Epigenetic inheritance of acquired traits through sperm RNAs and sperm RNA modifications

A Tunable Mechanism Determines the Duration of the Transgenerational Small RNA Inheritance in C. elegans

(2016) Leah Houri-Ze’evi et al.   CELL

Long-Lived Binding of Sox2 to DNA Predicts Cell Fate in the Four-Cell Mouse Embryo

(2016) Melanie D. White et al.   CELL

The 3D Genome as Moderator of Chromosomal Communication

(2016) Job Dekker et al.   CELL

Heterogeneity in Oct4 and Sox2 Targets Biases Cell Fate in 4-Cell Mouse Embryos

(2016) Mubeen Goolam et al.   CELL

Obesity and Bariatric Surgery Drive Epigenetic Variation of Spermatozoa in Humans

(2016) Ida Donkin et al.   Cell Metabolism

Paternal Psychological Stress Reprograms Hepatic Gluconeogenesis in Offspring

(2016) Ling Wu et al.   Cell Metabolism

Single-cell triple omics sequencing reveals genetic, epigenetic and transcriptomic heterogeneity in hepatocellular carcinomas

(2016) Yu Hou et al.   CELL RESEARCH

Cross-kingdom inhibition of breast cancer growth by plant miR159

(2016) Andrew R Chin et al.   CELL RESEARCH

DNA methylation on N6-adenine in mammalian embryonic stem cells

(2016) Tao P. Wu et al.   NATURE

Epigenetic germline inheritance of diet-induced obesity and insulin resistance

(2016) Peter Huypens et al.   NATURE GENETICS

Parallel single-cell sequencing links transcriptional and epigenetic heterogeneity

(2016) Christof Angermueller et al.   NATURE METHODS

Breaking the germ line–soma barrier

(2016) M. Azim Surani   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Seminal Fluid and Mate Choice: New Predictions

(2016) Angela J. Crean et al.   TRENDS IN ECOLOGY & EVOLUTION

High-fat diet reprograms the epigenome of rat spermatozoa and transgenerationally affects metabolism of the offspring

(2016) Thais de Castro Barbosa et al.   Molecular Metabolism

Discovery of a Novel Seminal Fluid Microbiome and Influence of Estrogen Receptor Alpha Genetic Status

(2016) Angela B. Javurek et al.   Scientific Reports

Post-transcriptional Wnt Signaling Governs Epididymal Sperm Maturation

(2015) Stefan Koch et al.   CELL

DNA Methylation on N6-Adenine in C. elegans

(2015) Eric Lieberman Greer et al.   CELL

Parthenogenetic haploid embryonic stem cells efficiently support mouse generation by oocyte injection

(2015) Cuiqing Zhong et al.   CELL RESEARCH

Birth of fertile bimaternal offspring following intracytoplasmic injection of parthenogenetic haploid embryonic stem cells

(2015) Zhikun Li et al.   CELL RESEARCH

A novel chemopreventive strategy based on therapeutic microRNAs produced in plants

(2015) Sizolwenkosi Mlotshwa et al.   CELL RESEARCH

Detection of dietary plant-based small RNAs in animals

(2015) Jian Yang et al.   CELL RESEARCH

Extracellular vesicles shuffling intercellular messages: for good or for bad

(2015) Alessandra Lo Cicero et al.   CURRENT OPINION IN CELL BIOLOGY

Dynamic transcriptional symmetry-breaking in pre-implantation mammalian embryo development revealed by single-cell RNA-seq

(2015) Junchao Shi et al.   DEVELOPMENT

Sperm-borne miRNAs and endo-siRNAs are important for fertilization and preimplantation embryonic development

(2015) Shuiqiao Yuan et al.   DEVELOPMENT

Genetic and Epigenetic Variation, but Not Diet, Shape the Sperm Methylome

(2015) Jeremy M. Shea et al.   DEVELOPMENTAL CELL

Environmentally induced epigenetic transgenerational inheritance of sperm epimutations promote genetic mutations

(2015) Michael K Skinner et al.   Epigenetics

Small extracellular vesicles as tumor biomarkers for glioblastoma

(2015) Keon Mahmoudi et al.   MOLECULAR ASPECTS OF MEDICINE

Tumour exosome integrins determine organotropic metastasis

(2015) Ayuko Hoshino et al.   NATURE

Efficient and quantitative high-throughput tRNA sequencing

(2015) Guanqun Zheng et al.   NATURE METHODS

ARM-seq: AlkB-facilitated RNA methylation sequencing reveals a complex landscape of modified tRNA fragments

(2015) Aaron E Cozen et al.   NATURE METHODS

Single-cell epigenomics: techniques and emerging applications

(2015) Omer Schwartzman et al.   NATURE REVIEWS GENETICS

Molecular insights into transgenerational non-genetic inheritance of acquired behaviours

(2015) Johannes Bohacek et al.   NATURE REVIEWS GENETICS

RNA-mediated epigenetic regulation of gene expression

(2015) Daniel Holoch et al.   NATURE REVIEWS GENETICS

Effects of psychological stress on male fertility

(2015) Vinod H. Nargund   Nature Reviews Urology

Transgenerational epigenetic programming via sperm microRNA recapitulates effects of paternal stress

(2015) Ali B. Rodgers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Double-stranded RNA made inC. elegansneurons can enter the germline and cause transgenerational gene silencing

(2015) Sindhuja Devanapally et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sperm tsRNAs contribute to intergenerational inheritance of an acquired metabolic disorder

(2015) Q. Chen et al.   SCIENCE

Disruption of histone methylation in developing sperm impairs offspring health transgenerationally

(2015) K. Siklenka et al.   SCIENCE

Biogenesis and function of tRNA fragments during sperm maturation and fertilization in mammals

(2015) U. Sharma et al.   SCIENCE

Synaptic vesicles contain small ribonucleic acids (sRNAs) including transfer RNA fragments (trfRNA) and microRNAs (miRNA)

(2015) Huinan Li et al.   Scientific Reports

Ddx1 knockout results in transgenerational wild-type lethality in mice

(2015) Matthew R. Hildebrandt et al.   Scientific Reports

Breeding scheme and maternal small RNAs affect the efficiency of transgenerational inheritance of a paramutation in mice

(2015) Shuiqiao Yuan et al.   Scientific Reports

Confrontation, Consolidation, and Recognition: The Oocyte’s Perspective on the Incoming Sperm

(2015) David Miller   Cold Spring Harbor Perspectives in Medicine

Deleterious effects of endocrine disruptors are corrected in the mammalian germline by epigenome reprogramming

(2015) Khursheed Iqbal et al.   GENOME BIOLOGY

mir-34b/c and mir-449a/b/c are required for spermatogenesis, but not for the first cleavage division in mice

(2015) S. Yuan et al.   Biology Open

Diet-Induced Obesity in Male C57BL/6 Mice Decreases Fertility as a Consequence of Disrupted Blood-Testis Barrier

(2015) Yong Fan et al.   PLoS One

RNA-mediated paternal heredity of diet-induced obesity and metabolic disorders

(2015) Valérie Grandjean et al.   Scientific Reports

Paternal Diet Defines Offspring Chromatin State and Intergenerational Obesity

(2014) Anita Öst et al.   CELL

Starvation-Induced Transgenerational Inheritance of Small RNAs in C. elegans

(2014) Oded Rechavi et al.   CELL

Human colorectal cancer-specific CCAT1-L lncRNA regulates long-range chromatin interactions at the MYC locus

(2014) Jian-Feng Xiang et al.   CELL RESEARCH

Honeysuckle-encoded atypical microRNA2911 directly targets influenza A viruses

(2014) Zhen Zhou et al.   CELL RESEARCH

Revisiting telegony: offspring inherit an acquired characteristic of their mother's previous mate

(2014) Angela J. Crean et al.   ECOLOGY LETTERS

tRNA fragments in human health and disease

(2014) Paul Anderson et al.   FEBS LETTERS

Transgenerationally inherited piRNAs trigger piRNA biogenesis by changing the chromatin of piRNA clusters and inducing precursor processing

(2014) Adrien Le Thomas et al.   GENES & DEVELOPMENT

Analysis of orthologous groups reveals archease and DDX1 as tRNA splicing factors

(2014) Johannes Popow et al.   NATURE

Coverage recommendations for methylation analysis by whole-genome bisulfite sequencing

(2014) Michael J Ziller et al.   NATURE METHODS

Implication of sperm RNAs in transgenerational inheritance of the effects of early trauma in mice

(2014) Katharina Gapp et al.   NATURE NEUROSCIENCE

Emerging roles of tRNA in adaptive translation, signalling dynamics and disease

(2014) Sebastian Kirchner et al.   NATURE REVIEWS GENETICS

The rise of regulatory RNA

(2014) Kevin V. Morris et al.   NATURE REVIEWS GENETICS

Gene expression regulation mediated through reversible m6A RNA methylation

(2014) Ye Fu et al.   NATURE REVIEWS GENETICS

Small RNAs break out: the molecular cell biology of mobile small RNAs

(2014) Peter Sarkies et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Topological organization of multichromosomal regions by the long intergenic noncoding RNA Firre

(2014) Ezgi Hacisuleyman et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Exosomes in human semen carry a distinctive repertoire of small non-coding RNAs with potential regulatory functions

(2014) L. Vojtech et al.   NUCLEIC ACIDS RESEARCH

Soma-to-Germline Transmission of RNA in Mice Xenografted with Human Tumour Cells: Possible Transport by Exosomes

(2014) Cristina Cossetti et al.   PLoS One

Paternally induced transgenerational inheritance of susceptibility to diabetes in mammals

(2014) Yanchang Wei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

G-quadruplex structures contribute to the neuroprotective effects of angiogenin-induced tRNA fragments

(2014) Pavel Ivanov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epigenetic inheritance uncoupled from sequence-specific recruitment

(2014) K. Ragunathan et al.   SCIENCE

Parenting from before conception

(2014) M. Lane et al.   SCIENCE

In utero undernourishment perturbs the adult sperm methylome and intergenerational metabolism

(2014) E. J. Radford et al.   SCIENCE

Identification and characterization of an ancient class of small RNAs enriched in serum associating with active infection

(2014) Yunfang Zhang et al.   Journal of Molecular Cell Biology

Sexual Conflict and Sperm Competition

(2014) Dominic A. Edward et al.   Cold Spring Harbor Perspectives in Biology

The RNA-Binding Protein DDX1 Promotes Primary MicroRNA Maturation and Inhibits Ovarian Tumor Progression

(2014) Cecil Han et al.   Cell Reports

Extracellular Vesicle-Mediated Transfer of Genetic Information between the Hematopoietic System and the Brain in Response to Inflammation

(2014) Kirsten Ridder et al.   PLOS BIOLOGY

A High-Throughput Quantitative Approach Reveals More Small RNA Modifications in Mouse Liver and Their Correlation with Diabetes

(2013) Menghong Yan et al.   ANALYTICAL CHEMISTRY

5′ tRNA halves are present as abundant complexes in serum, concentrated in blood cells, and modulated by aging and calorie restriction

(2013) Joseph M Dhahbi et al.   BMC GENOMICS

Paternal obesity initiates metabolic disturbances in two generations of mice with incomplete penetrance to the F2 generation and alters the transcriptional profile of testis and sperm microRNA content

(2013) Tod Fullston et al.   FASEB JOURNAL

The presence, role and clinical use of spermatozoal RNAs

(2013) Meritxell Jodar et al.   HUMAN REPRODUCTION UPDATE

Paternal Stress Exposure Alters Sperm MicroRNA Content and Reprograms Offspring HPA Stress Axis Regulation

(2013) A. B. Rodgers et al.   JOURNAL OF NEUROSCIENCE

Genome-Wide Analysis Reveals Origin of Transfer RNA Genes from tRNA Halves

(2013) Zhixiang Zuo et al.   MOLECULAR BIOLOGY AND EVOLUTION

High-resolution Xist binding maps reveal two-step spreading during X-chromosome inactivation

(2013) Matthew D. Simon et al.   NATURE

Parental olfactory experience influences behavior and neural structure in subsequent generations

(2013) Brian G Dias et al.   NATURE NEUROSCIENCE

The Xist lncRNA Exploits Three-Dimensional Genome Architecture to Spread Across the X Chromosome

(2013) J. M. Engreitz et al.   SCIENCE

RNA–Mediated Epigenetic Heredity Requires the Cytosine Methyltransferase Dnmt2

(2013) Jafar Kiani et al.   PLoS Genetics

piRNAs Can Trigger a Multigenerational Epigenetic Memory in the Germline of C. elegans

(2012) Alyson Ashe et al.   CELL

piRNAs Initiate an Epigenetic Memory of Nonself RNA in the C. elegans Germline

(2012) Masaki Shirayama et al.   CELL

Regulation of small RNA stability: methylation and beyond

(2012) Lijuan Ji et al.   CELL RESEARCH

A novel class of tRNA-derived small RNAs extremely enriched in mature mouse sperm

(2012) Hongying Peng et al.   CELL RESEARCH

Uptake of Extracellular Double-Stranded RNA by SID-2

(2012) Deborah L. McEwan et al.   MOLECULAR CELL

A nuclear Argonaute promotes multigenerational epigenetic inheritance and germline immortality

(2012) Bethany A. Buckley et al.   NATURE

Multigenerational epigenetic adaptation of the hepatic wound-healing response

(2012) Müjdat Zeybel et al.   NATURE MEDICINE

Chromatin replication and epigenome maintenance

(2012) Constance Alabert et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

RNA cytosine methylation by Dnmt2 and NSun2 promotes tRNA stability and protein synthesis

(2012) Francesca Tuorto et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

MODOMICS: a database of RNA modification pathways—2013 update

(2012) Magdalena A. Machnicka et al.   NUCLEIC ACIDS RESEARCH

Primary epimutations introduced during intracytoplasmic sperm injection (ICSI) are corrected by germline-specific epigenetic reprogramming

(2012) E. de Waal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transgenerational epigenetic effects of the Apobec1 cytidine deaminase deficiency on testicular germ cell tumor susceptibility and embryonic viability

(2012) V. R. Nelson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chronic stress, glucocorticoid receptor resistance, inflammation, and disease risk

(2012) S. Cohen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inflammatory Mechanisms in Obesity

(2011) Margaret F. Gregor et al.   Annual Review of Immunology

Exogenous plant MIR168a specifically targets mammalian LDLRAP1: evidence of cross-kingdom regulation by microRNA

(2011) Lin Zhang et al.   CELL RESEARCH

Oct4 kinetics predict cell lineage patterning in the early mammalian embryo

(2011) Nicolas Plachta et al.   NATURE CELL BIOLOGY

Sperm-borne microRNA-34c is required for the first cleavage division in mouse

(2011) W.-M. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma

(2011) J. D. Arroyo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role for piRNAs and Noncoding RNA in de Novo DNA Methylation of the Imprinted Mouse Rasgrf1 Locus

(2011) T. Watanabe et al.   SCIENCE

Paternally Induced Transgenerational Environmental Reprogramming of Metabolic Gene Expression in Mammals

(2010) Benjamin R. Carone et al.   CELL

RNA methylation by Dnmt2 protects transfer RNAs against stress-induced cleavage

(2010) M. Schaefer et al.   GENES & DEVELOPMENT

Emerging properties of animal gene regulatory networks

(2010) Eric H. Davidson   NATURE

Chronic high-fat diet in fathers programs β-cell dysfunction in female rat offspring

(2010) Sheau-Fang Ng et al.   NATURE

Repressive and active histone methylation mark distinct promoters in human and mouse spermatozoa

(2010) Urszula Brykczynska et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The RNA modification database, RNAMDB: 2011 update

(2010) W. A. Cantara et al.   NUCLEIC ACIDS RESEARCH

Epigenetic Reprogramming in Plant and Animal Development

(2010) Suhua Feng et al.   SCIENCE

The miR-124-Sox9 paramutation: RNA-mediated epigenetic control of embryonic and adult growth

(2009) V. Grandjean et al.   DEVELOPMENT

A soma-to-germline transformation in long-lived Caenorhabditis elegans mutants

(2009) Sean P. Curran et al.   NATURE

Postcopulatory sexual selection: Darwin's omission and its consequences

(2009) W. G. Eberhard   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A new perspective on Darwin’s Pangenesis

(2008) Yongsheng Liu   BIOLOGICAL REVIEWS

RNA Induction and Inheritance of Epigenetic Cardiac Hypertrophy in the Mouse

(2008) Kay D. Wagner et al.   DEVELOPMENTAL CELL

Sperm Sociality: Cooperation, Altruism, and Spite

(2008) Tommaso Pizzari et al.   PLOS BIOLOGY