Novel therapeutic targets and emerging treatments for atherosclerotic cardiovascular disease
出版年份 2023 全文链接
标题
Novel therapeutic targets and emerging treatments for atherosclerotic cardiovascular disease
作者
关键词
-
出版物
European Heart Journal-Cardiovascular Pharmacotherapy
Volume -, Issue -, Pages -
出版商
Oxford University Press (OUP)
发表日期
2023-10-07
DOI
10.1093/ehjcvp/pvad074
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Bempedoic acid lowers high-sensitivity C-reactive protein and low-density lipoprotein cholesterol: Analysis of pooled data from four phase 3 clinical trials
- (2023) Erik S.G. Stroes et al. ATHEROSCLEROSIS
- Very High High-Density Lipoprotein Cholesterol Levels and Cardiovascular Mortality
- (2022) Chang Liu et al. AMERICAN JOURNAL OF CARDIOLOGY
- Effect of Vupanorsen on Non–High-Density Lipoprotein Cholesterol Levels in Statin-Treated Patients With Elevated Cholesterol: TRANSLATE-TIMI 70
- (2022) Brian A. Bergmark et al. CIRCULATION
- Effect of olezarsen targeting APOC-III on lipoprotein size and particle number measured by NMR in patients with hypertriglyceridemia
- (2022) Ewa Karwatowska-Prokopczuk et al. Journal of Clinical Lipidology
- Efficacy and Safety of an Investigational Single-course CRISPR Base Editing Therapy Targeting PCSK9 in Non-human Primate and Mouse Models
- (2022) Richard G. Lee et al. CIRCULATION
- An in vivo CRISPR base editing therapy to inactivate the ANGPTL3 gene: nomination of a development candidate for VERVE-201
- (2022) A Khera et al. EUROPEAN HEART JOURNAL
- Low-dose interleukin 2 for the reduction of vascular inflammation in acute coronary syndromes (IVORY): protocol and study rationale for a randomised, double-blind, placebo-controlled, phase II clinical trial
- (2022) Rouchelle Sriranjan et al. BMJ Open
- Small Interfering RNA to Reduce Lipoprotein(a) in Cardiovascular Disease
- (2022) Michelle L. O’Donoghue et al. NEW ENGLAND JOURNAL OF MEDICINE
- Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk
- (2022) Aruna Das Pradhan et al. NEW ENGLAND JOURNAL OF MEDICINE
- Mortality in STEMI patients without standard modifiable risk factors: a sex-disaggregated analysis of SWEDEHEART registry data
- (2021) Gemma A Figtree et al. LANCET
- A phase I study assessing the safety, tolerability, immunogenicity, and low-density lipoprotein cholesterol-lowering activity of immunotherapeutics targeting PCSK9
- (2021) Markus Zeitlinger et al. EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
- IL-6 inhibition with ziltivekimab in patients at high atherosclerotic risk (RESCUE): a double-blind, randomised, placebo-controlled, phase 2 trial
- (2021) Paul M Ridker et al. LANCET
- In vivo CRISPR base editing of PCSK9 durably lowers cholesterol in primates
- (2021) Kiran Musunuru et al. NATURE
- Clonal haematopoiesis and atherosclerosis: a chicken or egg question?
- (2021) Fátima Sánchez-Cabo et al. Nature Reviews Cardiology
- Efficacy and safety of volanesorsen in patients with multifactorial chylomicronaemia (COMPASS): a multicentre, double-blind, randomised, placebo-controlled, phase 3 trial
- (2021) Ioanna Gouni-Berthold et al. Lancet Diabetes & Endocrinology
- Clonal Hematopoiesis of Indeterminate Potential: an Expanding Genetic Cause of Cardiovascular Disease
- (2021) Romit Bhattacharya et al. Current Atherosclerosis Reports
- 2021 ESC Guidelines on cardiovascular disease prevention in clinical practice
- (2021) Frank L J Visseren et al. EUROPEAN HEART JOURNAL
- Pre-Clinical Evaluation of the Nanoliposomal antiPCSK9 Vaccine in Healthy Non-Human Primates
- (2021) Amir Abbas Momtazi-Borojeni et al. Vaccines
- Effect of Alirocumab on Lipoprotein(a) and Cardiovascular Risk After Acute Coronary Syndrome
- (2020) Vera A. Bittner et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Lipoprotein(a) Reduction in Persons with Cardiovascular Disease
- (2020) Sotirios Tsimikas et al. NEW ENGLAND JOURNAL OF MEDICINE
- Gut Microbiota and Cardiovascular Disease
- (2020) Marco Witkowski et al. CIRCULATION RESEARCH
- Association of Clonal Hematopoiesis of Indeterminate Potential With Inflammatory Gene Expression in Patients With Severe Degenerative Aortic Valve Stenosis or Chronic Postischemic Heart Failure
- (2020) Wesley Tyler Abplanalp et al. JAMA Cardiology
- Rationale and design of ApoA-I event reducing in ischemic syndromes II (AEGIS-II): A phase 3, multicenter, double-blind, randomized, placebo-controlled, parallel-group study to investigate the efficacy and safety of CSL112 in subjects after acute myocardial infarction
- (2020) C. Michael Gibson et al. AMERICAN HEART JOURNAL
- Lipoprotein(a) lowering by alirocumab reduces the total burden of cardiovascular events independent of low-density lipoprotein cholesterol lowering: ODYSSEY OUTCOMES trial
- (2020) Michael Szarek et al. EUROPEAN HEART JOURNAL
- Colchicine in Patients with Chronic Coronary Disease
- (2020) Stefan M. Nidorf et al. NEW ENGLAND JOURNAL OF MEDICINE
- Evinacumab for Homozygous Familial Hypercholesterolemia
- (2020) Frederick J. Raal et al. NEW ENGLAND JOURNAL OF MEDICINE
- Effects of n-3 Fatty Acid Supplements in Elderly Patients after Myocardial Infarction: A Randomized Controlled Trial
- (2020) Are Annesønn Kalstad et al. CIRCULATION
- Effect of High-Dose Omega-3 Fatty Acids vs Corn Oil on Major Adverse Cardiovascular Events in Patients at High Cardiovascular Risk
- (2020) Stephen J. Nicholls et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Global Burden of Cardiovascular Diseases and Risk Factors, 1990–2019
- (2020) Gregory A. Roth et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- The Short-Chain Fatty Acid Propionate Protects from Hypertensive Cardiovascular Damage
- (2019) Hendrik Bartolomaeus et al. CIRCULATION
- Lipoprotein(a), PCSK9 Inhibition and Cardiovascular Risk: Insights from the FOURIER Trial
- (2019) Michelle L. O'Donoghue et al. CIRCULATION
- Oxidized phospholipids as a unifying theory for lipoprotein(a) and cardiovascular disease
- (2019) Michael B. Boffa et al. Nature Reviews Cardiology
- Dietary supplementation with inulin-propionate ester or inulin improves insulin sensitivity in adults with overweight and obesity with distinct effects on the gut microbiota, plasma metabolome and systemic inflammatory responses: a randomised cross-over trial
- (2019) Edward S Chambers et al. GUT
- Intestinal Microbiota in Cardiovascular Health and Disease
- (2019) W.H. Wilson Tang et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: a proof-of-concept exploratory study
- (2019) Clara Depommier et al. NATURE MEDICINE
- Inhibition of Angiopoietin-Like Protein 3 With a Monoclonal Antibody Reduces Triglycerides in Hypertriglyceridemia
- (2019) Zahid Ahmad et al. CIRCULATION
- Volanesorsen and Triglyceride Levels in Familial Chylomicronemia Syndrome
- (2019) Joseph L. Witztum et al. NEW ENGLAND JOURNAL OF MEDICINE
- Genetic IL-6 Signaling Deficiency Attenuates Cardiovascular Risk in Clonal Hematopoiesis
- (2019) Alexander G. Bick et al. CIRCULATION
- Efficacy and Safety of Low-Dose Colchicine after Myocardial Infarction
- (2019) Jean-Claude Tardif et al. NEW ENGLAND JOURNAL OF MEDICINE
- Function of T regulatory type 1 cells is down-regulated and is associated with the clinical presentation of coronary artery disease
- (2018) Zhendong Zhu et al. HUMAN IMMUNOLOGY
- Advances in lipid-lowering therapy through gene-silencing technologies
- (2018) Børge G. Nordestgaard et al. Nature Reviews Cardiology
- Association of LPA Variants With Risk of Coronary Disease and the Implications for Lipoprotein(a)-Lowering Therapies
- (2018) Stephen Burgess et al. JAMA Cardiology
- Development of a gut microbe–targeted nonlethal therapeutic to inhibit thrombosis potential
- (2018) Adam B. Roberts et al. NATURE MEDICINE
- Effect of Serial Infusions of CER-001, a Pre-β High-Density Lipoprotein Mimetic, on Coronary Atherosclerosis in Patients Following Acute Coronary Syndromes in the CER-001 Atherosclerosis Regression Acute Coronary Syndrome Trial
- (2018) Stephen J. Nicholls et al. JAMA Cardiology
- Effect of Infusion of High-Density Lipoprotein Mimetic Containing Recombinant Apolipoprotein A-I Milano on Coronary Disease in Patients With an Acute Coronary Syndrome in the MILANO-PILOT Trial
- (2018) Stephen J. Nicholls et al. JAMA Cardiology
- Vitamin D Supplements and Prevention of Cancer and Cardiovascular Disease
- (2018) JoAnn E. Manson et al. NEW ENGLAND JOURNAL OF MEDICINE
- Alirocumab and Cardiovascular Outcomes after Acute Coronary Syndrome
- (2018) Gregory G. Schwartz et al. NEW ENGLAND JOURNAL OF MEDICINE
- Low-Dose Methotrexate for the Prevention of Atherosclerotic Events
- (2018) Paul M Ridker et al. NEW ENGLAND JOURNAL OF MEDICINE
- Cardiovascular Risk Reduction with Icosapent Ethyl for Hypertriglyceridemia
- (2018) Deepak L. Bhatt et al. NEW ENGLAND JOURNAL OF MEDICINE
- Gut microbe-generated metabolite trimethylamine-N-oxide as cardiovascular risk biomarker: a systematic review and dose-response meta-analysis
- (2017) Gabriele Giacomo Schiattarella et al. EUROPEAN HEART JOURNAL
- Recent advances on CD4 + T cells in atherosclerosis and its implications for therapy
- (2017) Caitríona Grönberg et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Evolocumab and Clinical Outcomes in Patients with Cardiovascular Disease
- (2017) Marc S. Sabatine et al. NEW ENGLAND JOURNAL OF MEDICINE
- Effects of Anacetrapib in Patients with Atherosclerotic Vascular Disease
- (2017) NEW ENGLAND JOURNAL OF MEDICINE
- Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease
- (2017) Paul M Ridker et al. NEW ENGLAND JOURNAL OF MEDICINE
- Clonal hematopoiesis associated with TET2 deficiency accelerates atherosclerosis development in mice
- (2017) José J. Fuster et al. SCIENCE
- Gut Microbiota Metabolites and Risk of Major Adverse Cardiovascular Disease Events and Death: A Systematic Review and Meta‐Analysis of Prospective Studies
- (2017) Yoriko Heianza et al. Journal of the American Heart Association
- Prevalence of Elevated Lp(a) Mass Levels and Patient Thresholds in 532 359 Patients in the United StatesHighlights
- (2016) Steve Varvel et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Akkermansia MuciniphilaProtects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation inApoe−/−MiceCLINICAL PERSPECTIVE
- (2016) Jin Li et al. CIRCULATION
- Safety and Tolerability of CSL112, a Reconstituted, Infusible, Plasma-Derived Apolipoprotein A-I, After Acute Myocardial InfarctionClinical Perspective
- (2016) C. Michael Gibson et al. CIRCULATION
- Epidemiology of Atherosclerosis and the Potential to Reduce the Global Burden of Atherothrombotic Disease
- (2016) William Herrington et al. CIRCULATION RESEARCH
- Effect of a single dose of the interleukin-6 receptor antagonist tocilizumab on inflammation and troponin T release in patients with non-ST-elevation myocardial infarction: a double-blind, randomized, placebo-controlled phase 2 trial
- (2016) Ola Kleveland et al. EUROPEAN HEART JOURNAL
- Effect of Losmapimod on Cardiovascular Outcomes in Patients Hospitalized With Acute Myocardial Infarction
- (2016) Michelle L. O’Donoghue et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Lipoprotein apheresis to treat elevated lipoprotein (a)
- (2016) Elisa Waldmann et al. JOURNAL OF LIPID RESEARCH
- Antisense oligonucleotides targeting apolipoprotein(a) in people with raised lipoprotein(a): two randomised, double-blind, placebo-controlled, dose-ranging trials
- (2016) Nicholas J Viney et al. LANCET
- Trimethylamine N‐Oxide Promotes Vascular Inflammation Through Signaling of Mitogen‐Activated Protein Kinase and Nuclear Factor‐κB
- (2016) Marcus M. Seldin et al. Journal of the American Heart Association
- The Gut Microbial Endocrine Organ: Bacterially Derived Signals Driving Cardiometabolic Diseases
- (2015) J. Mark Brown et al. Annual Review of Medicine
- Non-lethal Inhibition of Gut Microbial Trimethylamine Production for the Treatment of Atherosclerosis
- (2015) Zeneng Wang et al. CELL
- Antisense inhibition of apolipoprotein (a) to lower plasma lipoprotein (a) levels in humans
- (2015) Mark J. Graham et al. JOURNAL OF LIPID RESEARCH
- Antisense therapy targeting apolipoprotein(a): a randomised, double-blind, placebo-controlled phase 1 study
- (2015) Sotirios Tsimikas et al. LANCET
- CSL112 Enhances Biomarkers of Reverse Cholesterol Transport After Single and Multiple Infusions in Healthy Subjects
- (2014) Andreas Gille et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- HDL-mediated mechanisms of protection in cardiovascular disease
- (2014) A. Kontush CARDIOVASCULAR RESEARCH
- Inflammation and Cardiovascular Disease: From Pathogenesis to Therapeutic Target
- (2014) Enrica Golia et al. Current Atherosclerosis Reports
- Effect of Darapladib on Major Coronary Events After an Acute Coronary Syndrome
- (2014) Michelle L. O’Donoghue et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction
- (2014) Ron Do et al. NATURE
- Effects of Extended-Release Niacin with Laropiprant in High-Risk Patients
- (2014) NEW ENGLAND JOURNAL OF MEDICINE
- Age-Related Clonal Hematopoiesis Associated with Adverse Outcomes
- (2014) Siddhartha Jaiswal et al. NEW ENGLAND JOURNAL OF MEDICINE
- Loss-of-Function Mutations in APOC3, Triglycerides, and Coronary Disease
- (2014) NEW ENGLAND JOURNAL OF MEDICINE
- Common variants associated with plasma triglycerides and risk for coronary artery disease
- (2013) Ron Do et al. NATURE GENETICS
- Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis
- (2013) Robert A Koeth et al. NATURE MEDICINE
- Genome engineering using the CRISPR-Cas9 system
- (2013) F Ann Ran et al. Nature Protocols
- Regulatory T-Cell Response to Apolipoprotein B100–Derived Peptides Reduces the Development and Progression of Atherosclerosis in Mice
- (2012) Olivier Herbin et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Cholesterol lowering and inhibition of sterol absorption by Lactobacillus reuteri NCIMB 30242: a randomized controlled trial
- (2012) M L Jones et al. EUROPEAN JOURNAL OF CLINICAL NUTRITION
- Omega-3 fatty acid supplementation and cardiovascular disease
- (2012) Donald B. Jump et al. JOURNAL OF LIPID RESEARCH
- Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study
- (2012) Benjamin F Voight et al. LANCET
- Triglycerides and Cardiovascular Disease
- (2011) Michael Miller et al. CIRCULATION
- Residual Cardiovascular Risk Despite Optimal LDL Cholesterol Reduction with Statins: The Evidence, Etiology, and Therapeutic Challenges
- (2011) Uchechukwu K. Sampson et al. Current Atherosclerosis Reports
- Niacin in Patients with Low HDL Cholesterol Levels Receiving Intensive Statin Therapy
- (2011) NEW ENGLAND JOURNAL OF MEDICINE
- Exome Sequencing,ANGPTL3Mutations, and Familial Combined Hypolipidemia
- (2010) Kiran Musunuru et al. NEW ENGLAND JOURNAL OF MEDICINE
- S447X variant of the lipoprotein lipase gene, lipids, and risk of coronary heart disease in 3 prospective cohort studies
- (2009) Majken K. Jensen et al. AMERICAN HEART JOURNAL
- Genetic Variants Associated with Lp(a) Lipoprotein Level and Coronary Disease
- (2009) Robert Clarke et al. NEW ENGLAND JOURNAL OF MEDICINE
- Effects of succinobucol (AGI-1067) after an acute coronary syndrome: a randomised, double-blind, placebo-controlled trial
- (2008) Jean-Claude Tardif et al. LANCET
- Rosuvastatin to Prevent Vascular Events in Men and Women with Elevated C-Reactive Protein
- (2008) Paul M Ridker et al. NEW ENGLAND JOURNAL OF MEDICINE
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started