Concomitant binding of Afadin to LGN and F-actin directs planar spindle orientation

s-Afadin binds more preferentially to the cell adhesion molecules nectins than l-afadin

(2014) Reiko Kobayashi et al.   GENES TO CELLS

SLK-dependent activation of ERMs controls LGN–NuMA localization and spindle orientation

(2014) Mickael Machicoane et al.   JOURNAL OF CELL BIOLOGY

Dlg1 controls planar spindle orientation in the neuroepithelium through direct interaction with LGN

(2014) Mehdi Saadaoui et al.   JOURNAL OF CELL BIOLOGY

Par3–mInsc and Gαi3 cooperate to promote oriented epidermal cell divisions through LGN

(2014) Scott E. Williams et al.   NATURE CELL BIOLOGY

Genetic Ablation of Afadin Causes Mislocalization and Deformation of Paneth Cells in the Mouse Small Intestinal Epithelium

(2014) Miki Tanaka-Okamoto et al.   PLoS One

Shaping up to divide: Coordinating actin and microtubule cytoskeletal remodelling during mitosis

(2014) Oscar M. Lancaster et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Huntingtin Regulates Mammary Stem Cell Division and Differentiation

(2014) Salah Elias et al.   Stem Cell Reports

Cortical Dynein and Asymmetric Membrane Elongation Coordinately Position the Spindle in Anaphase

(2013) Tomomi Kiyomitsu et al.   CELL

NuMA phosphorylation dictates dynein-dependent spindle positioning

(2013) Sachin Kotak et al.   CELL CYCLE

Discs Large Links Spindle Orientation to Apical-Basal Polarity in Drosophila Epithelia

(2013) Dan T. Bergstralh et al.   CURRENT BIOLOGY

Mechanisms of spindle positioning: cortical force generators in the limelight

(2013) Sachin Kotak et al.   CURRENT OPINION IN CELL BIOLOGY

De novo lumen formation and elongation in the developing nephron: a central role for afadin in apical polarity

(2013) Z. Yang et al.   DEVELOPMENT

NuMA phosphorylation by CDK1 couples mitotic progression with cortical dynein function

(2013) Sachin Kotak et al.   EMBO JOURNAL

Formin-mediated actin polymerization cooperates with Mushroom body defect (Mud)-Dynein during Frizzled-Dishevelled spindle orientation

(2013) C. A. Johnston et al.   JOURNAL OF CELL SCIENCE

Structural and Biochemical Characterization of the Interaction between LGN and Frmpd1

(2013) Zhu Pan et al.   JOURNAL OF MOLECULAR BIOLOGY

Evidence for dynein and astral microtubule–mediated cortical release and transport of Gαi/LGN/NuMA complex in mitotic cells

(2013) Zhen Zheng et al.   MOLECULAR BIOLOGY OF THE CELL

NuMA localization, stability, and function in spindle orientation involve 4.1 and Cdk1 interactions

(2013) Lindsey Seldin et al.   MOLECULAR BIOLOGY OF THE CELL

Cell cycle–regulated membrane binding of NuMA contributes to efficient anaphase chromosome separation

(2013) Zhen Zheng et al.   MOLECULAR BIOLOGY OF THE CELL

Epithelial junctions maintain tissue architecture by directing planar spindle orientation

(2013) Yu-ichiro Nakajima et al.   NATURE

Genetic Deletion of Afadin Causes Hydrocephalus by Destruction of Adherens Junctions in Radial Glial and Ependymal Cells in the Midbrain

(2013) Hideaki Yamamoto et al.   PLoS One

Spindle orientation in mammalian cerebral cortical development

(2012) Madeline A Lancaster et al.   CURRENT OPINION IN NEUROBIOLOGY

Cortical dynein is critical for proper spindle positioning in human cells

(2012) Sachin Kotak et al.   JOURNAL OF CELL BIOLOGY

Mitotic spindle (DIS)orientation and DISease: Cause or consequence?

(2012) Anna Noatynska et al.   JOURNAL OF CELL BIOLOGY

Chromosome- and spindle-pole-derived signals generate an intrinsic code for spindle position and orientation

(2012) Tomomi Kiyomitsu et al.   NATURE CELL BIOLOGY

Structure of an Enzyme-Derived Phosphoprotein Recognition Domain

(2012) Christopher A. Johnston et al.   PLoS One

On the inscrutable role of Inscuteable: structural basis and functional implications for the competitive binding of NuMA and Inscuteable to LGN

(2012) M. Mapelli et al.   Open Biology

Mitotic Spindle Orientation in Asymmetric and Symmetric Cell Divisions during Animal Development

(2011) Xavier Morin et al.   DEVELOPMENTAL CELL

Guanylate kinase domains of the MAGUK family scaffold proteins as specific phospho-protein-binding modules

(2011) Jinwei Zhu et al.   EMBO JOURNAL

The Rap1–Rgl–Ral signaling network regulates neuroblast cortical polarity and spindle orientation

(2011) Ana Carmena et al.   JOURNAL OF CELL BIOLOGY

Canoe binds RanGTP to promote PinsTPR/Mud-mediated spindle orientation

(2011) Brett Wee et al.   JOURNAL OF CELL BIOLOGY

Mitotic spindle misorientation in cancer - out of alignment and into the fire

(2011) J. C. Pease et al.   JOURNAL OF CELL SCIENCE

LGN/mInsc and LGN/NuMA Complex Structures Suggest Distinct Functions in Asymmetric Cell Division for the Par3/mInsc/LGN and Gαi/LGN/NuMA Pathways

(2011) Jinwei Zhu et al.   MOLECULAR CELL

Asymmetric cell divisions promote Notch-dependent epidermal differentiation

(2011) Scott E. Williams et al.   NATURE

Inscuteable and NuMA proteins bind competitively to Leu-Gly-Asn repeat-enriched protein (LGN) during asymmetric cell divisions

(2011) S. Culurgioni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis for interaction between the conserved cell polarity proteins Inscuteable and Leu-Gly-Asn repeat-enriched protein (LGN)

(2011) S. Yuzawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Role of Afadin in Vascular Endothelial Growth Factor– and Sphingosine 1-Phosphate–Induced Angiogenesis

(2010) Hideto Tawa et al.   CIRCULATION RESEARCH

The Fz-Dsh Planar Cell Polarity Pathway Induces Oriented Cell Division via Mud/NuMA in Drosophila and Zebrafish

(2010) Marion Ségalen et al.   DEVELOPMENTAL CELL

LGN regulates mitotic spindle orientation during epithelial morphogenesis

(2010) Zhen Zheng et al.   JOURNAL OF CELL BIOLOGY

Asymmetric cell division: recent developments and their implications for tumour biology

(2010) Juergen A. Knoblich   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Identification of an Aurora-A/PinsLINKER/ Dlg Spindle Orientation Pathway using Induced Cell Polarity in S2 Cells

(2009) Christopher A. Johnston et al.   CELL

Molecular components of the adherens junction

(2008) Carien M. Niessen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The PDZ Protein Canoe Regulates the Asymmetric Division of Drosophila Neuroblasts and Muscle Progenitors

(2008) Stephan Speicher et al.   CURRENT BIOLOGY

Cdc42 controls spindle orientation to position the apical surface during epithelial morphogenesis

(2008) Aron B. Jaffe et al.   JOURNAL OF CELL BIOLOGY