Condensates of SARS-CoV-2 Nucleoprotein on Viral RNA and Their Small Molecule Modulators (A Review)

Conformational Dynamics of Intrinsically Disordered Proteins Regulate Biomolecular Condensate Chemistry

(2022) Anton Abyzov et al.   CHEMICAL REVIEWS

Phase Separation by the SARS-CoV-2 Nucleocapsid Protein: Consensus and Open Questions

(2022) Sean M. Cascarina et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A novel phosphorylation site in SARS-CoV-2 nucleocapsid regulates its RNA-binding capacity and phase separation in host cells

(2022) Junyu Wu et al.   Journal of Molecular Cell Biology

Identification of novel SARS-CoV-2 RNA dependent RNA polymerase (RdRp) inhibitors: From in silico screening to experimentally validated inhibitory activity

(2022) Tanaporn Uengwetwanit et al.   Computational and Structural Biotechnology Journal

Insights into the specificity for the interaction of the promiscuous SARS-CoV-2 nucleocapsid protein N-terminal domain with deoxyribonucleic acids

(2022) Icaro Putinhon Caruso et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Double-stranded RNA drives SARS-CoV-2 nucleocapsid protein to undergo phase separation at specific temperatures

(2022) Christine A Roden et al.   NUCLEIC ACIDS RESEARCH

Phase separation in viral infections

(2022) Haohua Li et al.   TRENDS IN MICROBIOLOGY

Structure of SARS-CoV-2 membrane protein essential for virus assembly

(2022) Zhikuan Zhang et al.   Nature Communications

A review of the effects of ATP and hydroxychloroquine on the phase separation of the SARS-CoV-2 nucleocapsid protein

(2022) Mei Dang et al.   Biophysical Reviews

Contributions of the N‐terminal intrinsically disordered region of the severe acute respiratory syndrome coronavirus 2 nucleocapsid protein to RNA‐induced phase separation

(2022) Milan Zachrdla et al.   PROTEIN SCIENCE

Nucleoside Analogs and Perylene Derivatives Modulate Phase Separation of SARS-CoV-2 N Protein and Genomic RNA In Vitro

(2022) Julia Svetlova et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The SARS-CoV-2 nucleocapsid phosphoprotein forms mutually exclusive condensates with RNA and the membrane-associated M protein

(2021) Shan Lu et al.   Nature Communications

SARS-CoV-2 nucleocapsid protein phase separates with G3BPs to disassemble stress granules and facilitate viral production

(2021) Lingling Luo et al.   Science Bulletin

SARS-CoV-2 Nucleocapsid Protein Targets RIG-I-Like Receptor Pathways to Inhibit the Induction of Interferon Response

(2021) Soo Jin Oh et al.   Cells

1,6-hexanediol rapidly immobilizes and condenses chromatin in living human cells

(2021) Yuji Itoh et al.   Life Science Alliance

Identification and functional analysis of the SARS-COV-2 nucleocapsid protein

(2021) Tianyi Gao et al.   BMC MICROBIOLOGY

The role of liquid–liquid phase separation in regulating enzyme activity

(2021) Brian G. O'Flynn et al.   CURRENT OPINION IN CELL BIOLOGY

Adenosine triphosphate energy‐independently controls protein homeostasis with unique structure and diverse mechanisms

(2021) Jianxing Song   PROTEIN SCIENCE

GCG inhibits SARS-CoV-2 replication by disrupting the liquid phase condensation of its nucleocapsid protein

(2021) Ming Zhao et al.   Nature Communications

The SARS-CoV-2 nucleocapsid protein is dynamic, disordered, and phase separates with RNA

(2021) Jasmine Cubuk et al.   Nature Communications

Understanding the phase separation characteristics of nucleocapsid protein provides a new therapeutic opportunity against SARS-CoV-2

(2021) Dan Zhao et al.   Protein & Cell

Targeting liquid–liquid phase separation of SARS-CoV-2 nucleocapsid protein promotes innate antiviral immunity by elevating MAVS activity

(2021) Shuai Wang et al.   NATURE CELL BIOLOGY

The SARS-CoV-2 Nucleocapsid Protein and Its Role in Viral Structure, Biological Functions, and a Potential Target for Drug or Vaccine Mitigation

(2021) Zhihua Bai et al.   Viruses-Basel

Structures and functions of coronavirus replication–transcription complexes and their relevance for SARS-CoV-2 drug design

(2021) Brandon Malone et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

CTD of SARS‐CoV ‐2 N protein is a cryptic domain for binding ATP and nucleic acid that interplay in modulating phase separation

(2021) Mei Dang et al.   PROTEIN SCIENCE

Determinants for intrinsically disordered protein recruitment into phase-separated protein condensates

(2021) Yongsang Jo et al.   Chemical Science

Physical Principles Underlying the Complex Biology of Intracellular Phase Transitions

(2020) Jeong-Mo Choi et al.   Annual Review of Biophysics

A unified analytical theory of heteropolymers for sequence-specific phase behaviors of polyelectrolytes and polyampholytes

(2020) Yi-Hsuan Lin et al.   JOURNAL OF CHEMICAL PHYSICS

The Architecture of SARS-CoV-2 Transcriptome

(2020) Dongwan Kim et al.   CELL

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

(2020) David E. Gordon et al.   NATURE

Composition-dependent thermodynamics of intracellular phase separation

(2020) Joshua A. Riback et al.   NATURE

Structural and functional properties of SARS-CoV-2 spike protein: potential antivirus drug development for COVID-19

(2020) Yuan Huang et al.   ACTA PHARMACOLOGICA SINICA

A proposed role for the SARS‐CoV‐2 nucleocapsid protein in the formation and regulation of biomolecular condensates

(2020) Sean M. Cascarina et al.   FASEB JOURNAL

The SARS-CoV-2 main protease as drug target

(2020) Sven Ullrich et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Molecular Architecture of the SARS-CoV-2 Virus

(2020) Hangping Yao et al.   CELL

Analysis of RNA–protein networks with RNP-MaP defines functional hubs on RNA

(2020) Chase A. Weidmann et al.   NATURE BIOTECHNOLOGY

Investigating the Structure of Neurotoxic Protein Aggregates Inside Cells

(2020) Felix J.B. Bäuerlein et al.   TRENDS IN CELL BIOLOGY

SARS‐CoV‐2 nucleocapsid protein phase‐separates with RNA and with human hnRNPs

(2020) Theodora Myrto Perdikari et al.   EMBO JOURNAL

Liquid–Liquid Phase Separation by Intrinsically Disordered Protein Regions of Viruses: Roles in Viral Life Cycle and Control of Virus–Host Interactions

(2020) Stefania Brocca et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Short- and Long-Range RNA-RNA Interactome of SARS-CoV-2

(2020) Omer Ziv et al.   MOLECULAR CELL

Genomic RNA Elements Drive Phase Separation of the SARS-CoV-2 Nucleocapsid

(2020) Christiane Iserman et al.   MOLECULAR CELL

Nucleocapsid protein of SARS-CoV-2 phase separates into RNA-rich polymerase-containing condensates

(2020) Adriana Savastano et al.   Nature Communications

SARS-CoV-2 structure and replication characterized by in situ cryo-electron tomography

(2020) Steffen Klein et al.   Nature Communications

Structural basis of RNA recognition by the SARS-CoV-2 nucleocapsid phosphoprotein

(2020) Dhurvas Chandrasekaran Dinesh et al.   PLoS Pathogens

Considerations and Challenges in Studying Liquid-Liquid Phase Separation and Biomolecular Condensates

(2019) Simon Alberti et al.   CELL

A unified mechanism for LLPS of ALS/FTLD-causing FUS as well as its modulation by ATP and oligonucleic acids

(2019) Jian Kang et al.   PLOS BIOLOGY

A Molecular Grammar Governing the Driving Forces for Phase Separation of Prion-like RNA Binding Proteins

(2018) Jie Wang et al.   CELL

Pi-Pi contacts are an overlooked protein feature relevant to phase separation

(2018) Robert McCoy Vernon et al.   eLife

ATP as a biological hydrotrope

(2017) Avinash Patel et al.   SCIENCE

Compositional Control of Phase-Separated Cellular Bodies

(2016) Salman F. Banani et al.   CELL

Lipoic acid – biological activity and therapeutic potential

(2014) Anna Gorąca et al.   Pharmacological Reports