared to the healthy controls did not reach statistical significance. Further investigation is needed to determine if JH can be considered a potential feature of pediatric GI disorders.
TURKISH JOURNAL OF PEDIATRICS
(2021)
Letter
Pediatrics
Riccardo Davanzo, Massimo Agosti, Irene Cetin, Antonio Chiantera, Giovanni Corsello, Luca A. Ramenghi, Annamaria Staiano, Marcello Tavio, Alberto Villani, Elsa Viora, Fabio Mosca
Summary: Although knowledge about the administration of COVID-19 vaccine to breastfeeding mothers is limited, Italian scientific societies concluded that COVID-19 vaccination is compatible with breastfeeding due to the well-demonstrated health benefits of breastfeeding and the unlikely health risks for nursed infants according to biological plausibility.
ITALIAN JOURNAL OF PEDIATRICS
(2021)
Review
Pediatrics
Lucia Quaglietta, Massimo Martinelli, Annamaria Staiano
Summary: Ibuprofen in children may lead to severe adverse events, including necrotizing soft tissue infections during chickenpox, which suggests cautious use.
ITALIAN JOURNAL OF PEDIATRICS
(2021)
