The functions of Ca2+/calmodulin-dependent protein kinase II (CaMKII) in diabetes progression

Adipocyte CAMK2 deficiency improves obesity-associated glucose intolerance

(2021) Wen Dai et al.   Molecular Metabolism

Protective effect of hypoglycemic granule against diabetes‐induced liver injury by alleviating glycolipid metabolic disorder and oxidative stress

(2020) Xiaosong Yang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Glucagon stimulates gluconeogenesis by INSP3R1-mediated hepatic lipolysis

(2020) Rachel J. Perry et al.   NATURE

Berberine Attenuates Hyperglycemia by Inhibiting the Hepatic Glucagon Pathway in Diabetic Mice

(2020) Ying Zhong et al.   Oxidative Medicine and Cellular Longevity

U1 snRNP regulates cancer cell migration and invasion in vitro

(2020) Jung-Min Oh et al.   Nature Communications

Protective effects of essential oil from Fructus Alpiniae zerumbet on retinal Müller gliosis via the PPAR-γ-p-CREB signaling pathway

(2020) Hong Yang et al.   Chinese Medicine

Distinct Types of Cell Death and the Implication in Diabetic Cardiomyopathy

(2020) Yun Chen et al.   Frontiers in Pharmacology

Xanthine oxidase inhibitor allopurinol improves atrial electrical remodeling in diabetic rats by inhibiting CaMKII/NCX signaling

(2020) Yajuan Yang et al.   LIFE SCIENCES

Cardioprotective effect of pioglitazone and curcumin against diabetic cardiomyopathy in type 1 diabetes mellitus: impact on CaMKII/NF-κB/TGF-β1 and PPAR-γ signaling pathway

(2020) Aya A. Gbr et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Amelioration of diabetes-induced cognitive impairment by Transient Receptor Potential Vanilloid 2 (TRPV2) channel inhibitor: Behavioral and mechanistic study

(2020) P. Thapak et al.   NEUROCHEMISTRY INTERNATIONAL

Hyperglycemia regulates cardiac K+ channels via O-GlcNAc-CaMKII and NOX2-ROS-PKC pathways

(2020) Bence Hegyi et al.   BASIC RESEARCH IN CARDIOLOGY

CaM Kinase II-δ Is Required for Diabetic Hyperglycemia and Retinopathy but Not Nephropathy

(2020) Jessy Chen et al.   DIABETES

TAAR1 promotes anti-diabetic signaling in insulin-secreting cells

(2019) Emily S. Michael et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuroprotective Effect of Astragalus Polysacharin on Streptozotocin (STZ)-Induced Diabetic Rats

(2019) Guyue Zhang et al.   MEDICAL SCIENCE MONITOR

Deep ocean minerals inhibit IL-6 and IGFIIR hypertrophic signalling pathways to attenuate diabetes-induced hypertrophy in rat hearts

(2019) Chieh-Hsiang Lu et al.   JOURNAL OF APPLIED PHYSIOLOGY

O-GlcNAcylation of Histone Deacetylase 4 Protects the Diabetic Heart from Failure

(2019) Mariya Kronlage et al.   CIRCULATION

Mechanism of AMPK-mediated apoptosis of rat gastric smooth muscle cells under high glucose condition

(2019) Xiang-zi Zhang et al.   BIOSCIENCE REPORTS

DL-3-n-butylphthalide (NBP) ameliorates cognitive deficits and CaMKII-mediated long-term potentiation impairment in the hippocampus of diabetic db/db mice

(2019) Ming Gao et al.   NEUROLOGICAL RESEARCH

MicroRNA-219 decreases hippocampal long-term potentiation inhibition and hippocampal neuronal cell apoptosis in type 2 diabetes mellitus mice by suppressing the NMDAR signaling pathway

(2018) Ling Zhang et al.   CNS Neuroscience & Therapeutics

Zafirlukast promotes insulin secretion by increasing calcium influx through L-type calcium channels

(2018) Hyeon-Jeong Hwang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

A New Activator of Hepatocyte CaMKII in Fasting and Type 2 Diabetes

(2018) Lale Ozcan et al.   DIABETES

Hyperglycemia Induces Osteoclastogenesis and Bone Destruction Through the Activation of Ca2+/Calmodulin-Dependent Protein Kinase II

(2018) Yanxin Shen et al.   CALCIFIED TISSUE INTERNATIONAL

Saxagliptin but Not Sitagliptin Inhibits CaMKII and PKC via DPP9 Inhibition in Cardiomyocytes

(2018) Chintan N. Koyani et al.   Frontiers in Physiology

Physiological and Pathological Roles of CaMKII-PP1 Signaling in the Brain

(2017) Norifumi Shioda et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Thioesterase-mediated control of cellular calcium homeostasis enables hepatic ER stress

(2017) Baran A. Ersoy et al.   JOURNAL OF CLINICAL INVESTIGATION

Calcium-calmodulin-dependent protein kinase mediates the intracellular signalling pathways of cardiac apoptosis in mice with impaired glucose tolerance

(2017) Marilen Federico et al.   JOURNAL OF PHYSIOLOGY-LONDON

Roles of impaired intracellular calcium cycling in arrhythmogenicity of diabetic mouse model

(2017) Chung-Chuan Chou et al.   PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY

Ror2 signaling regulates Golgi structure and transport through IFT20 for tumor invasiveness

(2017) Michiru Nishita et al.   Scientific Reports

Curcumin Attenuates Retinal Vascular Leakage by Inhibiting Calcium/Calmodulin-Dependent Protein Kinase II Activity in Streptozotocin-Induced Diabetes

(2016) Jun Li et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Ryanodine receptor phosphorylation by CaMKII promotes spontaneous Ca2+ release events in a rodent model of early stage diabetes: The arrhythmogenic substrate

(2016) Leandro Sommese et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

The Effects of Pycnogenol® as Add-on Drug to Metformin Therapy in Diabetic Rats

(2016) Stanislava Jankyova et al.   PHYTOTHERAPY RESEARCH

Macrophage-dependent IL-1β production induces cardiac arrhythmias in diabetic mice

(2016) Gustavo Monnerat et al.   Nature Communications

The mechanism of action of ursolic acid as insulin secretagogue and insulinomimetic is mediated by cross-talk between calcium and kinases to regulate glucose balance

(2015) Allisson Jhonatan Gomes Castro et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Calcium Sensing Receptor Regulating Smooth Muscle Cells Proliferation Through Initiating Cystathionine-Gamma-Lyase/Hydrogen Sulfide Pathway in Diabetic Rat

(2015) Xin Zhong et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

S-Nitrosylation Induces Both Autonomous Activation and Inhibition of Calcium/Calmodulin-dependent Protein Kinase II δ

(2015) Jeffrey R. Erickson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Npas4 Transcription Factor Expression Is Regulated by Calcium Signaling Pathways and Prevents Tacrolimus-induced Cytotoxicity in Pancreatic Beta Cells

(2015) Thilo Speckmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Caloric restriction improves diabetes-induced cognitive deficits by attenuating neurogranin-associated calcium signaling in high-fat diet-fed mice

(2015) Hwajin Kim et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Diabetes mellitus affects activity of calcium/calmodulin-dependent protein kinase II alpha in rat trigeminal ganglia

(2015) Milka Jerić et al.   JOURNAL OF CHEMICAL NEUROANATOMY

Curcumin Inhibits Neuronal Loss in the Retina and Elevates Ca2+/Calmodulin-Dependent Protein Kinase II Activity in Diabetic Rats

(2015) Jun Li et al.   JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS

The Anthocyanin Delphinidin 3-Rutinoside Stimulates Glucagon-Like Peptide-1 Secretion in Murine GLUTag Cell Line via the Ca2+/Calmodulin-Dependent Kinase II Pathway

(2015) Masaki Kato et al.   PLoS One

Activation of GPR40 attenuates chronic inflammation induced impact on pancreatic β-cells health and function

(2014) Mahesh Verma et al.   BMC CELL BIOLOGY

Exercise Ameliorates Insulin Resistance via Ca2+Signals Distinct From Those of Insulin for GLUT4 Translocation in Skeletal Muscles

(2014) Dae-Ryoung Park et al.   DIABETES

Inhibition of Pancreatic β-Cell Ca2+/Calmodulin-dependent Protein Kinase II Reduces Glucose-stimulated Calcium Influx and Insulin Secretion, Impairing Glucose Tolerance

(2014) Prasanna K. Dadi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Melatonin prevents mitochondrial dysfunction and insulin resistance in rat skeletal muscle

(2014) Bruno G. Teodoro et al.   JOURNAL OF PINEAL RESEARCH

Calmodulin dependent protein kinase II activation by exercise regulates saturated & unsaturated fatty acids and improves some metabolic syndrome markers

(2014) Emmanuel Mukwevho et al.   LIFE SCIENCES

Glabridin induces glucose uptake via the AMP-activated protein kinase pathway in muscle cells

(2014) Keisuke Sawada et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Activation of Calcium/Calmodulin-Dependent Protein Kinase II in Obesity Mediates Suppression of Hepatic Insulin Signaling

(2013) Lale Ozcan et al.   Cell Metabolism

Folic acid reverses nitric oxide synthase uncoupling and prevents cardiac dysfunction in insulin resistance: Role of Ca2+/calmodulin-activated protein kinase II

(2013) Nathan D. Roe et al.   FREE RADICAL BIOLOGY AND MEDICINE

Diabetes increases mortality after myocardial infarction by oxidizing CaMKII

(2013) Min Luo et al.   JOURNAL OF CLINICAL INVESTIGATION

Diabetic hyperglycaemia activates CaMKII and arrhythmias by O-linked glycosylation

(2013) Jeffrey R. Erickson et al.   NATURE

Calcium Signaling through CaMKII Regulates Hepatic Glucose Production in Fasting and Obesity

(2012) Lale Ozcan et al.   Cell Metabolism

Inositol-1,4,5-trisphosphate receptor regulates hepatic gluconeogenesis in fasting and diabetes

(2012) Yiguo Wang et al.   NATURE

The cAMP/PKA Pathway Rapidly Activates SIRT1 to Promote Fatty Acid Oxidation Independently of Changes in NAD+

(2011) Zachary Gerhart-Hines et al.   MOLECULAR CELL

Impairment of CaMKII activation and attenuation of neuropathic pain in mice lacking NR2B phosphorylated at Tyr1472

(2010) Shinji Matsumura et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Involvement of spinal phosphorylation cascade of Tyr1472-NR2B, Thr286-CaMKII, and Ser831-GluR1 in neuropathic pain

(2010) Tayo Katano et al.   NEUROPHARMACOLOGY