Fragment-based domain shuffling approach for the synthesis of pyran-based macrocycles

Factors Determining the Selection of Organic Reactions by Medicinal Chemists and the Use of These Reactions in Arrays (Small Focused Libraries)

(2010) Tony W. J. Cooper et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Nitrile-Containing Pharmaceuticals: Efficacious Roles of the Nitrile Pharmacophore

(2010) Fraser F. Fleming et al.   JOURNAL OF MEDICINAL CHEMISTRY

Total Synthesis of (−)-Callipeltoside A

(2010) Thomas R. Hoye et al.   JOURNAL OF ORGANIC CHEMISTRY

An Aldol-Based Build/Couple/Pair Strategy for the Synthesis of Medium- and Large-Sized Rings: Discovery of Macrocyclic Histone Deacetylase Inhibitors

(2010) Lisa A. Marcaurelle et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Rethinking screening

(2010) Thomas Kodadek   Nature Chemical Biology

Grand Challenge Commentary: Accessing new chemical space for 'undruggable' targets

(2010) Sivaraman Dandapani et al.   Nature Chemical Biology

Small molecules of different origins have distinct distributions of structural complexity that correlate with protein-binding profiles

(2010) P. A. Clemons et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Syntheses of aminoalcohol-derived macrocycles leading to a small-molecule binder to and inhibitor of Sonic Hedgehog

(2009) Lee F. Peng et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The Halichondrins and E7389

(2009) Katrina L. Jackson et al.   CHEMICAL REVIEWS

Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success

(2009) Frank Lovering et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of a 35-Member Stereoisomer Library of Bistramide A: Evaluation of Effects on actin State, Cell Cycle and Tumor Cell Growth

(2009) Iwona E. Wrona et al.   JOURNAL OF ORGANIC CHEMISTRY

Total Synthesis of (+)-Sorangicin A

(2009) Amos B. Smith et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Molecular diversity by design

(2009) Stuart L. Schreiber   NATURE

Synthesis of macrocyclic scaffolds suitable for diversity-oriented synthesis of macrolides

(2009) Michael E. Grimwood et al.   TETRAHEDRON

The exploration of macrocycles for drug discovery — an underexploited structural class

(2008) Edward M. Driggers et al.   NATURE REVIEWS DRUG DISCOVERY

Towards the Optimal Screening Collection: A Synthesis Strategy

(2007) Thomas E. Nielsen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION