Translating genome-wide association findings into new therapeutics for psychiatry

A Brief History of Placebos and Clinical Trials in Psychiatry

(2017) Edward Shorter   CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE

Gene-set analysis based on the pharmacological profiles of drugs to identify repurposing opportunities in schizophrenia

(2016) Simone de Jong et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Schizophrenia risk from complex variation of complement component 4

(2016) Aswin Sekar et al.   NATURE

Integrative approaches for large-scale transcriptome-wide association studies

(2016) Alexander Gusev et al.   NATURE GENETICS

The road to precision psychiatry: translating genetics into disease mechanisms

(2016) Michael J Gandal et al.   NATURE NEUROSCIENCE

Gene expression elucidates functional impact of polygenic risk for schizophrenia

(2016) Menachem Fromer et al.   NATURE NEUROSCIENCE

Developing and evaluating polygenic risk prediction models for stratified disease prevention

(2016) Nilanjan Chatterjee et al.   NATURE REVIEWS GENETICS

Phenotypic Manifestation of Genetic Risk for Schizophrenia During Adolescence in the General Population

(2016) Hannah J. Jones et al.   JAMA Psychiatry

Systems Biology Approaches to a Rational Drug Discovery Paradigm

(2015) Philip Prathipati et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Evidence for several independent genetic variants affecting lipoprotein (a) cholesterol levels

(2015) W. Lu et al.   HUMAN MOLECULAR GENETICS

Polygenic risk scores in imaging genetics: Usefulness and applications

(2015) Danai Dima et al.   JOURNAL OF PSYCHOPHARMACOLOGY

The support of human genetic evidence for approved drug indications

(2015) Matthew R Nelson et al.   NATURE GENETICS

Understanding multicellular function and disease with human tissue-specific networks

(2015) Casey S Greene et al.   NATURE GENETICS

A gene-based association method for mapping traits using reference transcriptome data

(2015) Eric R Gamazon et al.   NATURE GENETICS

The PsychENCODE project

(2015) Schahram Akbarian et al.   NATURE NEUROSCIENCE

Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways

(2015)   NATURE NEUROSCIENCE

BrainSeq: Neurogenomics to Drive Novel Target Discovery for Neuropsychiatric Disorders

(2015) Christian R. Schubert et al.   NEURON

Failed drug discovery in psychiatry: time for human genome-guided solutions

(2015) Andreas Papassotiropoulos et al.   TRENDS IN COGNITIVE SCIENCES

MAGMA: Generalized Gene-Set Analysis of GWAS Data

(2015) Christiaan A. de Leeuw et al.   PLoS Computational Biology

Opportunities for New Drug Development in Psychiatry

(2015) Patricio O’Donnell et al.   JAMA Psychiatry

Polygenic Risk Score, Parental Socioeconomic Status, Family History of Psychiatric Disorders, and the Risk for Schizophrenia

(2015) Esben Agerbo et al.   JAMA Psychiatry

A community-based resource for automatic exome variant-calling and annotation in Mendelian disorders

(2014) Margherita Mutarelli et al.   BMC GENOMICS

From the era of genome analysis to the era of genomic drug discovery: a pioneering example of rheumatoid arthritis

(2014) Y. Okada   CLINICAL GENETICS

Pathways Targeted by Antidiabetes Drugs Are Enriched for Multiple Genes Associated With Type 2 Diabetes Risk

(2014) Ayellet V. Segrè et al.   DIABETES

De novo mutations in schizophrenia implicate synaptic networks

(2014) Menachem Fromer et al.   NATURE

A polygenic burden of rare disruptive mutations in schizophrenia

(2014) Shaun M. Purcell et al.   NATURE

Biological insights from 108 schizophrenia-associated genetic loci

(2014)   NATURE

Zinc transport and diabetes risk

(2014) Ewan Pearson   NATURE GENETICS

Translating Human Genetics into Novel Treatment Targets for Schizophrenia

(2014) Christian R. Schubert et al.   NEURON

The Benefits of Using Genetic Information to Design Prevention Trials

(2013) Youna Hu et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Implementing genomic medicine in the clinic: the future is here

(2013) Teri A. Manolio et al.   GENETICS IN MEDICINE

Effect of an RNA interference drug on the synthesis of proprotein convertase subtilisin/kexin type 9 (PCSK9) and the concentration of serum LDL cholesterol in healthy volunteers: a randomised, single-blind, placebo-controlled, phase 1 trial

(2013) Kevin Fitzgerald et al.   LANCET

CNVs conferring risk of autism or schizophrenia affect cognition in controls

(2013) Hreinn Stefansson et al.   NATURE

Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs

(2013) S Hong Lee et al.   NATURE GENETICS

Genome-wide association analysis identifies 13 new risk loci for schizophrenia

(2013) Stephan Ripke et al.   NATURE GENETICS

Use of genome-wide association studies for drug repositioning

(2012) Philippe Sanseau et al.   NATURE BIOTECHNOLOGY

Psychiatry, The Pharmaceutical Industry, and The Road to Better Therapeutics

(2012) H. C. Fibiger   SCHIZOPHRENIA BULLETIN

Genome-wide association analysis of copy number variation in recurrent depressive disorder

(2011) J J H Rucker et al.   MOLECULAR PSYCHIATRY

Combined Influence of LDLR and HMGCR Sequence Variation on Lipid-Lowering Response to Simvastatin

(2010) Lara M. Mangravite et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls

(2010)   NATURE

Biological, clinical and population relevance of 95 loci for blood lipids

(2010) Tanya M. Teslovich et al.   NATURE