Mass spectrometry captures off-target drug binding and provides mechanistic insights into the human metalloprotease ZMPSTE24

High-resolution mass spectrometry of small molecules bound to membrane proteins

(2016) Joseph Gault et al.   NATURE METHODS

Resolution of Stepwise Cooperativities of Copper Binding by the Homotetrameric Copper-Sensitive Operon Repressor (CsoR): Impact on Structure and Stability

(2015) Alexander D. Jacobs et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Clipping or Extracting: Two Ways to Membrane Protein Degradation

(2015) Dönem Avci et al.   TRENDS IN CELL BIOLOGY

Quantifying the stabilizing effects of protein–ligand interactions in the gas phase

(2015) Timothy M. Allison et al.   Nature Communications

Mass Spectrometry Quantifies Protein Interactions-From Molecular Chaperones to Membrane Porins

(2014) Jonathan T. S. Hopper et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Rhomboid-Like Superfamily: Molecular Mechanisms and Biological Roles

(2014) Matthew Freeman   Annual Review of Cell and Developmental Biology

Membrane proteins bind lipids selectively to modulate their structure and function

(2014) Arthur Laganowsky et al.   NATURE

Application of the Exactive Plus EMR for automated protein-ligand screening by non-covalent mass spectrometry

(2014) Hannah J. Maple et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

From Protein Complexes to Subunit Backbone Fragments: A Multi-stage Approach to Native Mass Spectrometry

(2013) Mikhail E. Belov et al.   ANALYTICAL CHEMISTRY

Aging and HIV/AIDS: pathogenetic role of therapeutic side effects

(2013) Rebecca A Torres et al.   LABORATORY INVESTIGATION

Mechanism of farnesylated CAAX protein processing by the intramembrane protease Rce1

(2013) Ioannis Manolaridis et al.   NATURE

Mass spectrometry reveals synergistic effects of nucleotides, lipids, and drugs binding to a multidrug resistance efflux pump

(2013) J. Marcoux et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Structural Basis of ZMPSTE24-Dependent Laminopathies

(2013) A. Quigley et al.   SCIENCE

Structure of the Integral Membrane Protein CAAX Protease Ste24p

(2013) E. E. Pryor et al.   SCIENCE

Mass spectrometry based tools to investigate protein–ligand interactions for drug discovery

(2012) Kamila J. Pacholarz et al.   CHEMICAL SOCIETY REVIEWS

The promiscuous binding of pharmaceutical drugs and their transporter-mediated uptake into cells: what we (need to) know and how we can do so

(2012) Douglas B. Kell et al.   DRUG DISCOVERY TODAY

Human ZMPSTE24 disease mutations: residual proteolytic activity correlates with disease severity

(2012) Jemima Barrowman et al.   HUMAN MOLECULAR GENETICS

Small-Molecule Inhibition of c-MYC:MAX Leucine Zipper Formation Is Revealed by Ion Mobility Mass Spectrometry

(2012) Sophie R. Harvey et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

High-sensitivity Orbitrap mass analysis of intact macromolecular assemblies

(2012) Rebecca J Rose et al.   NATURE METHODS

HIV Protease Inhibitors Do Not Cause the Accumulation of Prelamin A in PBMCs from Patients Receiving First Line Therapy: The ANRS EP45 “Aging” Study

(2012) Sophie Perrin et al.   PLoS One

Severe hepatocellular disease in mice lacking one or bothCaaXprenyltransferases

(2011) Shao H. Yang et al.   JOURNAL OF LIPID RESEARCH

Early onset mandibuloacral dysplasia due to compound heterozygous mutations in ZMPSTE24

(2010) Zahid Ahmad et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Direct Synthesis of Lamin A, Bypassing Prelamin A Processing, Causes Misshapen Nuclei in Fibroblasts but No Detectable Pathology in Mice

(2010) Catherine Coffinier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Posttranslational Processing of Prelamin A and Disease

(2009) Brandon S.J. Davies et al.   Annual Review of Genomics and Human Genetics

ZMPSTE24, an integral membrane zinc metalloprotease with a connection to progeroid disorders

(2009) Jemima Barrowman et al.   BIOLOGICAL CHEMISTRY

HIV-protease inhibitors block the enzymatic activity of purified Ste24p

(2008) Sarah E. Hudon et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Second generation HIV protease inhibitors against resistant virus

(2008) Zhijian Lu   Expert Opinion on Drug Discovery

A Potent HIV Protease Inhibitor, Darunavir, Does Not Inhibit ZMPSTE24 or Lead to an Accumulation of Farnesyl-prelamin A in Cells

(2008) Catherine Coffinier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY