Review
Pharmacology & Pharmacy
Luis Ortega-Paz, Salvatore Giordano, Davide Capodanno, Roxana Mehran, C. Michael Gibson, Dominick J. J. Angiolillo
Summary: Cardiovascular diseases are a major global cause of death. Despite advances, recurrent adverse cardiovascular events after myocardial infarction remain common, especially in the first year. High-density lipoprotein (HDL) has been a therapeutic target for long-term prevention, but increasing HDL levels has shown no improvement in outcomes. Recent focus has shifted to increasing HDL functionality, leading to the development of apolipoprotein-AI-based therapies like CSL112. Phase 2b trials, such as AEGIS, have shown promising results, leading to ongoing Phase 3 trials.
CLINICAL PHARMACOKINETICS
(2023)
Review
Biochemistry & Molecular Biology
Yasuhiro Endo, Masanori Fujita, Katsunori Ikewaki
Summary: Cardiovascular disease (CVD) is the leading cause of death in Western countries. Recent epidemiology studies have shown a U-shaped relationship between high-density lipoprotein cholesterol (HDL-C) levels and CVD mortality, with increased mortality in patients with extremely high HDL-C levels. HDL-C raising therapy using nicotinic acids or CETP inhibitors has shown limited efficacy in reducing CVD events. As a result, the focus has shifted to evaluating HDL functionality as a novel biomarker for CVD risk. This review provides an overview of the current status and future perspectives on HDL functions, based on findings from basic research and clinical trials.
Article
Multidisciplinary Sciences
Emmanuel Opoku, Stela Berisha, Gregory Brubaker, Peggy Robinet, Jonathan D. Smith
Summary: Transgenic overexpression of apoA1 and the MPO resistant 4WF isoform can delay the progression of atherosclerosis and promote lesion regression in mouse models, with the 4WF isoform showing similar effectiveness in promoting lesion regression compared to the unmodified apoA1 isoform.
Article
Pharmacology & Pharmacy
Ruo Man Wu, Chun Yan Wang, Jie Wang, Xiao Le Xu
Summary: This study found that paeoniflorin has potential therapeutic value for atherosclerosis by promoting reverse cholesterol transport (RCT) and inhibiting inflammation. It reduced atherosclerosis, improved hyperlipidemia, and mitigated hepatic steatosis.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Alberto Cordero, Belen Alvarez-Alvarez, David Escribano, Jose Ma Garcia-Acuna, Belen Cid-Alvarez, Moises Rodriguez-Manero, M. Amparo Quintanilla, Rosa Agra-Bermejo, Pilar Zuazola, Jose R. Gonzalez-Juanatey
Summary: Elevated remnant cholesterol is commonly found in ACS patients and is negatively correlated with age and positively correlated with body mass index. Remnant cholesterol is not associated with higher risk of in-hospital mortality, but it is associated with higher long-term risk of mortality and heart failure.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Medicine, Research & Experimental
Vasily A. Kudinov, Tatiana I. Torkhovskaya, Tamara S. Zakharova, Galina E. Morozevich, Rafael I. Artyushev, Marina Yu. Zubareva, Sergey S. Markin
Summary: The study demonstrates that lipidating HDL with phospholipid nanoparticles can improve HDL functionality, enhance cholesterol efflux capacity, and provide protection against atherosclerosis progression.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Ikechukwu Esobi, Oladosu Olanrewaju, Jing Echesabal-Chen, Alexis Stamatikos
Summary: The study demonstrates the successful regulation of ABC transporter expression using the LoxP-Stop-LoxP (LSL) system in vitro. Overexpression of ABCA1 and ABCG1 enhances cholesterol efflux to apoAI and HDL, respectively. This research highlights the potential of the LSL system for studying ABC transporter function at the cellular level.
Article
Biochemistry & Molecular Biology
Na Yang, Miao Wang, Jing Liu, Jun Liu, Yongchen Hao, Dong Zhao
Summary: One-fifth of patients hospitalized for acute coronary syndrome have elevated remnant cholesterol concentrations, even among those who reach target levels of LDL-C or/and non-HDL-C. This highlights the need to consider remnant cholesterol as a target for secondary prevention of ASCVD.
Article
Pharmacology & Pharmacy
Cheng Zhang, Xuewen Wu, Pengmin Shi, Hongyu Ma, Fei Fang, Qianlang Feng, Shuang Zhao, Ruipu Zhang, Jinyuan Huang, Xinting Xu, Weilie Xiao, Guang Cao, Xu Ji
Summary: In this study, it was found that diterpenoids from the traditional Chinese medicine Callicarpa rubella could effectively inhibit oxidized low-density lipoprotein-induced macrophage foam cell formation by promoting cholesterol efflux, suggesting their potential as drugs for the treatment of atherosclerosis.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Olivier Kamtchueng Simo, Hicham Berrougui, Tamas Fulop, Abdelouahed Khalil
Summary: Aging may reduce the ability of HDL to mediate reverse cholesterol transport, while an atherogenic diet can enhance this process. Cholesterol accumulation in the aortas is more pronounced in aged mice, exacerbating susceptibility to diet-induced atherosclerosis. The dysregulation of membrane cholesterol transporters' expression levels contributes to this phenomenon.
Article
Biochemistry & Molecular Biology
Laeticia Scherler, Sofia N. Verouti, Daniel Ackermann, Bruno Vogt, Genevieve Escher
Summary: In this study, adenine was used to induce nephropathy in mice, showing the loss of protective effects of renal cholesterol and vitamin D-3 metabolism under this condition. It was found that adenine enhanced cholesterol efflux and eliminated lipids in feces, which had a protective effect against atherosclerosis but also affected bone growth.
Article
Peripheral Vascular Disease
Shizuya Yamashita, Hidenori Arai, Hideaki Bujo, Daisaku Masuda, Tohru Ohama, Toshiyuki Ishibashi, Koji Yanagi, Yasuji Doi, Satoshi Nakagawa, Koichi Yamashiro, Kenichiro Tanabe, Toru Kita, Masunori Matsuzaki, Yasushi Saito, Masanori Fukushima, Yuji Matsuzawa
Summary: The study found that despite reducing HDL-C levels, probucol may help reduce cardiovascular events in patients with coronary heart disease.
JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
(2021)
Article
Cardiac & Cardiovascular Systems
Emil Hagstrom, P. Gabriel Steg, Michael Szarek, Deepak L. Bhatt, Vera A. Bittner, Nicolas Danchin, Rafael Diaz, Shaun G. Goodman, Robert A. Harrington, J. Wouter Jukema, Evangelos Liberopoulos, Nikolaus Marx, Jennifer McGinniss, Garen Manvelian, Robert Pordy, Michel Scemama, Harvey D. White, Andreas M. Zeiher, Gregory G. Schwartz
Summary: This study investigated the predictive role of apolipoprotein B (apoB) levels in residual risk after acute coronary syndrome and found that apoB provides additional predictive information. The study also found that lowering apoB levels with the medication alirocumab can reduce cardiovascular events. Therefore, controlling apoB levels is important for reducing the risk after acute coronary syndrome.
Article
Medicine, General & Internal
Shiva Ganjali, Elahe Mahdipour, Seyed Hamid Aghaee-Bakhtiari, Majid Ghayour-Mobarhan, Sara Saffar Soflaei, Maciej Banach, Anatol Kontush, Amirhossein Sahebkar
Summary: This study aimed to evaluate the compositional and functional alterations of high-density lipoprotein (HDL) in patients with in-stent restenosis (ISR). The capacity of HDL to efflux cholesterol from lipid-loaded macrophages and to take up free cholesterol from triglyceride-rich lipoproteins during lipolysis was assessed. The results showed that the functional capacity of HDL was not associated with ISR.
ARCHIVES OF MEDICAL SCIENCE
(2023)
Article
Cardiac & Cardiovascular Systems
Ulf Landmesser, Jennifer McGinniss, Ph Gabriel Steg, Deepak L. Bhatt, Vera A. Bittner, Rafael Diaz, Mirza Dilic, Shaun G. Goodman, J. Wouter Jukema, Megan Loy, Ivan Pecin, Robert Pordy, Steen H. Poulsen, Michael Szarek, Harvey D. White, Gregory G. Schwartz
Summary: In patients with recent ACS and high LDL-C despite optimized statin therapy, the addition of alirocumab allowed 94.6% to achieve the 2019 European guideline LDL-C goal <1.4 mmol/L, and 85.2% of those with recurrent cardiovascular events to achieve <1.0 mmol/L. In contrast, the addition of ezetimibe to optimized statin therapy was projected to achieve LDL-C <1.4 mmol/L in only 10.6% of patients at baseline.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2022)
Article
Toxicology
Eva Herzog, Ingo Pragst, Marcel Waelchli, Andreas Gille, Sabrina Schenk, Jochen Mueller-Cohrs, Svetlana Diditchenko, Paolo Zanoni, Marina Cuchel, Andreas Seubert, Daniel J. Rader, Samuel D. Wright
JOURNAL OF APPLIED TOXICOLOGY
(2016)
Article
Biochemistry & Molecular Biology
Cong Tang, Kashan Ahmed, Andreas Gille, Shun Lu, Hermann-Josef Groene, Sorin Tunaru, Stefan Offermanns
Article
Neurosciences
M. K. Nohr, K. L. Egerod, S. H. Christiansen, A. Gille, S. Offermanns, T. W. Schwartz, M. Moller
Article
Cardiac & Cardiovascular Systems
Pierluigi Tricoci, Denise M. D'Andrea, Paul A. Gurbel, Zhenling Yao, Marina Cuchel, Brion Winston, Robert Schott, Robert Weiss, Michael A. Blazing, Louis Cannon, Alison Bailey, Dominick J. Angiolillo, Andreas Gille, Charles L. Shear, Samuel D. Wright, John H. Alexander
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2015)
Article
Cardiac & Cardiovascular Systems
Svetlana A. Didichenko, Alexei V. Navdaev, Alexandre M. O. Cukier, Andreas Gille, Patrick Schuetz, Martin O. Spycher, Patrice Therond, M. John Chapman, Anatol Kontush, Samuel D. Wright
CIRCULATION RESEARCH
(2016)
Meeting Abstract
Cardiac & Cardiovascular Systems
Andreas Gille, Danielle Duffy, Michael Tortorici, Samuel Wright, Larry Deckelbaum, Denise D'Andrea
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2017)
Article
Multidisciplinary Sciences
Cecilie Morland, Krister A. Andersson, Oyvind P. Haugen, Alena Hadzic, Liv Kleppa, Andreas Gille, Johanne E. Rinholm, Vuk Palibrk, Elisabeth H. Diget, Lauritz H. Kennedy, Tomas Stolen, Eivind Hennestad, Olve Moldestad, Yiqing Cai, Maja Puchades, Stefan Offermanns, Koen Vervaeke, Magnar Bjoras, Ulrik Wisloff, Jon Storm-Mathisen, Linda H. Bergersen
NATURE COMMUNICATIONS
(2017)
Article
Hematology
Andreas Gille, Denise D'Andrea, Michael A. Tortorici, Gunter Hartel, Samuel D. Wright
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2018)
Article
Pharmacology & Pharmacy
Rachael Easton, Andreas Gille, Denise D'Andrea, Roslyn Davis, Samuel D. Wright, Charles Shear
JOURNAL OF CLINICAL PHARMACOLOGY
(2014)
Article
Pharmacology & Pharmacy
Andreas Gille, Danielle Duffy, Michael A. Tortorici, Samuel D. Wright, Lawrence I. Deckelbaum, Denise M. D'Andrea
JOURNAL OF CLINICAL PHARMACOLOGY
(2019)
Article
Pharmacology & Pharmacy
Bo Zheng, Danielle Duffy, Pierluigi Tricoci, Helen Kastrissios, Marc Pfister, Samuel D. Wright, Andreas Gille, Michael A. Tortorici
Summary: The pharmacometric analysis of CSL112 administration in patients with acute myocardial infarction (AMI) showed that a fixed 6 g dose can significantly increase cholesterol efflux capacity (CEC), potentially reducing the risk of early recurrent cardiovascular events in AMI patients.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Michael A. Tortorici, Danielle Duffy, Rebecca Evans, John Feaster, Andreas Gille, Timothy G. K. Mant, Samuel D. Wright, Denise D'Andrea
CLINICAL PHARMACOLOGY IN DRUG DEVELOPMENT
(2019)
Meeting Abstract
Cardiac & Cardiovascular Systems
Andreas Gille, Samuel D. Wright, Michael Tortorici, Danielle Duffy, Charlie Liss, Megan K. Yee, Lawrence I. Deckelbaum, Denise M. D'Andrea, C. M. Gibson
Meeting Abstract
Cardiac & Cardiovascular Systems
M. A. Tortorici, A. Gille, C. Liss, S. Wright, D. D'Andrea, M. K. Yee, J. Szachniewicz, S. Atar, J. Trebacz, C. M. Gibson
EUROPEAN HEART JOURNAL
(2017)
Meeting Abstract
Physiology
L. Bergersen, C. Morland, K. Andersson, O. Haugen, A. Hadzic, L. Kleppa, A. Gille, J. Rinholm, E. Holm-Diget, L. Kennedy, T. Stolen, E. Hennestad, Y. Cai, M. Puchades, S. Offermanns, K. Vervaeke, U. Wisloff, J. Storm-Mathisen