标题
Structural and conformational determinants of macrocycle cell permeability
作者
关键词
-
出版物
Nature Chemical Biology
Volume 12, Issue 12, Pages 1065-1074
出版商
Springer Nature
发表日期
2016-10-17
DOI
10.1038/nchembio.2203
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Improving the passive permeability of macrocyclic peptides: Balancing permeability with other physicochemical properties
- (2015) Praew Thansandote et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Exploring experimental and computational markers of cyclic peptides: Charting islands of permeability
- (2015) Conan K. Wang et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Probing the Physicochemical Boundaries of Cell Permeability and Oral Bioavailability in Lipophilic Macrocycles Inspired by Natural Products
- (2015) Andrew T. Bockus et al. JOURNAL OF MEDICINAL CHEMISTRY
- Going Out on a Limb: Delineating The Effects of β-Branching, N-Methylation, and Side Chain Size on the Passive Permeability, Solubility, and Flexibility of Sanguinamide A Analogues
- (2015) Andrew T. Bockus et al. JOURNAL OF MEDICINAL CHEMISTRY
- How Beyond Rule of 5 Drugs and Clinical Candidates Bind to Their Targets
- (2015) Bradley C. Doak et al. JOURNAL OF MEDICINAL CHEMISTRY
- Cell-Permeable Cyclic Peptides from Synthetic Libraries Inspired by Natural Products
- (2015) William M. Hewitt et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Improving on Nature: Making a Cyclic Heptapeptide Orally Bioavailable
- (2014) Daniel S. Nielsen et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Oral Druggable Space beyond the Rule of 5: Insights from Drugs and Clinical Candidates
- (2014) Bradley Croy Doak et al. CHEMISTRY & BIOLOGY
- Discovery and Development of Simeprevir (TMC435), a HCV NS3/4A Protease Inhibitor
- (2014) Åsa Rosenquist et al. JOURNAL OF MEDICINAL CHEMISTRY
- An NMR Method for the Quantitative Assessment of Intramolecular Hydrogen Bonding; Application to Physicochemical, Environmental, and Biochemical Properties
- (2014) Michael H. Abraham et al. JOURNAL OF ORGANIC CHEMISTRY
- Tools and rules for macrocycles
- (2014) Christian Heinis Nature Chemical Biology
- How proteins bind macrocycles
- (2014) Elizabeth A Villar et al. Nature Chemical Biology
- Rational design and synthesis of an orally bioavailable peptide guided by NMR amide temperature coefficients
- (2014) Conan K. Wang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Molecular Docking Characterizes Substrate-Binding Sites and Efflux Modulation Mechanisms within P-Glycoprotein.
- (2013) Ricardo J. Ferreira et al. Journal of Chemical Information and Modeling
- Macrocyclic Drugs and Clinical Candidates: What Can Medicinal Chemists Learn from Their Properties?
- (2013) Fabrizio Giordanetto et al. JOURNAL OF MEDICINAL CHEMISTRY
- Rapid Measurement of Intracellular Unbound Drug Concentrations
- (2013) André Mateus et al. MOLECULAR PHARMACEUTICS
- How hydrogen bonds impact P-glycoprotein transport and permeability
- (2012) Prashant V. Desai et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Structural Biology and Drug Discovery of Difficult Targets: The Limits of Ligandability
- (2012) Sachin Surade et al. CHEMISTRY & BIOLOGY
- Macrocycles in new drug discovery
- (2012) Jamie Mallinson et al. Future Medicinal Chemistry
- Use of 3D Properties to Characterize Beyond Rule-of-5 Property Space for Passive Permeation
- (2012) Cristiano R. W. Guimarães et al. Journal of Chemical Information and Modeling
- Structural Modifications that Alter the P-Glycoprotein Efflux Properties of Compounds
- (2012) Stephen A. Hitchcock JOURNAL OF MEDICINAL CHEMISTRY
- Quantifying the chemical beauty of drugs
- (2012) G. Richard Bickerton et al. Nature Chemistry
- Escape from Flatland 2: complexity and promiscuity
- (2012) Frank Lovering MedChemComm
- Build/Couple/Pair Strategy for the Synthesis of Stereochemically Diverse Macrolactams via Head-to-Tail Cyclization
- (2012) Mark E. Fitzgerald et al. ACS Combinatorial Science
- LIBSVM
- (2012) Chih-Chung Chang et al. ACM Transactions on Intelligent Systems and Technology
- Fragment-based domain shuffling approach for the synthesis of pyran-based macrocycles
- (2011) E. Comer et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Intramolecular hydrogen bonding to improve membrane permeability and absorption in beyond rule of five chemical space
- (2011) Alexander Alex et al. MedChemComm
- Lipophilicity in drug discovery
- (2010) Michael J Waring Expert Opinion on Drug Discovery
- Physicochemical Space for Optimum Oral Bioavailability: Contribution of Human Intestinal Absorption and First-Pass Elimination
- (2010) Manthena V. S. Varma et al. JOURNAL OF MEDICINAL CHEMISTRY
- Intramolecular Hydrogen Bonding in Medicinal Chemistry
- (2010) Bernd Kuhn et al. JOURNAL OF MEDICINAL CHEMISTRY
- An Aldol-Based Build/Couple/Pair Strategy for the Synthesis of Medium- and Large-Sized Rings: Discovery of Macrocyclic Histone Deacetylase Inhibitors
- (2010) Lisa A. Marcaurelle et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Membrane transporters in drug development
- (2010) NATURE REVIEWS DRUG DISCOVERY
- Application of a Dried-DMSO rapid throughput 24-h equilibrium solubility in advancing discovery candidates
- (2009) Yun W. Alelyunas et al. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
- Molecular diversity by design
- (2009) Stuart L. Schreiber NATURE
- Identification of Novel Specific and General Inhibitors of the Three Major Human ATP-Binding Cassette Transporters P-gp, BCRP and MRP2 Among Registered Drugs
- (2009) Pär Matsson et al. PHARMACEUTICAL RESEARCH
- The exploration of macrocycles for drug discovery — an underexploited structural class
- (2008) Edward M. Driggers et al. NATURE REVIEWS DRUG DISCOVERY
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