Ikaros is a principal regulator of Aire + mTEC homeostasis, thymic mimetic cell diversity, and central tolerance

Thymic epithelial cells co-opt lineage-defining transcription factors to eliminate autoreactive T cells

(2022) Daniel A. Michelson et al.   CELL

ArchR is a scalable software package for integrative single-cell chromatin accessibility analysis

(2021) Jeffrey M. Granja et al.   NATURE GENETICS

Single-cell transcriptional profiling of human thymic stroma uncovers novel cellular heterogeneity in the thymic medulla

(2021) Jhoanne L. Bautista et al.   Nature Communications

CD4+ T cells require Ikaros to inhibit their differentiation toward a pathogenic cell fate

(2021) Chiara Bernardi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ssvQC: an integrated CUT&RUN quality control workflow for histone modifications and transcription factors

(2021) Joseph Boyd et al.   BMC Research Notes

Diversity in medullary thymic epithelial cells controls the activity and availability of iNKT cells

(2020) Beth Lucas et al.   Nature Communications

Chd4 choreographs self-antigen expression for central immune tolerance

(2020) Yoshihiko Tomofuji et al.   NATURE IMMUNOLOGY

ImmGen at 15

(2020)   NATURE IMMUNOLOGY

Combined transient ablation and single-cell RNA-sequencing reveals the development of medullary thymic epithelial cells

(2020) Kristen L Wells et al.   eLife

Lack of Ikaros Deregulates Inflammatory Gene Programs in T Cells

(2019) Carolina Lyon de Ana et al.   JOURNAL OF IMMUNOLOGY

Allogeneic hematopoietic stem cell transplant outcomes for patients with dominant negative IKZF1/IKAROS mutations

(2019) Erinn S. Kellner et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Metascape provides a biologist-oriented resource for the analysis of systems-level datasets

(2019) Yingyao Zhou et al.   Nature Communications

Assessing the Functional Relevance of Variants in the IKAROS Family Zinc Finger Protein 1 (IKZF1) in a Cohort of Patients With Primary Immunodeficiency

(2019) Zoya Eskandarian et al.   Frontiers in Immunology

Ikaros prevents autoimmunity by controlling anergy and Toll-like receptor signaling in B cells

(2019) Tanja A. Schwickert et al.   NATURE IMMUNOLOGY

The Ikaros family in lymphocyte development

(2018) Beate Heizmann et al.   CURRENT OPINION IN IMMUNOLOGY

A kindred with mutant IKAROS and autoimmunity

(2018) Erika Van Nieuwenhove et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Dominant-negative IKZF1 mutations cause a T, B, and myeloid cell combined immunodeficiency

(2018) David Boutboul et al.   JOURNAL OF CLINICAL INVESTIGATION

Single-cell mapping of the thymic stroma identifies IL-25-producing tuft epithelial cells

(2018) Chamutal Bornstein et al.   NATURE

Thymic tuft cells promote an IL-4-enriched medulla and shape thymocyte development

(2018) Corey N. Miller et al.   NATURE

Tuft Cells—Systemically Dispersed Sensory Epithelia Integrating Immune and Neural Circuitry

(2018) Claire E. O'Leary et al.   Annual Review of Immunology

The making of a lymphocyte: the choice among disparate cell fates and the IKAROS enigma

(2017) Katia Georgopoulos   GENES & DEVELOPMENT

Abnormal hematopoiesis and autoimmunity in human subjects with germline IKZF1 mutations

(2017) Akihiro Hoshino et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Central immune tolerance depends on crosstalk between the classical and alternative NF-κB pathways in medullary thymic epithelial cells

(2017) Marc Riemann et al.   JOURNAL OF AUTOIMMUNITY

Essential role of CCL21 in establishment of central self-tolerance in T cells

(2017) Mina Kozai et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Genetic analysis of Ikaros target genes and tumor suppressor function in BCR-ABL1 + pre–B ALL

(2017) Hilde Schjerven et al.   JOURNAL OF EXPERIMENTAL MEDICINE

chromVAR: inferring transcription-factor-associated accessibility from single-cell epigenomic data

(2017) Alicia N Schep et al.   NATURE METHODS

Common variants near IKZF1 are associated with primary Sjögren's syndrome in Han Chinese

(2017) Susu Qu et al.   PLoS One

Superenhancer reprogramming drives a B-cell–epithelial transition and high-risk leukemia

(2016) Yeguang Hu et al.   GENES & DEVELOPMENT

Aire Enforces Immune Tolerance by Directing Autoreactive T Cells into the Regulatory T Cell Lineage

(2016) Sven Malchow et al.   IMMUNITY

LYN- and AIRE-mediated tolerance checkpoint defects synergize to trigger organ-specific autoimmunity

(2016) Irina Proekt et al.   JOURNAL OF CLINICAL INVESTIGATION

Intestinal epithelial tuft cells initiate type 2 mucosal immunity to helminth parasites

(2016) François Gerbe et al.   NATURE

Tuft cells, taste-chemosensory cells, orchestrate parasite type 2 immunity in the gut

(2016) M. R. Howitt et al.   SCIENCE

Fezf2 Orchestrates a Thymic Program of Self-Antigen Expression for Immune Tolerance

(2015) Hiroyuki Takaba et al.   CELL

Regulation of gene expression dynamics during developmental transitions by the Ikaros transcription factor

(2015) Teresita L. Arenzana et al.   GENES & DEVELOPMENT

T Cell Adolescence: Maturation Events Beyond Positive Selection

(2015) Kristin A. Hogquist et al.   JOURNAL OF IMMUNOLOGY

Tuft-cell-derived IL-25 regulates an intestinal ILC2–epithelial response circuit

(2015) Jakob von Moltke et al.   NATURE

Aire controls gene expression in the thymic epithelium with ordered stochasticity

(2015) Matthew Meredith et al.   NATURE IMMUNOLOGY

Single-cell transcriptome analysis reveals coordinated ectopic gene-expression patterns in medullary thymic epithelial cells

(2015) Philip Brennecke et al.   NATURE IMMUNOLOGY

Regulatory T cells generated early in life play a distinct role in maintaining self-tolerance

(2015) S. Yang et al.   SCIENCE

Ikaros mediates gene silencing in T cells through Polycomb repressive complex 2

(2015) Attila Oravecz et al.   Nature Communications

Population and single-cell genomics reveal theAiredependency, relief from Polycomb silencing, and distribution of self-antigen expression in thymic epithelia

(2014) Stephen N. Sansom et al.   GENOME RESEARCH

Restriction of IL-22–Producing T Cell Responses and Differential Regulation of Regulatory T Cell Compartments by Zinc Finger Transcription Factor Ikaros

(2014) Jennifer J. Heller et al.   JOURNAL OF IMMUNOLOGY

The transcriptional regulator Aire coopts the repressive ATF7ip-MBD1 complex for the induction of immunotolerance

(2014) Michael Waterfield et al.   NATURE IMMUNOLOGY

Stage-specific control of early B cell development by the transcription factor Ikaros

(2014) Tanja A Schwickert et al.   NATURE IMMUNOLOGY

Genome-wide identification of Ikaros targets elucidates its contribution to mouse B-cell lineage specification and pre-B-cell differentiation

(2013) I. Ferreiros-Vidal et al.   BLOOD

Generation of Functional Thymic Epithelium from Human Embryonic Stem Cells that Supports Host T Cell Development

(2013) Audrey V. Parent et al.   Cell Stem Cell

Ikaros is absolutely required for pre-B cell differentiation by attenuating IL-7 signals

(2013) Beate Heizmann et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Lymphotoxin   Receptor Regulates the Development of CCL21-Expressing Subset of Postnatal Medullary Thymic Epithelial Cells

(2013) E. Lkhagvasuren et al.   JOURNAL OF IMMUNOLOGY

Selective regulation of lymphopoiesis and leukemogenesis by individual zinc fingers of Ikaros

(2013) Hilde Schjerven et al.   NATURE IMMUNOLOGY

Ikaros promotes early-born neuronal fates in the cerebral cortex

(2013) J. M. Alsio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aire-Dependent Thymic Development of Tumor-Associated Regulatory T Cells

(2013) S. Malchow et al.   SCIENCE

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Detection of an autoreactive T-cell population within the polyclonal repertoire that undergoes distinct autoimmune regulator (Aire)-mediated selection

(2012) R. T. Taniguchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aire's Partners in the Molecular Control of Immunological Tolerance

(2010) Jakub Abramson et al.   CELL

Global relevance of Aire binding to hypomethylated lysine-4 of histone-3

(2010) A. S. Koh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ikaros-1 couples cell cycle arrest of late striatal precursors with neurogenesis of enkephalinergic neurons

(2009) Raquel Martín-Ibáñez et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus

(2009) Jian-Wen Han et al.   NATURE GENETICS

Mechanisms of an autoimmunity syndrome in mice caused by a dominant mutation in Aire

(2008) Maureen A. Su et al.   JOURNAL OF CLINICAL INVESTIGATION

Ikaros Represses the Transcriptional Response to Notch Signaling in T-Cell Development

(2008) E. Kleinmann et al.   MOLECULAR AND CELLULAR BIOLOGY

Regulation of B cell fate commitment and immunoglobulin heavy-chain gene rearrangements by Ikaros

(2008) Damien Reynaud et al.   NATURE IMMUNOLOGY

Promiscuous gene expression patterns in single medullary thymic epithelial cells argue for a stochastic mechanism

(2008) J. Derbinski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA