An oncogenic Ezh2 mutation induces tumors through global redistribution of histone 3 lysine 27 trimethylation

Integrative analysis of 111 reference human epigenomes

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Loss of BAP1 function leads to EZH2-dependent transformation

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Structural basis of histone H3K27 trimethylation by an active polycomb repressive complex 2

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Mutation-Specific RAS Oncogenicity Explains NRAS Codon 61 Selection in Melanoma

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An Orally Bioavailable Chemical Probe of the Lysine Methyltransferases EZH2 and EZH1

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EZH2 Is Required for Germinal Center Formation and Somatic EZH2 Mutations Promote Lymphoid Transformation

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Durable tumor regression in genetically altered malignant rhabdoid tumors by inhibition of methyltransferase EZH2

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Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal

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Coordinated Silencing of MYC-Mediated miR-29 by HDAC3 and EZH2 as a Therapeutic Target of Histone Modification in Aggressive B-Cell Lymphomas

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A Landscape of Driver Mutations in Melanoma

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EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations

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Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma

(2012) Michael Krauthammer et al.   NATURE GENETICS

Genetic inactivation of the polycomb repressive complex 2 in T cell acute lymphoblastic leukemia

(2012) Panagiotis Ntziachristos et al.   NATURE MEDICINE

Mutation of A677 in histone methyltransferase EZH2 in human B-cell lymphoma promotes hypertrimethylation of histone H3 on lysine 27 (H3K27)

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Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing

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The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.

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Epigenetic Silencing Mediated through Activated PI3K/AKT Signaling in Breast Cancer

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Inactivating mutations of acetyltransferase genes in B-cell lymphoma

(2011) Laura Pasqualucci et al.   NATURE

Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma

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ChIP-seq analysis reveals distinct H3K27me3 profiles that correlate with transcriptional activity

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BEDTools: a flexible suite of utilities for comparing genomic features

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Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation

(2010) D. B. Yap et al.   BLOOD

Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes

(2010) Gorica Nikoloski et al.   NATURE GENETICS

Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin

(2010) Ryan D Morin et al.   NATURE GENETICS

Somatic p16INK4a loss accelerates melanomagenesis

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Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas

(2010) C. J. Sneeringer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Galaxy: a comprehensive approach for supporting accessible, reproducible, and transparent computational research in the life sciences

(2010) Jeremy Goecks et al.   GENOME BIOLOGY

Polycomb protein Ezh2 regulates pancreatic  -cell Ink4a/Arf expression and regeneration in diabetes mellitus

(2009) H. Chen et al.   GENES & DEVELOPMENT

BrafV600E cooperates with Pten loss to induce metastatic melanoma

(2009) David Dankort et al.   NATURE GENETICS

MYC stimulates EZH2 expression by repression of its negative regulator miR-26a

(2008) S. Sander et al.   BLOOD

Utilization of Pathway Signatures to Reveal Distinct Types of B Lymphoma in the E -myc Model and Human Diffuse Large B-Cell Lymphoma

(2008) S. Mori et al.   CANCER RESEARCH

Gene silencing in cancer by histone H3 lysine 27 trimethylation independent of promoter DNA methylation

(2008) Yutaka Kondo et al.   NATURE GENETICS

Model-based Analysis of ChIP-Seq (MACS)

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