Human vascularized bile duct-on-a chip: a multi-cellular micro-physiological system for studying cholestatic liver disease

Human Cholangiocytes Form a Polarized and Functional Bile Duct on Hollow Fiber Membranes

(2022) Zhenguo Wang et al.   Frontiers in Bioengineering and Biotechnology

Downregulation of TGR5 (GPBAR1) in biliary epithelial cells contributes to the pathogenesis of sclerosing cholangitis

(2021) Maria Reich et al.   JOURNAL OF HEPATOLOGY

Biliary organoids uncover delayed epithelial development and barrier function in biliary atresia

(2021) Surya P. Amarachintha et al.   HEPATOLOGY

Monocytes as potential mediators of pathogen‐induced Th17 differentiation in patients with primary sclerosing cholangitis (PSC)

(2020) Lilly Kristin Kunzmann et al.   HEPATOLOGY

Cholangiocyte pathobiology

(2019) Jesus M. Banales et al.   Nature Reviews Gastroenterology & Hepatology

Return to sender: Lymphocyte trafficking mechanisms as contributors to primary sclerosing cholangitis

(2019) Manon de Krijger et al.   JOURNAL OF HEPATOLOGY

Microfabricated blood vessels for modeling the vascular transport barrier

(2019) William J. Polacheck et al.   Nature Protocols

Isolation and propagation of primary human cholangiocyte organoids for the generation of bioengineered biliary tissue

(2019) Olivia C. Tysoe et al.   Nature Protocols

Organoids-on-a-chip

(2019) Sunghee Estelle Park et al.   SCIENCE

A Bile Duct‐on‐a‐Chip with Organ‐Level Functions

(2019) Yu Du et al.   HEPATOLOGY

The Spectrum of Reactive Cholangiocytes in Primary Sclerosing Cholangitis

(2019) Maria Eugenia Guicciardi et al.   HEPATOLOGY

Primary sclerosing cholangitis

(2018) Jessica K Dyson et al.   LANCET

IL-23 and IL-1β Drive Human Th17 Cell Differentiation and Metabolic Reprogramming in Absence of CD28 Costimulation

(2018) Shankar Revu et al.   Cell Reports

Bile-derived organoids from patients with primary sclerosing cholangitis recapitulate their inflammatory immune profile

(2018) Carol J. Soroka et al.   HEPATOLOGY

Primary sclerosing cholangitis – a comprehensive review

(2017) Tom H. Karlsen et al.   JOURNAL OF HEPATOLOGY

Multilineage communication regulates human liver bud development from pluripotency

(2017) J. Gray Camp et al.   NATURE

A non-canonical Notch complex regulates adherens junctions and vascular barrier function

(2017) William J. Polacheck et al.   NATURE

The dendritic cell-T helper 17-macrophage axis controls cholangiocyte injury and disease progression in murine and human biliary atresia

(2016) Celine S. Lages et al.   HEPATOLOGY

Primary Sclerosing Cholangitis

(2016) Konstantinos N. Lazaridis et al.   NEW ENGLAND JOURNAL OF MEDICINE

Long-Term Culture of Genome-Stable Bipotent Stem Cells from Adult Human Liver

(2015) Meritxell Huch et al.   CELL

Animal Models in Primary Biliary Cirrhosis and Primary Sclerosing Cholangitis

(2014) Marion J. Pollheimer et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Increased T helper type 17 response to pathogen stimulation in patients with primary sclerosing cholangitis

(2013) Janosch Katt et al.   HEPATOLOGY

Vascularized and functional human liver from an iPSC-derived organ bud transplant

(2013) Takanori Takebe et al.   NATURE

Biomimetic model to reconstitute angiogenic sprouting morphogenesis in vitro

(2013) D.-H. T. Nguyen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CXCR3-dependent recruitment and CCR6-mediated positioning of Th-17 cells in the inflamed liver

(2012) Ye Htun Oo et al.   JOURNAL OF HEPATOLOGY

From 3D cell culture to organs-on-chips

(2011) Dongeun Huh et al.   TRENDS IN CELL BIOLOGY

Influence of dominant bile duct stenoses and biliary infections on outcome in primary sclerosing cholangitis

(2009) Gerda Rudolph et al.   JOURNAL OF HEPATOLOGY