Article
Nanoscience & Nanotechnology
Jing-Wen Cui, Hui-Cong Feng, Chang Xu, Ding-Yuan Jiang, Kai-Hua Zhang, Na-Na Gao, Yuan Wang, He Tian, Chang Liu
Summary: Platelet-derived nanoparticles loaded with ginkgolide B (GB) were developed to counteract oxidative stress, inflammation, and ferroptosis in stroke patients, improving motor recovery.
ACS APPLIED NANO MATERIALS
(2023)
Article
Agriculture, Multidisciplinary
Jiaming Liu, Tao Ye, Yuhe Zhang, Rui Zhang, Yu Kong, Yang Zhang, Jing Sun
Summary: The study revealed that Ginkgolide B (GB) significantly improved cognitive function, neurodegeneration, and neuropathological changes in AD model mice. Treatment with GB reduced levels of RAGE and Bax while increasing Bcl-2 levels in AD model mice. Additionally, GB treatment reversed dysbiosis in gut microbiota by restoring the abundance of certain bacterial species.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Nutrition & Dietetics
Yang Li, Miao Sun, Fuyang Cao, Yu Chen, Linlin Zhang, Hao Li, Jiangbei Cao, Jie Song, Yulong Ma, Weidong Mi, Xiaoying Zhang
Summary: The study found that the ferroptosis inhibitor liproxstatin-1 can ameliorate inflammation-related cognitive impairment by reducing the release of inflammatory mediators and oxidative stress, and by regulating iron metabolism and iron ferroptosis-related proteins.
Article
Biochemistry & Molecular Biology
Ji-Ren An, Jia-Nan Su, Gui-Yan Sun, Qing-Feng Wang, Ya-Dong Fan, Nan Jiang, Yu-Feng Yang, Yan Shi
Summary: Studies have shown that liraglutide has a superior efficacy in improving cognitive impairment associated with diabetes, reducing oxidative stress, lipid peroxidation, and iron overload, inhibiting ferroptosis, and ultimately restoring cognitive function.
NEUROCHEMICAL RESEARCH
(2022)
Article
Food Science & Technology
Hyunuk Kang, Hui Zhou, Yushan Ye, Jiangfan Yang, Zhonghua Liu, Puming He, Bo Li, Yuanyuan Wu, Yaomin Wang, Youying Tu
Summary: Tieguanyin tea extracts have positive effects on the cognitive ability and neuroprotection of APP/PS1 mice by alleviating inflammation and improving antioxidant capacity.
Article
Chemistry, Medicinal
Luyang Wang, Yunxi Zhao, Zhenyang Su, Kun Zhao, Peng Li, Tianhua Xu
Summary: Ginkgolide A (GA) has been found to have inhibitory effects on septic cardiomyopathy by alleviating mitochondrial injury and cardiac dysfunction, reducing inflammation and apoptosis, and increasing antioxidant enzyme expression. The study also revealed that GA targets the FoxO1 pathway to attenuate cardiomyocyte inflammation, oxidative stress, and apoptosis.
PHYTOTHERAPY RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Zhaojin Zeng, Haohua Huang, Jinming Zhang, Yuanyuan Liu, Wenshan Zhong, Weimou Chen, Ye Lu, Yujie Qiao, Haijin Zhao, Xiaojing Meng, Fei Zou, Shaoxi Cai, Hangming Dong
Summary: This study found that ferroptosis plays an important role in house dust mite-induced asthma models, and ferroptosis inhibitors can reduce airway inflammation. This research reveals that ferroptosis may be a potential treatment target for house dust mite-induced asthma.
Article
Multidisciplinary Sciences
Eric M. Burton, Jewel Voyer, Benjamin E. Gewurz
Summary: Epstein-Barr virus (EBV) infection plays a role in multiple cancers, and this study examines how EBV infection affects sensitivity to ferroptosis, a form of cell death driven by lipid peroxidation and membrane damage. The study finds that EBV-infected B cells are sensitive to blockage of glutathione biosynthesis and have elevated levels of lipid reactive oxygen species (ROS) that require SLC7A11 and GPX4 activity to prevent ferroptosis. Different stimulation methods affect the sensitivity of B cells to ferroptosis, and EBV-transformed B cells become progressively resistant to ferroptosis induction.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Plant Sciences
Chen Fu, Yifan Wu, Shaojiao Liu, Chaoqin Luo, Yuqiao Lu, Menghan Liu, Lingfeng Wang, Yunling Zhang, Xuemei Liu
Summary: This study aims to investigate the effect of Rehmannioside A on cognitive impairment after ischemia in rats and SH-SY5Y cells, and further evaluate the anti-oxidative and anti-ferroptosis mechanisms.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Jing Chen, Zhijie Ou, Tiantian Gao, Yuwei Yang, Anmei Shu, Huiqin Xu, Yuping Chen, Zhiyang Lv
Summary: This study found that Ginkgolide B (GB), an active ingredient in Ginkgo biloba extract, may improve diabetic nephropathy (DN) by inhibiting GPX4 ubiquitination and alleviating oxidative stress and ferroptosis in mouse podocytes and DN mice. These findings suggest that GB may be an effective therapeutic option for DN.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Immunology
Yan Gao, Juntong Li, Qinglin Wu, Shasha Wang, Songwei Yang, Xun Li, Naihong Chen, Lin Li, Lan Zhang
Summary: TSG effectively alleviated Aβ-induced cytotoxicity in neuronal cells within APP/PS1 mice by regulating ferroptosis related proteins and enzymes, promoting activation of several antioxidative pathways, and reducing oxidative stress and inflammation levels. These findings highlight a novel mechanism of TSG in reversing Aβ-induced injury, suggesting its potential as a promising candidate in the treatment of neurodegenerative diseases, especially AD.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Immunology
Yili Zhang, Xinyi Huang, Baoyu Qi, Chuanrui Sun, Kai Sun, Ning Liu, Liguo Zhu, Xu Wei
Summary: Ferroptosis plays a crucial role in musculoskeletal disorders and has potential as a treatment strategy. However, more research is needed to understand its toxicity to other organs.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Pharmacology & Pharmacy
You Kyoung Shin, Geun Hee Seol
Summary: Mild cognitive impairment (MCI) is a growing public health challenge. This review discusses the potential role of linalyl acetate (LA), a component of clary sage and lavender essential oils, in preventing MCI by reducing oxidative stress, inflammation, and endothelial dysfunction. Currently, no approved agents exist for MCI treatment, making the search for safe natural products of great interest.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yi Yang, Xiangjie Wang, Haolin Zhang, Jiali Li, Jingyi Chen, Miao Yu, Guangxing Li, Ruili Zhang, Ming Ge
Summary: Organophosphorus flame retardants (OPFRs) are commonly used in various industries as a substitute for brominated flame retardants (BFRs). However, OPFRs pose risks to the environment and animal health, particularly in the farming industry. This study investigates the specific toxic effects of exposure to 2-ethylhexyl diphenyl phosphate (EHDPHP) on chickens, and reveals that it can cause damage to chicken livers through oxidative stress and ferroptosis.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Immunology
Xiaojia Li, Xiaoping Wang, Bin Huang, Rui Huang
Summary: This study revealed the protective effect of Sennoside A (SA) against Alzheimer's disease and investigated its mechanism. SA mitigated cognitive impairment, neuronal apoptosis, oxidative stress, and inflammation in AD mice and BV2 cells. SA relieved ferroptosis, inflammation, and cognitive impairment in aging mice through decreasing TRAF6.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)