Protein-structure-guided discovery of functional mutations across 19 cancer types

Comprehensive assessment of cancer missense mutation clustering in protein structures

(2015) Atanas Kamburov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A spatial simulation approach to account for protein structure when identifying non-random somatic mutations

(2014) Gregory A Ryslik et al.   BMC BIOINFORMATICS

Mechismo: predicting the mechanistic impact of mutations and modifications on molecular interactions

(2014) Matthew J. Betts et al.   NUCLEIC ACIDS RESEARCH

OncodriveCLUST: exploiting the positional clustering of somatic mutations to identify cancer genes

(2013) David Tamborero et al.   BIOINFORMATICS

MuPIT interactive: webserver for mapping variant positions to annotated, interactive 3D structures

(2013) Noushin Niknafs et al.   HUMAN GENETICS

Mutational heterogeneity in cancer and the search for new cancer-associated genes

(2013) Michael S. Lawrence et al.   NATURE

Integrated molecular analysis of clear-cell renal cell carcinoma

(2013) Yusuke Sato et al.   NATURE GENETICS

IntOGen-mutations identifies cancer drivers across tumor types

(2013) Abel Gonzalez-Perez et al.   NATURE METHODS

DrugBank 4.0: shedding new light on drug metabolism

(2013) Vivian Law et al.   NUCLEIC ACIDS RESEARCH

Common and Rare EGFR and KRAS Mutations in a Dutch Non-Small-Cell Lung Cancer Population and Their Clinical Outcome

(2013) Gerald S. M. A. Kerner et al.   PLoS One

Next-Generation Sequencing of Lung Cancer EGFR Exons 18-21 Allows Effective Molecular Diagnosis of Small Routine Samples (Cytology and Biopsy)

(2013) Dario de Biase et al.   PLoS One

Cancer Genome Landscapes

(2013) B. Vogelstein et al.   SCIENCE

SMAD2, SMAD3 and SMAD4 Mutations in Colorectal Cancer

(2012) N. I. Fleming et al.   CANCER RESEARCH

Oncogenic MAP2K1 mutations in human epithelial tumors

(2012) Young Lim Choi et al.   CARCINOGENESIS

Tyrosine kinase inhibitors in acute and chronic leukemias

(2012) Maro Ohanian et al.   EXPERT OPINION ON PHARMACOTHERAPY

MuSiC: Identifying mutational significance in cancer genomes

(2012) N. D. Dees et al.   GENOME RESEARCH

Interpreting protein networks with three-dimensional structures

(2012) Joan Teyra et al.   NATURE METHODS

Functional impact bias reveals cancer drivers

(2012) Abel Gonzalez-Perez et al.   NUCLEIC ACIDS RESEARCH

Reorganizing the protein space at the Universal Protein Resource (UniProt)

(2011)   NUCLEIC ACIDS RESEARCH

Predicting the functional impact of protein mutations: application to cancer genomics

(2011) Boris Reva et al.   NUCLEIC ACIDS RESEARCH

Prioritization of driver mutations in pancreatic cancer using cancer-specific high-throughput annotation of somatic mutations (CHASM)

(2010) Hannah Carter et al.   CANCER BIOLOGY & THERAPY

LS-SNP/PDB: annotated non-synonymous SNPs mapped to Protein Data Bank structures

(2009) Michael Ryan et al.   BIOINFORMATICS

Functional Analysis of Epidermal Growth Factor Receptor (EGFR) Mutations and Potential Implications for EGFR Targeted Therapy

(2009) R. K. Kancha et al.   CLINICAL CANCER RESEARCH

Four Distances between Pairs of Amino Acids Provide a Precise Description of their Interaction

(2009) Mati Cohen et al.   PLoS Computational Biology

Activity of Bosutinib, Dasatinib, and Nilotinib Against 18 Imatinib-Resistant BCR/ABL Mutants

(2008) Sara Redaelli et al.   JOURNAL OF CLINICAL ONCOLOGY

Activation of tyrosine kinases by mutation of the gatekeeper threonine

(2008) Mohammad Azam et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY