Rho/Rho-Associated Coiled-Coil Forming Kinase Pathway as Therapeutic Targets for Statins in Atherosclerosis

Nitrate therapy and nitrate tolerance in patients with coronary artery disease

(2013) Thomas Münzel et al.   CURRENT OPINION IN PHARMACOLOGY

Rho-Associated Coiled-Coil-Containing Kinase 2 Deficiency in Bone Marrow–Derived Cells Leads to Increased Cholesterol Efflux and Decreased Atherosclerosis

(2012) Qian Zhou et al.   CIRCULATION

FHL2 prevents cardiac hypertrophy in mice with cardiac-specific deletion of ROCK2

(2012) Ryuji Okamoto et al.   FASEB JOURNAL

Atorvastatin Inhibits Myocardin Expression in Vascular Smooth Muscle Cells

(2012) Jingjing Li et al.   HYPERTENSION

The Controversies of Statin Therapy

(2012) J. Wouter Jukema et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Diabetes-induced vascular dysfunction involves arginase I

(2011) Maritza J. Romero et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Are statins diabetogenic?

(2011) Uchechukwu K Sampson et al.   CURRENT OPINION IN CARDIOLOGY

Statins and the risk of new-onset diabetes

(2011) David Preiss et al.   CURRENT OPINION IN LIPIDOLOGY

Rho and Rho-Kinase Activity in Adipocytes Contributes to a Vicious Cycle in Obesity That May Involve Mechanical Stretch

(2011) Y. Hara et al.   Science Signaling

Pleiotropic Effects of Statins

(2010) Qian Zhou et al.   CIRCULATION JOURNAL

Acute vasodilator effects of inhaled fasudil, a specific Rho-kinase inhibitor, in patients with pulmonary arterial hypertension

(2010) Hiroshi Fujita et al.   HEART AND VESSELS

Increased leukocyte rho kinase (ROCK) activity and endothelial dysfunction in cigarette smokers

(2010) Takayuki Hidaka et al.   HYPERTENSION RESEARCH

ROCK1 plays an essential role in the transition from cardiac hypertrophy to failure in mice

(2010) Jianjian Shi et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The role of Rho protein signaling in hypertension

(2010) Gervaise Loirand et al.   Nature Reviews Cardiology

Revisited and Revised: Is RhoA Always a Villain in Cardiac Pathophysiology?

(2010) Shigeki Miyamoto et al.   Journal of Cardiovascular Translational Research

ROCK1 functions as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability

(2009) S. Vemula et al.   BLOOD

Statins and Cardiovascular Diseases: From Cholesterol Lowering to Pleiotropy

(2009) Qian Zhou et al.   CURRENT PHARMACEUTICAL DESIGN

Rho Kinase: An Important Mediator of Atherosclerosis and Vascular Disease

(2009) Qian Zhou et al.   CURRENT PHARMACEUTICAL DESIGN

Should All Diabetic Patients Be Treated With a Statin?

(2009) Y. Kamari et al.   DIABETES CARE

Advanced glycation end products increase endothelial permeability through the RAGE/Rho signaling pathway

(2009) Akiko Hirose et al.   FEBS LETTERS

Pharmacological Characterization of SAR407899, a Novel Rho-Kinase Inhibitor

(2009) Matthias Löhn et al.   HYPERTENSION

Targeted Disruption of ROCK1 Causes Insulin Resistancein Vivo

(2009) Dae Ho Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cyclic GMP Kinase and RhoA Ser188 Phosphorylation Integrate Pro- and Antifibrotic Signals in Blood Vessels

(2009) N. Sawada et al.   MOLECULAR AND CELLULAR BIOLOGY

Chemokines and Cardiovascular Risk

(2008) Pål Aukrust et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Statins inhibit Rho kinase activity in patients with atherosclerosis

(2008) Anju Nohria et al.   ATHEROSCLEROSIS

RhoA induces expression of inflammatory cytokine in adipocytes

(2008) Yuki Nakayama et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inhibitory Effects of Eicosapentaenoic Acid on Chronic Cerebral Vasospasm after Subarachnoid Hemorrhage: Possible Involvement of a Sphingosylphosphorylcholine-Rho-Kinase Pathway

(2008) Satoshi Shirao et al.   CEREBROVASCULAR DISEASES

Deficiency of ROCK1 in bone marrow-derived cells protects against atherosclerosis in LDLR−/− mice

(2008) Hong-Wei Wang et al.   FASEB JOURNAL

ROCK1 mediates leukocyte recruitment and neointima formation following vascular injury

(2008) Kensuke Noma et al.   JOURNAL OF CLINICAL INVESTIGATION

High glucose-induced upregulation of Rho / Rho-kinase via platelet-derived growth factor receptor−β increases migration of aortic smooth muscle cells

(2008) Noboru Akiyama et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Disruption of ROCK1 gene attenuates cardiac dilation and improves contractile function in pathological cardiac hypertrophy

(2008) Jianjian Shi et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Phosphorylation of Profilin by ROCK1 Regulates Polyglutamine Aggregation

(2008) J. Shao et al.   MOLECULAR AND CELLULAR BIOLOGY

Safety and Efficacy of Fasudil Monotherapy and Fasudil-Ozagrel Combination Therapy in Patients With Subarachnoid Hemorrhage: Sub-analysis of the Post-marketing Surveillance Study

(2008) Yoshio SUZUKI et al.   NEUROLOGIA MEDICO-CHIRURGICA

Cardiac Plasticity

(2008) Joseph A. Hill et al.   NEW ENGLAND JOURNAL OF MEDICINE

Platelet-vessel wall interactions in atherosclerotic disease

(2008) Harald Langer et al.   THROMBOSIS AND HAEMOSTASIS

Pleiotropic effects of statin therapy: molecular mechanisms and clinical results

(2008) Chao-Yung Wang et al.   TRENDS IN MOLECULAR MEDICINE

High glucose induces plasminogen activator inhibitor-1 expression through Rho/Rho-kinase-mediated NF-κB activation in bovine aortic endothelial cells

(2007) Hitoshi Iwasaki et al.   ATHEROSCLEROSIS

Diabetes-induced Coronary Vascular Dysfunction Involves Increased Arginase Activity

(2007) Maritza J. Romero et al.   CIRCULATION RESEARCH