The Spectrum of Reactive Cholangiocytes in Primary Sclerosing Cholangitis

Cholangiocyte pathobiology

(2019) Jesus M. Banales et al.   Nature Reviews Gastroenterology & Hepatology

Invasive Ductular Reaction Operates Hepatobiliary Junctions upon Hepatocellular Injury in Rodents and Humans

(2019) Laure-Alix Clerbaux et al.   AMERICAN JOURNAL OF PATHOLOGY

YAP, but Not RSPO-LGR4/5, Signaling in Biliary Epithelial Cells Promotes a Ductular Reaction in Response to Liver Injury

(2019) Lara Planas-Paz et al.   Cell Stem Cell

Activated Hepatic Stellate Cells and Portal Fibroblasts contribute to cholestatic liver fibrosis in MDR2 knockout mice

(2019) Takahiro Nishio et al.   JOURNAL OF HEPATOLOGY

Senolytic therapies for healthy longevity

(2019) Jan M. van Deursen   SCIENCE

Mitochondrial dysfunction and cell senescence: deciphering a complex relationship

(2019) James Chapman et al.   FEBS LETTERS

Peribiliary gland niche participates in biliary tree regeneration in mouse and in human primary sclerosing cholangitis

(2019) Guido Carpino et al.   HEPATOLOGY

The transcription factor ETS1 promotes apoptosis resistance of senescent cholangiocytes by epigenetically up-regulating the apoptosis suppressor BCL2L1

(2019) Steven P. O'Hara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Secretin/Secretin Receptor Axis Modulates Ductular Reaction and Liver Fibrosis through Changes in Transforming Growth Factor (TGF)-β1–Mediated Biliary Senescence

(2018) Nan Wu et al.   AMERICAN JOURNAL OF PATHOLOGY

Macrophages contribute to the pathogenesis of sclerosing cholangitis in mice

(2018) Maria Eugenia Guicciardi et al.   JOURNAL OF HEPATOLOGY

Knockout of secretin receptor reduces biliary damage and liver fibrosis in Mdr2−/− mice by diminishing senescence of cholangiocytes

(2018) Tianhao Zhou et al.   LABORATORY INVESTIGATION

Ductular reaction in liver diseases: pathological mechanisms and translational significances

(2018) Keisaku Sato et al.   HEPATOLOGY

Nuclear Translocation of RELB is Increased in Diseased Human Liver and Promotes Ductular Reaction and Biliary Fibrosis in Mice

(2018) Christin Elßner et al.   GASTROENTEROLOGY

High-throughput sequencing identifies aetiology-dependent differences in ductular reaction in human chronic liver disease

(2018) Olivier Govaere et al.   JOURNAL OF PATHOLOGY

MerTK expressing hepatic macrophages promote the resolution of inflammation in acute liver failure

(2017) Evangelos Triantafyllou et al.   GUT

Targeting senescent cholangiocytes and activated fibroblasts with B-cell lymphoma-extra large inhibitors ameliorates fibrosis in multidrug resistance 2 gene knockout (Mdr2−/− ) mice

(2017) Anja Moncsek et al.   HEPATOLOGY

ETS Proto-oncogene 1 Transcriptionally Up-regulates the Cholangiocyte Senescence-associated Protein Cyclin-dependent Kinase Inhibitor 2A

(2017) Steven P. O'Hara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Development and characterization of cholangioids from normal and diseased human cholangiocytes as an in vitro model to study primary sclerosing cholangitis

(2017) Lorena Loarca et al.   LABORATORY INVESTIGATION

Cholangiocytes act as facultative liver stem cells during impaired hepatocyte regeneration

(2017) Alexander Raven et al.   NATURE

Biliary tract instillation of a SMAC mimetic induces TRAIL-dependent acute sclerosing cholangitis-like injury in mice

(2017) Maria Eugenia Guicciardi et al.   Cell Death & Disease

Cellular senescence mediates fibrotic pulmonary disease

(2017) Marissa J. Schafer et al.   Nature Communications

Cellular Senescence: A Translational Perspective

(2017) James L. Kirkland et al.   EBioMedicine

The characteristics of activated portal fibroblasts/myofibroblasts in liver fibrosis

(2016) Daniel Karin et al.   DIFFERENTIATION

Characterization of hepatic stellate cells, portal fibroblasts, and mesothelial cells in normal and fibrotic livers

(2016) Ingrid Lua et al.   JOURNAL OF HEPATOLOGY

Reparative inflammation takes charge of tissue regeneration

(2016) Michael Karin et al.   NATURE

Primary Sclerosing Cholangitis

(2016) Konstantinos N. Lazaridis et al.   NEW ENGLAND JOURNAL OF MEDICINE

Absence of the intestinal microbiota exacerbates hepatobiliary disease in a murine model of primary sclerosing cholangitis

(2015) James H. Tabibian et al.   HEPATOLOGY

The Cholangiopathies

(2015) Konstantinos N. Lazaridis et al.   MAYO CLINIC PROCEEDINGS

Cholangiocyte senescence by way of N-ras activation is a characteristic of primary sclerosing cholangitis

(2014) James H. Tabibian et al.   HEPATOLOGY

Characterization of cultured cholangiocytes isolated from livers of patients with primary sclerosing cholangitis

(2014) James H Tabibian et al.   LABORATORY INVESTIGATION

Origin of myofibroblasts in the fibrotic liver in mice

(2014) K. Iwaisako et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Links Between Hepatic Fibrosis, Ductular Reaction, and Progenitor Cell Expansion

(2013) Michael J. Williams et al.   GASTROENTEROLOGY

Cellular senescence and the senescent secretory phenotype: therapeutic opportunities

(2013) Tamara Tchkonia et al.   JOURNAL OF CLINICAL INVESTIGATION

Bone marrow injection stimulates hepatic ductular reactions in the absence of injury via macrophage-mediated TWEAK signaling

(2013) T. G. Bird et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immune surveillance of senescent cells--biological significance in cancer- and non-cancer pathologies

(2012) L. Hoenicke et al.   CARCINOGENESIS

The dynamic biliary epithelia: Molecules, pathways, and disease

(2012) Steven P. O’Hara et al.   JOURNAL OF HEPATOLOGY

Hepatic progenitor cell-mediated regeneration and fibrosis: Chicken or egg?

(2009) Andrew D. Clouston et al.   HEPATOLOGY

TWEAK-FN14 signaling induces lysosomal degradation of a cIAP1–TRAF2 complex to sensitize tumor cells to TNFα

(2008) James E. Vince et al.   JOURNAL OF CELL BIOLOGY