Adipose Tissue and Metabolic Health

Regulation of beige adipocyte thermogenesis by the cold-repressed ER protein NNAT

(2023) Kyung-Mi Choi et al.   Molecular Metabolism

Adipose mitochondrial complex I deficiency modulates inflammation and glucose homeostasis in a sex-dependent manner

(2022) Kyung-Mi Choi et al.   ENDOCRINOLOGY

Batokines: Mediators of Inter-Tissue Communication (a Mini-Review)

(2022) Felix T. Yang et al.   Current Obesity Reports

T-bet+ B cells accumulate in adipose tissue and exacerbate metabolic disorder during obesity

(2022) Thomas Hägglöf et al.   Cell Metabolism

Tirzepatide Once Weekly for the Treatment of Obesity

(2022) Ania M. Jastreboff et al.   NEW ENGLAND JOURNAL OF MEDICINE

Loss of UCP1 function augments recruitment of futile lipid cycling for thermogenesis in murine brown fat

(2022) Josef Oeckl et al.   Molecular Metabolism

Extracellular vesicles mediate the communication of adipose tissue with brain and promote cognitive impairment associated with insulin resistance

(2022) Jin Wang et al.   Cell Metabolism

Brown adipose tissue is associated with cardiometabolic health

(2021) Tobias Becher et al.   NATURE MEDICINE

A guide to understanding endoplasmic reticulum stress in metabolic disorders

(2021) Imke L. Lemmer et al.   Molecular Metabolism

Creatine kinase B controls futile creatine cycling in thermogenic fat

(2021) Janane F. Rahbani et al.   NATURE

The cellular and functional complexity of thermogenic fat

(2021) Paul Cohen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Signaling Pathways Regulating Thermogenesis

(2021) Chihiro Tabuchi et al.   Frontiers in Endocrinology

Adipocyte function and the development of cardiometabolic disease

(2021) Maude Giroud et al.   JOURNAL OF PHYSIOLOGY-LONDON

In vivo isotope tracing reveals the versatility of glucose as a brown adipose tissue substrate

(2021) Su Myung Jung et al.   Cell Reports

β3-Adrenergic receptors regulate human brown/beige adipocyte lipolysis and thermogenesis

(2021) Cheryl Cero et al.   JCI Insight

LETMD1 is required for mitochondrial structure and thermogenic function of brown adipocytes

(2021) Madigan M. Snyder et al.   FASEB JOURNAL

Defective brown adipose tissue thermogenesis and impaired glucose metabolism in mice lacking Letmd1

(2021) Kyung-Mi Choi et al.   Cell Reports

UCP1-independent thermogenesis

(2020) Anna Roesler et al.   BIOCHEMICAL JOURNAL

Adipose Tissue Macrophage Phenotypes and Characteristics: The Key to Insulin Resistance in Obesity and Metabolic Disorders

(2020) Yinhua Ni et al.   Obesity

Regulation of adipose tissue inflammation by interleukin 6

(2020) Myoung Sook Han et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting FGF21 for the Treatment of Nonalcoholic Steatohepatitis

(2020) Mohammad Zarei et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

The NLRP3 inflammasome regulates adipose tissue metabolism

(2020) Nicole G. Barra et al.   BIOCHEMICAL JOURNAL

The β3-adrenergic receptor agonist mirabegron improves glucose homeostasis in obese humans

(2020) Brian S. Finlin et al.   JOURNAL OF CLINICAL INVESTIGATION

Chronic mirabegron treatment increases human brown fat, HDL cholesterol, and insulin sensitivity

(2020) Alana E. O’Mara et al.   JOURNAL OF CLINICAL INVESTIGATION

Origin and Function of Stress-Induced IL-6 in Murine Models

(2020) Hua Qing et al.   CELL

Human Brown Adipocyte Thermogenesis Is Driven by β2-AR Stimulation

(2020) Denis P. Blondin et al.   Cell Metabolism

Partial leptin deficiency confers resistance to diet-induced obesity in mice

(2020) Shangang Zhao et al.   Molecular Metabolism

Brown Adipose Expansion and Remission of Glycemic Dysfunction in Obese SM/J Mice

(2020) Caryn Carson et al.   Cell Reports

A Novel Endocrine Role for the BAT-Released Lipokine 12,13-diHOME to Mediate Cardiac Function

(2020) Kelsey M. Pinckard et al.   CIRCULATION

Adipose tissue in health and disease

(2020) Innocence Harvey et al.   Open Biology

Transition from metabolically benign to metabolically unhealthy obesity and 10-year cardiovascular disease incidence: The ATTICA cohort study

(2019) Matina Kouvari et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Beyond adiponectin and leptin: adipose tissue-derived mediators of inter-organ communication

(2019) Jan-Bernd Funcke et al.   JOURNAL OF LIPID RESEARCH

Metabolically healthy obesity: facts and fantasies

(2019) Gordon I. Smith et al.   JOURNAL OF CLINICAL INVESTIGATION

Brown Adipocytes Secrete GDF15 in Response to Thermogenic Activation

(2019) Laura Campderrós et al.   Obesity

New insights into the secretory functions of brown adipose tissue

(2019) Joan Villarroya et al.   JOURNAL OF ENDOCRINOLOGY

Genetic and epigenetic control of adipose development

(2018) Olga Gulyaeva et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

12,13-diHOME: An Exercise-Induced Lipokine that Increases Skeletal Muscle Fatty Acid Uptake

(2018) Kristin I. Stanford et al.   Cell Metabolism

Substantial Metabolic Activity of Human Brown Adipose Tissue during Warm Conditions and Cold-Induced Lipolysis of Local Triglycerides

(2018) Graeme Weir et al.   Cell Metabolism

Deconstructing Adipogenesis Induced by β3-Adrenergic Receptor Activation with Single-Cell Expression Profiling

(2018) Rayanne B. Burl et al.   Cell Metabolism

Impact of nutrient overload on metabolic homeostasis

(2018) Haowen Qiu et al.   NUTRITION REVIEWS

Brown Adipose Tissue Controls Skeletal Muscle Function via the Secretion of Myostatin

(2018) Xingxing Kong et al.   Cell Metabolism

Acute metabolic and cardiovascular effects of mirabegron in healthy individuals

(2018) Rebecca K. C. Loh et al.   DIABETES OBESITY & METABOLISM

New Advances in Adaptive Thermogenesis: UCP1 and Beyond

(2018) Edward T. Chouchani et al.   Cell Metabolism

Thermal stress induces glycolytic beige fat formation via a myogenic state

(2018) Yong Chen et al.   NATURE

Association of In Vivo Adipose Tissue Cellular Kinetics With Markers of Metabolic Health in Humans

(2017) Ursula A. White et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Adipose-derived circulating miRNAs regulate gene expression in other tissues

(2017) Thomas Thomou et al.   NATURE

UCP1-independent signaling involving SERCA2b-mediated calcium cycling regulates beige fat thermogenesis and systemic glucose homeostasis

(2017) Kenji Ikeda et al.   NATURE MEDICINE

The cold-induced lipokine 12,13-diHOME promotes fatty acid transport into brown adipose tissue

(2017) Matthew D Lynes et al.   NATURE MEDICINE

Health Effects of Overweight and Obesity in 195 Countries over 25 Years

(2017)   NEW ENGLAND JOURNAL OF MEDICINE

Omentectomy in Addition to Bariatric Surgery—a 5-Year Follow-up

(2017) Daniel P Andersson et al.   OBESITY SURGERY

Mapping of human brown adipose tissue in lean and obese young men

(2017) Brooks P. Leitner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dietary fatty acid metabolism of brown adipose tissue in cold-acclimated men

(2017) Denis P. Blondin et al.   Nature Communications

Skeletal Muscle Thermogenesis and Its Role in Whole Body Energy Metabolism

(2017) Muthu Periasamy et al.   Diabetes & Metabolism Journal

Adipocyte lipolysis and insulin resistance

(2016) Pauline Morigny et al.   BIOCHIMIE

Zfp423 Maintains White Adipocyte Identity through Suppression of the Beige Cell Thermogenic Gene Program

(2016) Mengle Shao et al.   Cell Metabolism

Brown Adipose Tissue Activation Is Linked to Distinct Systemic Effects on Lipid Metabolism in Humans

(2016) Maria Chondronikola et al.   Cell Metabolism

Adipose tissue in control of metabolism

(2016) Liping Luo et al.   JOURNAL OF ENDOCRINOLOGY

Glucagon-like peptide 1 decreases lipotoxicity in non-alcoholic steatohepatitis

(2016) Matthew J. Armstrong et al.   JOURNAL OF HEPATOLOGY

Liraglutide and Cardiovascular Outcomes in Type 2 Diabetes

(2016) Steven P. Marso et al.   NEW ENGLAND JOURNAL OF MEDICINE

Insulin-independent reversal of type 1 diabetes in nonobese diabetic mice with brown adipose tissue transplant

(2015) Subhadra C. Gunawardana et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

A Creatine-Driven Substrate Cycle Enhances Energy Expenditure and Thermogenesis in Beige Fat

(2015) Lawrence Kazak et al.   CELL

Browning of Subcutaneous White Adipose Tissue in Humans after Severe Adrenergic Stress

(2015) Labros S. Sidossis et al.   Cell Metabolism

Impaired Mitochondrial Biogenesis in Adipose Tissue in Acquired Obesity

(2015) Sini Heinonen et al.   DIABETES

Uncoupling Protein 1 and Sarcolipin Are Required to Maintain Optimal Thermogenesis, and Loss of Both Systems Compromises Survival of Mice under Cold Stress

(2015) Leslie A. Rowland et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FGF21 Revolutions: Recent Advances Illuminating FGF21 Biology and Medicinal Properties

(2015) Alexei Kharitonenkov et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Brown fat activation reduces hypercholesterolaemia and protects from atherosclerosis development

(2015) Jimmy F. P. Berbée et al.   Nature Communications

What We Talk About When We Talk About Fat

(2014) Evan D. Rosen et al.   CELL

Ablation of PRDM16 and Beige Adipose Causes Metabolic Dysfunction and a Subcutaneous to Visceral Fat Switch

(2014) Paul Cohen et al.   CELL

Omentectomy in addition to gastric bypass surgery and influence on insulin sensitivity: A randomized double blind controlled trial

(2014) Daniel P. Andersson et al.   CLINICAL NUTRITION

Brown Adipose Tissue Improves Whole-Body Glucose Homeostasis and Insulin Sensitivity in Humans

(2014) M. Chondronikola et al.   DIABETES

GLP-1 Agonism Stimulates Brown Adipose Tissue Thermogenesis and Browning Through Hypothalamic AMPK

(2014) D. Beiroa et al.   DIABETES

Adipose tissue mitochondrial dysfunction triggers a lipodystrophic syndrome with insulin resistance, hepatosteatosis, and cardiovascular complications

(2014) Cecile Vernochet et al.   FASEB JOURNAL

Glucose uptake in brown fat cells is dependent on mTOR complex 2–promoted GLUT1 translocation

(2014) Jessica M. Olsen et al.   JOURNAL OF CELL BIOLOGY

Disruption of GIP/GIPR Axis in Human Adipose Tissue Is Linked to Obesity and Insulin Resistance

(2014) Victòria Ceperuelo-Mallafré et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Interplay between FGF21 and insulin action in the liver regulates metabolism

(2014) Brice Emanuelli et al.   JOURNAL OF CLINICAL INVESTIGATION

Coupling of lipolysis and de novo lipogenesis in brown, beige, and white adipose tissues during chronic β3-adrenergic receptor activation

(2014) Emilio P. Mottillo et al.   JOURNAL OF LIPID RESEARCH

In vivo2H2O administration reveals impaired triglyceride storage in adipose tissue of insulin-resistant humans

(2014) Candice A. Allister et al.   JOURNAL OF LIPID RESEARCH

Dissecting adipose tissue lipolysis: molecular regulation and implications for metabolic disease

(2014) Thomas Svava Nielsen et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Enhanced ROS production and oxidative damage in subcutaneous white adipose tissue mitochondria in obese and type 2 diabetes subjects

(2014) Mrittika Chattopadhyay et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Regulation of adipocyte lipolysis

(2014) Gema Frühbeck et al.   NUTRITION RESEARCH REVIEWS

A Classical Brown Adipose Tissue mRNA Signature Partly Overlaps with Brite in the Supraclavicular Region of Adult Humans

(2013) Naja Zenius Jespersen et al.   Cell Metabolism

EBF2 Determines and Maintains Brown Adipocyte Identity

(2013) Sona Rajakumari et al.   Cell Metabolism

Impact of brown adipose tissue on body fatness and glucose metabolism in healthy humans

(2013) M Matsushita et al.   INTERNATIONAL JOURNAL OF OBESITY

Adipocyte Mitochondrial Function Is Reduced in Human Obesity Independent of Fat Cell Size

(2013) Xiao Yin et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Mechanism of Fatty-Acid-Dependent UCP1 Uncoupling in Brown Fat Mitochondria

(2012) Andriy Fedorenko et al.   CELL

Production of Functional Classical Brown Adipocytes from Human Pluripotent Stem Cells using Specific Hemopoietin Cocktail without Gene Transfer

(2012) Miwako Nishio et al.   Cell Metabolism

FGF21 regulates PGC-1  and browning of white adipose tissues in adaptive thermogenesis

(2012) f. M. Fisher et al.   GENES & DEVELOPMENT

Brown adipose tissue regulates glucose homeostasis and insulin sensitivity

(2012) Kristin I. Stanford et al.   JOURNAL OF CLINICAL INVESTIGATION

Adipose tissue heterogeneity: Implication of depot differences in adipose tissue for obesity complications

(2012) Mi-Jeong Lee et al.   MOLECULAR ASPECTS OF MEDICINE

Sarcolipin is a newly identified regulator of muscle-based thermogenesis in mammals

(2012) Naresh C Bal et al.   NATURE MEDICINE

The unfolded protein response: controlling cell fate decisions under ER stress and beyond

(2012) Claudio Hetz   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Visceral fat and metabolic inflammation: the portal theory revisited

(2012) F. Item et al.   Obesity Reviews

Short-term effects of liraglutide on visceral fat adiposity, appetite, and food preference: a pilot study of obese Japanese patients with type 2 diabetes

(2011) Kana Inoue et al.   Cardiovascular Diabetology

Different Metabolic Responses of Human Brown Adipose Tissue to Activation by Cold and Insulin

(2011) Janne Orava et al.   Cell Metabolism

Lack of Interleukin-1 Receptor I (IL-1RI) Protects Mice From High-Fat Diet-Induced Adipose Tissue Inflammation Coincident With Improved Glucose Homeostasis

(2011) F. C. McGillicuddy et al.   DIABETES

Thermogenic Activation Induces FGF21 Expression and Release in Brown Adipose Tissue

(2011) Elayne Hondares et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification and Validation of Novel Adipokines Released from Primary Human Adipocytes

(2011) Stefan Lehr et al.   MOLECULAR & CELLULAR PROTEOMICS

Brown adipose tissue activity controls triglyceride clearance

(2011) Alexander Bartelt et al.   NATURE MEDICINE

The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

(2011) Bolormaa Vandanmagsar et al.   NATURE MEDICINE

A critical appraisal of the prevalence and metabolic significance of brown adipose tissue in adult humans

(2010) Paul Lee et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Glucose-Dependent Insulinotropic Polypeptide May Enhance Fatty Acid Re-esterification in Subcutaneous Abdominal Adipose Tissue in Lean Humans

(2010) M. Asmar et al.   DIABETES

Gluteofemoral body fat as a determinant of metabolic health

(2010) K N Manolopoulos et al.   INTERNATIONAL JOURNAL OF OBESITY

Exendin-4, a GLP-1 receptor agonist, directly induces adiponectin expression through protein kinase A pathway and prevents inflammatory adipokine expression

(2009) Le Thi Kim Chung et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The major inflammatory mediator interleukin-6 and obesity

(2009) Katalin Eder et al.   INFLAMMATION RESEARCH

Macrophage-derived human resistin exacerbates adipose tissue inflammation and insulin resistance in mice

(2009) Mohammed Qatanani et al.   JOURNAL OF CLINICAL INVESTIGATION

Normalization of obesity-associated insulin resistance through immunotherapy

(2009) Shawn Winer et al.   NATURE MEDICINE

Functional Brown Adipose Tissue in Healthy Adults

(2009) Kirsi A. Virtanen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cold-Activated Brown Adipose Tissue in Healthy Men

(2009) Wouter D. van Marken Lichtenbelt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Identification and Importance of Brown Adipose Tissue in Adult Humans

(2009) Aaron M. Cypess et al.   NEW ENGLAND JOURNAL OF MEDICINE

Liver, Muscle, and Adipose Tissue Insulin Action Is Directly Related to Intrahepatic Triglyceride Content in Obese Subjects

(2008) Kevin M. Korenblat et al.   GASTROENTEROLOGY

Visceral fat: A key mediator of steatohepatitis in metabolic liver disease

(2008) David van der Poorten et al.   HEPATOLOGY

Long-term Effects of Large-volume Liposuction on Metabolic Risk Factors for Coronary Heart Disease

(2008) B. Selma Mohammed et al.   Obesity