MAP kinase ERK5 modulates cancer cell sensitivity to extrinsic apoptosis induced by death-receptor agonists

Patient-derived organoids in translational oncology and drug screening

(2023) Ruixin Yang et al.   CANCER LETTERS

Genomic Validation of Endometrial Cancer Patient-Derived Xenograft Models as a Preclinical Tool

(2022) Beatriz Villafranca-Magdalena et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Harnessing TRAIL-induced cell death for cancer therapy: a long walk with thrilling discoveries

(2022) Antonella Montinaro et al.   CELL DEATH AND DIFFERENTIATION

The ERK5/NF-κB signaling pathway targets endometrial cancer proliferation and survival

(2022) Nora Diéguez-Martínez et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Adaptive NK cell response to human cytomegalovirus: Facts and open issues

(2022) Miguel López-Botet et al.   SEMINARS IN IMMUNOLOGY

NK cell-based cancer immunotherapy: from basic biology to clinical development

(2021) Sizhe Liu et al.   Journal of Hematology & Oncology

An ERK5–KLF2 signalling module regulates early embryonic gene expression and telomere rejuvenation in stem cells

(2021) Helen A. Brown et al.   BIOCHEMICAL JOURNAL

ERK5 Inhibition Induces Autophagy-Mediated Cancer Cell Death by Activating ER Stress

(2021) Andrés Gámez-García et al.   Frontiers in Cell and Developmental Biology

Targeted Avenues for Cancer Treatment: The MEK5–ERK5 Signaling Pathway

(2020) Diane M. Pereira et al.   TRENDS IN MOLECULAR MEDICINE

Mechanisms of Apoptosis Resistance to NK Cell-Mediated Cytotoxicity in Cancer

(2020) Christian Sordo-Bahamonde et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Natural killer group 2D receptor and its ligands in cancer immune escape

(2019) Shixin Duan et al.   Molecular Cancer

Impact of ERK5 on the Hallmarks of Cancer

(2019) Barbara Stecca et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

CRISPR-mediated upregulation of DR5 and downregulation of cFLIP synergistically sensitize HeLa cells to TRAIL-mediated apoptosis

(2019) Naresh Poondla et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Regulation of death receptor signaling by the autophagy protein TP53INP2

(2019) Saška Ivanova et al.   EMBO JOURNAL

Mechanisms of natural killer cell‐mediated cellular cytotoxicity

(2019) Isabel Prager et al.   JOURNAL OF LEUKOCYTE BIOLOGY

KRAS Suppression-Induced Degradation of MYC Is Antagonized by a MEK5-ERK5 Compensatory Mechanism

(2018) Angelina V. Vaseva et al.   CANCER CELL

Caspase-8: regulating life and death

(2017) Bart Tummers et al.   IMMUNOLOGICAL REVIEWS

TRAIL-death receptor endocytosis and apoptosis are selectively regulated by dynamin-1 activation

(2017) Carlos R. Reis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ERK5 kinase activity is dispensable for cellular immune response and proliferation

(2016) Emme C. K. Lin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MEK5/ERK5 signaling inhibition increases colon cancer cell sensitivity to 5-fluorouracil through a p53-dependent mechanism

(2016) Diane M. Pereira et al.   Oncotarget

Getting TRAIL back on track for cancer therapy

(2014) J Lemke et al.   CELL DEATH AND DIFFERENTIATION

The mitogen-activated protein kinase ERK5 regulates the development and growth of hepatocellular carcinoma

(2014) Elisabetta Rovida et al.   GUT

Autophagy-regulating TP53INP2 mediates muscle wasting and is repressed in diabetes

(2014) David Sala et al.   JOURNAL OF CLINICAL INVESTIGATION

Potent Antimyeloma Activity of a Novel ERK5/CDK Inhibitor

(2013) S. Alvarez-Fernandez et al.   CLINICAL CANCER RESEARCH

Extracellular Signal-Regulated Kinase 5: A Potential Therapeutic Target for Malignant Mesotheliomas

(2013) A. Shukla et al.   CLINICAL CANCER RESEARCH

Canonical and Kinase Activity-Independent Mechanisms for Extracellular Signal-Regulated Kinase 5 (ERK5) Nuclear Translocation Require Dissociation of Hsp90 from the ERK5-Cdc37 Complex

(2013) T. Erazo et al.   MOLECULAR AND CELLULAR BIOLOGY

TRAIL resistance in human neuroblastoma SK-N-AS cells is dependent on protein kinase C and involves inhibition of caspase-3 proteolytic processing

(2012) Tom Gatsinzi et al.   JOURNAL OF NEURO-ONCOLOGY

BMK1 is involved in the regulation of p53 through disrupting the PML–MDM2 interaction

(2012) Q Yang et al.   ONCOGENE

ABT-737 promotes tBid mitochondrial accumulation to enhance TRAIL-induced apoptosis in glioblastoma cells

(2012) S Cristofanon et al.   Cell Death & Disease

Ovarian cancer ascites protects from TRAIL-induced cell death through αvβ5 integrin-mediated focal adhesion kinase and Akt activation

(2010) D Lane et al.   ONCOGENE

Cullin3-Based Polyubiquitination and p62-Dependent Aggregation of Caspase-8 Mediate Extrinsic Apoptosis Signaling

(2009) Zhaoyu Jin et al.   CELL

The nuclear cofactor DOR regulates autophagy in mammalian and Drosophila cells

(2009) Caroline Mauvezin et al.   EMBO REPORTS

ERK5 Knockdown Generates Mouse Leukemia Cells with Low MHC Class I Levels That Activate NK Cells and Block Tumorigenesis

(2009) S. Charni et al.   JOURNAL OF IMMUNOLOGY

Expression of Erk5 in Early Stage Breast Cancer and Association with Disease Free Survival Identifies this Kinase as a Potential Therapeutic Target

(2009) Juan Carlos Montero et al.   PLoS One

Identification of pharmacological inhibitors of the MEK5/ERK5 pathway

(2008) Revati J. Tatake et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Ubiquitin-Proteasome System Is a Key Component of the SUMO-2/3 Cycle

(2008) Joost Schimmel et al.   MOLECULAR & CELLULAR PROTEOMICS