Recovery of walking after paralysis by regenerating characterized neurons to their natural target region

Walking naturally after spinal cord injury using a brain–spine interface

(2023) Henri Lorach et al.   NATURE

The neurons that restore walking after paralysis

(2022) Claudia Kathe et al.   NATURE

Natural and targeted circuit reorganization after spinal cord injury

(2022) Mark A. Anderson et al.   NATURE NEUROSCIENCE

Targeting Central Nervous System Regeneration with Cell Type Specificity

(2021) Mark A. Anderson   NEUROSURGERY CLINICS OF NORTH AMERICA

Conserved genetic signatures parcellate cardinal spinal neuron classes into local and projection subsets

(2021) Peter J. Osseward et al.   SCIENCE

Prioritization of cell types responsive to biological perturbations in single-cell data with Augur

(2021) Jordan W. Squair et al.   Nature Protocols

Engineering spinal cord repair

(2021) Jordan W Squair et al.   CURRENT OPINION IN BIOTECHNOLOGY

Wireless closed-loop optogenetics across the entire dorsoventral spinal cord in mice

(2021) Claudia Kathe et al.   NATURE BIOTECHNOLOGY

An active vesicle priming machinery suppresses axon regeneration upon adult CNS injury

(2021) Brett J. Hilton et al.   NEURON

Confronting false discoveries in single-cell differential expression

(2021) Jordan W. Squair et al.   Nature Communications

Injured adult neurons regress to an embryonic transcriptional growth state

(2020) Gunnar H. D. Poplawski et al.   NATURE

Brainstem neurons that command mammalian locomotor asymmetries

(2020) Jared M. Cregg et al.   NATURE NEUROSCIENCE

Cell type prioritization in single-cell data

(2020) Michael A. Skinnider et al.   NATURE BIOTECHNOLOGY

Comprehensive Integration of Single-Cell Data

(2019) Tim Stuart et al.   CELL

The mesoSPIM initiative: open-source light-sheet microscopes for imaging cleared tissue

(2019) Fabian F. Voigt et al.   NATURE METHODS

Reactivation of Dormant Relay Pathways in Injured Spinal Cord by KCC2 Manipulations

(2018) Bo Chen et al.   CELL

Dissecting spinal cord regeneration

(2018) Michael V. Sofroniew   NATURE

Cortico–reticulo–spinal circuit reorganization enables functional recovery after severe spinal cord contusion

(2018) Leonie Asboth et al.   NATURE NEUROSCIENCE

Neuronal atlas of the dorsal horn defines its architecture and links sensory input to transcriptional cell types

(2018) Martin Häring et al.   NATURE NEUROSCIENCE

Graded Arrays of Spinal and Supraspinal V2a Interneuron Subtypes Underlie Forelimb and Hindlimb Motor Control

(2018) Marito Hayashi et al.   NEURON

Injured adult motor and sensory axons regenerate into appropriate organotypic domains of neural progenitor grafts

(2018) Jennifer N. Dulin et al.   Nature Communications

Massively Parallel Single Nucleus Transcriptional Profiling Defines Spinal Cord Neurons and Their Activity during Behavior

(2018) Anupama Sathyamurthy et al.   Cell Reports

Clustering trees: a visualisation for evaluating clusterings at multiple resolutions

(2018) Luke Zappia et al.   GigaScience

Molecular Architecture of the Mouse Nervous System

(2018) Amit Zeisel et al.   CELL

Required growth facilitators propel axon regeneration across complete spinal cord injury

(2018) Mark A. Anderson et al.   NATURE

Restoration of Visual Function by Enhancing Conduction in Regenerated Axons

(2016) Fengfeng Bei et al.   CELL

Astrocyte scar formation aids central nervous system axon regeneration

(2016) Mark A. Anderson et al.   NATURE

Decoding the organization of spinal circuits that control locomotion

(2016) Ole Kiehn   NATURE REVIEWS NEUROSCIENCE

Long-Distance Descending Spinal Neurons Ensure Quadrupedal Locomotor Stability

(2016) Ludwig Ruder et al.   NEURON

Intrinsic Control of Axon Regeneration

(2016) Zhigang He et al.   NEURON

Descending Command Neurons in the Brainstem that Halt Locomotion

(2015) Julien Bouvier et al.   CELL

Pronounced species divergence in corticospinal tract reorganization and functional recovery after lateralized spinal cord injury favors primates

(2015) Lucia Friedli et al.   Science Translational Medicine

Muscle Spindle Feedback Directs Locomotor Recovery and Circuit Reorganization after Spinal Cord Injury

(2014) Aya Takeoka et al.   CELL

Motor-Circuit Communication Matrix from Spinal Cord to Brainstem Neurons Revealed by Developmental Origin

(2014) Chiara Pivetta et al.   CELL

Skilled reaching relies on a V2a propriospinal internal copy circuit

(2014) Eiman Azim et al.   NATURE

Brainstem nucleus MdV mediates skilled forelimb motor tasks

(2014) Maria Soledad Esposito et al.   NATURE

Targeting cells with single vectors using multiple-feature Boolean logic

(2014) Lief E Fenno et al.   NATURE METHODS

Advanced CLARITY for rapid and high-resolution imaging of intact tissues

(2014) Raju Tomer et al.   Nature Protocols

Lhx3-Chx10 Reticulospinal Neurons in Locomotor Circuits

(2013) F. Bretzner et al.   JOURNAL OF NEUROSCIENCE

A Novel Growth-Promoting Pathway Formed by GDNF-Overexpressing Schwann Cells Promotes Propriospinal Axonal Regeneration, Synapse Formation, and Partial Recovery of Function after Spinal Cord Injury

(2013) L.-X. Deng et al.   JOURNAL OF NEUROSCIENCE

Structural and molecular interrogation of intact biological systems

(2013) Kwanghun Chung et al.   NATURE

Locomotor Rhythm Generation Linked to the Output of Spinal Shox2 Excitatory Interneurons

(2013) Kimberly J. Dougherty et al.   NEURON

Sustained local delivery of bioactive nerve growth factor in the central nervous system via tunable diblock copolypeptide hydrogel depots

(2012) Bingbing Song et al.   BIOMATERIALS

LINC Complexes Form by Binding of Three KASH Peptides to Domain Interfaces of Trimeric SUN Proteins

(2012) Brian A. Sosa et al.   CELL

Long-Distance Growth and Connectivity of Neural Stem Cells after Severe Spinal Cord Injury

(2012) Paul Lu et al.   CELL

Motor Circuits in Action: Specification, Connectivity, and Function

(2012) Silvia Arber   NEURON

Restoring Voluntary Control of Locomotion after Paralyzing Spinal Cord Injury

(2012) R. van den Brand et al.   SCIENCE

SnapShot: Spinal Cord Development

(2011) William A. Alaynick et al.   CELL

Sustained axon regeneration induced by co-deletion of PTEN and SOCS3

(2011) Fang Sun et al.   NATURE

Functional organization of V2a-related locomotor circuits in the rodent spinal cord

(2010) Kimberly J. Dougherty et al.   Annals of the New York Academy of Sciences

Firing and Cellular Properties of V2a Interneurons in the Rodent Spinal Cord

(2010) K. J. Dougherty et al.   JOURNAL OF NEUROSCIENCE

Recovery of motoneuron and locomotor function after spinal cord injury depends on constitutive activity in 5-HT2C receptors

(2010) Katherine C Murray et al.   NATURE MEDICINE

Monosynaptic Rabies Virus Reveals Premotor Network Organization and Synaptic Specificity of Cholinergic Partition Cells

(2010) Anna E. Stepien et al.   NEURON

Measured motion: searching for simplicity in spinal locomotor networks

(2009) Sten Grillner et al.   CURRENT OPINION IN NEUROBIOLOGY

Chemotropic guidance facilitates axonal regeneration and synapse formation after spinal cord injury

(2009) Laura Taylor Alto et al.   NATURE NEUROSCIENCE

Genetic Ablation of V2a Ipsilateral Interneurons Disrupts Left-Right Locomotor Coordination in Mammalian Spinal Cord

(2008) Steven A. Crone et al.   NEURON

Recovery of supraspinal control of stepping via indirect propriospinal relay connections after spinal cord injury

(2007) Gregoire Courtine et al.   NATURE MEDICINE