Expression of human thrombomodulin by GalTKO.hCD46 pigs modulates coagulation cascade activation by endothelial cells and during ex vivo lung perfusion with human blood

Pig endothelial protein C receptor is functionally compatible with the human protein C pathway

(2019) Evelyn J. Salvaris et al.   XENOTRANSPLANTATION

Thromboxane and histamine mediate PVR elevation during xenogeneic pig lung perfusion with human blood

(2018) Lars Burdorf et al.   XENOTRANSPLANTATION

Consistent success in life-supporting porcine cardiac xenotransplantation

(2018) Matthias Längin et al.   NATURE

Cardiac xenografts show reduced survival in the absence of transgenic human thrombomodulin expression in donor pigs

(2018) Avneesh K. Singh et al.   XENOTRANSPLANTATION

Platelet sequestration and activation during GalTKO.hCD46 pig lung perfusion by human blood is primarily mediated by GPIb, GPIIb/IIIa, and von Willebrand Factor

(2016) Lars Burdorf et al.   XENOTRANSPLANTATION

Chimeric 2C10R4 anti-CD40 antibody therapy is critical for long-term survival of GTKO.hCD46.hTBM pig-to-primate cardiac xenograft

(2016) Muhammad M. Mohiuddin et al.   Nature Communications

Functional Difference Between Membrane-bound and Soluble Human Thrombomodulin

(2015) Yuko Miwa et al.   TRANSPLANTATION

Human thrombomodulin regulates complement activation as well as the coagulation cascade in xeno-immune response

(2015) Hwajung Kim et al.   XENOTRANSPLANTATION

Pig-to-baboon heterotopic heart transplantation - exploratory preliminary experience with pigs transgenic for human thrombomodulin and comparison of three costimulation blockade-based regimens

(2015) Hayato Iwase et al.   XENOTRANSPLANTATION

Early graft failure of GalTKO pig organs in baboons is reduced by expression of a human complement pathway-regulatory protein

(2015) Agnes M. Azimzadeh et al.   XENOTRANSPLANTATION

Progress towards overcoming coagulopathy and hemostatic dysfunction associated with xenotransplantation

(2015) Peter J. Cowan et al.   International Journal of Surgery

Four-Dimensional Characterization of Thrombosis in a Live-Cell, Shear-Flow Assay: Development and Application to Xenotransplantation

(2015) Donald G. Harris et al.   PLoS One

Expression of Human CD46 Modulates Inflammation Associated With GalTKO Lung Xenograft Injury

(2014) L. Burdorf et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Pig-to-baboon liver xenoperfusion utilizing GalTKO.hCD46 pigs and glycoprotein Ib blockade

(2014) John C. LaMattina et al.   XENOTRANSPLANTATION

Development of a consensus protocol to quantify primate anti-non-Gal xenoreactive antibodies using pig aortic endothelial cells

(2014) Agnes M. Azimzadeh et al.   XENOTRANSPLANTATION

Regulatory Sequences of the Porcine THBD Gene Facilitate Endothelial-Specific Expression of Bioactive Human Thrombomodulin in Single- and Multitransgenic Pigs

(2013) Annegret Wuensch et al.   TRANSPLANTATION

Regulation of human platelet aggregation by genetically modified pig endothelial cells and thrombin inhibition

(2013) Hayato Iwase et al.   XENOTRANSPLANTATION

Cardiac xenotransplantation

(2012) Guerard W. Byrne et al.   Current Opinion in Organ Transplantation

Quantitative analysis of thrombomodulin-mediated conversion of protein C to APC: Translation from in vitro to in vivo

(2012) Ronald Carnemolla et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Production of cloned pigs expressing human thrombomodulin in endothelial cells

(2012) Satoko Yazaki et al.   XENOTRANSPLANTATION

B-Cell Depletion Extends the Survival of GTKO.hCD46Tg Pig Heart Xenografts in Baboons for up to 8 Months

(2011) M. M. Mohiuddin et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Absence of Gal epitope prolongs survival of swine lungs in an ex vivo model of hyperacute rejection

(2011) Bao-Ngoc H. Nguyen et al.   XENOTRANSPLANTATION

Molecular Intercommunication between the Complement and Coagulation Systems

(2010) U. Amara et al.   JOURNAL OF IMMUNOLOGY

Potential value of human thrombomodulin and DAF expression for coagulation control in pig-to-human xenotransplantation

(2010) Yuko Miwa et al.   XENOTRANSPLANTATION

Complement regulation in the GalT KO era

(2010) Shuji Miyagawa et al.   XENOTRANSPLANTATION

Results of Gal-Knockout Porcine Thymokidney Xenografts

(2009) A. D. Griesemer et al.   AMERICAN JOURNAL OF TRANSPLANTATION

The vascular and coagulation issues in xenotransplantation

(2009) Peter J Cowan et al.   Current Opinion in Organ Transplantation

The discovery of the endothelial cell protein C receptor

(2009) C. T. ESMON   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Pigs transgenic for human thrombomodulin have elevated production of activated protein C

(2009) Björn Petersen et al.   XENOTRANSPLANTATION

Current status of xenotransplantation and prospects for clinical application

(2009) Richard N. Pierson et al.   XENOTRANSPLANTATION

Pig Thrombomodulin Binds Human Thrombin but Is a Poor Cofactor for Activation of Human Protein C and TAFI

(2008) J. C. Roussel et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Coagulation dysregulation as a barrier to xenotransplantation in the primate

(2008) Chih Che Lin et al.   TRANSPLANT IMMUNOLOGY