Subversion of host genome integrity by bacterial pathogens

Chlamydia cell biology and pathogenesis

(2016) Cherilyn Elwell et al.   NATURE REVIEWS MICROBIOLOGY

The Typhoid Toxin Promotes Host Survival and the Establishment of a Persistent Asymptomatic Infection

(2016) Lisa Del Bel Belluz et al.   PLoS Pathogens

Bacteria Moving into Focus of Human Cancer

(2015) Francesco Boccellato et al.   Cell Host & Microbe

Salmonella Manipulation of Host Signaling Pathways Provokes Cellular Transformation Associated with Gallbladder Carcinoma

(2015) Tiziana Scanu et al.   Cell Host & Microbe

Neisseria meningitidiscauses cell cycle arrest of human brain microvascular endothelial cells at S phase via p21 and cyclin G2

(2015) Wilhelm F. Oosthuysen et al.   CELLULAR MICROBIOLOGY

In Vitro Expansion of Human Gastric Epithelial Stem Cells and Their Responses to Bacterial Infection

(2015) Sina Bartfeld et al.   GASTROENTEROLOGY

Helicobacter pylori Activates and Expands Lgr5+ Stem Cells Through Direct Colonization of the Gastric Glands

(2015) Michael Sigal et al.   GASTROENTEROLOGY

DNA Damage Primes the Type I Interferon System via the Cytosolic DNA Sensor STING to Promote Anti-Microbial Innate Immunity

(2015) Anetta Härtlova et al.   IMMUNITY

The colibactin warhead crosslinks DNA

(2015) Maria I. Vizcaino et al.   Nature Chemistry

Modulation of p53 during bacterial infections

(2015) Christine Siegl et al.   NATURE REVIEWS MICROBIOLOGY

Streptococcus pneumoniaesecretes hydrogen peroxide leading to DNA damage and apoptosis in lung cells

(2015) Prashant Rai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Helicobacter pylori bacteria alter the p53 stress response via ERK-HDM2 pathway

(2015) Vikas Bhardwaj et al.   Oncotarget

Helicobacter pylori Infection Causes Characteristic DNA Damage Patterns in Human Cells

(2015) Max Koeppel et al.   Cell Reports

H. pylori -Induced DNA Strand Breaks Are Introduced by Nucleotide Excision Repair Endonucleases and Promote NF-κB Target Gene Expression

(2015) Mara L. Hartung et al.   Cell Reports

Calcium and ROS: A mutual interplay

(2015) Agnes Görlach et al.   Redox Biology

The use of transformed IMR90 cell model to identify the potential extra-telomeric effects of hTERT in cell migration and DNA damage response

(2014) Xu Cao et al.   BMC BIOCHEMISTRY

Listeria monocytogenesinduces host DNA damage and delays the host cell cycle to promote infection

(2014) Elsa Leitão et al.   CELL CYCLE

Cytolethal distending toxin (CDT) is a radiomimetic agent and induces persistent levels of DNA double-strand breaks in human fibroblasts

(2014) Jörg Fahrer et al.   DNA REPAIR

Accumulation of Somatic Mutations in TP53 in Gastric Epithelium With Helicobacter pylori Infection

(2014) Takahiro Shimizu et al.   GASTROENTEROLOGY

A novel human gastric primary cell culture system for modellingHelicobacter pyloriinfection in vitro

(2014) Philipp Schlaermann et al.   GUT

Bacterial genotoxin colibactin promotes colon tumour growth by inducing a senescence-associated secretory phenotype

(2014) Antony Cougnoux et al.   GUT

Helicobacter pylori Infection Introduces DNA Double-Strand Breaks in Host Cells

(2014) Katsuhiro Hanada et al.   INFECTION AND IMMUNITY

Streptococcus pneumoniae–Induced Oxidative Stress in Lung Epithelial Cells Depends on Pneumococcal Autolysis and Is Reversible by Resveratrol

(2014) Janine Zahlten et al.   JOURNAL OF INFECTIOUS DISEASES

Dynamin-mediated lipid acquisition is essential forChlamydia trachomatisdevelopment

(2014) Rajendra Kumar Gurumurthy et al.   MOLECULAR MICROBIOLOGY

Whole-genome sequencing and comprehensive molecular profiling identify new driver mutations in gastric cancer

(2014) Kai Wang et al.   NATURE GENETICS

Oxidative DNA Damage as a Potential Early Biomarker of Helicobacter pylori Associated Carcinogenesis

(2014) Yasir Raza et al.   PATHOLOGY & ONCOLOGY RESEARCH

Multinucleation during C. trachomatis Infections Is Caused by the Contribution of Two Effector Pathways

(2014) Heather M. Brown et al.   PLoS One

Restriction Endonucleases from Invasive Neisseria gonorrhoeae Cause Double-Strand Breaks and Distort Mitosis in Epithelial Cells during Infection

(2014) Linda Weyler et al.   PLoS One

Evolutionary aspects of cancer resistance

(2014) George Klein   SEMINARS IN CANCER BIOLOGY

Chlamydia infection depends on a functional MDM2-p53 axis

(2014) Erik González et al.   Nature Communications

Tumor Suppressor p53 Alters Host Cell Metabolism to Limit Chlamydia trachomatis Infection

(2014) Christine Siegl et al.   Cell Reports

Listeria monocytogenes Dampens the DNA Damage Response

(2014) Ascel Samba-Louaka et al.   PLoS Pathogens

Uptake and Processing of the Cytolethal Distending Toxin by Mammalian Cells

(2014) Joseph DiRienzo   Toxins

Accumulation of abasic sites induces genomic instability in normal human gastric epithelial cells during Helicobacter pylori infection

(2014) D Kidane et al.   Oncogenesis

The Cytolethal Distending Toxin Effects on Mammalian Cells: A DNA Damage Perspective

(2014) Elisabeth Bezine et al.   Cells

End-resection at DNA double-strand breaks in the three domains of life: Figure 1

(2013) John K. Blackwood et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Chlamydia Infection Promotes Host DNA Damage and Proliferation but Impairs the DNA Damage Response

(2013) Cindrilla Chumduri et al.   Cell Host & Microbe

Salmonella entericadelivers its genotoxin through outer membrane vesicles secreted from infected cells

(2013) Riccardo Guidi et al.   CELLULAR MICROBIOLOGY

Chlamydia trachomatis inhibits telomeric DNA damage signaling via transient hTERT upregulation

(2013) Inken Padberg et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

p53 SUMOylation promotes its nuclear export by facilitating its release from the nuclear export receptor CRM1

(2013) Aleixo Santiago et al.   MOLECULAR BIOLOGY OF THE CELL

Chlamydia Induces Anchorage Independence in 3T3 Cells and Detrimental Cytological Defects in an Infection Model

(2013) Andrea E. Knowlton et al.   PLoS One

Escherichia coli Producing Colibactin Triggers Premature and Transmissible Senescence in Mammalian Cells

(2013) Thomas Secher et al.   PLoS One

Pro-inflammatory properties and neutrophil activation by Helicobacter pylori urease

(2013) Augusto F. Uberti et al.   TOXICON

A Distinct Replication Fork Protection Pathway Connects Fanconi Anemia Tumor Suppressors to RAD51-BRCA1/2

(2012) Katharina Schlacher et al.   CANCER CELL

Activation-induced cytidine deaminase (AID) linking immunity, chronic inflammation, and cancer

(2012) Diana Mechtcheriakova et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Calpain Activation by the Shigella flexneri Effector VirA Regulates Key Steps in the Formation and Life of the Bacterium's Epithelial Niche

(2012) Jean Bergounioux et al.   Cell Host & Microbe

From single-strand breaks to double-strand breaks during S-phase: a new mode of action of theEscherichia coli Cytolethal Distending Toxin

(2012) Y. Fedor et al.   CELLULAR MICROBIOLOGY

Chronic exposure to the cytolethal distending toxins of Gram-negative bacteria promotes genomic instability and altered DNA damage response

(2012) Riccardo Guidi et al.   CELLULAR MICROBIOLOGY

H. pylori Infection Is Associated with DNA Damage of Lgr5-Positive Epithelial Stem Cells in the Stomach of Patients with Gastric Cancer

(2012) Takeshi Uehara et al.   DIGESTIVE DISEASES AND SCIENCES

Neisseria gonorrhoeae infection causes DNA damage and affects the expression of p21, p27 and p53 in non-tumor epithelial cells

(2012) Katarina Vielfort et al.   JOURNAL OF CELL SCIENCE

Mitochondrial superoxide flashes: From discovery to new controversies

(2012) Lan Wei et al.   JOURNAL OF GENERAL PHYSIOLOGY

Activation of p53/ATM-dependent DNA damage signaling pathway by shiga toxin in mammalian cells

(2012) Kaisar A. Talukder et al.   MICROBIAL PATHOGENESIS

Chromatin organization is a major influence on regional mutation rates in human cancer cells

(2012) Benjamin Schuster-Böckler et al.   NATURE

Pathogenic bacterium Helicobacter pylori alters the expression profile of p53 protein isoforms and p53 response to cellular stresses

(2012) J. Wei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intestinal Inflammation Targets Cancer-Inducing Activity of the Microbiota

(2012) J. C. Arthur et al.   SCIENCE

Double-Strand Break Repair-Independent Role for BRCA2 in Blocking Stalled Replication Fork Degradation by MRE11

(2011) Katharina Schlacher et al.   CELL

Identification of two independent SUMO-interacting motifs in Daxx: Evolutionary conservation from Drosophila to humans and their biochemical functions

(2011) Aleixo Santiago et al.   CELL CYCLE

Listeriolysin O Suppresses Phospholipase C-Mediated Activation of the Microbicidal NADPH Oxidase to Promote Listeria monocytogenes Infection

(2011) Grace Y. Lam et al.   Cell Host & Microbe

Spermine Oxidase Mediates the Gastric Cancer Risk Associated With Helicobacter pylori CagA

(2011) Rupesh Chaturvedi et al.   GASTROENTEROLOGY

Neisseria gonorrhoeae-Mediated Inhibition of Apoptotic Signalling in Polymorphonuclear Leukocytes

(2011) Adrienne Chen et al.   INFECTION AND IMMUNITY

Role of oxidative stress and DNA damage in human carcinogenesis

(2011) Thomas B. Kryston et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Interplay between oncogene-induced DNA damage response and heterochromatin in senescence and cancer

(2011) Raffaella Di Micco et al.   NATURE CELL BIOLOGY

Carcinogenic bacterial pathogen Helicobacter pylori triggers DNA double-strand breaks and a DNA damage response in its host cells

(2011) I. M. Toller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Helicobacter pylori cytotoxin-associated gene A (CagA) subverts the apoptosis-stimulating protein of p53 (ASPP2) tumor suppressor pathway of the host

(2011) L. Buti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chlamydia pneumoniae Infection and Risk for Lung Cancer

(2010) A. K. Chaturvedi et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

The MRN complex in double-strand break repair and telomere maintenance

(2010) Brandon J. Lamarche et al.   FEBS LETTERS

Up-regulation of Activation-Induced Cytidine Deaminase Causes Genetic Aberrations at the CDKN2b-CDKN2a in Gastric Cancer

(2010) Yuko Matsumoto et al.   GASTROENTEROLOGY

Helicobacter pylori γ-Glutamyl Transpeptidase Is a Pathogenic Factor in the Development of Peptic Ulcer Disease

(2010) Min Gong et al.   GASTROENTEROLOGY

CpG Methylation and Reduced Expression of O6-Methylguanine DNA Methyltransferase Is Associated With Helicobacter pylori Infection

(2010) Antonia R. Sepulveda et al.   GASTROENTEROLOGY

Regulation of p53 Tumor Suppressor by Helicobacter pylori in Gastric Epithelial Cells

(2010) Jinxiong Wei et al.   GASTROENTEROLOGY

Host DNA Repair Proteins in Response toPseudomonas aeruginosain Lung Epithelial Cells and in Mice

(2010) Min Wu et al.   INFECTION AND IMMUNITY

Enhancement of Reactive Oxygen Species Production and Chlamydial Infection by the Mitochondrial Nod-like Family Member NLRX1

(2010) Ali A. Abdul-Sater et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Involvement of activation-induced cytidine deaminase in the development of colitis-associated colorectal cancers

(2010) Yoko Endo et al.   JOURNAL OF GASTROENTEROLOGY

The DNA Damage Response: Making It Safe to Play with Knives

(2010) Alberto Ciccia et al.   MOLECULAR CELL

When bacteria become mutagenic and carcinogenic: Lessons from H. pylori

(2010) Eliette Touati   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Myc Is Required for Activation of the ATM-Dependent Checkpoints in Response to DNA Damage

(2010) Lina Guerra et al.   PLoS One

Role of the ATM-Checkpoint Kinase 2 Pathway in CDT-Mediated Apoptosis of Gingival Epithelial Cells

(2010) Mounia Alaoui-El-Azher et al.   PLoS One

Escherichia coli induces DNA damage in vivo and triggers genomic instability in mammalian cells

(2010) G. Cuevas-Ramos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Loss-of-Function Screen Reveals Ras- and Raf-Independent MEK-ERK Signaling During Chlamydia trachomatis Infection

(2010) R. K. Gurumurthy et al.   Science Signaling

DNA Repair in Mammalian Cells

(2009) T. Nouspikel   CELLULAR AND MOLECULAR LIFE SCIENCES

Helicobacter pylori Infection Induces Genetic Instability of Nuclear and Mitochondrial DNA in Gastric Cells

(2009) A. M. D. Machado et al.   CLINICAL CANCER RESEARCH

Control of the G2/M checkpoints after exposure to low doses of ionising radiation: Implications for hyper-radiosensitivity

(2009) Marie Fernet et al.   DNA REPAIR

Genetic Structure and Distribution of the Colibactin Genomic Island among Members of the Family Enterobacteriaceae

(2009) J. Putze et al.   INFECTION AND IMMUNITY

Bacterial intoxication evokes cellular senescence with persistent DNA damage and cytokine signalling

(2009) Hana Blazkova et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The DNA-damage response in human biology and disease

(2009) Stephen P. Jackson et al.   NATURE

DNA Damage and Repair: From Molecular Mechanisms to Health Implications

(2008) Fabio Altieri et al.   ANTIOXIDANTS & REDOX SIGNALING

NLRX1 is a mitochondrial NOD-like receptor that amplifies NF-κB and JNK pathways by inducing reactive oxygen species production

(2008) Ivan Tattoli et al.   EMBO REPORTS

Geographic variation of gallbladder cancer mortality and risk factors in Chile: A population‐based ecologic study

(2008) Marcelo E. Andia et al.   INTERNATIONAL JOURNAL OF CANCER

Mitochondria-Dependent Reactive Oxygen Species-Mediated Programmed Cell Death Induced by 3,3'-Diindolylmethane through Inhibition of F0F1-ATP Synthase in Unicellular Protozoan Parasite Leishmania donovani

(2008) A. Roy et al.   MOLECULAR PHARMACOLOGY

Two levels of protection for the B cell genome during somatic hypermutation

(2008) Man Liu et al.   NATURE

A Bacterial Cytotoxin Identifies the RhoA Exchange Factor Net1 as a Key Effector in the Response to DNA Damage

(2008) Lina Guerra et al.   PLoS One