Small-molecule WNK inhibition regulates cardiovascular and renal function

WNK4 is the major WNK positively regulating NCC in the mouse kidney

(2014) Daiei Takahashi et al.   BIOSCIENCE REPORTS

Discovery of Novel SPAK Inhibitors That Block WNK Kinase Signaling to Cation Chloride Transporters

(2014) E. Kikuchi et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Chemical library screening for WNK signalling inhibitors using fluorescence correlation spectroscopy

(2013) Takayasu Mori et al.   BIOCHEMICAL JOURNAL

The CUL3–KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt interaction

(2013) Akihito Ohta et al.   BIOCHEMICAL JOURNAL

Towards automated crystallographic structure refinement withphenix.refine

(2012) Pavel V. Afonine et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Advances in WNK Signaling of Salt and Potassium Metabolism: Clinical Implications

(2012) Juan Pablo Arroyo et al.   AMERICAN JOURNAL OF NEPHROLOGY

WNK kinases and the kidney

(2012) Ewout J. Hoorn et al.   EXPERIMENTAL CELL RESEARCH

Activation of the renal Na+:Cl- cotransporter by angiotensin II is a WNK4-dependent process

(2012) M. Castaneda-Bueno et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The WNKs: Atypical Protein Kinases With Pleiotropic Actions

(2011) James A. McCormick et al.   PHYSIOLOGICAL REVIEWS

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Role of the WNK-activated SPAK kinase in regulating blood pressure

(2010) Fatema H. Rafiqi et al.   EMBO Molecular Medicine

Pathophysiological roles of WNK kinases in the kidney

(2010) Shinichi Uchida   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Targeted disruption of the Wnk4 gene decreases phosphorylation of Na-Cl cotransporter, increases Na excretion and lowers blood pressure

(2009) Akihito Ohta et al.   HUMAN MOLECULAR GENETICS

WNK Kinases and Renal Sodium Transport in Health and Disease

(2008) James A. McCormick et al.   HYPERTENSION

Molecular Physiology of the WNK Kinases

(2007) Kristopher T. Kahle et al.   Annual Review of Physiology