Glucose fluctuations aggravate myocardial fibrosis via activating the CaMKII/Stat3 signaling in type 2 diabtetes

Ablation of CaMKIIδ oxidation by CRISPR-Cas9 base editing as a therapy for cardiac disease

(2023) Simon Lebek et al.   SCIENCE

Cardiac-specific BACH1 ablation attenuates pathological cardiac hypertrophy by inhibiting the Ang II type 1 receptor expression and the Ca2+/CaMKII pathway

(2023) Xiangxiang Wei et al.   CARDIOVASCULAR RESEARCH

Metformin suppresses cardiac fibroblast proliferation under high-glucose conditions via regulating the mitochondrial complex I protein Grim-19 involved in the Sirt1/Stat3 signaling pathway

(2023) Yongguang Li et al.   FREE RADICAL BIOLOGY AND MEDICINE

CaMKII regulates the proteins TPM1 and MYOM2 and promotes diacetylmorphine-induced abnormal cardiac rhythms

(2023) Min Ji et al.   Scientific Reports

Higher glucose fluctuation is associated with a higher risk of cardiovascular disease: Insights from pooled results among patients with diabetes

(2023) Feng Li et al.   Journal of Diabetes

Visit-to-Visit Variability in Fasting Blood Glucose Predicts the New-Onset Heart Failure: Results From Two Large Chinese Cohorts

(2023) Yueying Wang et al.   CURRENT PROBLEMS IN CARDIOLOGY

Elevated MCU Expression by CaMKIIδB Limits Pathological Cardiac Remodeling

(2022) Pei Wang et al.   CIRCULATION

DYRK1B-STAT3 Drives Cardiac Hypertrophy and Heart Failure by Impairing Mitochondrial Bioenergetics

(2022) Lingfang Zhuang et al.   CIRCULATION

Novel CaMKII-δ Inhibitor Hesperadin Exerts Dual Functions to Ameliorate Cardiac Ischemia/Reperfusion Injury and Inhibit Tumor Growth

(2022) Junxia Zhang et al.   CIRCULATION

Pirfenidone attenuates cardiac hypertrophy against isoproterenol by inhibiting activation of the janus tyrosine kinase-2/signal transducer and activator of transcription 3 (JAK-2/STAT3) signaling pathway

(2022) Zhenhuan Chen et al.   Bioengineered

The functions of Ca2+/calmodulin-dependent protein kinase II (CaMKII) in diabetes progression

(2022) Khaled Benchoula et al.   Journal of Cell Communication and Signaling

Glucose Fluctuations Aggravate Myocardial Fibrosis via the Nuclear Factor-κB-Mediated Nucleotide-Binding Oligomerization Domain-Like Receptor Protein 3 Inflammasome Activation

(2022) Zhen-Ye Zhang et al.   Frontiers in Cardiovascular Medicine

CaMKII as a Therapeutic Target in Cardiovascular Disease

(2022) Oscar E. Reyes Gaido et al.   Annual Review of Pharmacology and Toxicology

RGS11-CaMKII complex mediated redox control attenuates chemotherapy-induced cardiac fibrosis

(2022) Kiran Das et al.   Redox Biology

Glycaemic variability and risk of adverse cardiovascular events in acute coronary syndrome

(2022) Lei Zhang et al.   Diabetes & Vascular Disease Research

Continuous glucose monitoring and metrics for clinical trials: an international consensus statement

(2022) Tadej Battelino et al.   Lancet Diabetes & Endocrinology

Alleviation of Inflammation and Oxidative Stress in Pressure Overload-Induced Cardiac Remodeling and Heart Failure via IL-6/STAT3 Inhibition by Raloxifene

(2021) Shengqi Huo et al.   Oxidative Medicine and Cellular Longevity

Significant abnormal glycemic variability increased the risk for arrhythmias in elderly type 2 diabetic patients

(2021) Jianbo Zhang et al.   BMC Endocrine Disorders

Glucose fluctuation accelerates cardiac injury of diabetic mice via sodium-dependent glucose cotransporter 1 (SGLT1)

(2021) Weihua Wu et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

RIPK3-Mediated Necroptosis in Diabetic Cardiomyopathy Requires CaMKII Activation

(2021) Yun Chen et al.   Oxidative Medicine and Cellular Longevity

CaMKII inhibitor KN‐93 impaired angiogenesis and aggravated cardiac remodelling and heart failure via inhibiting NOX2/mtROS/p‐VEGFR2 and STAT3 pathways

(2021) Yajuan Ni et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Glycaemic management in diabetes: old and new approaches

(2021) Antonio Ceriello et al.   Lancet Diabetes & Endocrinology

Enhanced CaMKII-Dependent Late I Na Induces Atrial Proarrhythmic Activity in Patients With Sleep-Disordered Breathing

(2020) Simon Lebek et al.   CIRCULATION RESEARCH

Hyperglycemia Acutely Increases Cytosolic Reactive Oxygen Species via O -linked GlcNAcylation and CaMKII Activation in Mouse Ventricular Myocytes

(2020) Shan Lu et al.   CIRCULATION RESEARCH

CaMKII signaling in heart diseases: Emerging role in diabetic cardiomyopathy

(2019) Bence Hegyi et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Inhibition of EGFR-STAT3 attenuates cardiomyopathy in streptozotocin-induced type 1 diabetes

(2019) Wu Luo et al.   JOURNAL OF ENDOCRINOLOGY

βIV-Spectrin regulates STAT3 targeting to tune cardiac response to pressure overload

(2018) Sathya D. Unudurthi et al.   JOURNAL OF CLINICAL INVESTIGATION

Cardiac STAT3 Deficiency Impairs Contractility and Metabolic Homeostasis in Hypertension

(2016) Raffaele Altara et al.   Frontiers in Pharmacology