An in vivo multiplexed small-molecule screening platform

Identifying compound efficacy targets in phenotypic drug discovery

(2016) Markus Schirle et al.   DRUG DISCOVERY TODAY

Genetic Diversity of Pancreatic Ductal Adenocarcinoma and Opportunities for Precision Medicine

(2016) Erik S. Knudsen et al.   GASTROENTEROLOGY

Cellular and molecular modifier pathways in tauopathies: the big picture from screening invertebrate models

(2016) Shabab B. Hannan et al.   JOURNAL OF NEUROCHEMISTRY

High-throughput identification of genotype-specific cancer vulnerabilities in mixtures of barcoded tumor cell lines

(2016) Channing Yu et al.   NATURE BIOTECHNOLOGY

Cancer statistics, 2015

(2015) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

RUNX3 Controls a Metastatic Switch in Pancreatic Ductal Adenocarcinoma

(2015) Martin C. Whittle et al.   CELL

Using C. elegans to discover therapeutic compounds for ageing-associated neurodegenerative diseases

(2015) Xi Chen et al.   Chemistry Central Journal

15 years of zebrafish chemical screening

(2015) Andrew J Rennekamp et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

α/β Hydrolase Domain-containing 6 (ABHD6) Degrades the Late Endosomal/Lysosomal Lipid Bis(monoacylglycero)phosphate

(2015) Maria A. Pribasnig et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A model of breast cancer heterogeneity reveals vascular mimicry as a driver of metastasis

(2015) Elvin Wagenblast et al.   NATURE

Virtual microdissection identifies distinct tumor- and stroma-specific subtypes of pancreatic ductal adenocarcinoma

(2015) Richard A Moffitt et al.   NATURE GENETICS

Studying clonal dynamics in response to cancer therapy using high-complexity barcoding

(2015) Hyo-eun C Bhang et al.   NATURE MEDICINE

Combinatorial labeling of single cells for gene expression cytometry

(2015) H. C. Fan et al.   SCIENCE

An implantable microdevice to perform high-throughput in vivo drug sensitivity testing in tumors

(2015) Oliver Jonas et al.   Science Translational Medicine

A technology platform to assess multiple cancer agents simultaneously within a patient’s tumor

(2015) Richard A. Klinghoffer et al.   Science Translational Medicine

Cancer metastases: challenges and opportunities

(2015) Xiangming Guan   Acta Pharmaceutica Sinica B

The landscape of metastatic progression patterns across major human cancers

(2015) Jan Budczies et al.   Oncotarget

Mesenchymal-Mode Migration Assay and Antimetastatic Drug Screening with High-Throughput Microfluidic Channel Networks

(2014) Yuanqing Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

In vivo metabolite profiling as a means to identify uncharacterized lipase function: Recent success stories within the alpha beta hydrolase domain (ABHD) enzyme family

(2014) Gwynneth Thomas et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

α/β-Hydrolase Domain-6-Accessible Monoacylglycerol Controls Glucose-Stimulated Insulin Secretion

(2014) Shangang Zhao et al.   Cell Metabolism

Target identification for a Hedgehog pathway inhibitor reveals the receptor GPR39

(2014) Frederic Bassilana et al.   Nature Chemical Biology

The hereditary spastic paraplegia-related enzyme DDHD2 is a principal brain triglyceride lipase

(2014) J. M. Inloes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential Tks5 isoform expression contributes to metastatic invasion of lung adenocarcinoma

(2013) C. M.-C. Li et al.   GENES & DEVELOPMENT

Discovery and Optimization of Piperidyl-1,2,3-Triazole Ureas as Potent, Selective, and in Vivo-Active Inhibitors of α/β-Hydrolase Domain Containing 6 (ABHD6)

(2013) Ku-Lung Hsu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Diverse and heritable lineage imprinting of early haematopoietic progenitors

(2013) Shalin H. Naik et al.   NATURE

Small-molecule inhibition of a depalmitoylase enhances Toxoplasma host-cell invasion

(2013) Matthew A Child et al.   Nature Chemical Biology

Implication of the anti-inflammatory bioactive lipid prostaglandin D2-glycerol ester in the control of macrophage activation and inflammation by ABHD6

(2013) M. Alhouayek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Serine Hydrolase ABHD6 Is a Critical Regulator of the Metabolic Syndrome

(2013) Gwynneth Thomas et al.   Cell Reports

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

(2012) Jordi Barretina et al.   NATURE

DAGLβ inhibition perturbs a lipid network involved in macrophage inflammatory responses

(2012) Ku-Lung Hsu et al.   Nature Chemical Biology

Monoacylglycerol Lipase Exerts Dual Control over Endocannabinoid and Fatty Acid Pathways to Support Prostate Cancer

(2011) Daniel K. Nomura et al.   CHEMISTRY & BIOLOGY

Tracking single hematopoietic stem cells in vivo using high-throughput sequencing in conjunction with viral genetic barcoding

(2011) Rong Lu et al.   NATURE BIOTECHNOLOGY

Chemical genetic screen identifies Toxoplasma DJ-1 as a regulator of parasite secretion, attachment, and invasion

(2011) C. I. Hall et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quantitative reactivity profiling predicts functional cysteines in proteomes

(2010) Eranthie Weerapana et al.   NATURE

Distant metastasis occurs late during the genetic evolution of pancreatic cancer

(2010) Shinichi Yachida et al.   NATURE

The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors

(2010) William R Marrs et al.   NATURE NEUROSCIENCE

High expression of the evolutionarily conserved α/β hydrolase domain containing 6 (ABHD6) in Ewing tumors

(2009) Daniela Max et al.   CANCER SCIENCE

Monoacylglycerol Lipase Regulates a Fatty Acid Network that Promotes Cancer Pathogenesis

(2009) Daniel K. Nomura et al.   CELL

Multiplex peptide stable isotope dimethyl labeling for quantitative proteomics

(2009) Paul J Boersema et al.   Nature Protocols

Identification of proteases that regulate erythrocyte rupture by the malaria parasite Plasmodium falciparum

(2008) Shirin Arastu-Kapur et al.   Nature Chemical Biology

Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses

(2008) S. Jones et al.   SCIENCE