Article
Biochemistry & Molecular Biology
Francesca Antonelli, Arianna Casciati, Montserrat Belles, Noemi Serra, Maria Victoria Linares-Vidal, Carmela Marino, Mariateresa Mancuso, Simonetta Pazzaglia
Summary: Radiation therapy is a primary treatment modality for brain tumors, but long-term neurocognitive decline significantly affects quality of life. Recent evidence suggests that modulating the Shh signaling pathway can mitigate hippocampal radiation injury and improve brain repair and functional recovery after radio-induced injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Ping Zhang, Yungang Cao, Songfang Chen, Liang Shao
Summary: The combination therapy of vinpocetine and dexamethasone showed more effective anti-inflammatory and antioxidative effects in reducing inflammatory cytokines and increasing antioxidants compared to dexamethasone monotherapy, leading to improved cognitive impairment in NPC patients with radiation injury.
Article
Environmental Sciences
Mohamed Amr El-Missiry, Sameh Shabana, Sara J. Ghazala, Azza I. Othman, Maggie E. Amer
Summary: The study demonstrated that melatonin has potential neuroprotective properties in reducing inflammation, oxidative stress, and apoptosis in the brains of rats exposed to gamma radiation. This suggests that melatonin may have beneficial effects in clinical and occupational settings involving radiation exposure. Further research is needed to fully understand its neuroprotective effects in humans.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Food Science & Technology
Hyunuk Kang, Hui Zhou, Yushan Ye, Jiangfan Yang, Zhonghua Liu, Puming He, Bo Li, Yuanyuan Wu, Yaomin Wang, Youying Tu
Summary: Tieguanyin tea extracts have positive effects on the cognitive ability and neuroprotection of APP/PS1 mice by alleviating inflammation and improving antioxidant capacity.
Article
Biochemistry & Molecular Biology
Kwanwoo Lee, Motofumi Kumazoe, Yuki Marugame, Yoshinori Fujimura, Hirofumi Tachibana
Summary: This study investigates the effects of mild chronic colitis on cognitive functions and hippocampal neurogenesis from adolescent mice to adult mice. The results suggest that mild chronic colitis induces cognitive impairment and decreases adult neurogenesis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Medicine, Research & Experimental
Xingyong Chen, Yanguang Mao, Yueting Guo, Dongyun Xiao, Zejing Lin, Yiyi Huang, Ying Chun Liu, Xu Zhang, Yinzhou Wang
Summary: This study aims to explore the contribution of the immunoproteasome subunit LMP2 in neurobehavioral functions. The results showed that LMP2 gene deletion caused metabolic abnormalities, cognitive impairment, increased anxiety-like behavior, multiple myelin loss, increased blood-brain barrier leakage, and enhanced amyloid-beta protein deposition in rats. These factors led to chronic oxidative stress and neuroinflammation in the brain, contributing to cognitive impairment.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Li Shao, Chen Dong, Deqin Geng, Qing He, Yu Shi
Summary: GB improved cognitive dysfunction in senescence-accelerated P8 (SAMP8) mice by attenuating oxidative stress, neuroinflammation, and ferroptosis, which alleviated cognitive defects induced by Alzheimer's disease.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Plant Sciences
Fan Wang, Kuo Zhang, Mengying Zhai, Xin Lin, Yuxuan Hu, Lijin Feng, Jingyu Yang, Hongjian Yu, Chunfu Wu
Summary: LBP significantly improves ethanol-induced cognitive impairment in mice by promoting hippocampal neurogenesis and reducing oxidative stress.
Article
Oncology
Pi-Shan Sung, Pei-Wen Chen, Chia-Jui Yen, Meng-Ru Shen, Chih-Hung Chen, Kuen-Jer Tsai, Chou-Ching K. Lin
Summary: The study revealed that memantine could potentially treat paclitaxel-induced chemotherapy-induced cognitive impairment (CICI) by enhancing neurogenesis and modulating inflammation. Different treatment strategies may lead to variations in the treatment efficacy.
Review
Cell Biology
Qin-Qi Wang, Gang Yin, Jiang-Rong Huang, Shi-Jun Xi, Feng Qian, Rui-Xue Lee, Xiao-Chun Peng, Feng-Ru Tang
Summary: Population aging poses challenges to the global economy and healthcare services. Brain aging, influenced by external factors like ionizing radiation, can lead to various neurological disorders. Treatment targeting radiation-induced oxidative stress and neuroinflammation may prevent radiation-induced brain aging and related neurological disorders.
Article
Biochemistry & Molecular Biology
Yilong Hao, Tao Ren, Xiaoke Huang, Mi Li, Jong-Ho Lee, Qianming Chen, Rui Liu, Qingfeng Tang
Summary: Exposure to ionizing radiation leads to oxidative damages in living cells. The pentose phosphate pathway (PPP) is the major route to produce NADPH in mammalian cells, and G6PD is the rate-limiting step of PPP. However, whether G6PD is timely co-opted under ionizing radiation to cope with oxidative stress remains elusive.
Review
Pharmacology & Pharmacy
You Kyoung Shin, Geun Hee Seol
Summary: Mild cognitive impairment (MCI) is a growing public health challenge. This review discusses the potential role of linalyl acetate (LA), a component of clary sage and lavender essential oils, in preventing MCI by reducing oxidative stress, inflammation, and endothelial dysfunction. Currently, no approved agents exist for MCI treatment, making the search for safe natural products of great interest.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Qun Liu, Yan Huang, Mengyun Duan, Qun Yang, Boxu Ren, Fengru Tang
Summary: Radiation-induced brain injury (RIBI) is an important factor affecting the prognosis of head and neck tumor patients after radiotherapy. Microglia undergo changes and trigger chronic neuroinflammation, leading to neurocognitive disorders. Understanding the pathophysiology and mechanisms of microglia after irradiation may help develop new therapies to prevent related neurological disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Ismael Martinez-Guardado, Silvia Arboleya, Francisco Javier Grijota, Aleksandra Kaliszewska, Miguel Gueimonde, Natalia Arias
Summary: Oxidative stress is a contributing factor in aging and neurological disorders. Physical exercise and probiotics intake can improve brain's stress response and provide neuroprotection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Nutrition & Dietetics
Maria Stefania Spagnuolo, Susanna Iossa, Luisa Cigliano
Summary: Excessive fructose consumption may lead to obesity and metabolic diseases, as well as impact brain health by promoting neuroinflammation and oxidative stress, and causing insulin resistance.
Article
Biochemical Research Methods
Vikram Subramanian, Sabine Borchard, Omid Azimzadeh, Wolfgang Sievert, Julian Merl-Pham, Mariateresa Mancuso, Emanuela Pasquali, Gabriele Multhoff, Bastian Popper, Hans Zischka, Michael J. Atkinson, Soile Tapio
JOURNAL OF PROTEOME RESEARCH
(2018)
Article
Biology
Claudia Dalke, Frauke Neff, Savneet Kaur Bains, Scott Bright, Deborah Lord, Peter Reitmeir, Ute Roessler, Daniel Samaga, Kristian Unger, Herbert Braselmann, Florian Wagner, Matthias Greiter, Maria Gomolka, Sabine Hornhardt, Sarah Kunze, Stefan J. Kempf, Lillian Garrett, Sabine M. Hoelter, Wolfgang Wurst, Michael Rosemann, Omid Azimzadeh, Soile Tapio, Michaela Aubele, Fabian Theis, Christoph Hoeschen, Predrag Slijepcevic, Munira Kadhim, Michael Atkinson, Horst Zitzelsberger, Ulrike Kulka, Jochen Graw
RADIATION AND ENVIRONMENTAL BIOPHYSICS
(2018)
Review
Biology
Paul N. Schofield, Ulrike Kulka, Soile Tapio, Bernd Grosche
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2019)
Article
Oncology
Zoe Schmal, Anna Isermann, Daniela Hladik, Christine von Toerne, Soile Tapio, Claudia E. Ruebe
RADIOTHERAPY AND ONCOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Daniela Hladik, Sonja Buratovic, Christine Von Toerne, Omid Azimzadeh, Prabal Subedi, Jos Philipp, Stefanie Winkler, Annette Feuchtinger, Elenore Samson, Stefanie M. Hauck, Bo Stenerlow, Per Eriksson, Michael J. Atkinson, Soile Tapio
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Biochemistry & Molecular Biology
Simone Moertl, Dominik Buschmann, Omid Azimzadeh, Michael Schneider, Rosemarie Kell, Klaudia Winkler, Soile Tapio, Sabine Hornhardt, Juliane Merl-Pham, Michael W. Pfaffl, Michael J. Atkinson
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Biochemistry & Molecular Biology
Omid Azimzadeh, Tamara Azizova, Juliane Merl-Pham, Andreas Blutke, Maria Moseeva, Olga Zubkova, Natasa Anastasov, Annette Feuchtinger, Stefanie M. Hauck, Michael J. Atkinson, Soile Tapio
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Biology
Carmen Kessel, Michael J. Atkinson, Thomas E. Schmid, Klaus Trott, Jan J. Wilkens, Natasa Anastasov, Michael Rosemann, Omid Azimzadeh, Soile Tapio, Simone Moertl, Ulrike M. Kulka, Michael Abend, Matthias Port, Christina Beinke, Mona Mustafa, Frauke Neff, Daniela Pfeiffer, Pascal Berberat, Stephanie E. Combs
Summary: The MSc Radiation Biology program has been evaluated over the last five years, showing a diverse student cohort with different nationalities and undergraduate backgrounds. Measures taken after regular quality meetings and student feedback have led to improvements in curriculum, workload, teacher training, and examination regulations.
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Simonetta Pazzaglia, Barbara Tanno, Francesca Antonelli, Paola Giardullo, Gabriele Babini, Prabal Subedi, Omid Azimzadeh, Zohaib N. Khan, Kateryna Oleksenko, Fabian Metzger, Christine von Toerne, Damien Traynor, Dinesh Medipally, Aidan D. Meade, Munira Kadhim, Fiona M. Lyng, Soile Tapio, Anna Saran, Mariateresa Mancuso
Summary: The study demonstrates the potential contribution of non-targeted radiation effects to hippocampal damage, indicating similarities and differences in molecular and histological changes induced by different irradiation doses and methods. It suggests that both targeted and non-targeted radiation effects may play a role in the pathogenesis of hippocampal radiation injury, with implications for human health.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biology
Soile Tapio
Summary: The purpose of this article is to describe the technical development in proteomics over the last two decades, specifically focusing on its application in radiation biology. It is not intended to be a scientific review, but rather a subjective viewpoint on the subject. Proteomics has rapidly evolved and greatly contributed to our understanding of biological mechanisms following radiation exposure, with potential for future use in clinical trials to investigate the effects of ionizing radiation.
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Simonetta Pazzaglia, Barbara Tanno, Ilaria De Stefano, Paola Giardullo, Simona Leonardi, Caterina Merla, Gabriele Babini, Seda Tuncay Cagatay, Ammar Mayah, Munira Kadhim, Fiona M. Lyng, Christine von Toerne, Zohaib N. Khan, Prabal Subedi, Soile Tapio, Anna Saran, Mariateresa Mancuso
Summary: Cell communication via exosomes could influence cell fate under stress situations like ionizing radiation. Studies suggest that exosomes may play a role in radiation effects and resistance to radiotherapy by carrying signaling mediators of radiation damage. There is a lack of comprehensive understanding of exosomes and their regulation under radiation in intact mammalian organisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Omid Azimzadeh, Vikram Subramanian, Wolfgang Sievert, Juliane Merl-Pham, Kateryna Oleksenko, Michael Rosemann, Gabriele Multhoff, Michael J. Atkinson, Soile Tapio
Summary: The study found that fenofibrate attenuates cardiac proteome alterations induced by radiation by activating PPAR alpha, restoring signaling pathways negatively affected by radiation including lipid metabolism, mitochondrial respiratory chain, and endothelial NO signaling. These results suggest a potential benefit of fenofibrate administration in preventing cardiovascular diseases following radiation exposure.
Article
Oncology
Barbara Tanno, Flavia Novelli, Simona Leonardi, Caterina Merla, Gabriele Babini, Paola Giardullo, Munira Kadhim, Damien Traynor, Dinesh K. R. Medipally, Aidan D. Meade, Fiona M. Lyng, Soile Tapio, Luca Marchetti, Anna Saran, Simonetta Pazzaglia, Mariateresa Mancuso
Summary: Radiation exposure can lead to heart disease in mice, even when only a portion of the body is irradiated. The study suggests that miRNAs released from irradiated cells may play a role in damaging unirradiated cardiac cells. Understanding the effects of radiation exposure on non-cancer diseases is crucial for developing preventive measures.
Article
Biochemistry & Molecular Biology
Jos Philipp, Ronan Le Gleut, Christine von Toerne, Prabal Subedi, Omid Azimzadeh, Michael J. Atkinson, Soile Tapio
Article
Biochemistry & Molecular Biology
Seda Tuncay Cagatay, Ammar Mayah, Mariateresa Mancuso, Paola Giardullo, Simonetta Pazzaglia, Anna Saran, Amuthachelvi Daniel, Damien Traynor, Aidan D. Meade, Fiona Lyng, Soile Tapio, Munira Kadhim
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)