Contribution of mucus concentration and secreted mucins Muc5ac and Muc5b to the pathogenesis of muco-obstructive lung disease

Acidic pH increases airway surface liquid viscosity in cystic fibrosis

(2016) Xiao Xiao Tang et al.   JOURNAL OF CLINICAL INVESTIGATION

Airway acidification initiates host defense abnormalities in cystic fibrosis mice

(2016) V. S. Shah et al.   SCIENCE

The Relationship of Mucus Concentration (Hydration) to Mucus Osmotic Pressure and Transport in Chronic Bronchitis

(2015) Wayne H. Anderson et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Endogenous airway mucins carry glycans that bind Siglec-F and induce eosinophil apoptosis

(2015) Takumi Kiwamoto et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Airway epithelial SPDEF integrates goblet cell differentiation and pulmonary Th2 inflammation

(2015) Priya Rajavelu et al.   JOURNAL OF CLINICAL INVESTIGATION

The polymeric mucin Muc5ac is required for allergic airway hyperreactivity

(2015) Christopher M. Evans et al.   Nature Communications

Immunomodulatory Cross-Talk between Conjunctival Goblet Cells and Dendritic Cells

(2015) Laura Contreras-Ruiz et al.   PLoS One

Increased expression of vascular endothelial growth factor and hypoxia inducible factor-1α in lung tissue of patients with chronic bronchitis

(2014) Seung Hyeun Lee et al.   CLINICAL BIOCHEMISTRY

Cystic fibrosis airway secretions exhibit mucin hyperconcentration and increased osmotic pressure

(2014) Ashley G. Henderson et al.   JOURNAL OF CLINICAL INVESTIGATION

Microbial sensing by goblet cells controls immune surveillance of luminal antigens in the colon

(2014) K A Knoop et al.   Mucosal Immunology

Deletion of airway cilia results in noninflammatory bronchiectasis and hyperreactive airways

(2013) Sandra K. Gilley et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Muc5b is required for airway defence

(2013) Michelle G. Roy et al.   NATURE

Mucus Enhances Gut Homeostasis and Oral Tolerance by Delivering Immunoregulatory Signals

(2013) M. Shan et al.   SCIENCE

Multi-Faceted Functions of Secretory IgA at Mucosal Surfaces

(2013) Blaise Corthésy   Frontiers in Immunology

Bicarbonate and functional CFTR channel are required for proper mucin secretion and link cystic fibrosis with its mucus phenotype

(2012) Jenny K. Gustafsson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mucus clearance, MyD88-dependent and MyD88-independent immunity modulate lung susceptibility to spontaneous bacterial infection and inflammation

(2012) A Livraghi-Butrico et al.   Mucosal Immunology

Molecular organization of the mucins and glycocalyx underlying mucus transport over mucosal surfaces of the airways

(2012) M Kesimer et al.   Mucosal Immunology

Goblet cells deliver luminal antigen to CD103+ dendritic cells in the small intestine

(2012) Jeremiah R. McDole et al.   NATURE

Genetically determined heterogeneity of lung disease in a mouse model of airway mucus obstruction

(2012) Alessandra Livraghi-Butrico et al.   PHYSIOLOGICAL GENOMICS

Overexpressing mouse model demonstrates the protective role of Muc5ac in the lungs

(2012) C. Ehre et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Periciliary Brush Promotes the Lung Health by Separating the Mucus Layer from Airway Epithelia

(2012) B. Button et al.   SCIENCE

Mucin Production during Prenatal and Postnatal Murine Lung Development

(2011) Michelle G. Roy et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Muc5ac: a critical component mediating the rejection of enteric nematodes

(2011) Sumaira Z. Hasnain et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Regulation of inducible BALT formation and contribution to immunity and pathology

(2010) S Y Foo et al.   Mucosal Immunology

Unpacking a gel-forming mucin: a view of MUC5B organization after granular release

(2009) Mehmet Kesimer et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Conditional Deletion ofDnaic1in a Murine Model of Primary Ciliary Dyskinesia Causes Chronic Rhinosinusitis

(2009) Lawrence E. Ostrowski et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Normal mouse intestinal mucus release requires cystic fibrosis transmembrane regulator–dependent bicarbonate secretion

(2009) Mary Abigail S. Garcia et al.   JOURNAL OF CLINICAL INVESTIGATION

Airway and Lung Pathology Due to Mucosal Surface Dehydration in  -Epithelial Na+ Channel-Overexpressing Mice: Role of TNF-  and IL-4R  Signaling, Influence of Neonatal Development, and Limited Efficacy of Glucocorticoid Treatment

(2009) A. Livraghi et al.   JOURNAL OF IMMUNOLOGY

Tracheobronchial air-liquid interface cell culture: a model for innate mucosal defense of the upper airways?

(2008) Mehmet Kesimer et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

MUC5B Is the Major Mucin in the Gel Phase of Sputum in Chronic Obstructive Pulmonary Disease

(2008) Sara Kirkham et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Munc13-2−/−baseline secretion defect reveals source of oligomeric mucins in mouse airways

(2008) Yunxiang Zhu et al.   JOURNAL OF PHYSIOLOGY-LONDON

Mucins in the mucosal barrier to infection

(2008) S K Linden et al.   Mucosal Immunology

Development of Chronic Bronchitis and Emphysema in β-Epithelial Na+Channel–Overexpressing Mice

(2007) Marcus A. Mall et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Structure and Function of the Polymeric Mucins in Airways Mucus

(2007) David J. Thornton et al.   Annual Review of Physiology