To RNA‐binding and beyond: Emerging facets of the role of Rbfox proteins in development and disease

Rbfox1 is required for myofibril development and maintaining fiber type–specific isoform expression in Drosophila muscles

(2022) Elena Nikonova et al.   Life Science Alliance

Local translation provides the asymmetric distribution of CaMKII required for associative memory formation

(2022) Nannan Chen et al.   CURRENT BIOLOGY

The Splicing of the Mitochondrial Calcium Uniporter Genuine Activator MICU1 Is Driven by RBFOX2 Splicing Factor during Myogenic Differentiation

(2022) Denis Vecellio Reane et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Comprehensive Identification and Alternative Splicing of Microexons in Drosophila

(2021) Ting-Lin Pang et al.   Frontiers in Genetics

A Candidate RNAi Screen Reveals Diverse RNA-Binding Protein Phenotypes in Drosophila Flight Muscle

(2021) Shao-Yen Kao et al.   Cells

RNA-Binding Proteins in the Post-transcriptional Control of Skeletal Muscle Development, Regeneration and Disease

(2021) De-Li Shi et al.   Frontiers in Cell and Developmental Biology

Rbfox-1 contributes to CaMKIIα expression and intracerebral hemorrhage-induced secondary brain injury via blocking micro-RNA-124

(2020) Fang Shen et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Origin, Conservation, and Loss of Alternative Splicing Events that Diversify the Proteome in Saccharomycotina Budding Yeasts

(2020) Jennifer E Hurtig et al.   RNA

Integrating GWAS and Transcriptomics to Identify the Molecular Underpinnings of Thermal Stress Responses in Drosophila melanogaster

(2020) Melise C. Lecheta et al.   Frontiers in Genetics

Concentration-dependent splicing is enabled by Rbfox motifs of intermediate affinity

(2020) Bridget E. Begg et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

RNA-binding proteins in human genetic disease

(2020) Fátima Gebauer et al.   NATURE REVIEWS GENETICS

Expression of RNA-binding protein Rbfox1l demarcates a restricted population of dorsal telencephalic neurons within the adult zebrafish brain

(2019) Fengjun Ma et al.   GENE EXPRESSION PATTERNS

Conserved functions of RNA-binding proteins in muscle

(2019) Elena Nikonova et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Rbfox family proteins make the homo- and hetero-oligomeric complexes

(2018) Sunkyung Choi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Subphenotype meta-analysis of testicular cancer genome-wide association study data suggests a role for RBFOX family genes in cryptorchidism susceptibility

(2018) Yanping Wang et al.   HUMAN REPRODUCTION

The Splicing FactorRNA-Binding Fox Protein 1Mediates the Cellular Immune Response inDrosophila melanogaster

(2018) Ashley E. Nazario-Toole et al.   JOURNAL OF IMMUNOLOGY

rbFOX1/MBNL1 competition for CCUG RNA repeats binding contributes to myotonic dystrophy type 1/type 2 differences

(2018) Chantal Sellier et al.   Nature Communications

Stress-dependent miR-980 regulation of Rbfox1/A2bp1 promotes ribonucleoprotein granule formation and cell survival

(2018) Mariya M. Kucherenko et al.   Nature Communications

The impact of genome variation and diet on the metabolic phenotype and microbiome composition of Drosophila melanogaster

(2018) Lisa Jehrke et al.   Scientific Reports

A transcriptomics resource reveals a transcriptional transition during ordered sarcomere morphogenesis in flight muscle

(2018) Maria L Spletter et al.   eLife

Regulation of Adult CNS Axonal Regeneration by the Post-transcriptional Regulator Cpeb1

(2018) Wilson Pak-Kin Lou et al.   Frontiers in Molecular Neuroscience

Perspective: A Neuro-Hormonal Systems Approach to Understanding the Complexity of Cryptorchidism Susceptibility

(2018) Julia S. Barthold et al.   Frontiers in Endocrinology

Screening of Genetic Factor in the Interaction Between Periodontitis and Metabolic Traits Using Candidate Gene Association Study (CGAS)

(2018) Kyung-Hui Moon   BIOCHEMICAL GENETICS

The interaction of circRNAs and RNA binding proteins: An important part of circRNA maintenance and function

(2018) Jiankun Zang et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Genomic Analysis of Genotype-by-Social Environment Interaction forDrosophila melanogasterAggressive Behavior

(2017) Palle Duun Rohde et al.   GENETICS

Ancient antagonism between CELF and RBFOX families tunes mRNA splicing outcomes

(2017) Matthew R. Gazzara et al.   GENOME RESEARCH

Single nucleotide polymorphisms and cancer susceptibility

(2017) Na Deng et al.   Oncotarget

Overexpression of miRNA-9 Generates Muscle Hypercontraction Through Translational Repression of Troponin-T in Drosophila melanogaster Indirect Flight Muscles

(2017) Prasanna Katti et al.   G3-Genes Genomes Genetics

Genomic Analysis of Genotype-by-Social Environment Interaction forDrosophila melanogasterAggressive Behavior

(2017) Palle Duun Rohde et al.   GENETICS

RBFOX1, encoding a splicing regulator, is a candidate gene for aggressive behavior

(2017) Noèlia Fernàndez-Castillo et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Rbfox Proteins Regulate Splicing as Part of a Large Multiprotein Complex LASR

(2016) Andrey Damianov et al.   CELL

Repression of Pumilio Protein Expression by Rbfox1 Promotes Germ Cell Differentiation

(2016) Arnaldo Carreira-Rosario et al.   DEVELOPMENTAL CELL

RBFox2 Binds Nascent RNA to Globally Regulate Polycomb Complex 2 Targeting in Mammalian Genomes

(2016) Chaoliang Wei et al.   MOLECULAR CELL

Cytoplasmic Rbfox1 Regulates the Expression of Synaptic and Autism-Related Genes

(2016) Ji-Ann Lee et al.   NEURON

Rbfox proteins regulate microRNA biogenesis by sequence-specific binding to their precursors and target downstream Dicer

(2016) Yu Chen et al.   NUCLEIC ACIDS RESEARCH

MiR-980 Is a Memory Suppressor MicroRNA that Regulates the Autism-Susceptibility Gene A2bp1

(2016) Tugba Guven-Ozkan et al.   Cell Reports

Essential role of the nuclear isoform of RBFOX1, a candidate gene for autism spectrum disorders, in the brain development

(2016) Nanako Hamada et al.   Scientific Reports

Putative synaptic genes defined from a Drosophila whole body developmental transcriptome by a machine learning approach

(2015) Flavio Pazos Obregón et al.   BMC GENOMICS

Insulin-independent role of adiponectin receptor signaling in Drosophila germline stem cell maintenance

(2015) Kaitlin M. Laws et al.   DEVELOPMENTAL BIOLOGY

Identification of Genes That Promote or Inhibit Olfactory Memory Formation in Drosophila

(2015) Erica Walkinshaw et al.   GENETICS

The RNA-binding protein Rbfox1 regulates splicing required for skeletal muscle structure and function

(2015) Simona Pedrotti et al.   HUMAN MOLECULAR GENETICS

Repression of the Central Splicing Regulator RBFox2 Is Functionally Linked to Pressure Overload-Induced Heart Failure

(2015) Chaoliang Wei et al.   Cell Reports

Identification of Genes That Promote or Inhibit Olfactory Memory Formation in Drosophila

(2015) Erica Walkinshaw et al.   GENETICS

Role of the cytoplasmic isoform of RBFOX1/A2BP1 in establishing the architecture of the developing cerebral cortex

(2015) Nanako Hamada et al.   Molecular Autism

RBFOX and PTBP1 proteins regulate the alternative splicing of micro-exons in human brain transcripts

(2014) Yang I. Li et al.   GENOME RESEARCH

circRNA Biogenesis Competes with Pre-mRNA Splicing

(2014) Reut Ashwal-Fluss et al.   MOLECULAR CELL

Genetic Influences on Hand Osteoarthritis in Finnish Women – A Replication Study of Candidate Genes

(2014) Satu Hämäläinen et al.   PLoS One

RBFOX1 Cooperates with MBNL1 to Control Splicing in Muscle, Including Events Altered in Myotonic Dystrophy Type 1

(2014) Roscoe Klinck et al.   PLoS One

circBase: a database for circular RNAs

(2014) Petar Glažar et al.   RNA

Changes in rRNA Transcription Influence Proliferation and Cell Fate Within a Stem Cell Lineage

(2014) Q. Zhang et al.   SCIENCE

Genome-wide analysis in Drosophila reveals age-specific effects of SNPs on fitness traits

(2014) Mary F. Durham et al.   Nature Communications

Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism

(2014) Roser Corominas et al.   Nature Communications

HITS-CLIP and Integrative Modeling Define the Rbfox Splicing-Regulatory Network Linked to Brain Development and Autism

(2014) Sebastien M. Weyn-Vanhentenryck et al.   Cell Reports

The Drosophila putative histone acetyltransferase Enok maintains female germline stem cells through regulating Bruno and the niche

(2013) Tianchi Xin et al.   DEVELOPMENTAL BIOLOGY

Biochemical and morphological characterization of A2BP1 in neuronal tissue

(2013) Nanako Hamada et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Rare autosomal copy number variations in early-onset familial Alzheimer’s disease

(2013) B V Hooli et al.   MOLECULAR PSYCHIATRY

Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia

(2013) Virginie J M Verhoeven et al.   NATURE GENETICS

Neutralization of terminal differentiation in gliomagenesis

(2013) Jian Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Integrated high-resolution array CGH and SKY analysis of homozygous deletions and other genomic alterations present in malignant mesothelioma cell lines

(2013) Geula Klorin et al.   Cancer Genetics

Rbfox1 Downregulation and Altered Calpain 3 Splicing by FRG1 in a Mouse Model of Facioscapulohumeral Muscular Dystrophy (FSHD)

(2013) Mariaelena Pistoni et al.   PLoS Genetics

Rare inheritedA2BP1deletion in a proband with autism and developmental hemiparesis

(2012) L.K. Davis et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Genome-Wide Association for Sensitivity to Chronic Oxidative Stress in Drosophila melanogaster

(2012) Katherine W. Jordan et al.   PLoS One

A Screen for Genes Expressed in the Olfactory Organs of Drosophila melanogaster Identifies Genes Involved in Olfactory Behaviour

(2012) Narelle E. Tunstall et al.   PLoS One

Allele-Biased Expression in Differentiating Human Neurons: Implications for Neuropsychiatric Disorders

(2012) Mingyan Lin et al.   PLoS One

Single nucleotide polymorphism array analysis of microsatellite-stable, diploid/near-diploid colorectal carcinomas without the CpG island methylator phenotype

(2012) MICHAEL LINNEBACHER et al.   Oncology Letters

Sequential stages in the age-dependent gradual formation and accumulation of tubular aggregates in fast twitch muscle fibers: SERCA and calsequestrin involvement

(2011) Simona Boncompagni et al.   AGE

Copy Number Variants for Schizophrenia and Related Psychotic Disorders in Oceanic Palau: Risk and Transmission in Extended Pedigrees

(2011) Nadine Melhem et al.   BIOLOGICAL PSYCHIATRY

Rbfox-regulated alternative splicing is critical for zebrafish cardiac and skeletal muscle functions

(2011) Thomas L. Gallagher et al.   DEVELOPMENTAL BIOLOGY

Developmental Expression Mapping of a Gene Implicated in Multiple Neurodevelopmental Disorders, A2bp1 (Fox1)

(2011) Elizabeth A.D. Hammock et al.   DEVELOPMENTAL NEUROSCIENCE

Complex Congenital Heart Defects in Association with Maternal Diabetes and Partial Deletion of theA2BP1Gene

(2011) Seema Lale et al.   Fetal and Pediatric Pathology

Genome-wide meta-analysis for severe diabetic retinopathy

(2011) M. A. Grassi et al.   HUMAN MOLECULAR GENETICS

Rbfox proteins regulate alternative splicing of neuronal sodium channel SCN8A

(2011) Janelle E. O'Brien et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Transcriptomic analysis of autistic brain reveals convergent molecular pathology

(2011) Irina Voineagu et al.   NATURE

Gout and Type 2 diabetes have a mutual inter-dependent effect on genetic risk factors and higher incidences

(2011) H.-M. Lai et al.   RHEUMATOLOGY

Mechanisms of activation and repression by the alternative splicing factors RBFOX1/2

(2011) S. Sun et al.   RNA

Genome-Wide Association Study Identifies Novel Restless Legs Syndrome Susceptibility Loci on 2p14 and 16q12.1

(2011) Juliane Winkelmann et al.   PLoS Genetics

Prognostic significance of genetic alterations detected by high-density single nucleotide polymorphism array in gastric cancer

(2010) Motohisa Tada et al.   CANCER SCIENCE

Drosophila Ataxin 2-binding protein 1 marks an intermediate step in the molecular differentiation of female germline cysts

(2010) O. Y. Tastan et al.   DEVELOPMENT

Interaction between Ataxin-2 Binding Protein 1 and Cubitus-interruptus during wing development in Drosophila

(2010) N. Usha et al.   DEVELOPMENTAL BIOLOGY

Evaluation of A2BP1 as an Obesity Gene

(2010) L. Ma et al.   DIABETES

A2BP1 as a novel susceptible gene for primary biliary cirrhosis in Japanese patients

(2010) Satoru Joshita et al.   HUMAN IMMUNOLOGY

Systematic genetic analysis of muscle morphogenesis and function in Drosophila

(2010) Frank Schnorrer et al.   NATURE

The landscape of somatic copy-number alteration across human cancers

(2010) Rameen Beroukhim et al.   NATURE

Expansion of the eukaryotic proteome by alternative splicing

(2010) Timothy W. Nilsen et al.   NATURE

Aberrant alternative splicing and extracellular matrix gene expression in mouse models of myotonic dystrophy

(2010) Hongqing Du et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Genetic utility of broadly defined bipolar schizoaffective disorder as a diagnostic concept

(2009) M. L. Hamshere et al.   BRITISH JOURNAL OF PSYCHIATRY

Fox-1 family of RNA-binding proteins

(2009) Hidehito Kuroyanagi   CELLULAR AND MOLECULAR LIFE SCIENCES

An inducible change in Fox-1/A2BP1 splicing modulates the alternative splicing of downstream neuronal target exons

(2009) J.-A. Lee et al.   GENES & DEVELOPMENT

Genome-Wide Analysis of Survival in Early-Stage Non–Small-Cell Lung Cancer

(2009) Yen-Tsung Huang et al.   JOURNAL OF CLINICAL ONCOLOGY

A genome-wide association study suggests that a locus within the ataxin 2 binding protein 1 gene is associated with hand osteoarthritis: the Treat-OA consortium

(2009) G Zhai et al.   JOURNAL OF MEDICAL GENETICS

Developmental Control of CaV1.2 L-Type Calcium Channel Splicing by Fox Proteins

(2009) Z. Z. Tang et al.   MOLECULAR AND CELLULAR BIOLOGY

Rare structural variants found in attention-deficit hyperactivity disorder are preferentially associated with neurodevelopmental genes

(2009) J Elia et al.   MOLECULAR PSYCHIATRY

Cancer-associated regulation of alternative splicing

(2009) Julian P Venables et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Autoregulation of Fox protein expression to produce dominant negative splicing factors

(2009) A. Damianov et al.   RNA

Global analysis of aberrant pre-mRNA splicing in glioblastoma using exon expression arrays

(2008) Hannah C Cheung et al.   BMC GENOMICS

Defining the regulatory network of the tissue-specific splicing factors Fox-1 and Fox-2

(2008) C. Zhang et al.   GENES & DEVELOPMENT

Repression of Prespliceosome Complex Formation at Two Distinct Steps by Fox-1/Fox-2 Proteins

(2008) H.-L. Zhou et al.   MOLECULAR AND CELLULAR BIOLOGY

Alternative isoform regulation in human tissue transcriptomes

(2008) Eric T. Wang et al.   NATURE

Expression of 24,426 human alternative splicing events and predicted cis regulation in 48 tissues and cell lines

(2008) John C Castle et al.   NATURE GENETICS

Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing

(2008) Qun Pan et al.   NATURE GENETICS

Genome-wide association study provides evidence for a breast cancer risk locus at 6q22.33

(2008) B. Gold et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A postnatal switch of CELF and MBNL proteins reprograms alternative splicing in the developing heart

(2008) A. Kalsotra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA