Microglia Mediate Contact-Independent Neuronal Network Remodeling via Secreted Neuraminidase-3 Associated with Extracellular Vesicles

Neu1 Is Released From Activated Microglia, Stimulating Microglial Phagocytosis and Sensitizing Neurons to Glutamate

(2022) David H. Allendorf et al.   Frontiers in Cellular Neuroscience

Cell-surface tethered promiscuous biotinylators enable comparative small-scale surface proteomic analysis of human extracellular vesicles and cells

(2022) Lisa L Kirkemo et al.   eLife

Advanced in vitro models: Microglia in action

(2022) Bilal Cakir et al.   NEURON

Microglia states and nomenclature: A field at its crossroads

(2022) Rosa C. Paolicelli et al.   NEURON

Specificities of exosome versus small ectosome secretion revealed by live intracellular tracking of CD63 and CD9

(2021) Mathilde Mathieu et al.   Nature Communications

Reduced sialylation triggers homeostatic synapse and neuronal loss in middle-aged mice

(2020) Christine Klaus et al.   NEUROBIOLOGY OF AGING

Lipopolysaccharide activates microglia via neuraminidase 1 desialylation of Toll‐like Receptor 4

(2020) David Hans Allendorf et al.   JOURNAL OF NEUROCHEMISTRY

CD22 blockade restores homeostatic microglial phagocytosis in ageing brains

(2019) John V. Pluvinage et al.   NATURE

Activated microglia desialylate their surface, stimulating complement receptor 3‐mediated phagocytosis of neurons

(2019) David H. Allendorf et al.   GLIA

Microglial activation by microbial neuraminidase through TLR2 and TLR4 receptors

(2019) María del Mar Fernández-Arjona et al.   Journal of Neuroinflammation

Inflammation leads to distinct populations of extracellular vesicles from microglia

(2018) Yiyi Yang et al.   Journal of Neuroinflammation

Keeping it trim: roles of neuraminidases in CNS function

(2018) Alexey V. Pshezhetsky et al.   GLYCOCONJUGATE JOURNAL

Bidirectional Microglia–Neuron Communication in Health and Disease

(2018) Zsuzsanna Szepesi et al.   Frontiers in Cellular Neuroscience

Persistent reduction in sialylation of cerebral glycoproteins following postnatal inflammatory exposure

(2018) Ekaterina P. Demina et al.   Journal of Neuroinflammation

Activated Microglia Desialylate and Phagocytose Cells via Neuraminidase, Galectin-3, and Mer Tyrosine Kinase

(2017) Koji Nomura et al.   JOURNAL OF IMMUNOLOGY

Molecular basis of human CD22 function and therapeutic targeting

(2017) June Ereño-Orbea et al.   Nature Communications

Human Sialidase Neu3 is S-Acylated and Behaves Like an Integral Membrane Protein

(2017) Macarena Rodriguez-Walker et al.   Scientific Reports

A Photostable Silicon Rhodamine Platform for Optical Voltage Sensing

(2015) Yi-Lin Huang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Microglia: Dynamic Mediators of Synapse Development and Plasticity

(2015) Yuwen Wu et al.   TRENDS IN IMMUNOLOGY

Biomolecular characterization of exosomes released from cancer stem cells: Possible implications for biomarker and treatment of cancer

(2015) Dhruv Kumar et al.   Oncotarget

Mapping substrate interactions of the human membrane-associated neuraminidase, NEU3, using STD NMR

(2014) Amgad Albohy et al.   GLYCOBIOLOGY

Microglial CR3 Activation Triggers Long-Term Synaptic Depression in the Hippocampus via NADPH Oxidase

(2014) Jingfei Zhang et al.   NEURON

Sialic Acids in the Brain: Gangliosides and Polysialic Acid in Nervous System Development, Stability, Disease, and Regeneration

(2014) Ronald L. Schnaar et al.   PHYSIOLOGICAL REVIEWS

Structural Basis for Substrate Specificity of Mammalian Neuraminidases

(2014) Victoria Smutova et al.   PLoS One

The role of protein glycosylation in Alzheimer disease

(2013) Sophia Schedin-Weiss et al.   FEBS Journal

The Complement System: An Unexpected Role in Synaptic Pruning During Development and Disease

(2012) Alexander H. Stephan et al.   Annual Review of Neuroscience

Microglia and neurodegeneration: The role of systemic inflammation

(2012) Colm Cunningham   GLIA

Sialic Acid on the Neuronal Glycocalyx Prevents Complement C1 Binding and Complement Receptor-3-Mediated Removal by Microglia

(2012) B. Linnartz et al.   JOURNAL OF NEUROSCIENCE

Substrate Recognition of the Membrane-Associated Sialidase NEU3 Requires a Hydrophobic Aglycone

(2011) Mahendra S. Sandbhor et al.   BIOCHEMISTRY

Blockade of endogenous neuraminidase leads to an increase of neuronal excitability and activity-dependent synaptogenesis in the rat hippocampus

(2010) Elena Isaeva et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Insight into substrate recognition and catalysis by the human neuraminidase 3 (NEU3) through molecular modeling and site-directed mutagenesis

(2010) Amgad Albohy et al.   GLYCOBIOLOGY

Secretory Mechanisms and Intercellular Transfer of MicroRNAs in Living Cells

(2010) Nobuyoshi Kosaka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synaptic Depression and Aberrant Excitatory Network Activity in Alzheimer’s Disease: Two Faces of the Same Coin?

(2009) Jorge J. Palop et al.   NEUROMOLECULAR MEDICINE

Limited Inhibitory Effects of Oseltamivir and Zanamivir on Human Sialidases

(2008) K. Hata et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY