标题
Novel therapeutic strategies targeting fibroblasts and fibrosis in heart disease
作者
关键词
-
出版物
NATURE REVIEWS DRUG DISCOVERY
Volume 15, Issue 9, Pages 620-638
出版商
Springer Nature
发表日期
2016-06-26
DOI
10.1038/nrd.2016.89
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注意：仅列出部分参考文献，下载原文获取全部文献信息。- Cardiac Mechano-Gated Ion Channels and Arrhythmias
- (2016) Rémi Peyronnet et al. CIRCULATION RESEARCH
- Targeting myocardial reperfusion injuries with cyclosporine in the CIRCUS Trial - pharmacological reasons for failure
- (2016) Laurent Monassier et al. FUNDAMENTAL & CLINICAL PHARMACOLOGY
- Plakophilin-2 loss promotes TGF-β1/p38 MAPK-dependent fibrotic gene expression in cardiomyocytes
- (2016) Adi D. Dubash et al. JOURNAL OF CELL BIOLOGY
- Monocyte and macrophage contributions to cardiac remodeling
- (2016) Maarten Hulsmans et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Prolongation of atrio-ventricular node conduction in a rabbit model of ischaemic cardiomyopathy: Role of fibrosis and connexin remodelling
- (2016) Ashley M. Nisbet et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Fibroblast–myocyte coupling in the heart: Potential relevance for therapeutic interventions
- (2016) Emily Ongstad et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Matricellular Protein CCN5 Reverses Established Cardiac Fibrosis
- (2016) Dongtak Jeong et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- The Living Scar – Cardiac Fibroblasts and the Injured Heart
- (2016) Eva A. Rog-Zielinska et al. TRENDS IN MOLECULAR MEDICINE
- The plasma membrane calcium ATPase 4 signalling in cardiac fibroblasts mediates cardiomyocyte hypertrophy
- (2016) Tamer M. A. Mohamed et al. Nature Communications
- Fibrosis of the Neonatal Mouse Heart After Cryoinjury Is Accompanied by Wnt Signaling Activation and Epicardial‐to‐Mesenchymal Transition
- (2016) Makiko Mizutani et al. Journal of the American Heart Association
- Inhibition of mammalian target of rapamycin protects against reperfusion injury in diabetic heart through STAT3 signaling
- (2015) Anindita Das et al. BASIC RESEARCH IN CARDIOLOGY
- Acellular human heart matrix: A critical step toward whole heart grafts
- (2015) Pedro L. Sánchez et al. BIOMATERIALS
- The winding road to regenerating the human heart
- (2015) Kaytlyn A. Gerbin et al. CARDIOVASCULAR PATHOLOGY
- A Micropeptide Encoded by a Putative Long Noncoding RNA Regulates Muscle Performance
- (2015) Douglas M. Anderson et al. CELL
- A Century of Cholesterol and Coronaries: From Plaques to Genes to Statins
- (2015) Joseph L. Goldstein et al. CELL
- Genetic lineage tracing identifies in situ Kit-expressing cardiomyocytes
- (2015) Qiaozhen Liu et al. CELL RESEARCH
- Type III TGFβ receptor and Src direct hyaluronan-mediated invasive cell motility
- (2015) Patrick Allison et al. CELLULAR SIGNALLING
- Defining the Limit of Embryonic Heart Regeneration
- (2015) Yuji Nakada et al. CIRCULATION
- Transformative Impact of Proteomics on Cardiovascular Health and Disease
- (2015) Merry L. Lindsey et al. CIRCULATION
- Cardiac Cell Therapy: Lost in Meta-Analyses
- (2015) B. Assmus et al. CIRCULATION RESEARCH
- Molecular Basis of Cardioprotection: Signal Transduction in Ischemic Pre-, Post-, and Remote Conditioning
- (2015) G. Heusch CIRCULATION RESEARCH
- Adult Bone Marrow Cell Therapy for Ischemic Heart DiseaseNovelty and Significance
- (2015) Muhammad R. Afzal et al. CIRCULATION RESEARCH
- Direct Cardiac Reprogramming: Progress and Challenges in Basic Biology and Clinical Applications
- (2015) T. Sadahiro et al. CIRCULATION RESEARCH
- Meta-Analysis of Cell-based CaRdiac stUdiEs (ACCRUE) in Patients With Acute Myocardial Infarction Based on Individual Patient Data
- (2015) M. Gyongyosi et al. CIRCULATION RESEARCH
- Mitochondrial Reactive Oxygen Species at the Heart of the Matter: New Therapeutic Approaches for Cardiovascular Diseases
- (2015) O. S. Kornfeld et al. CIRCULATION RESEARCH
- Getting to the Heart of the Matter
- (2015) Andrew Leask CIRCULATION RESEARCH
- Use of Mesenchymal Stem Cells for Therapy of Cardiac Disease
- (2015) V. Karantalis et al. CIRCULATION RESEARCH
- Recombinant tissue plasminogen activators (rtPA): A review
- (2015) P Gurman et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
- The proepicardium keeps a potential for glomerular marker expression which supports its evolutionary origin from the pronephros
- (2015) Elena Cano et al. EVOLUTION & DEVELOPMENT
- Inhibitory effects of relaxin on cardiac fibroblast-to-myofibroblast transition: an electrophysiological study
- (2015) Roberta Squecco et al. EXPERIMENTAL PHYSIOLOGY
- Serelaxin and acute heart failure
- (2015) Jeremy Tietjens et al. HEART
- Battle of the hemichannels – Connexins and Pannexins in ischemic brain injury
- (2015) J.O. Davidson et al. INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
- Signaling Pathways That Control Rho Kinase Activity Maintain the Embryonic Epicardial Progenitor State
- (2015) Mykhaylo V. Artamonov et al. JOURNAL OF BIOLOGICAL CHEMISTRY
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- (2015) Andrew P. Voorhees et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
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- (2015) Thomas Moore-Morris et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- In Search of Living Valve Substitutes∗
- (2015) Magdi H. Yacoub JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
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- (2015) Adrián Ruiz-Villalba et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Remote Ischemic Conditioning
- (2015) Gerd Heusch et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
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- (2015) Mortimer Korf-Klingebiel et al. NATURE MEDICINE
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- (2015) Yaqi Shen et al. Oxidative Medicine and Cellular Longevity
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- (2015) Rengasayee Veeraraghavan et al. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
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- (2015) Gabrielle B. Adkins et al. PHARMACOLOGY & THERAPEUTICS
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- (2015) Anindita Das et al. PHARMACOLOGY & THERAPEUTICS
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- (2015) Elizabeth D. Pratico et al. STEM CELLS AND DEVELOPMENT
- Ablation of atrial fibrillation
- (2015) Matthew Wright et al. TRENDS IN CARDIOVASCULAR MEDICINE
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- (2015) Christopher B. Fordyce et al. TRENDS IN PHARMACOLOGICAL SCIENCES
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- (2015) Nishat Sultana et al. Nature Communications
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- (2015) Ana Rosa Soares et al. Scientific Reports
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- (2015) J. Rother et al. Open Biology
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- (2015) Yan Y. Sanders et al. PLoS One
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- (2014) Brandon C. Varr et al. Current Atherosclerosis Reports
- Myocardin-related transcription factors control the motility of epicardium-derived cells and the maturation of coronary vessels
- (2014) M. A. Trembley et al. DEVELOPMENT
- Induction of diverse cardiac cell types by reprogramming fibroblasts with cardiac transcription factors
- (2014) Y.-J. Nam et al. DEVELOPMENT
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- (2014) N. Muraoka et al. EMBO JOURNAL
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- (2014) M. J. Gonzales et al. EUROPACE
- The history of coronary reperfusion
- (2014) Frans Van de Werf EUROPEAN HEART JOURNAL
- Serelaxin: a potential new drug for the treatment of acute heart failure
- (2014) Natalia Neverova et al. EXPERT OPINION ON INVESTIGATIONAL DRUGS
- Connective Tissue Growth Factor Inhibition Attenuates Left Ventricular Remodeling and Dysfunction in Pressure Overload–Induced Heart Failure
- (2014) Zoltán Szabó et al. HYPERTENSION
- Internal Ribosomal Entry Site (IRES) Activity Generates Endogenous Carboxyl-terminal Domains of Cx43 and Is Responsive to Hypoxic Conditions
- (2014) Mahboob Ul-Hussain et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Cardiac fibroblast–derived microRNA passenger strand-enriched exosomes mediate cardiomyocyte hypertrophy
- (2014) Claudia Bang et al. JOURNAL OF CLINICAL INVESTIGATION
- Resident fibroblast lineages mediate pressure overload–induced cardiac fibrosis
- (2014) Thomas Moore-Morris et al. JOURNAL OF CLINICAL INVESTIGATION
- Caveolin-1 deletion exacerbates cardiac interstitial fibrosis by promoting M2 macrophage activation in mice after myocardial infarction
- (2014) Pooja Shivshankar et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Cardiac fibroblast in development and wound healing
- (2014) Arjun Deb et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Fibroblast–myocyte electrotonic coupling: Does it occur in native cardiac tissue?
- (2014) Peter Kohl et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
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- (2014) Peter Kohl JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
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- (2014) Fernando Rodríguez-Pascual et al. LIFE SCIENCES
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- (2014) Alison Abbott NATURE
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- (2014) Jop H. van Berlo et al. NATURE
- Injectable and bioresponsive hydrogels for on-demand matrix metalloproteinase inhibition
- (2014) Brendan P. Purcell et al. NATURE MATERIALS
- Translational strategies and challenges in regenerative medicine
- (2014) Stefanie Dimmeler et al. NATURE MEDICINE
- MicroRNAs in myocardial infarction
- (2014) Reinier A. Boon et al. Nature Reviews Cardiology
- Novel therapeutic strategies for cardioprotection
- (2014) Joost P.G. Sluijter et al. PHARMACOLOGY & THERAPEUTICS
- Inhibition of TGFβ Signaling Increases Direct Conversion of Fibroblasts to Induced Cardiomyocytes
- (2014) Jamie L. Ifkovits et al. PLoS One
- Role of Caveolin-1 in Atrial Fibrillation as an Anti-Fibrotic Signaling Molecule in Human Atrial Fibroblasts
- (2014) Shao-lei Yi et al. PLoS One
- Hypoxia Preconditioned Mesenchymal Stem Cells Prevent Cardiac Fibroblast Activation and Collagen Production via Leptin
- (2014) Panpan Chen et al. PLoS One
- Coupled agent-based and finite-element models for predicting scar structure following myocardial infarction
- (2014) Andrew D. Rouillard et al. PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY
- Local Hydrogel Release of Recombinant TIMP-3 Attenuates Adverse Left Ventricular Remodeling After Experimental Myocardial Infarction
- (2014) S. R. Eckhouse et al. Science Translational Medicine
- The ten advances that have defined modern cardiology
- (2014) Eugene Braunwald TRENDS IN CARDIOVASCULAR MEDICINE
- Application of Adipose-Derived Stem Cells in Heart Disease
- (2014) Lina Chen et al. Journal of Cardiovascular Translational Research
- Type-1 pericytes accumulate after tissue injury and produce collagen in an organ-dependent manner
- (2014) Alexander Birbrair et al. Stem Cell Research & Therapy
- Reoxygenation‐Derived Toxic Reactive Oxygen/Nitrogen Species Modulate the Contribution of Bone Marrow Progenitor Cells to Remodeling After Myocardial Infarction
- (2014) Nicanor I. Moldovan et al. Journal of the American Heart Association
- Fibroblast KATP currents modulate myocyte electrophysiology in infarcted hearts
- (2013) Najate Benamer et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Lack of specificity of fibroblast-specific protein 1 in cardiac remodeling and fibrosis
- (2013) Ping Kong et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Adult c-kitpos Cardiac Stem Cells Are Necessary and Sufficient for Functional Cardiac Regeneration and Repair
- (2013) Georgina M. Ellison et al. CELL
- The pathogenesis of cardiac fibrosis
- (2013) Ping Kong et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- A TRP to cardiac fibroblast differentiation
- (2013) Charles K. Thodeti et al. Channels
- Cardioprotection and Myocardial Reperfusion
- (2013) Richard S. Vander Heide et al. CIRCULATION RESEARCH
- Direct Cardiac Reprogramming
- (2013) Li Qian et al. CIRCULATION RESEARCH
- Patching the Heart
- (2013) Lei Ye et al. CIRCULATION RESEARCH
- Tcf21 regulates the specification and maturation of proepicardial cells
- (2013) P. Tandon et al. DEVELOPMENT
- Tbx18 regulates development of the epicardium and coronary vessels
- (2013) San-Pin Wu et al. DEVELOPMENTAL BIOLOGY
- Impact of intracoronary bone marrow cell therapy on left ventricular function in the setting of ST-segment elevation myocardial infarction: a collaborative meta-analysis
- (2013) Ronak Delewi et al. EUROPEAN HEART JOURNAL
- Association of Fibrosis With Mortality and Sudden Cardiac Death in Patients With Nonischemic Dilated Cardiomyopathy
- (2013) Ankur Gulati et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Acetylsalicylic Acid Inhibits IL-18-Induced Cardiac Fibroblast Migration Through the Induction of RECK
- (2013) Jalahalli M. Siddesha et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Cardiac fibrosis and arrhythmogenesis: The road to repair is paved with perils
- (2013) Thao P. Nguyen et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Adverse fibrosis in the aging heart depends on signaling between myeloid and mesenchymal cells; role of inflammatory fibroblasts
- (2013) Katarzyna A. Cieslik et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Single-target RNA interference for the blockade of multiple interacting proinflammatory and profibrotic pathways in cardiac fibroblasts
- (2013) Juliane Tank et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Myofibroblasts: Trust your heart and let fate decide
- (2013) Jennifer Davis et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Bves and NDRG4 regulate directional epicardial cell migration through autocrine extracellular matrix deposition
- (2013) Emily C. Benesh et al. MOLECULAR BIOLOGY OF THE CELL
- MicroRNA-34a regulates cardiac ageing and function
- (2013) Reinier A. Boon et al. NATURE
- Relaxin Prevents Cardiac Fibroblast-Myofibroblast Transition via Notch-1-Mediated Inhibition of TGF-β/Smad3 Signaling
- (2013) Chiara Sassoli et al. PLoS One
- Reprogramming of human fibroblasts toward a cardiac fate
- (2013) Y.-J. Nam et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The perinexus: Sign-post on the path to a new model of cardiac conduction?
- (2013) J. Matthew Rhett et al. TRENDS IN CARDIOVASCULAR MEDICINE
- Stretch-Induced Upregulation of Connective Tissue Growth Factor in Rabbit Cardiomyocytes
- (2013) Erik Blaauw et al. Journal of Cardiovascular Translational Research
- Autoregulation of Connexin43 Gap Junction Formation by Internally Translated Isoforms
- (2013) James W. Smyth et al. Cell Reports
- Sca1-Derived Cells Are a Source of Myocardial Renewal in the Murine Adult Heart
- (2013) Shizuka Uchida et al. Stem Cell Reports
- Optimized Local Infarct Restraint Improves Left Ventricular Function and Limits Remodeling
- (2012) Kevin J. Koomalsingh et al. ANNALS OF THORACIC SURGERY
- Cardiac Regenerative Capacity and Mechanisms
- (2012) Kazu Kikuchi et al. Annual Review of Cell and Developmental Biology
- Selective inhibition of Cx43 hemichannels by Gap19 and its impact on myocardial ischemia/reperfusion injury
- (2012) Nan Wang et al. BASIC RESEARCH IN CARDIOLOGY
- Inefficient Reprogramming of Fibroblasts into Cardiomyocytes Using Gata4, Mef2c, and Tbx5
- (2012) Jenny X. Chen et al. CIRCULATION RESEARCH
- MicroRNA-Mediated In Vitro and In Vivo Direct Reprogramming of Cardiac Fibroblasts to Cardiomyocytes
- (2012) Tilanthi M. Jayawardena et al. CIRCULATION RESEARCH
- High-Resolution 3-Dimensional Reconstruction of the Infarct Border Zone
- (2012) Sally L. Rutherford et al. CIRCULATION RESEARCH
- Role for MicroRNA-21 in Atrial Profibrillatory Fibrotic Remodeling Associated With Experimental Postinfarction Heart Failure
- (2012) Sophie Cardin et al. Circulation-Arrhythmia and Electrophysiology
- Anisotropic Reinforcement of Acute Anteroapical Infarcts Improves Pump Function
- (2012) Gregory M. Fomovsky et al. Circulation-Heart Failure
- The bHLH transcription factor Tcf21 is required for lineage-specific EMT of cardiac fibroblast progenitors
- (2012) A. Acharya et al. DEVELOPMENT
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- (2012) Gregory M. Fomovsky et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Single intravenous low-dose injections of connexin 43 mimetic peptides protect ischemic heart in vivo against myocardial infarction
- (2012) Ghayda Hawat et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
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- (2012) Aurélien Chatelier et al. JOURNAL OF PHYSIOLOGY-LONDON
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- (2012) Eduardo Marbán et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
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- (2012) Li Qian et al. NATURE
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- (2012) T. Desplantez et al. PHARMACOLOGICAL RESEARCH
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- (2012) Sundaravadivel Balasubramanian et al. PLoS One
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- (2010) J. L. Ifkovits et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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- (2009) Florian H. Seeger et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
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- (2009) Mary M. Maleckar et al. BIOPHYSICAL JOURNAL
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- (2009) Ryan H. Cunnington et al. CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
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- (2009) Susanne W.M. van den Borne et al. CARDIOVASCULAR RESEARCH
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- (2009) Marcin Bujak et al. CIRCULATION RESEARCH
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- (2009) Yuko Asazuma-Nakamura et al. EXPERIMENTAL CELL RESEARCH
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- (2009) Yuanfang Xie et al. HEART RHYTHM
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- (2009) Scott P. Levick et al. HYPERTENSION
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- (2009) Chien-hui Liao et al. JOURNAL OF CLINICAL INVESTIGATION
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- (2009) Norifumi Takeda et al. JOURNAL OF CLINICAL INVESTIGATION
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- (2009) Leon Espira et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
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- (2009) Sarah McCurdy et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
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- (2009) Marc Klapholz MAYO CLINIC PROCEEDINGS
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- (2009) Ofelia M Martínez-Estrada et al. NATURE GENETICS
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- (2009) Susanne W. M. van den Borne et al. Nature Reviews Cardiology
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- (2009) Stacey Rentschler et al. PEDIATRIC CARDIOLOGY
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- (2009) Karen E. Porter et al. PHARMACOLOGY & THERAPEUTICS
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- (2009) Olaf Bergmann et al. SCIENCE
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- (2009) A. Bonauer et al. SCIENCE
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- (2008) Vincent Jacquemet et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
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- (2008) Elena Tourkina et al. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
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- (2008) Derek J. Hausenloy et al. ATHEROSCLEROSIS
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- (2008) Brett Burstein et al. CIRCULATION
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- (2008) Lior Yankelson et al. CIRCULATION
- PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR γ-INDEPENDENT EFFECTS OF THIAZOLIDINEDIONES ON HUMAN CARDIAC MYOFIBROBLAST FUNCTION
- (2008) Romana S Mughal et al. CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
- Panoramic imaging reveals basic mechanisms of induction and termination of ventricular tachycardia in rabbit heart with chronic infarction: Implications for low-voltage cardioversion
- (2008) Crystal M. Ripplinger et al. HEART RHYTHM
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- (2008) Masashi Shimazaki et al. JOURNAL OF EXPERIMENTAL MEDICINE
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- (2008) Lili Li et al. MOLECULAR BIOLOGY REPORTS
- MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts
- (2008) Thomas Thum et al. NATURE
- Perfusion-decellularized matrix: using nature's platform to engineer a bioartificial heart
- (2008) Harald C Ott et al. NATURE MEDICINE
- Dysregulation of microRNAs after myocardial infarction reveals a role of miR-29 in cardiac fibrosis
- (2008) E. van Rooij et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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- (2008) Che-Hong Chen et al. SCIENCE
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- (2008) Mary E. Tedder et al. TISSUE ENGINEERING PART A
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- (2007) Claudio Pratola et al. CIRCULATION
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- (2007) Samir Saba et al. HEART RHYTHM
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