Oxidative guanine base damage regulates human telomerase activity

Potent and Selective Inhibitors of MTH1 Probe Its Role in Cancer Cell Survival

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Two-step mechanism involving active-site conformational changes regulates human telomerase DNA binding

(2015) Christopher G. Tomlinson et al.   BIOCHEMICAL JOURNAL

Human telomerase: biogenesis, trafficking, recruitment, and activation

(2015) Jens C. Schmidt et al.   GENES & DEVELOPMENT

Oxidative stress inhibits distant metastasis by human melanoma cells

(2015) Elena Piskounova et al.   NATURE

Control of telomerase action at human telomeres

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Pools and Pols: Mechanism of a mutator phenotype

(2015) Christal D. Sohl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Telomeres are partly shielded from ultraviolet-induced damage and proficient for nucleotide excision repair of photoproducts

(2015) Dhvani Parikh et al.   Nature Communications

Control of telomerase action at human telomeres

(2015) Dirk Hockemeyer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

MTH1 expression is required for effective transformation by oncogenic HRAS

(2015) Maria G. Giribaldi et al.   Oncotarget

Base excision repair: A critical player in many games

(2014) Susan S. Wallace   DNA REPAIR

MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool

(2014) Helge Gad et al.   NATURE

Uncovering the polymerase-induced cytotoxicity of an oxidized nucleotide

(2014) Bret D. Freudenthal et al.   NATURE

Rapid induction of alternative lengthening of telomeres by depletion of the histone chaperone ASF1

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G-quadruplex conformation and dynamics are determined by loop length and sequence

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Inventory of telomerase components in human cells reveals multiple subpopulations of hTR and hTERT

(2014) Linghe Xi et al.   NUCLEIC ACIDS RESEARCH

MutT Homolog 1 (MTH1) maintains multiple KRAS-driven pro-malignant pathways

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Cooperative hybridization of γPNA miniprobes to a repeating sequence motif and application to telomere analysis

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Telomeric Overhang Length Determines Structural Dynamics and Accessibility to Telomerase and ALT-Associated Proteins

(2014) Helen Hwang et al.   STRUCTURE

Chronic inflammation induces telomere dysfunction and accelerates ageing in mice

(2014) Diana Jurk et al.   Nature Communications

Induction of Telomere Dysfunction Mediated by the Telomerase Substrate Precursor 6-Thio-2′-Deoxyguanosine

(2014) Ilgen Mender et al.   Cancer Discovery

ARTD1/PARP1 Negatively Regulates Glycolysis by Inhibiting Hexokinase 1 Independent of NAD + Depletion

(2014) Elise Fouquerel et al.   Cell Reports

Neil3 and NEIL1 DNA Glycosylases Remove Oxidative Damages from Quadruplex DNA and Exhibit Preferences for Lesions in the Telomeric Sequence Context

(2013) Jia Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Quantitative visualization of DNA G-quadruplex structures in human cells

(2013) Giulia Biffi et al.   Nature Chemistry

The telomere syndromes

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In Vitro and Ex Vivo Inhibition of Human Telomerase by Anti-HIV Nucleoside Reverse Transcriptase Inhibitors (NRTIs) but Not by Non-NRTIs

(2012) Kyle R. Hukezalie et al.   PLoS One

Human Telomeres Are Tethered to the Nuclear Envelope during Postmitotic Nuclear Assembly

(2012) Laure Crabbe et al.   Cell Reports

8-Oxoguanine in a quadruplex of the human telomere DNA sequence

(2011) Michaela Vorlícková et al.   FEBS Journal

Factors that influence telomeric oxidative base damage and repair by DNA glycosylase OGG1

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POT1–TPP1 enhances telomerase processivity by slowing primer dissociation and aiding translocation

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Reactive oxygen species in cancer

(2010) Geou-Yarh Liou et al.   FREE RADICAL RESEARCH

Reactive species and DNA damage in chronic inflammation: reconciling chemical mechanisms and biological fates

(2010) Pallavi Lonkar et al.   INTERNATIONAL JOURNAL OF CANCER

DNA polymerases involved in the incorporation of oxidized nucleotides into DNA: Their efficiency and template base preference

(2010) Atsushi Katafuchi et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice

(2010) Mariela Jaskelioff et al.   NATURE

Characterization of Oxidative Guanine Damage and Repair in Mammalian Telomeres

(2010) Zhilong Wang et al.   PLoS Genetics

DNA Polymerase Fidelity: Comparing Direct Competition of Right and Wrong dNTP Substrates with Steady State and Pre-Steady State Kinetics

(2009) Jeffrey G. Bertram et al.   BIOCHEMISTRY

Mammalian Telomeres Resemble Fragile Sites and Require TRF1 for Efficient Replication

(2009) Agnel Sfeir et al.   CELL

Deletion of Ogg1 DNA glycosylase results in telomere base damage and length alteration in yeast

(2009) Jian Lu et al.   EMBO JOURNAL

In VivoStoichiometry of Shelterin Components

(2009) Kaori K. Takai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Continuous elimination of oxidized nucleotides is necessary to prevent rapid onset of cellular senescence

(2009) P. Rai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Trace amounts of 8-oxo-dGTP in mitochondrial dNTP pools reduce DNA polymerase   replication fidelity

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