标题
The regulation and functions of the nuclear RNA exosome complex
作者
关键词
-
出版物
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 17, Issue 4, Pages 227-239
出版商
Springer Nature
发表日期
2016-01-04
DOI
10.1038/nrm.2015.15
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- The Exosome Is Recruited to RNA Substrates through Specific Adaptor Proteins
- (2015) Matthias Thoms et al. CELL
- Mammalian NET-Seq Reveals Genome-wide Nascent Transcription Coupled to RNA Processing
- (2015) Takayuki Nojima et al. CELL
- RNA Exosome-Regulated Long Non-Coding RNA Transcription Controls Super-Enhancer Activity
- (2015) Evangelos Pefanis et al. CELL
- Widespread exon skipping triggers degradation by nuclear RNA surveillance in fission yeast
- (2015) Danny A. Bitton et al. GENOME RESEARCH
- DIS3 shapes the RNA polymerase II transcriptome in humans by degrading a variety of unwanted transcripts
- (2015) Teresa Szczepińska et al. GENOME RESEARCH
- RRP6/EXOSC10 is required for the repair of DNA double-strand breaks by homologous recombination
- (2015) C. Marin-Vicente et al. JOURNAL OF CELL SCIENCE
- Poly(A) Polymerase and the Nuclear Poly(A) Binding Protein, PABPN1, Coordinate the Splicing and Degradation of a Subset of Human Pre-mRNAs
- (2015) Lisa Muniz et al. MOLECULAR AND CELLULAR BIOLOGY
- Regulated Intron Retention and Nuclear Pre-mRNA Decay Contribute toPABPN1Autoregulation
- (2015) Danny Bergeron et al. MOLECULAR AND CELLULAR BIOLOGY
- RNA degradation paths in a 12-subunit nuclear exosome complex
- (2015) Debora Lika Makino et al. NATURE
- R loops: new modulators of genome dynamics and function
- (2015) José M. Santos-Pereira et al. NATURE REVIEWS GENETICS
- Transcription termination and the control of the transcriptome: why, where and how to stop
- (2015) Odil Porrua et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- RBM7 subunit of the NEXT complex binds U-rich sequences and targets 3′-end extended forms of snRNAs
- (2015) Dominika Hrossova et al. NUCLEIC ACIDS RESEARCH
- Breaking bad: R-loops and genome integrity
- (2015) Julie Sollier et al. TRENDS IN CELL BIOLOGY
- The fission yeast MTREC complex targets CUTs and unspliced pre-mRNAs to the nuclear exosome
- (2015) Yang Zhou et al. Nature Communications
- The Nuclear PolyA-Binding Protein Nab2p Is Essential for mRNA Production
- (2015) Manfred Schmid et al. Cell Reports
- The Human Nuclear Exosome Targeting Complex Is Loaded onto Newly Synthesized RNA to Direct Early Ribonucleolysis
- (2015) Michal Lubas et al. Cell Reports
- The Exosome Component Rrp6 Is Required for RNA Polymerase II Termination at Specific Targets of the Nrd1-Nab3 Pathway
- (2015) Melanie J. Fox et al. PLoS Genetics
- Exosome substrate targeting: the long and short of it
- (2014) Phil Mitchell BIOCHEMICAL SOCIETY TRANSACTIONS
- Crystal structure of the YTH domain of YTHDF2 reveals mechanism for recognition of N6-methyladenosine
- (2014) Tingting Zhu et al. CELL RESEARCH
- The eukaryotic RNA exosome
- (2014) Kurt Januszyk et al. CURRENT OPINION IN STRUCTURAL BIOLOGY
- The exosome‐binding factors Rrp6 and Rrp47 form a composite surface for recruiting the Mtr4 helicase
- (2014) Benjamin Schuch et al. EMBO JOURNAL
- A quantitative 14-3-3 interaction screen connects the nuclear exosome targeting complex to the DNA damage response
- (2014) Melanie Blasius et al. GENES & DEVELOPMENT
- lncRNA recruits RNAi and the exosome to dynamically regulate pho1 expression in response to phosphate levels in fission yeast
- (2014) S. Shah et al. GENES & DEVELOPMENT
- Widespread intron retention in mammals functionally tunes transcriptomes
- (2014) Ulrich Braunschweig et al. GENOME RESEARCH
- Roadblock Termination by Reb1p Restricts Cryptic and Readthrough Transcription
- (2014) Jessie Colin et al. MOLECULAR CELL
- Molecular Basis for Coordinating Transcription Termination with Noncoding RNA Degradation
- (2014) Agnieszka Tudek et al. MOLECULAR CELL
- An Rrp6-like Protein Positively Regulates Noncoding RNA Levels and DNA Methylation in Arabidopsis
- (2014) Huiming Zhang et al. MOLECULAR CELL
- R-loops induce repressive chromatin marks over mammalian gene terminators
- (2014) Konstantina Skourti-Stathaki et al. NATURE
- Structure of an Rrp6–RNA exosome complex bound to poly(A) RNA
- (2014) Elizabeth V. Wasmuth et al. NATURE
- Noncoding RNA transcription targets AID to divergently transcribed loci in B cells
- (2014) Evangelos Pefanis et al. NATURE
- Transcript-RNA-templated DNA recombination and repair
- (2014) Havva Keskin et al. NATURE
- The SKIV2L RNA exosome limits activation of the RIG-I-like receptors
- (2014) Sterling C Eckard et al. NATURE IMMUNOLOGY
- The RNA exosome promotes transcription termination of backtracked RNA polymerase II
- (2014) Jean-François Lemay et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- The Exosome and Trans-Acting Small Interfering RNAs Regulate Cuticular Wax Biosynthesis during Arabidopsis Inflorescence Stem Development
- (2014) Patricia Lam et al. PLANT PHYSIOLOGY
- Post-transcriptional regulation of meiotic genes by a nuclear RNA silencing complex
- (2014) E. D. Egan et al. RNA
- Quality control of spliced mRNAs requires the shuttling SR proteins Gbp2 and Hrb1
- (2014) Alexandra Hackmann et al. Nature Communications
- Nuclear stability and transcriptional directionality separate functionally distinct RNA species
- (2014) Robin Andersson et al. Nature Communications
- EXOSC8 mutations alter mRNA metabolism and cause hypomyelination with spinal muscular atrophy and cerebellar hypoplasia
- (2014) Veronika Boczonadi et al. Nature Communications
- Long non-coding RNA-mediated transcriptional interference of a permease gene confers drug tolerance in fission yeast
- (2014) Ryan Ard et al. Nature Communications
- Out of Balance: R-loops in Human Disease
- (2014) Matthias Groh et al. PLoS Genetics
- The RNA Helicases AtMTR4 and HEN2 Target Specific Subsets of Nuclear Transcripts for Degradation by the Nuclear Exosome in Arabidopsis thaliana
- (2014) Heike Lange et al. PLoS Genetics
- Stress-Induced Nuclear RNA Degradation Pathways Regulate Yeast Bromodomain Factor 2 to Promote Cell Survival
- (2014) Kevin Roy et al. PLoS Genetics
- PAR-CLIP data indicate that Nrd1-Nab3-dependent transcription termination regulates expression of hundreds of protein coding genes in yeast
- (2014) Shaun Webb et al. GENOME BIOLOGY
- Post-Transcriptional Regulation of DNA Damage-Responsive Gene Expression
- (2013) Bruce C. McKay ANTIOXIDANTS & REDOX SIGNALING
- RNA decay machines: The exosome
- (2013) Aleksander Chlebowski et al. Biochimica et Biophysica Acta-Gene Regulatory Mechanisms
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- (2013) Alex Charles Tuck et al. CELL
- Mtr4-like Protein Coordinates Nuclear RNA Processing for Heterochromatin Assembly and for Telomere Maintenance
- (2013) Nathan N. Lee et al. CELL
- Orchestrated Intron Retention Regulates Normal Granulocyte Differentiation
- (2013) Justin J.-L. Wong et al. CELL
- Transcriptome Surveillance by Selective Termination of Noncoding RNA Synthesis
- (2013) Daniel Schulz et al. CELL
- The Yeast Ski Complex: Crystal Structure and RNA Channeling to the Exosome Complex
- (2013) Felix Halbach et al. CELL
- Regulation of Axon Guidance by Compartmentalized Nonsense-Mediated mRNA Decay
- (2013) Dilek Colak et al. CELL
- Chromatin-associated ncRNA activities
- (2013) Claudia Keller et al. CHROMOSOME RESEARCH
- Spliceosome-mediated decay (SMD) regulates expression of nonintronic genes in budding yeast
- (2013) A. Volanakis et al. GENES & DEVELOPMENT
- A SUMO-dependent interaction between Senataxin and the exosome, disrupted in the neurodegenerative disease AOA2, targets the exosome to sites of transcription-induced DNA damage
- (2013) P. Richard et al. GENES & DEVELOPMENT
- E3-ubiquitin ligase Nedd4 determines the fate of AID-associated RNA polymerase II in B cells
- (2013) J. Sun et al. GENES & DEVELOPMENT
- Poly(A) Tail-Mediated Gene Regulation by Opposing Roles of Nab2 and Pab2 Nuclear Poly(A)-Binding Proteins in Pre-mRNA Decay
- (2013) V. Grenier St-Sauveur et al. MOLECULAR AND CELLULAR BIOLOGY
- Crystal structure of an RNA-bound 11-subunit eukaryotic exosome complex
- (2013) Debora Lika Makino et al. NATURE
- N6-methyladenosine-dependent regulation of messenger RNA stability
- (2013) Xiao Wang et al. NATURE
- Bimodal expression of PHO84 is modulated by early termination of antisense transcription
- (2013) Manuele Castelnuovo et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Visualization of distinct substrate-recruitment pathways in the yeast exosome by EM
- (2013) Jun-Jie Liu et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Polyadenylation site–induced decay of upstream transcripts enforces promoter directionality
- (2013) Evgenia Ntini et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- The RNA exosome complex central channel controls both exonuclease and endonuclease Dis3 activities in vivo and in vitro
- (2013) Karolina Drążkowska et al. NUCLEIC ACIDS RESEARCH
- Cotranscriptional recruitment of yeast TRAMP complex to intronic sequences promotes optimal pre-mRNA splicing
- (2013) Ka-Yiu Edwin Kong et al. NUCLEIC ACIDS RESEARCH
- The Sm Complex Is Required for the Processing of Non-Coding RNAs by the Exosome
- (2013) Sarah Coy et al. PLoS One
- The Human Nuclear Poly(A)-Binding Protein Promotes RNA Hyperadenylation and Decay
- (2013) Stefan M. Bresson et al. PLoS Genetics
- The homologous recombination machinery modulates the formation of RNA–DNA hybrids and associated chromosome instability
- (2013) Lamia Wahba et al. eLife
- The ribonuclease Dis3 is an essential regulator of the developmental transcriptome
- (2012) Dezhi Hou et al. BMC GENOMICS
- Microprocessor, Setx, Xrn2, and Rrp6 Co-operate to Induce Premature Termination of Transcription by RNAPII
- (2012) Alexandre Wagschal et al. CELL
- Mmi1 RNA surveillance machinery directs RNAi complex RITS to specific meiotic genes in fission yeast
- (2012) Edwige Hiriart et al. EMBO JOURNAL
- The yeastRPL9Bgene is regulated by modulation between two modes of transcription termination
- (2012) Rajani Kanth Gudipati et al. EMBO JOURNAL
- Coordinated regulation of neuronal mRNA steady-state levels through developmentally controlled intron retention
- (2012) K. Yap et al. GENES & DEVELOPMENT
- Nuclear Retention Prevents Premature Cytoplasmic Appearance of mRNA
- (2012) Thomas Beuchert Kallehauge et al. MOLECULAR CELL
- Exo- and Endoribonucleolytic Activities of Yeast Cytoplasmic and Nuclear RNA Exosomes Are Dependent on the Noncatalytic Core and Central Channel
- (2012) Elizabeth V. Wasmuth et al. MOLECULAR CELL
- Transcriptome-wide Analysis of Exosome Targets
- (2012) Claudia Schneider et al. MOLECULAR CELL
- Rrp6p Controls mRNA Poly(A) Tail Length and Its Decoration with Poly(A) Binding Proteins
- (2012) Manfred Schmid et al. MOLECULAR CELL
- Extensive Degradation of RNA Precursors by the Exosome in Wild-Type Cells
- (2012) Rajani Kanth Gudipati et al. MOLECULAR CELL
- Long Noncoding RNAs with snoRNA Ends
- (2012) Qing-Fei Yin et al. MOLECULAR CELL
- R Loops: From Transcription Byproducts to Threats to Genome Stability
- (2012) Andrés Aguilera et al. MOLECULAR CELL
- RNAi triggered by specialized machinery silences developmental genes and retrotransposons
- (2012) Soichiro Yamanaka et al. NATURE
- Mutations in the RNA exosome component gene EXOSC3 cause pontocerebellar hypoplasia and spinal motor neuron degeneration
- (2012) Jijun Wan et al. NATURE GENETICS
- Tri-snRNP-associated proteins interact with subunits of the TRAMP and nuclear exosome complexes, linking RNA decay and pre-mRNA splicing
- (2012) Anita Nag et al. RNA Biology
- Rarely at rest
- (2012) Steven W. Hardwick et al. RNA Biology
- Hexanucleotide motifs mediate recruitment of the RNA elimination machinery to silent meiotic genes
- (2012) A. Yamashita et al. Open Biology
- Diverse Forms of RPS9 Splicing Are Part of an Evolving Autoregulatory Circuit
- (2012) Alex M. Plocik et al. PLoS Genetics
- The RNA Helicase Mtr4p Modulates Polyadenylation in the TRAMP Complex
- (2011) Huijue Jia et al. CELL
- Mpk1 MAPK Association with the Paf1 Complex Blocks Sen1-Mediated Premature Transcription Termination
- (2011) Ki-Young Kim et al. CELL
- Introns within Ribosomal Protein Genes Regulate the Production and Function of Yeast Ribosomes
- (2011) Julie Parenteau et al. CELL
- The RNA Exosome Targets the AID Cytidine Deaminase to Both Strands of Transcribed Duplex DNA Substrates
- (2011) Uttiya Basu et al. CELL
- The nuclear RNA polymerase II surveillance system targets polymerase III transcripts
- (2011) Wiebke Wlotzka et al. EMBO JOURNAL
- RNase H and Multiple RNA Biogenesis Factors Cooperate to Prevent RNA:DNA Hybrids from Generating Genome Instability
- (2011) Lamia Wahba et al. MOLECULAR CELL
- Yeast Sen1 Helicase Protects the Genome from Transcription-Associated Instability
- (2011) Hannah E. Mischo et al. MOLECULAR CELL
- Human Senataxin Resolves RNA/DNA Hybrids Formed at Transcriptional Pause Sites to Promote Xrn2-Dependent Termination
- (2011) Konstantina Skourti-Stathaki et al. MOLECULAR CELL
- A Pre-mRNA Degradation Pathway that Selectively Targets Intron-Containing Genes Requires the Nuclear Poly(A)-Binding Protein
- (2011) Caroline Lemieux et al. MOLECULAR CELL
- Interaction Profiling Identifies the Human Nuclear Exosome Targeting Complex
- (2011) Michal Lubas et al. MOLECULAR CELL
- PROMoter uPstream Transcripts share characteristics with mRNAs and are produced upstream of all three major types of mammalian promoters
- (2011) Pascal Preker et al. NUCLEIC ACIDS RESEARCH
- Antisense RNA polymerase II divergent transcripts are P-TEFb dependent and substrates for the RNA exosome
- (2011) R. A. Flynn et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The eukaryotic RNA exosome: Same scaffold but variable catalytic subunits
- (2011) Søren Lykke-Andersen et al. RNA Biology
- The crystal structure of S. cerevisiae Ski2, a DExH helicase associated with the cytoplasmic functions of the exosome
- (2011) F. Halbach et al. RNA
- Clr4/Suv39 and RNA Quality Control Factors Cooperate to Trigger RNAi and Suppress Antisense RNA
- (2011) K. Zhang et al. SCIENCE
- Transcriptome-Wide Binding Sites for Components of the Saccharomyces cerevisiae Non-Poly(A) Termination Pathway: Nrd1, Nab3, and Sen1
- (2011) Tyler J. Creamer et al. PLoS Genetics
- Cross-talk in transcription, splicing and chromatin: who makes the first call?
- (2010) Ross Alexander et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- The human core exosome interacts with differentially localized processive RNases: hDIS3 and hDIS3L
- (2010) Rafal Tomecki et al. EMBO JOURNAL
- Importance of polyadenylation in the selective elimination of meiotic mRNAs in growing S. pombe cells
- (2010) Soichiro Yamanaka et al. EMBO JOURNAL
- Negative Regulation of Meiotic Gene Expression by the Nuclear Poly(a)-binding Protein in Fission Yeast
- (2010) Olivier St-André et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A link between nuclear RNA surveillance, the human exosome and RNA polymerase II transcriptional termination
- (2010) Sérgio F. de Almeida et al. NUCLEIC ACIDS RESEARCH
- Splice-Site Mutations Cause Rrp6-Mediated Nuclear Retention of the Unspliced RNAs and Transcriptional Down-Regulation of the Splicing-Defective Genes
- (2010) Andrea B. Eberle et al. PLoS One
- Structural analysis reveals the characteristic features of Mtr4, a DExH helicase involved in nuclear RNA processing and surveillance
- (2010) J. R. Weir et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Genome-wide analysis reveals distinct substrate specificities of Rrp6, Dis3, and core exosome subunits
- (2010) D. L. Kiss et al. RNA
- The Yeast Exosome Functions as a Macromolecular Cage to Channel RNA Substrates for Degradation
- (2009) Fabien Bonneau et al. CELL
- Fail-Safe Transcriptional Termination for Protein-Coding Genes in S. cerevisiae
- (2009) Ana G. Rondón et al. MOLECULAR CELL
- Bidirectional promoters generate pervasive transcription in yeast
- (2009) Zhenyu Xu et al. NATURE
- Widespread bidirectional promoters are the major source of cryptic transcripts in yeast
- (2009) Helen Neil et al. NATURE
- Regulation of NAB2 mRNA 3'-end formation requires the core exosome and the Trf4p component of the TRAMP complex
- (2009) K. M. Roth et al. RNA
- Exosome-mediated quality control: Substrate recruitment and molecular activity
- (2008) A LEBRETON et al. Biochimica et Biophysica Acta-Gene Regulatory Mechanisms
- L30 Binds the Nascent RPL30 Transcript to Repress U2 snRNP Recruitment
- (2008) Sara Macías et al. MOLECULAR CELL
- Transcription Termination and RNA Degradation Contribute to Silencing of RNA Polymerase II Transcription within Heterochromatin
- (2008) Lidia Vasiljeva et al. MOLECULAR CELL
- Nuclear mRNA Surveillance in THO/sub2 Mutants Is Triggered by Inefficient Polyadenylation
- (2008) Cyril Saguez et al. MOLECULAR CELL
- The exosome contains domains with specific endoribonuclease, exoribonuclease and cytoplasmic mRNA decay activities
- (2008) Daneen Schaeffer et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- TRAMP-mediated RNA surveillance prevents spurious entry of RNAs into the Schizosaccharomyces pombe siRNA pathway
- (2008) Marc Bühler et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- The Nrd1–Nab3–Sen1 termination complex interacts with the Ser5-phosphorylated RNA polymerase II C-terminal domain
- (2008) Lidia Vasiljeva et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- RNA Exosome Depletion Reveals Transcription Upstream of Active Human Promoters
- (2008) Pascal Preker et al. SCIENCE
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