Article
Cell Biology
Shumei Ma, Xinxin Fu, Lin Liu, Yi Liu, Hao Feng, Heya Jiang, Xiaomei Liu, Rui Liu, Zhenzhen Liang, Mengke Li, Zhujun Tian, Boqi Hu, Yongheng Bai, Bing Liang, Xiaodong Liu
Summary: The study revealed that in breast cancer MDA-MB-231 cells, radiation-induced cell death is iron-dependent and exhibits characteristics of autophagy. The accumulation of iron increases oxidative stress, leading to enhanced autophagy and cell death.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Takeshi Yamamoto, Yoshitsugu Takabatake, Satoshi Minami, Shinsuke Sakai, Ryuta Fujimura, Atsushi Takahashi, Tomoko Namba-Hamano, Jun Matsuda, Tomonori Kimura, Isao Matsui, Jun-Ya Kaimori, Hiroaki Takeda, Masatomo Takahashi, Yoshihiro Izumi, Takeshi Bamba, Taiji Matsusaka, Fumio Niimura, Motoko Yanagita, Yoshitaka Isaka
Summary: The study found that supplementation with EPA can alleviate renal lipotoxicity by reducing phospholipid accumulation in lysosomes, improving mitochondrial dysfunction, reducing inflammation and fibrosis. EPA alleviates renal lipotoxicity by improving lysosomal function and autophagic flux in both high-fat diet-fed mice and isolated PTECs cultured in palmitic acid, indicating its potential as a novel treatment for obesity-related kidney diseases.
Article
Multidisciplinary Sciences
Shi Tai, Jiaxing Sun, Yuying Zhou, Zhaowei Zhu, Yuhu He, Mingxian Chen, Hui Yang, Yichao Xiao, Tao Tu, Liang Tang, Xuping Li, Jianping Zeng, Xilong Zheng, Shenghua Zhou
Summary: In this study, it was found that metformin prevents VSMC and vascular senescence by promoting autolysosome formation. Specifically, metformin enhanced the autophagic flux at the autophagosome-lysosome fusion level, thereby inhibiting Ang II-induced cellular and vascular senescence.
JOURNAL OF ADVANCED RESEARCH
(2022)
Article
Multidisciplinary Sciences
Teiko Komori Nomura, Satoshi Endo, Takuma Kuwano, Kazuya Fukasawa, Shigeo Takashima, Tomoki Todo, Kyoji Furuta, Takuhei Yamamoto, Eiichi Hinoi, Hiroko Koyama, Ryo Honda
Summary: ARL-17477 is a selective inhibitor of neuronal nitric oxide synthase (NOS1) that also exhibits NOS1-independent pharmacological activity in inhibiting the autophagy-lysosomal system, thus preventing cancer growth. The compound demonstrates anticancer effects against a wide spectrum of cancers, with preferential impact on cancer stem-like cells and KRAS-mutant cancer cells. The mechanism of action involves the increase of certain protein levels and impairment of lysosomal fusion, indicating its potential as a dual inhibitor targeting NOS1 and the autophagy-lysosomal system for cancer therapy.
SCIENTIFIC REPORTS
(2023)
Review
Cell Biology
Srimanta Patra, Shankargouda Patil, Daniel J. J. Klionsky, Sujit K. K. Bhutia
Summary: Recent studies have shown that lysosomes, traditionally thought of as static garbage disposals, play a dynamic and multi-functional role in maintaining cellular homeostasis. Lysosomes sense cellular metabolic status and regulate the balance between catabolism and anabolism through signaling pathways, proteins, and transcription factors. Lysosomes also interact with other organelles and their positioning and motility are critical for cellular adaptation. Furthermore, lysosomes can orchestrate different cell death mechanisms to maintain cellular homeostasis, highlighting their central role as a signaling hub.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Article
Cell Biology
Aleksandra Hac, Karolina Pierzynowska, Anna Herman-Antosiewicz
Summary: S6K1 plays a crucial role in autophagy by controlling tubulin acetylation, thereby influencing autophagic flux; the absence of S6K1 disrupts acetylated microtubule network, impairing fusion between autophagosomes and lysosomes.
Article
Biochemistry & Molecular Biology
Ruben Cebrian, Ricardo Lucas, Maria Victoria Fernandez-Cantos, Koen Slot, Pablo Penalver, Marta Martinez-Garcia, Antonio Parraga-Leo, Maria Violante de Paz, Federico Garcia, Oscar P. P. Kuipers, Juan Carlos Morales
Summary: In this study, a family of aminoalkyl resveratrol derivatives with antibacterial activity inspired by cationic amphipathic antimicrobial peptides was discovered. These molecules showed good antimicrobial activity against anaerobic bacteria and exhibited synergistic effects with traditional antibiotics against Gram-negative pathogens. The mechanism of action was found to be at the membrane level and no cross-resistance was observed, although some cytotoxicity was detected.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Willa Wen-You Yim, Hayashi Yamamoto, Noboru Mizushima
Summary: Damaged lysosomes can be repaired by the calcium release-dependent recruitment of the ESCRT machinery. However, the involvement of annexins in this process has not been fully understood. This study shows that ANXA1 and ANXA2 are important for the repair of damaged lysosomes, and their recruitment is calcium-dependent and independent of the ESCRT mechanism.
Article
Pharmacology & Pharmacy
Xin He, Wei Yuan, Fei Liu, Juan Feng, Yanxia Guo
Summary: This study demonstrates the neuroprotective effects of ghrelin in 6-OHDA-induced PD models by improving autophagic flux dysfunction and restoring TFEB level. This effect is achieved through regulating the expression of autophagy-related proteins, increasing cell viability, and reducing the levels of apoptosis-related proteins.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Infectious Diseases
James Jennings, Dunja Asceric, Nermina Malanovic, Georg Pabst
Summary: Membrane-active molecules are a promising strategy to target and kill pathogenic bacteria. This study tested a library of lipid-like compounds against Gram-negative bacteria to understand the structure-activity relationships and mechanisms of antimicrobial activity. The results showed that specific structural features, including hydrophobicity and charge density, play a crucial role in the antibacterial activity.
Article
Biochemistry & Molecular Biology
Yoshinori Tanaka, Shun-ya Kusumoto, Yuki Honma, Kosuke Takeya, Masumi Eto
Summary: In this study, we found that PGRN overexpression suppresses autophagic flux and worsens the pathology of neurodegenerative diseases.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Review
Cell Biology
Lawrence M. Schwartz
Summary: Cell death is a normal and essential component of development and homeostasis, but dysregulation of this process underlies most human diseases. Autophagy is a process mediated by the formation of double membrane vesicles, which allows cells to survive stresses and may also mediate cell death during development and pathogenesis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Yan Zhen, Maja Radulovic, Marina Vietri, Harald Stenmark
Summary: The compartmentalization of eukaryotic cells is essential for their viability, with membranes forming boundaries between organelles and the cytosol. Cellular membranes can be compromised by various factors, but there are evolved mechanisms like membrane scission and endocytosis to maintain membrane integrity.
Review
Cell Biology
Lucille Ferret, Karla Alvarez-Valadez, Jennifer Riviere, Alexandra Muller, Natalia Bohalova, Luo Yu, Lionel Guittat, Vaclav Brazda, Guido Kroemer, Jean-Louis Mergny, Mojgan Djavaheri-Mergny
Summary: Guanine-quadruplex structures (G4) are formed by guanine-rich DNA and RNA sequences and control gene expression mechanisms. G4 ligands have been developed for potential therapeutic applications in human diseases. Recent evidence suggests that G4 ligands may target cellular components such as lysosomes and mitochondria.
Article
Biochemistry & Molecular Biology
Ionela Cristina Nica, Miruna S. Stan, Roua G. Popescu, Nicoleta Nicula, Robert Ducu, Lucian Diamandescu, Anca Dinischiotu
Summary: Advancements in nanotechnology have led to the development of novel TiO2-based nanomaterials that are widely used in industry and biomedicine. Concerns have been raised about human exposure and cytotoxic effects associated with the increased use of engineered nanomaterials in industry. Research has shown that long-term exposure to TiO2 nanoparticles co-doped with iron and nitrogen can lead to disruptions in the cell cycle and lysosomal membrane permeabilization, triggering apoptosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Critical Care Medicine
Ivan Pavlov, Hangyong He, Bairbre McNicholas, Yonatan Perez, Elsa Tavernier, Matthew W. Trump, Julie A. Jackson, Wei Zhang, Daniel S. Rubin, Thomas Spiegel, Anthony Hung, Miguel Angel Ibarra Estrada, Oriol Roca, David L. Vines, David Cosgrave, Sara Mirza, John G. Laffey, Todd W. Rice, Stephan Ehrmann, Jie Li
Summary: Awake prone positioning (APP) can improve oxygenation in patients with acute respiratory failure due to COVID-19, but it does not reduce the intubation rate. Randomized controlled clinical studies are needed to confirm these findings due to the high heterogeneity and observational nature of the included studies.
Review
Chemistry, Multidisciplinary
Chao Pan, Zhuo Mao, Xue Yuan, Hanjie Zhang, Lin Mei, Xiaoyuan Ji
Summary: This review summarizes the recent progress and applications of heterojunction nanomedicine, discusses the catalytic mechanisms and properties in relation to biomedical applications, and presents some challenges and future directions in research.
Article
Environmental Sciences
Ang Li, Bo Li, Bin Lu, Dong Yang, Suxia Hou, Xiaolong Song
Summary: The generation estimation of retired mobile phones in China is calculated based on sales data and subscriber numbers. The study also analyzes the mass and material characteristics of retired mobile phones, and proposes policy implications for improving the sustainable management system.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Editorial Material
Ecology
Ming Nie, Wenwen Liu, Steven C. Pennings, Bo Li
Article
Geriatrics & Gerontology
Xiaohan Chen, Zhuo Fang, Yike Zhao, Wenbin Cheng, Honglin Chen, Genru Li, Jin Xu, Jiale Deng, Xiao Cai, Jianhua Zhuang, You Yin
Summary: This study aims to explore the evaluation ability of sleep parameters and plasma biomarkers for cognitive impairment in patients with cerebrovascular disease. The results showed that the integrated models of sleep parameters and plasma biomarkers can accurately assess cognitive status and the severity of cognitive impairment in patients.
JOURNALS OF GERONTOLOGY SERIES B-PSYCHOLOGICAL SCIENCES AND SOCIAL SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Shuna Chen, Jiaxin Kang, Huanqing Zhu, Kaixi Wang, Ziyi Han, Leyu Wang, Junsheng Liu, Yuanyuan Wu, Puming He, Youying Tu, Bo Li
Summary: L-theanine is the main amino acid in tea leaves and has both flavor and health benefits. Its immunomodulatory effects, particularly on reducing immunosuppression and improving immunity, have been studied in clinical and epidemiological research. Numerous studies on cells and animals have also shown that theanine plays a role in regulating inflammation, nerve damage, the intestinal tract, and tumors by regulating certain cellular functions.
Review
Biochemistry & Molecular Biology
Hongbo Chen, Fei Yu, Jiaxin Kang, Qiao Li, Hasitha Kalhari Warusawitharana, Bo Li
Summary: The composition and contents of organic acids vary in different types of tea. They play important roles in the metabolism of tea plants, nutrient absorption and growth regulation, as well as the aroma and taste quality of tea. However, the research on organic acids in tea is still limited. This article reviewed the progress made in studying organic acids in tea, including analysis methods, physiological functions, composition and influencing factors, sensory contributions, as well as health benefits like antioxidation and digestion promotion. It aims to provide references for further research on organic acids in tea.
Article
Plant Sciences
Yuanfei Pan, Mu Liu, Alejandro Sosa, Bo Li, Mang Shi, Xiaoyun Pan
Summary: This study investigates the metacommunities of endophytic fungi in the leaves of an invasive plant and finds that the structure of these fungal communities is influenced by multiple spatial scales and different drivers. These findings are important for understanding the global patterns of fungal diversity.
Review
Oncology
Ruichen Huang, Bi Zhao, Shi Hu, Qian Zhang, Xiaoping Su, Wei Zhang
Summary: Neoantigens generated by non-synonymous mutations can activate neoantigen-reactive T cells and effectively inhibit tumor growth. Immunotherapy based on these T cells has shown great success in treating melanoma and other solid tumors. Improvements in the preparation and function evaluation of these T cells, as well as ongoing clinical trials, are discussed in this review.
BIOMARKER RESEARCH
(2023)
Article
Biochemical Research Methods
Yunfei Yi, Chan Feng, Mian Yu, Lin Mei, Meiying Wu, Wei Tao
Summary: Efficient gene delivery in an integrated drug delivery system is crucial for multimodal antitumor therapy. This study presents a protocol for constructing a peptide-based siRNA delivery system that achieves tumor vascular normalization and gene silencing in 4T1 cells. The system highlights four major steps and has the potential to silence gene expression and perform other treatments based on different peptide segments.
Article
Computer Science, Interdisciplinary Applications
Xian Song, Bo Li, Pengyu Wang, Yizhao Zhou, Jian Wang, Yaqun Wang, Chengbing Fang, Meiyuan Jin
Summary: This article fabricated a flexible piezoelectric sensor to gather data for the pulse-taking procedure and used it to recognize whether a woman is pregnant. The pulse signal was processed by GoogleNet and achieved a 90.48% correction rate, which solidified the objectivity of pulse diagnosis and raised the digitalization level of TCM.
ENGINEERING REPORTS
(2023)
Review
Chemistry, Inorganic & Nuclear
Jun Li, Wang Liao, Dongqing Huang, Meitong Ou, Tongkai Chen, Xinlu Wang, Ruiyue Zhao, Lingyan Zhang, Lin Mei, Jun Liu, Ping Luan
Summary: Alzheimer's disease is a common central neurodegenerative disorder characterized by behavioral disturbance and progressive cognitive impairment. Accumulation of soluble oligomers and amyloid plaques outside nerve cells are crucial in its development. Advanced strategies for detecting and modulating amyloid beta (A beta) in diagnosis and treatment include the use of large-scale apparatus and novel devices, as well as therapeutic agents and nanomaterials.
COORDINATION CHEMISTRY REVIEWS
(2023)
Article
Chemistry, Multidisciplinary
Guozheng Xing, Xuya Yu, Yan Zhang, Shupei Sheng, Limin Jin, Dunwan Zhu, Lin Mei, Xia Dong, Feng Lv
Summary: Pyroptosis-based immunotherapy using macrophage-based biohybrid microrobots shows promise in breast cancer treatment, as it can evade drug resistance, inhibit metastasis, and trigger an immune response. This novel strategy combines photothermal conversion, targeted drug delivery, and controlled drug release to achieve tumor-specific pyroptosis and enhance immunotherapy.
Review
Medicine, Research & Experimental
Tong Yin, Yan Liu, Wenbo Ji, Jianhua Zhuang, Xiaohan Chen, Baofeng Gong, Jianjian Chu, Wendanqi Liang, Jie Gao, You Yin
Summary: With the increasing population aging, the prevalence of Alzheimer's disease (AD) is also on the rise. However, there is currently no effective treatment available to slow down or stop the progression of AD. This review highlights the engineering strategies of mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) and discusses their potential as therapeutics for AD. The review also presents the challenges and prospects associated with the clinical applications of engineered MSC-EVs in AD therapy.
Article
Remote Sensing
Xi Zhang, Xiangming Xiao, Xinxin Wang, Xiao Xu, Shiyun Qiu, Lianghao Pan, Jun Ma, Ruiting Ju, Jihua Wu, Bo Li
Summary: Biological invasions, especially by Spartina alterniflora, are significantly impacting the structure and functions of coastal ecosystems in China. Urgent efforts to control the spread of this invasive species are hindered by the lack of time-series data. By using satellite images, this study successfully generated annual maps of Spartina saltmarshes from 1985 to 2020, revealing a continuous expansion of Spartina along the coast. The invasion history and frequency of changes were found to be influenced by latitude, with low latitudes experiencing longer and more frequent invasions. Human interventions have contributed to the decline in certain areas, but natural spread remains the primary driver of its extensive invasion.
INTERNATIONAL JOURNAL OF APPLIED EARTH OBSERVATION AND GEOINFORMATION
(2023)
